Versus

ma:nyo Bifida Biome Complex Ampoule Versus Missha Time Revolution Night Repair Ampoule 5x

Ampoule
Ampoule
Korean Brand South Korea
Korean Brand South Korea

Updated on December 21, 2024

Overview

What they are

These products are both reef safe ampoules. They have a total of 21 ingredients in common

Cool Features

They both contain hyaluronic acid and niacinamide

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, parabens, silicones or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Bifida Biome Complex Ampoule

Bifida Ferment Lysate

Skin Conditioning
Helps hydrate Dry Skin Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Bifida Ferment Filtrate

Skin Conditioning

Lactobacillus Ferment Lysate

Skin Conditioning
Not safe for Fungal Acne Icon

Lactococcus Ferment Lysate

Skin Conditioning
Time Revolution Night Repair Ampoule 5x

Bifida Ferment Lysate

Skin Conditioning
Helps hydrate Dry Skin Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

1,2-Hexanediol

Skin Conditioning

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Betaine

Humectant
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots Icon

Propanediol

Solvent

Water

Skin Conditioning

Chondrus Crispus Extract

Skin Conditioning
Helps hydrate Dry Skin Icon

Saccharum Officinarum Extract

Moisturising

Pentylene Glycol

Skin Conditioning

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Polyquaternium-51

Skin Conditioning

Diethoxyethyl Succinate

Solvent

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Polyglyceryl-10 Laurate

Skin Conditioning
Not safe for Fungal Acne Icon

Hydrogenated Lecithin

Emulsifying

Carbomer

Emulsion Stabilising
1 / 0

Lactobacillus Ferment

Skin Conditioning

Lactobacillus Ferment Lysate

Skin Conditioning
Not safe for Fungal Acne Icon

Leuconostoc/Radish Root Ferment Filtrate

Antimicrobial
Not safe for Fungal Acne Icon

Lactococcus Ferment

Skin Conditioning

Lactobacillus/Acerola Cherry Ferment

Skin Protecting

Lactobacillus/Soybean Ferment Extract

Skin Conditioning

Lactobacillus/Punica Granatum Fruit Ferment Extract

Skin Conditioning

Lactococcus Ferment Lysate

Skin Conditioning

Bifida Ferment Filtrate

Skin Conditioning

Tromethamine

Buffering

Solanum Melongena Fruit Extract

Skin Conditioning

Daucus Carota Sativa Root Extract

Skin Conditioning

Brassica Oleracea Capitata Leaf Extract

Skin Conditioning

Beta Vulgaris Root Extract

Skin Conditioning

Vaccinium Angustifolium Fruit Extract

Skin Protecting

Ethylhexylglycerin

Skin Conditioning

Xanthan Gum

Emulsifying

Aspergillus Ferment

Skin Conditioning

Swiftlet Nest Extract

Skin Conditioning

Dextrin

Absorbent

Theobroma Cacao Extract

Skin Conditioning

Adenosine

Skin Conditioning
Good for Minimizing Pores IconGood for Scar Healing Icon

Citrus Aurantium Bergamia Fruit Oil

Masking
Fragrance IconOil Icon

Pelargonium Graveolens Flower Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Citrus Aurantium Dulcis Peel Oil

Masking
Oil Icon

Lavandula Angustifolia Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Anthemis Nobilis Flower Oil

Masking
Fragrance IconOil Icon

Santalum Album Oil

Masking
Oil IconMay cause irritation IconEU Allergen Icon

Limonene

Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Disodium EDTA

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Helianthus Annuus Seed Oil

Emollient
0 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Lupinus Albus Seed Extract

Skin Conditioning

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.

Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.

Learn more about Bifida Ferment Lysate
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.
  • It has mild preservative properties.

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Skin Conditioning

Bifida ferment filtrate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Skin Conditioning

Lactobacillus Ferment Lysate is a postbiotic with skin soothing properties. Postbiotics are inactive molecules produced by probiotic bacteria that provide skin benefits.

