Zeroid Dermanewal Sun Block SPF 50+

The Cosmetic Review Expert Panel has concluded the alkyl benzoate group to be safe as used in cosmetics; it wasn't found to be a skin irritant and unlikely to be absorbed due to its low water solubility.

This report recorded almost 1000 reported uses with concentrations up to 59% in leave-on products but your cosmetics will typically use 0.5-15% depending on the product.

It's often called a "SPF booster": this is because it keeps UV filters properly dissolved and evenly distributed to support a sunscreen's performance. It doesn't actually raise SPF on its own.

Overall, this ingredient is well tolerated.

This ingredient is fungal acne safe because it is an ester of benzoic acid.

Think of this ingredient as two parts stuck together: an oily part and an acid part. Malassezia only gets a meal when it can snip off a fatty acid to eat. With C12-15 Alkyl Benzoate, the acid part is benzoic acid, which isn't a fatty acid and which the yeast can't use as food.

Benzoic acid is actually used as a preservative to stop yeast from growing.

The oily part is a blend of C12-15 fatty alcohols but fatty alcohols in this size range can support only a little Malassezia growth (mostly for one species of Malassezia as well).

In the ingredient, those alcohols stay locked inside the molecule. The yeast can only reach them by snipping the benzoate bond, and that type of bond is harder for it to cut than a normal fatty bond.

So not much gets released. And whatever does get snipped comes packaged with benzoic acid, which discourages yeast growth.

You'll often see it paired with other UV filters to boost overall SPF because octisalate is a fairly week filter on its own.

The reason you'll see it so often is because it can help solubilize and stabilize the trickier filters like oxybenzone and avobenzone.

Unlike these filters, octisalate has pretty good photostability and doesn't create skin-damaging free radicals when exposed to sunlight.

The fatty-alcohol part of the molecule also gives it a light, emollient feel so it doubles as a nice texture enhancer.

Usage levels vary around the world:

Safety-wise, this ingredient has a pretty reassuring track record. The EU's Scientific Committee on Consumer Products (SCCP) found very low skin penetration in human skin tests and negative results for irritation, phototoxicity, and photoallergy.

The real-world allergy risk is pretty low too; a 2012 European study of 1,031 people recorded only 2 reactions to it (a rate of 0.19%).

You might have seen scary headlines about sunscreen getting into your blood.

In 2019, the FDA found that several chemical filters can absorb through the skin and show up in the bloodstream at small but measurable levels.

Here's the important part: these tiny levels are just a cutoff the FDA uses to decide which ingredients need more testing and doesn't mean anything harmful was found.

The researchers were clear that the results are no reason to stop wearing sunscreen.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Titanium dioxide provides broad-spectrum protection mostly in the UVB and UVAII range, with some protection in the UVAI range.

While its UVA protection isn’t as strong as zinc oxide’s, the difference is minor.

A common myth is that mineral UV filters reflect UV light. However, modern research shows titanium dioxide absorbs UV radiation like chemical filters (~95% absorption & 5% reflection).

Thanks to its non-irritating nature, titanium dioxide is suitable for sensitive, acne-prone, or redness-prone skin. It is unlikely to cause "eye sting" like other sunscreen ingredients.

A major drawback of this ingredient is its white cast and thick texture. This is why mineral sunscreens often leave a white cast and are less cosmetically elegant than chemical/hybrid sunscreens.

To improve white cast and spreadability, micronized or nano-sized titanium dioxide is often used.

There are ongoing concerns surrounding nano-titanium oxide's impact on marine ecosystems.

There is no conclusive evidence that any form of titanium oxide (or any other sunscreen ingredients) will cause harm to marine ecosystems or coral reefs. The science is still developing but many consumers are keeping a close eye on this issue.

Please note, many destinations have reef-safety sunscreen rules. For instance, the U.S. Virgin Islands advises all visitors to use non-nano mineral sunscreens.

Nano mineral sunscreens once raised safety concerns about absorption into skin.

Extensive research has shown that they do not penetrate healthy or damaged skin; they remain safely on the surface and the top layer of dead skin (stratum corneum).

