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Isntree TW-Real Bifida Ampoule Versus Missha Time Revolution Night Repair Ampoule 5x

Ampoule
Ampoule
Korean Brand South Korea
Korean Brand South Korea

Updated on December 21, 2024

Overview

What they are

These products are both reef safe ampoules. They have a total of 18 ingredients in common

Cool Features

They both contain ceramides, niacinamide and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, parabens or sulfates

What's Inside

They both contain fragrances and oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
TW-Real Bifida Ampoule

Water

Skin Conditioning

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Dipropylene Glycol

Masking

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Cyclopentasiloxane

Emollient
Silicon Icon

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Hydrogenated Polydecene

Emollient

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Dimethicone

Emollient
1 / 0 Silicon Icon

Pentaerythrityl Tetraethylhexanoate

Emollient

Bifida Ferment Lysate

Skin Conditioning
Helps hydrate Dry Skin Icon

Arachidyl Alcohol

Emollient

Butyrospermum Parkii Butter

Skin Conditioning
Helps hydrate Dry Skin IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

C12-16 Alcohols

Emollient

Polyglyceryl-2 Stearate

Emulsifying
Not safe for Fungal Acne Icon

Dimethicone/Vinyl Dimethicone Crosspolymer

Skin Conditioning

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Erythritol

Humectant

Polysorbate 60

Emulsifying
Not safe for Fungal Acne Icon

1,2-Hexanediol

Skin Conditioning

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Hydrogenated Lecithin

Emulsifying

Stearyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Arachidyl Glucoside

Emulsifying

Palmitic Acid

Emollient
2 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Carbomer

Emulsion Stabilising
1 / 0

Tromethamine

Buffering

Illicium Verum Fruit Extract

Perfuming
Fragrance Icon

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Mangifera Indica Seed Butter

Skin Conditioning
Not safe for Fungal Acne Icon

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Isohexadecane

Emollient

Persea Gratissima Oil

Skin Conditioning
0-3 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Hydroxyethylcellulose

Emulsion Stabilising

Scutellaria Baicalensis Root Extract

Astringent

Adenosine

Skin Conditioning
Good for Minimizing Pores IconGood for Scar Healing Icon

Polysorbate 80

Emulsifying
0 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

Disodium EDTA

Hydrogenated Vegetable Oil

Emollient
3 / 0 Oil IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

3-O-Ethyl Ascorbic Acid

Skin Conditioning
Vitamin C IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores Icon

Sorbitan Oleate

Emulsifying
3 / 0 Bad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Glucose

Humectant

Caprylic/Capric Triglyceride

Masking

Daucus Carota Sativa Root Extract

Skin Conditioning

Caprylyl Glycol

Emollient

Sodium Phosphate

Buffering

Pentylene Glycol

Skin Conditioning

Deoxyphytantriyl Palmitamide Mea

Skin Conditioning

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Ethylhexylglycerin

Skin Conditioning

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Lecithin

Emollient

Phosphatidylcholine

Emulsifying

Acetyl Hexapeptide-8

Humectant
Peptide IconHelps with Anti-Aging Icon

Sh-Oligopeptide-2

Skin Conditioning
Peptide Icon

Sh-Polypeptide-1

Skin Conditioning
Peptide Icon

Astaxanthin

Skin Conditioning

Sh-Oligopeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing Icon
Time Revolution Night Repair Ampoule 5x

Bifida Ferment Lysate

Skin Conditioning
Helps hydrate Dry Skin Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

