Sesderma Sespanthenol Gel Cream
A moisturizer with 48 ingredients, including retinoid, vitamin E, and hyaluronic acid.
Overview
What it is
General moisturizer with 48 ingredients that contains hyaluronic acid, peptides, retinoid and Vitamin E
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any common allergens or parabens
Fun facts
Sesderma is from Spain.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningPropanediol
SolventTriticum Vulgare Germ Extract
Skin ConditioningArachidyl Alcohol
EmollientCyclopentasiloxane
EmollientC10-18 Triglycerides
EmollientPanthenol
Skin ConditioningBehenyl Alcohol
EmollientSesamum Indicum Seed Oil
EmollientArachidyl Glucoside
EmulsifyingZinc Chloride
SoothingTranexamic Acid
AstringentSuccinic Acid
BufferingSodium Hyaluronate
HumectantGlycyrrhetinic Acid
Skin ConditioningCopper Sulfate
Skin ConditioningBoswellia Serrata Gum
MaskingNicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1
Skin ConditioningTriethanolamine
BufferingTocopheryl Acetate
AntioxidantCetyl Alcohol
EmollientDipropylene Glycol
MaskingLecithin
EmollientAcrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingAlcohol
AntimicrobialCarbomer
Emulsion StabilisingC13-14 Isoparaffin
EmollientPolysorbate 20
EmulsifyingDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningDisodium EDTA
BHT
AntioxidantDimethicone
EmollientPolysilicone-11
Laureth-7
EmulsifyingButylene Glycol
HumectantPantolactone
HumectantSodium Chloride
MaskingSodium Cholate
Skin ConditioningDecyl Glucoside
CleansingRetinyl Palmitate
Skin ConditioningDipotassium Phosphate
BufferingHexylene Glycol
EmulsifyingCaprylyl Glycol
EmollientPotassium Phosphate
BufferingTocopherol
AntioxidantPhenoxyethanol
PreservativeEthylhexylglycerin
Skin ConditioningParfum
MaskingWater, Propanediol, Triticum Vulgare Germ Extract, Arachidyl Alcohol, Cyclopentasiloxane, C10-18 Triglycerides, Panthenol, Behenyl Alcohol, Sesamum Indicum Seed Oil, Arachidyl Glucoside, Zinc Chloride, Tranexamic Acid, Succinic Acid, Sodium Hyaluronate, Glycyrrhetinic Acid, Copper Sulfate, Boswellia Serrata Gum, Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1, Triethanolamine, Tocopheryl Acetate, Cetyl Alcohol, Dipropylene Glycol, Lecithin, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Alcohol, Carbomer, C13-14 Isoparaffin, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Disodium EDTA, BHT, Dimethicone, Polysilicone-11, Laureth-7, Butylene Glycol, Pantolactone, Sodium Chloride, Sodium Cholate, Decyl Glucoside, Retinyl Palmitate, Dipotassium Phosphate, Hexylene Glycol, Caprylyl Glycol, Potassium Phosphate, Tocopherol, Phenoxyethanol, Ethylhexylglycerin, Parfum
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolThis ingredient is extracted from the germ part of the wheat plant. The germ of a plant refers to the seed embryo, or part that sprouts into a new plant.
Some studies have found wheat germ to help with wound healing.
Arachidyl Alcohol is a fatty alcohol made from peanut oil. It is an emollient, emulsifier, and thickener.
You'll most likely find this ingredient as an emulsifier in water-based cosmetics.
Cyclopentasiloxane, or D5, is a silicone used to improve texture of products and trap moisture.
D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.
It is also an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.
Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.
Learn more about CyclopentasiloxaneC10-18 Triglycerides is a skin conditioning and texture-enhancer.
It is created from glycerin and a mixture of C10-18 fatty acids.
This ingredient improves spreadability and helps thicken a product.
According to manufacturers, it usually comes from vegetable-based saturated fatty acids. Common bases for this ingredient are coconut oil, palm kernel oil, or both.
Due to the melting point being close to skin temperature, it is usually used in lip products.
Triglycerides are a main component of fat in the human body.