You'll likely find titanium dioxide bundled with alumina, silica, or dimethicone. These ingredients help make titanium dioxide highly photostable; this prevents it from interacting with other formula components under UV light.

The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics

There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.

Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.

The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.

This ingredient is volatile which means it will mostly evaporate (but it evaporates slower than older cyclomethicones, like Cyclotetrasiloxane).

Typical concentration ranges from 1-30% depending on if it's being used to tweak the feel of a product or acting as the main emollient.

Due to it being water-soluble, Ensulizole helps give sunscreens a light and non-oily texture.

Ensulizole is approved worldwide:

Another pro?

It's exceptionally photostable, barely degrades in sunlight, and acts as a "bodyguard" for less stable filters.

That's why you'll see it paired with avobenzone or octinoxate; this team up ensures they keep working through sun exposure.

Safety reviews have been reassuring across the board. This ingredient shows low absorption through the skin, rarely irritates, and lab studies found it doesn't act like a hormone in the body (a concern that's been raised about some older sunscreen filters).

On maximum concentrations:

In 2026, the US F.D.A finally added it as an OTC sunscreen ingredient at concentrations up to 6% for adults / children 6 months and older

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Another great benefit? This ingredient is highly photostable so it won't degrade easily under sunlight.

A common myth is that mineral UV filters are widely believed to primarily reflect UV light.

However, modern research shows titanium dioxide absorbs UV radiation like chemical filters (~95% absorption & 5% reflection).

Zinc oxide has great skin soothing properties so you'll likely find this in sunscreens formulated for sensitive skin or babies/children. It is unlikely to cause "eye sting" like other sunscreen ingredients.
Regulatory agencies consider zinc oxide to be non-toxic and safe. It has also been shown to not penetrate the skin.

Unfortunately, this ingredient does leave a visible white cast. This is why mineral sunscreens are often less cosmetically elegant than chemical or hybrid ones.

In cosmetics, zinc oxide can be found in both non-nano and nano-sized forms. The nano version is used to reduce white cast and improve the texture of sunscreen formulas.

There are ongoing concerns surrounding nano-zinc oxide's impact on marine ecosystems and whether it can be absorbed into skin.

Regarding marine ecosystems and coral reefs, there is no conclusive evidence that any form of zinc oxide (or any other sunscreen ingredients) will cause harm. The science is still developing but many consumers are keeping a close eye on this issue.

Please note, many destinations have reef-safety sunscreen rules. For instance, the U.S. Virgin Islands advises all visitors to use non-nano mineral sunscreens.

There has also been some stir about whether micronized or nano zinc oxide has potential photoxicity and absorption through the skin/lungs.

An in-vitro (done in a test tube or petri dish) study demonstrated micronized zinc oxide to have potential phototoxicity. There's no need to fret; the EU Commission's Scientific Committee on Consumer Safety has stated, "The relevance of these findings needs to be clarified by appropriate investigations in vivo." Or in other words, further studies done on living organisms are needed to prove this.

Current research shows zinc oxide nanoparticles do not penetrate intact or sunburned skin. They either remain on the surface or in the outermost layer of dead skin (stratum corneum).

Zinc oxide is one of only two classified mineral UV filters with titanium dioxide being the other one.

Fun fact: Zinc has been used throughout history as an ingredient in paint and medicine. An Indian text from 500BC is believed to list zinc oxide as a salve for open wound. The Ancient Greek physician Dioscorides has also mentioned the use of zinc as an ointment in 1AD.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient.

You might see this ingredient used in scrubs as a primary exfoliating ingredient.

Your skin's outermost layer (stratum corneum) is often described as a "brick wall" where skin cells are bricks and lipids hold everything together. Your lipids are Ceramides, Cholesterol, and free fatty acids.

These fatty acids are not just randomly squished together. They're arranged in very specific layered (lamellar) structures. Your barrier suffers when the layer structure gets disrupted from things like eczema, harsh weather, or over-exfoliating.

M/PO/AM is formulated within MLE technology to closely replicate your skin's natural layers, setting it apart from other ceramides.

