Explore Routine Login
Versus

Differin Adapalene Gel 0.1% Acne Treatment Versus Medik8 R-Retinoate Intense

Facial Treatment
Facial Treatment
American Brand United States
British Brand United Kingdom

Updated on May 16, 2024

Overview

What they are

These products are both facial treatments. They have a total of 3 ingredients in common

Cool Features

They both contain retinoid

Suited For

They're both likely to be good for fighting acne and anti aging

Free From

They both do not contain any harsh alcohols or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Notable Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Adapalene Gel 0.1% Acne Treatment
Adapalene
Retinoid IconHelps with Anti-Aging IconHelps fight Acne IconMay cause irritation IconMay worsen Rosacea Icon
RetinoidRetinoid Icon 2 Benefits 2 Concerns

Adapalene is a type of retinoid and common acne treatment.

Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Methylparaben Preservative
0 / 0 Preservative IconParaben IconNon-Reef-Safe IconMay worsen Eczema Icon
PreservativePreservative Icon ParabenParaben Icon 2 Concerns

Methylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.

0 Com. / 0 Irr.
Very Disliked Full details ->
Poloxamer 182 Emulsifying

We don't have a description for Poloxamer 182.

Unknown Full details ->
Propylene Glycol Humectant, Skin Conditioning, Solvent
0 / 0 May worsen Eczema Icon
May worsen EczemaMay worsen Eczema Icon

Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.

0 Com. / 0 Irr.
Disliked Full details ->
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Sodium Hydroxide Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

R-Retinoate Intense
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Caprylic/Capric Triglyceride Masking, Skin Conditioning

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Isododecane Emollient, Solvent

Isododecane is a fragrance, emollient, and solvent.

Disliked Full details ->
Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Cetearyl Alcohol Emollient, Emulsifying, Emulsion Stabilising
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
Fatty AlcoholFatty Alcohol Icon 3 Concerns

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

2 Com. / 1 Irr.
Very Disliked Full details ->
Dimethicone Emollient, Skin Conditioning, Skin Protecting
1 / 0 Silicon Icon
SiliconSilicon Icon

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

1 Com. / 0 Irr.
Very Disliked Full details ->
Cetearyl Olivate
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Cetearyl Olivate is an emulsifier and texture enhancer. It is derived from the fatty acids of olive oil and Cetearyl alcohol, and is biodegradable.

Disliked Full details ->
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Emulsion Stabilising

This long ingredient is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers.

Disliked Full details ->
Polylactic Acid Abrasive
Exfoliant Icon
ExfoliantExfoliant Icon

Polylactic Acid is an exfoliant.

Unknown Full details ->
Cyclodextrin Absorbent

We don't have a description for Cyclodextrin.

Unknown Full details ->
Ppg-12/Smdi Copolymer Emollient, Skin Conditioning

We don't have a description for Ppg-12/Smdi Copolymer.

Unknown Full details ->
Sorbitan Olivate Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

Very Disliked Full details ->
Titanium Dioxide Cosmetic Colorant, UV Absorber, UV Filter
0 / 0 Mineral UV Filter IconNon-Reef-Safe Icon
Mineral UV FilterMineral UV Filter Icon Non-Reef-SafeNon-Reef-Safe Icon

Titanium dioxide is known for its UVA and UVB protection properties. It is non-comedogenic and non-irritating. Titanium Dioxide is a physical sunscreen. Physical sunscreens reflect light and prevent it from reaching your skin.

0 Com. / 0 Irr.
Eclipta Prostrata Extract Skin Conditioning

We don't have a description for Eclipta Prostrata Extract.

Phenethyl Alcohol Masking

Phenethyl Alcohol is a colorless and aromatic alohol. It is naturally occuring in essential oils.

Very Disliked Full details ->
Melia Azadirachta Leaf Extract Skin Conditioning

Melia Azadirachta Leaf Extract is extract from the neem plant.

Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Cholesteryl Nonanoate Emollient

We don't have a description for Cholesteryl Nonanoate.

Unknown Full details ->
Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon Helps brighten skinHelps brighten skin Icon

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Rubus Chamaemorus Seed Oil Skin Conditioning
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Rubus Chamaemorus Seed Oil is an oil and isn't fungal acne safe.

Canola Oil Emollient, Skin Conditioning
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Canola Oil is Rapeseed oil with low amounts of erucic acid. It is an emollient and helps hydrate the skin. Emollients help hydrate and soften your skin by trapping moisture.

Disliked Full details ->
Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->
Pentylene Glycol Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

Retinal Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconCan worsen Dry Skin IconMay cause irritation IconMay worsen Rosacea Icon
RetinoidRetinoid Icon 7 Benefits 3 Concerns

Retinal is a form of retinoid. Retinoids are the gold-standard class of anti-aging ingredients.

