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Product Comparison

Here's our complete breakdown comparing the ingredients, attributes, and more of Drunk Elephant Protini Polypeptide Cream versus NeoStrata Dermal Replenishment .

Last updated on September 29, 2023. Published on September 28, 2023

Overview

What they are

These products are both reef safe general moisturizers. They have a total of 21 ingredients in common

Cool Features

They both contain peptides

Suited For

They're both likely to be good for dry skin and brightening skin

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain fragrances

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that need an update? Let us know.

General Moisturizer American Brand United States
General Moisturizer American Brand United States

General Moisturizer

All-purpose moisturizers hydrate the top layer of skin cells.

General Moisturizer

All-purpose moisturizers hydrate the top layer of skin cells.

Price

Ingredient Info

Click any item below to learn more and view relevant ingredients.
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free
alcohol-free
silicon-free
fragrance-free
sulfate-free
paraben-free
oil-free
fungal-acne safe
reef-safe
eu-allergen-free
vegan
cruelty-free

At a glance

Click on any of the items below to learn more

Notable Ingredients

Vitamin E
Hyaluronic Acid
Peptides (9)

Benefits

Hydrating (2)
Brightening (2)

Concerns

May Worsen Oily Skin (2)
Acne Trigger (2)

Benefits

Hydrating (4)
Redness Reducing
Reduces Irritation
Brightening

Concerns

May Worsen Oily Skin (2)
Acne Trigger (2)
Eczema
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Ingredients Compared

Ingredients that are highlighted in purple are present in both products.

Ingredients Side-by-side

Ingredients that are highlighted in purple are present in both products.

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Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1
What it does: Skin Conditioning, Solvent
Community Rating: Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 1.

NeoStrata Dermal Replenishment contains this as ingredient number 1.

2
What it does: Humectant, Skin Conditioning, Skin Protecting, Solvent
Community Rating: Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 3.

NeoStrata Dermal Replenishment contains this as ingredient number 2.

3
What it does: Skin Conditioning
Community Rating: Loved

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 17.

NeoStrata Dermal Replenishment contains this as ingredient number 18.

4
What it does: Skin Conditioning
Community Rating: Liked

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tripeptide-1 is a signal peptide. This means it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 18.

NeoStrata Dermal Replenishment contains this as ingredient number 17.

5
What it does: Masking, Skin Conditioning
Community Rating: Loved

Alanine is an amino acid and is already found in the human body.

Alanine has antioxidant properties and can help with anti-aging.

Alanine is used by fibrous proteins such as collagen, elastin, and keratin. These three help make a strong skin barrier. Having a healthy skin barrier leads to more plump and youthful skin.

Learn more about Alanine

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 19.

NeoStrata Dermal Replenishment contains this as ingredient number 23.

6
What it does: Masking, Skin Conditioning
Community Rating: Mixed

Arginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.

As a cosmetic ingredient, Arginine has antioxidant properties and can also help repair damaged skin. This ingredient is derived either synthetically or from animals.

Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.

Learn more about Arginine

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 20.

NeoStrata Dermal Replenishment contains this as ingredient number 25.

7
What it does: Buffering, Skin Conditioning
Community Rating: Loved

Glycine is an amino acid that helps build proteins. It is already present in our skin as our bodies produce them naturally.

Glycine helps keep skin hydrated and reduce signs of aging. Amino acids help transport moisture throughout our skin; glycine already plays a role in helping keep our skin moisturized.

As collagen is made up of glycine and other amino acids, it is believed Glycine may help our skin produce more collagen. Collagen helps keep skin plump and firm.

Learn more about Glycine

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 21.

NeoStrata Dermal Replenishment contains this as ingredient number 22.

8
What it does: Skin Conditioning
Community Rating: Loved

Proline is an amino-acid. It helps moisturize the skin and plays an important role in creating proteins.

Proline is one of the building blocks for producing collagen. As we age, our bodies produce less collagen. Collagen helps the skin look plump and firm.

In medicine, proline is used as an osmoprotectant. This means it helps prevent oxidative degradation in other drugs.

Our bodies are able to produce proline naturally, but certain conditions may inhibit this production. In that case, proline can be obtained from eating egg whites, soy protein, dairy products, asparagus, mushrooms, and seaweed.