Learn more about C10-18 TriglyceridesPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolBehenyl Alcohol is a type of fatty alcohol (these are different from the drying, solvent alcohols).
Fatty Alcohols have hydrating properties and are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils; behenyl alcohol is derived from the fats of vegetable oils.
Emollients help keep your skin soft and hydrated by creating a film that traps moisture in.
In 2000, Behenyl Alcohol was approved by the US as medicine to reduce the duration of cold sores.
Learn more about Behenyl AlcoholSesame oil comes from sesame seeds. Sesame oil is rich in fatty acids and Vitamin E.
It has antibacterial, antioxidant, and anti-inflammatory properties. The phenolic compounds of this ingredient (including vitamin E) give it these properties.
Unrefined sesame oil has a comedogenic rating of 3, while refined sesame oil has a rating of 1. This ingredient may not be fungal-acne safe.
The fatty acids in sesame oil include linoleic acid (41%), oleic acid (39%), palmitic acid (8%), stearic acid (5%), and some small traces of others.
Learn more about Sesamum Indicum Seed OilWe don't have a description for Arachidyl Glucoside yet.
We don't have a description for Zinc Chloride yet.
Tranexamic Acid is best used for treating hyperpigmentation, discoloration, and melasma. It can also help build a stronger skin barrier.
Once applied, Tranexamic Acid starts decreasing inflammation from UV exposure. Tranexamic Acid also prevents our skin cells from meeting the pigment production cells.
Its brightening property makes it great at reducing the appearance of acne scars and marks.
Fun fact: Tranexamic Acid is also a medication used to reduce heavy bleeding.
This acid is derived from lysine, an amino acid.
Learn more about Tranexamic AcidSuccinic acid is an odorless white powder. It is naturally found in our bodies but can also be derived from living organisms.
Succinic acid is water-soluble. The pH level of this ingredient is between 4.2 and 5.6.
While succinic acid posesses antimicrobial, antioxidant, and anti-inflammatory properties, these properties have not been studied in skincare products.
Fun fact: Succinic acid was known as the 'spirit of amber' in the past. This is because it used to be derived from distilling amber.
Learn more about Succinic AcidSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateGlycyrrhetinic acid is a compound found in licorice. It has skin conditioning, skin soothing, antibacterial, and antioxidant properties.
Not only is this a great ingredient for soothing inflammation, studies show this compound is effective at protecting skin against UV-B induced damage.
Fun fact: This ingredient is also used to mask the bitter taste of medicine.
Learn more about Glycyrrhetinic AcidCopper Sulfate is a type of sulfate.
Boswellia Serrata Gum is a fragrance.
Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1 is a peptide.
Triethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.
As an emulsifier, it prevents ingredients from separating and enhances texture by adding volume to a product.
PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.
Learn more about TriethanolamineTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateCetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Cetyl AlcoholDipropylene Glycol is a synthetically created stabilizer and solvent. It is a part of the glycol class in the alcohol family.
Dipropylene Glycol helps dissolve and evenly distribute ingredients. It also helps decrease viscosity and thin out texture.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolLecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.
This ingredient has emollient and emulsifying properties.
As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.
As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.
This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.
Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.
We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.
Some other names for this ingredient include soy lecithin and deoiled soy lecithin.
Learn more about LecithinWe don't have a description for Acrylamide/Sodium Acryloyldimethyltaurate Copolymer yet.
Alcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is usually an astringent alcohol.
These alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.
Other types of astringent alcohols include:
According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.
Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.
Fatty alcohols come from plant oils such as coconut oil. These can help hydrate the skin and are non-irritating. Some fatty alcohols include cetyl and stearyl alcohol.
Learn more about AlcoholCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
This ingredient is also known as "C13-14 Isoalkane".
C13-14 Isoparaffin is created from petroleum-based mineral oils. It is an emollient and helps thicken a product.
As an emollient, it helps keep the skin soft and smooth by creating a barrier on top. This barrier traps moisture in, keeping the skin hydrated.
C13-14 Isoparaffin may not be fungal-acne safe.
Learn more about C13-14 IsoparaffinPolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20This ingredient is a silicone used to improve the texture of products and absorb oil. It does not get absorbed into the skin.