Retinyl Retinoate Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconCan worsen Dry Skin IconMay cause irritation Icon
RetinoidRetinoid Icon 7 Benefits 2 Concerns

Retinyl Retinoate is a form of retinoid. It can be good for be good for oily skin. It can help to improve skin texture, reduce large pores, reduce the effects of aging, reduce the visibility of dark spots, heal scars, and fight acne. It can be bad for dry skin and cause irritation.

Citric Acid Buffering, Masking
AHA IconGood for Skin Texture IconGood for Minimizing Pores IconGood for Scar Healing IconHelps brighten skin IconMay cause irritation IconMay worsen Rosacea Icon
AHAAHA Icon 4 Benefits 2 Concerns

Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).

Disliked Full details ->
Alumina Abrasive, Absorbent
Exfoliant Icon
ExfoliantExfoliant Icon

Alumina is another name for the compound aluminum oxide. It is used as a thickener, absorbent, and abrasive.

Very Disliked Full details ->
Isostearic Acid Cleansing, Emulsifying
Bad for Acne Prone Skin IconNot safe for Fungal Acne Icon
2 Concerns

Isostearic acid is a saturated fatty acid. Its structure makes it a great surfactant.

Very Disliked Full details ->
Lecithin Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.

Disliked Full details ->
Polyglyceryl-3 Polyricinoleate Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

This ingredient is an emulsifier. It is created from Polyglycerin-3 and Ricinoleic Acid.

Very Disliked Full details ->
Polyhydroxystearic Acid Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polyhydroxystearic Acid is a soft wax made from castor oil.

Disliked Full details ->
Stearic Acid Cleansing, Emulsifying, Emulsion Stabilising
2-3 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Stearic Acid is a fatty acid. It is an emollient, emulsifier, and texture enhancer.

2-3 Com. / 0 Irr.
Very Disliked Full details ->
Ceramide AP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide AP is a type of Ceramide.

Moringa Oleifera Seed Oil Emollient, Skin Conditioning
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Moringa Oleifera Seed Oil is the oil expressed from the seeds of Moringa oleifera plant. It is more commonly known as Moringa seed oil.

Sodium Lauroyl Lactylate Emulsifying

Sodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.

Vanilla Planifolia Fruit Extract Skin Conditioning, Skin Protecting, Smoothing

Vanilla Planifolia Fruit Extract comes from the vanilla orchid native to central America. It is a skin-soothing ingredient.

Ethylhexylglycerin Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

Linoleic Acid Cleansing, Emollient, Skin Conditioning
Helps hydrate Dry Skin IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon 3 Concerns

Linoleic Acid is Vitamin F and a fatty acid. It is an emollient and helps thicken texture. Linoleic acid helps with hydrating skin and nourishing the skin's barrier. The top layer of skin, or epidermis, contains high amounts of linoleic acid naturally.

Palmitic Acid Emollient, Emulsifying
2 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Palmitic Acid is a fatty acid found in our skin. In cosmetics, it is usually derived from palm oil. It is a cleanser, emollient, and emulsifier.

2 Com. / 0 Irr.
Very Disliked Full details ->
Ceramide NP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide NP is a type of ceramide.

Daucus Carota Sativa Seed Oil Emollient, Masking, Skin Conditioning
Oil Icon
OilOil Icon

Daucus Carota Sativa Seed Oil is the oil obtained from the seed of the edible carrot. The oil is created by steaming and distilling the seeds of the plant.

Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Phytosterols Skin Conditioning

We don't have a description for Phytosterols.

Lonicera Japonica Flower Extract Skin Conditioning

Lonicera Japonica Flower Extract comes from the honeysuckle flower.

3-O-Ethyl Ascorbic Acid Skin Conditioning
Vitamin C IconHelps reduce Skin Redness IconGood for Skin Texture IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing Icon
Vitamin CVitamin C Icon 5 Benefits

You might know this ingredient as Ethyl Ascorbic Acid, a more stable version of ascorbic acid.

Lonicera Caprifolium Flower Extract Perfuming, Skin Conditioning
Fragrance Icon
FragranceFragrance Icon

This Honeysuckle flower extract comes from the Italian honeysuckle. It is an antioxidant, antimicrobial, and fragrance.

Sodium Polyaspartate Humectant, Skin Conditioning

We don't have a description for Sodium Polyaspartate.

Unknown Full details ->
Phytosphingosine Skin Conditioning

Phytosphingosine is a phospholipid naturally found in our skin. It helps moisturize, soothe, and protect skin.