The research behind M/PO/AM is pretty solid for eczema, aka atopic dermatitis. A 2003 study on children with eczema found that an MLE cream containing M/PO/AM outperformed a standard urea-based moisturizer. The study also found a 31-35% decrease in severity index compared to smaller improvements from the control cream.

Recently, a 2024 trial found that combining M/PO/AM with topical corticosteroid led to better outcomes than using the steroid alone. The trial noted improvements in skin hydration, dryness, itching, and quality of life scores.

Research has also shown that M/PO/AM can help reduce barrier-damaging side effects of long term topical steroid use.

This ingredient also goes by the trade name PC-9S. No notable allergy concerns have been flagged for this ingredient in the published literature.

They work by fitting perfectly into your stratum corneum's lipid matrix since they're structurally similar to cholesterol. Here, they reinforce your skin's barrier.

One small in vivo human study showed topical soybean phytosterols sped up barrier recovery within three days on tape-stripped skin.

Broader research credits them with:

Formulation use typically sit under 5%.

Testing in soy-allergic subjects found no sensitization signals, but be sure to patch test if you are unsure or have existing allergies.

Studies show the compounds in centella help with:

The combination of all these properties makes centella effective at soothing, hydrating, and protecting the skin.

Other great components of centella include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.

Typical concentrations range from 0.1-3%.

This ingredient is mild and non-irritating in nature.

Because it is derived from ricinoleic acid, this ingredient may not be fungal acne safe. Ricinoleic acid is an unsaturated fatty acid that the Malassezia yeast can metabolize.

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Depending on the concentration, it can drastically change the texture of a product from pasty solid (like lipstick) to sprayable liquid.

The CIR Expert Panel for Cosmetic Ingredient Safety has concluded this ingredient to be safe in cosmetics. The highest reported use concentration is 14.2% in lipsticks.

One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.

For most people, this is a well-tolerated and lightweight ingredient.

This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.

This ingredient is generally considered non-toxic, non-irritating, and has low absorption potential.

You might have heard that this ingredient clogs pores. This reputation comes from the older rabbit ear studies which are more sensitive than human skin to clogging.

Dermatologist Dr. Zoe Draelos has also confirmed in a peer-reviewed paper that products containing comedogenic ingredients are not necessarily comedogenic themselves.

A small subset of people (~2%) may experience contact sensitivity so patch testing is a reasonable idea if you have reactive skin.

Since this ingredient is an ester of myristic acid (a C14 fatty acid), it falls within the carbon chain range that is known to feed Malassezia. This ingredient may not be fungal acne safe.

This ingredient is sourced from plant-based oils like soybean or rapeseed.

Clinical studies found no signs of irritation from this ingredient.

Since Isostearic Acid is an 18-carbon fatty acid, it is in the range that Malassezia can feed on. This ingredient may not be fungal acne safe.

You might have seen sources that this ingredient is comedogenic. The original comedogenic testing on rabbit ear actually tested the ester, Isopropyl Isostearate and not Isostearic acid itself. There has been no comedogenic testing done on this ingredient, but it may be worth patch testing if you have acne-prone skin.

You'll typically find this ingredient in amounts between 0.1-20%.

According to manufacturers, this ingredient is an emollient and humectant. This means it helps hydrate the skin.

In medicine, this ingredient is used to help relieve heartburn and help heal ulcers.

There is currently no credible scientific evidence linking aluminum hydroxide in cosmetics to increased cancer risk.

Major health organizations allow the use of aluminum hydroxide in personal care products and have not flagged it as a carcinogenic risk at typical usage levels.

Although “aluminum” in an ingredient name can raise red flags for some consumers, the form and usage context matter significantly.

For typical topical applications, there is no substantial evidence of health risks - such as cancer, neurotoxicity, or systemic “aluminum overload.”

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

The Cosmetic Ingredient Review has found 4% of this ingredient in repeat-insult patch tests on humans to be non-sensitizing. There is a caveat that some reactions have shown up in patients with damaged or diseased skin.

Because it is an ester of a C18 fatty acid, it falls into the C11-24 range that the Malassezia yeast can metabolize. This means this ingredient may not be fungal acne safe.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.