Like other silicones, Dimethicone/Vinyl Dimethicone Crosspolymer helps condition the skin by creating a barrier. In this sense, it can act as an emollient and trap moisture in.
This ingredient is a type of elastomer.
Learn more about Dimethicone/Vinyl Dimethicone CrosspolymerDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTABHT is a synthetic antioxidant and preservative.
As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.
As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.
The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.
However, it was recently restricted for use in the UK as of April 2024.
Learn more about BHTDimethicone is a type of synthetic silicone created from natural materials such as quartz.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeWe don't have a description for Polysilicone-11 yet.
Laureth-7 is created by the ethoxylation of lauryl alcohol using ethylene oxide. Lauryl alcohol is a fatty alcohol with hydrating properties.
This ingredient is an emulsifier and cleansing ingredient. As an emulsifier, it is used to prevent ingredients from separating. It also helps cleanse the skin by gathering dirt, oil, and pollutants to be rinsed away.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolPantolactone is a synthetically created humectant.
As a humectant, Pantolactone helps draw moisture to the skin. It can help add hydration to your skin.
Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.
This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.
The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.
Scrubs may use salt as the primary exfoliating ingredient.
Learn more about Sodium ChlorideWe don't have a description for Sodium Cholate yet.
Decyl Glucoside is a glucose-based surfactant and emulsion stabilizer. It is created by reacting glucose with the fatty acids from plants.
Surfactants help clean the skin by trapping oil, sebum, and dirt to be washed away. As an emulsion stabilizer, it stabilizes the ingredients in a product by preventing them from separating.
This ingredient is biodegradable and non-toxic. This ingredient is commonly found in baby shampoos.
Decyl Glucoside is sometimes used to stabilize the UV filter Tinosorb.
Learn more about Decyl GlucosideRetinyl palmitate is a form of retinoid. Retinoids are the superstar class of anti-aging ingredients that include tretinoin and retinol.
This particular ingredient has had a bumpy year with its rise and fall in popularity.
First, Retinyl palmitate is created from palmitic acid and retinol. It is a retinol ester and considered one of the weaker forms of retinoid.
This is because all retinoids have to be converted to Tretinoin, AKA retinoic acid. Retinyl Palmitate is pretty far down the line and has to go through multiple conversions before its effects are seen.
Due to this long and ineffective conversion line, the benefits of Retinyl Palmitate are debated.
Studies show Retinyl Palmitate to help:
Dermatologists say this ingredient is ineffective because it isn't used in high enough concentrations in cosmetics.
This ingredient used to be found in sunscreens to boost the efficacy of sunscreen filters.
The downfall of Retinyl Palmitate was due to released reports about the ingredient being correlated to sun damage and skin tumors.
While there is a study showing this ingredient to cause DNA damage when exposed to UV-A, there is no concrete proof of it being linked to skin cancer. It is safe to use when used correctly.
All retinoids increase your skin's sensitivity to the sun in the first few months of usage. Be especially careful with reapplying sunscreen when using any form of retinoid.
Currently, this ingredient is still allowed in cosmetics all over the world. In Canada, cosmetics must have a warning label stating the product to contain Retinyl Palmitate
Fun fact: This ingredient is often added to low-fat milk to increase the levels of Vitamin A.
Learn more about Retinyl PalmitateDipotassium Phosphate is an inorganic salt. This just means it has a different structure than organic salts. It is a stabilizing and pH adjusting ingredient.
This ingredient is soluble in water.
Hexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.
As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.
As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.
Hexylene Glycol has a small molecular weight.
Learn more about Hexylene GlycolCaprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolPotassium Phosphate is the term for the salts of potassium and phosphate ions. Our bodies naturally create and use potassium phosphate.
In cosmetics, potassium phosphate is used to adjust the pH level of products. Our skin has a natural pH level. Maintaining this pH level is important for our skin barrier. If the skin barrier is disrupted, our skin can experience dehydration and irritation.
This ingredient is used in medicine to help treat low blood levels of phosphorus.
Learn more about Potassium PhosphateTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumReviews
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Where it's from
Sesderma is a Spanish brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Published July 25, 2025 • Added by renatagrismanauskaite