Parfum Masking, Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon
FragranceFragrance Icon 2 Concerns

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Very Disliked Full details ->
Copper Palmitoyl Heptapeptide-14 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

This peptide is the copper salt and formed by reacting palmitic acid and heptapeptide-14.

Heptapeptide-15 Palmitate Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Heptapeptide-15 Palmitate isn't fungal acne safe and is a peptide.

Ceramide EOP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide EOP is a type of Ceramide.

Cholesterol Emollient, Emulsifying, Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness Icon
2 Benefits

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

0 Com. / 0 Irr.
C12-16 Alcohols Emollient, Emulsion Stabilising

We don't have a description for C12-16 Alcohols.

Very Disliked Full details ->
Caprylyl Glycol Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Hydrogenated Lecithin Emulsifying, Skin Conditioning

Hydrogenated Lecithin is created from the hydrogenation of lecithin. Hydrogenation is a chemical reaction between molecule hydrogen and another element.

Glyceryl Caprylate Emollient, Emulsifying

Glyceryl Caprylate comes from glycerin and caprylic acid, a fatty acid from coconut.

Lactic Acid/Glycolic Acid Copolymer Skin Conditioning

We don't have a description for Lactic Acid/Glycolic Acid Copolymer.

Polyvinyl Alcohol

We don't have a description for Polyvinyl Alcohol.

Very Disliked Full details ->
Phenylpropanol Masking, Perfuming, Solvent
Fragrance Icon
FragranceFragrance Icon

Phenylpropanol is a fragrance.

Disliked Full details ->
BHA Antioxidant, Masking
Antioxidant Icon
AntioxidantAntioxidant Icon

This BHA stands for butylated hydroxyanisole. If you are looking for the beta-hydroxy acid, aka as Salicylic Acid, click here.

Limonene Perfuming, Solvent
Fragrance Icon
FragranceFragrance Icon

Limonene is a fragrance that adds scent and taste to a formulation.

Very Disliked Full details ->
Linalool Perfuming
Fragrance IconMay cause irritation IconEU Allergen Icon
FragranceFragrance Icon 2 Concerns

Linalool is a fragrance and helps add scent to products. It's derived from common plants such as cinnamon, mint, citrus, and lavender.

Very Disliked Full details ->
Citral Perfuming
Fragrance IconEU Allergen Icon
FragranceFragrance Icon EU AllergenEU Allergen Icon

Citral is a fragrance and used to add a lemon-like scent to products. It is both naturally found in plants and created synthetically. In plants, it is commonly occurring in lemon myrtle, lemongrass, lemon tea-tree, lemon verbena, and other citruses.

Unknown Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Emulsion Stabilising, Gel Forming
Disliked

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

Carbomer is commonly found in many types of cosmetics products. It is found to be safe in concentrations up to 15%. However, a high amount of carbomer can cause pilling or balling up of products. Most products contain 1% of less of carbomer.

Disliked

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Ingredient Ratings

Here's what our community thinks of the ingredients in these products.

Adapalene Gel 0.1% Acne Treatment
2
1
4
1
liked
mixed
disliked
not rated
R-Retinoate Intense
26
10
26
6
liked
mixed
disliked
not rated

When to use

1,894 Routines
8% use in am
92% use in pm
75% use every day
When to use See routines that use it ->
3 Routines
0% use in am
100% use in pm
67% use every day

Reviews

Here's what our community thinks

Differin Adapalene Gel 0.1% Acne Treatment 8 ingredients

4.8 /5
from 17 ratings
Absorbs Well (4) Works Well (4) Light (3)
BrittBrine's avatar

BrittBrine

8 months ago · Sensitive Skin
Review

This has probably been the product that has made the most difference in my skin. It's clearing up breakouts and acne that I've had for the longest...

This has probably been the product that has made the most difference in my skin. It's clearing up breakouts and acne that I've had for the longest time. My skin looks and feels so much better and I've only been using it for about 2-3 months now.

jojoswrld_'s avatar

johari 🪽

7 months ago · Unsure Skin
Review

Works! Doesn’t irritate my skin when used on a dry surface. I hate how my skin looks when it sends all the clogged sebum to the surface of my skin,...

Works! Doesn’t irritate my skin when used on a dry surface. I hate how my skin looks when it sends all the clogged sebum to the surface of my skin, but it clears over time and leaves the skin incredibly firm and smooth. It’s the only not cruelty-free product I use just because it’s benefitted me so greatly and, in my opinion, is indisputably the best prescription-grade retinoid especially for sensitive skin.

Medik8 R-Retinoate Intense 68 ingredients

R-Retinoate Intense hasn't been rated yet.
Rate it now