This ingredient comes from the secretion of the bacteria, Lactobacillus.

Studies show this ingredient can help calm redness and may help treat the signs of photoaging; however, the evidence is inconclusive and further studies are needed.

Learn more about Lactobacillus Ferment Lysate
Skin Conditioning

Lactococcus Ferment Lysate is a postbiotic created by fermenting Lactoccus lactis, a type of bacteria more commonly used to create Lactic acid.

Postbiotics are inactive molecules produced by probiotic bacteria that provide skin benefits.

This ingredient offers promising benefits, but it is relatively new and more evidence is needed to prove its efficacy. The manufacturer claims this ingredient:

A study from 2022 found this ingredient helped protect skin against damaged from UV exposure (though this should not replace your sunscreen!).

The lysate in the ingredient name refers to a fluid that forms from breaking down the cell membrane.

Learn more about Lactococcus Ferment Lysate
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Smoothing

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Learn more about Pentylene Glycol
Emollient, Skin Conditioning

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Learn more about Squalane
Emulsifying, Skin Conditioning

Hydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.

This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Buffering, Masking

Tromethamine helps balance the pH and improve the texture of a product. It is synthetically created.

As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.

Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Learn more about Tromethamine
Solvent

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin. 

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Learn more about Propanediol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Absorbent

Dextrin is used to thicken a product and helps bind ingredients together. It is created from starch and glycogen.

As an emulsifier, dextrin prevents ingredients from separating. This helps elongate a product's shelf life.

Studies show coating UV filters with dextrin prevents these ingredients from being absorbed. This helps UV ingredients last longer on the skin.

Learn more about Dextrin
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Skin Conditioning

Polyglyceryl-10 Laurate is an ester of lauric acid and Polyglycerin-10.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier. It helps gather dirt, oil, and other pollutants to be rinsed away. As an emulsifier, it helps prevent ingredients from separating, such as oil and water.

Polyglyceryl-10 Laurate may not be fungal acne safe.

Learn more about Polyglyceryl-10 Laurate
Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine

When to use

467 Routines
39% use in am
61% use in pm
92% use every day
When to use See routines that use it ->
137 Routines
10% use in am
90% use in pm
90% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

ma:nyo Bifida Biome Complex Ampoule 46 ingredients

3.8 /5
from 12 ratings
No Scent (6) Absorbs Well (5) Works Well (4)
samhoover's avatar

Samantha Hoover

5 months ago
Review

I'm in my late 20s and bought this for anti-aging because it's supposed to help with elasticity. But it's too sticky for my liking. It doesn’t irritate my skin and keeps it hydrated, so I’d recommend it for people with dry skin. Elasticity improvement isn’t something you see immediately, and my skin hasn’t lost much elasticity yet. I’m just using it for slow aging, but honestly, I don’t reach for Show more

#hydrating
#heavy
#sticky
#no scent
Tray's avatar

Tray

12 months ago
Review

WRP! I loved this serum. It was hydrating and sunk in well to my skin. My skin felt more plump and supple.

#hydrating
#absorbs well
#no scent
#works well

Missha Time Revolution Night Repair Ampoule 5x 54 ingredients

4.7 /5
from 3 ratings
Absorbs Well (2) Great Value (2) Hydrating (2)
gfunkpsych's avatar

gfunkpsych

10 months ago
Review

I have Eczema and have to be very careful about skincare products with any scents, so I was hesitant to purchase this serum. I had read that it was a dupe for the Estee Lauder’s iconic night repair serum and decided it to give it a go. To my pleasant surprise I love using it every night because of its scent. I also love it for the soft hydrated skin in the morning.

#great value
#works well
bujanabrahimi's avatar

🍯 Boo

8 months ago
Review

I got it to replace estee lauders advanced night repair serum. Tbh I didn’t see much difference in terms of quality but yet again none of them did wonders but none of them did harm.
Not purchasing again because now I have a much simpler routine.

#great value
#hydrating
#light
#absorbs well