1,2-Hexanediol

Skin Conditioning

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Betaine

Humectant
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Dark Spots Icon

Propanediol

Solvent

Water

Skin Conditioning

Chondrus Crispus Extract

Skin Conditioning
Helps hydrate Dry Skin Icon

Saccharum Officinarum Extract

Moisturising

Pentylene Glycol

Skin Conditioning

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Polyquaternium-51

Skin Conditioning

Diethoxyethyl Succinate

Solvent

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Panthenol

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon

Polyglyceryl-10 Laurate

Skin Conditioning
Not safe for Fungal Acne Icon

Hydrogenated Lecithin

Emulsifying

Carbomer

Emulsion Stabilising
1 / 0

Lactobacillus Ferment

Skin Conditioning

Lactobacillus Ferment Lysate

Skin Conditioning
Not safe for Fungal Acne Icon

Leuconostoc/Radish Root Ferment Filtrate

Antimicrobial
Not safe for Fungal Acne Icon

Lactococcus Ferment

Skin Conditioning

Lactobacillus/Acerola Cherry Ferment

Skin Protecting

Lactobacillus/Soybean Ferment Extract

Skin Conditioning

Lactobacillus/Punica Granatum Fruit Ferment Extract

Skin Conditioning

Lactococcus Ferment Lysate

Skin Conditioning

Bifida Ferment Filtrate

Skin Conditioning

Tromethamine

Buffering

Solanum Melongena Fruit Extract

Skin Conditioning

Daucus Carota Sativa Root Extract

Skin Conditioning

Brassica Oleracea Capitata Leaf Extract

Skin Conditioning

Beta Vulgaris Root Extract

Skin Conditioning

Vaccinium Angustifolium Fruit Extract

Skin Protecting

Ethylhexylglycerin

Skin Conditioning

Xanthan Gum

Emulsifying

Aspergillus Ferment

Skin Conditioning

Swiftlet Nest Extract

Skin Conditioning

Dextrin

Absorbent

Theobroma Cacao Extract

Skin Conditioning

Adenosine

Skin Conditioning
Good for Minimizing Pores IconGood for Scar Healing Icon

Citrus Aurantium Bergamia Fruit Oil

Masking
Fragrance IconOil Icon

Pelargonium Graveolens Flower Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Citrus Aurantium Dulcis Peel Oil

Masking
Oil Icon

Lavandula Angustifolia Oil

Masking
Fragrance IconOil IconMay cause irritation IconEU Allergen Icon

Anthemis Nobilis Flower Oil

Masking
Fragrance IconOil Icon

Santalum Album Oil

Masking
Oil IconMay cause irritation IconEU Allergen Icon

Limonene

Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Disodium EDTA

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Helianthus Annuus Seed Oil

Emollient
0 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Lupinus Albus Seed Extract

Skin Conditioning

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.
  • It has mild preservative properties.

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Skin Conditioning

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Learn more about Squalane
Smoothing

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Skin Conditioning

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.

Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.

Learn more about Bifida Ferment Lysate
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Emulsifying, Skin Conditioning

Hydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.

This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Buffering, Masking

Tromethamine helps balance the pH and improve the texture of a product. It is synthetically created.

As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.

Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Learn more about Tromethamine
Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Skin Conditioning

Ceramide NP is a type of ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here: Ceramide AP Ceramide EOP

Learn more about Ceramide NP

Daucus Carota Sativa Root Extract comes from the root commonly known as carrot (the orange kind we eat!).

This extract contains beta-carotene, a pigment responsible for giving plants the orange color. Beta-carotene is a potent antioxidant. Antioxidants may help reduce the signs of aging.

Beta-carotene is the reason we turn orange if we eat too many carrots.

It should be noted coming into contact with the leaves of wild carrots can cause skin irritation. The sap causes phytophotodermatitis, or sensitivity exposed to sunlight.

This ingredient is created using the edible parts of the carrot.

Learn more about Daucus Carota Sativa Root Extract
Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Learn more about Pentylene Glycol
Antioxidant, Masking, Skin Conditioning

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

Learn more about Tocopherol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Emollient, Emulsifying, Skin Conditioning

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.

Our bodies use cholestrol to create vitamin D, steroid hormones, and more.

Learn more about Cholesterol

When to use

22 Routines
36% use in am
64% use in pm
86% use every day
137 Routines
10% use in am
90% use in pm
90% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Isntree TW-Real Bifida Ampoule 62 ingredients

2.7 /5
from 3 ratings
Absorbs Well (2) Broke Me Out (1) Doesn't Work (1)
nikisadaghiani's avatar

Niki Sdni

6 months ago
Review

I haven’t used a full bottle only tried for few days, still didn’t like it that much, what does it suppose to do? Not a bad product, but many many better alternatives are available

#expensive
#hydrating
#absorbs well
#no scent
Suzamazen's avatar

Suzanne S.

21 days ago
Review

I absolutely loved the original version of this serum. It helped my oily, cystic-acne prone skin retain moisture and let my skin handle harsher products like acid exfoliants and benzoyl peroxide without completely stripping my skin. This new formulation is a list of the worst ingredients for oily and acne prone skin. Using the SkinSort match score, the original formulation was a 88% match for Show more

#broke me out

Missha Time Revolution Night Repair Ampoule 5x 54 ingredients

4.7 /5
from 3 ratings
Absorbs Well (2) Great Value (2) Hydrating (2)
gfunkpsych's avatar

gfunkpsych

10 months ago
Review

I have Eczema and have to be very careful about skincare products with any scents, so I was hesitant to purchase this serum. I had read that it was a dupe for the Estee Lauder’s iconic night repair serum and decided it to give it a go. To my pleasant surprise I love using it every night because of its scent. I also love it for the soft hydrated skin in the morning.

#great value
#works well
bujanabrahimi's avatar

🍯 Boo

8 months ago
Review

I got it to replace estee lauders advanced night repair serum. Tbh I didn’t see much difference in terms of quality but yet again none of them did wonders but none of them did harm.
Not purchasing again because now I have a much simpler routine.

#great value
#hydrating
#light
#absorbs well