Learn more about Proline

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 25.

NeoStrata Dermal Replenishment contains this as ingredient number 27.

9
What it does: Masking, Skin Conditioning
Community Rating: Loved

Serine is an amino acid naturally found in our body. Our bodies use amino acids to create protein.

Amino-acids help give keep our skin hydrated. They play an important role in the skin barrier, which keeps the skin plump and firm.

Serine is a non-essential amino acid, meaning we don't need to obtain it from eating foods.

Learn more about Serine

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 26.

NeoStrata Dermal Replenishment contains this as ingredient number 21.

10
What it does:
Community Rating: Loved

Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.

Threonine is vital for creating collagen and elastin. Collagen and elastin support youthful and firm skin. Our bodies decrease collagen production naturally with age.

Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

Learn more about Threonine

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 27.

NeoStrata Dermal Replenishment contains this as ingredient number 26.

11
What it does: Humectant, Masking, Skin Conditioning, Solvent
Community Rating: Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 37.

NeoStrata Dermal Replenishment contains this as ingredient number 34.

12
What it does: Humectant, Skin Conditioning
Community Rating: Loved

Sodium PCA is the sodium salt of pyroglutamic acid and is naturally occurring on human skin.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

Sodium PCA is a has conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Learn more about Sodium PCA

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 40.

NeoStrata Dermal Replenishment contains this as ingredient number 20.

13
What it does: Emulsifying
Community Rating: Very Disliked

Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.

As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.

Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.

Learn more about Sorbitan Isostearate

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 42.

NeoStrata Dermal Replenishment contains this as ingredient number 36.

14
What it does: Emulsion Stabilising, Gel Forming
Community Rating: Disliked

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

Carbomer is commonly found in many types of cosmetics products. It is found to be safe in concentrations up to 15%. However, a high amount of carbomer can cause pilling or balling up of products. Most products contain 1% of less of carbomer.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 43.

NeoStrata Dermal Replenishment contains this as ingredient number 37.

15
What it does: Emulsifying
Community Rating: Very Disliked

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 44.

NeoStrata Dermal Replenishment contains this as ingredient number 38.

16
What it does: Emulsifying
Community Rating: Very Disliked

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Learn more about Polysorbate 60

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 45.

NeoStrata Dermal Replenishment contains this as ingredient number 35.

17
What it does: Emulsion Stabilising
Community Rating: Disliked

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 47.

NeoStrata Dermal Replenishment contains this as ingredient number 11.

18
What it does: Emulsifying, Emulsion Stabilising, Gel Forming, Skin Conditioning
Community Rating: Disliked

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 48.

NeoStrata Dermal Replenishment contains this as ingredient number 43.

19
What it does: Emollient, Humectant, Skin Conditioning
Community Rating: Liked

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 51.

NeoStrata Dermal Replenishment contains this as ingredient number 41.

20
What it does: Antimicrobial, Preservative
Community Rating: Disliked

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Learn more about Chlorphenesin

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 52.

NeoStrata Dermal Replenishment contains this as ingredient number 45.

21
What it does: Preservative
Community Rating: Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Drunk Elephant Protini Polypeptide Cream contains this as ingredient number 53.

NeoStrata Dermal Replenishment contains this as ingredient number 44.

Here's what our community thinks of the ingredients in these two products.

52% are loved or liked
12% have mixed ratings
29% are disliked or very disliked
7% have no rating yet
37% are loved or liked
4% have mixed ratings
39% are disliked or very disliked
20% have no rating yet

Usage

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Reviews

Here's what our community thinks

Drunk Elephant Protini Polypeptide Cream 58 ingredients

4.2 /5
from 11 ratings
Expensive (2) Hydrating (2) Works Well (2) Absorbs Well (1) Light (1) Strong Scent (1)
sillygirl's avatar

sillygirl

3 months ago · Sensitive Skin
Review

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and...

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream texture with a light fragrance. i found it a little hard to blend while my face was still damp which is when i usually apply moisturizer. i don’t feel like it did much for my skin but moisturize it.. lol definitely wouldn’t pay $70 for it again

zankhaft's avatar

zankhaft

5 months ago · Sensitive Skin
Review

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight...

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a good hit of luxury.

NeoStrata Dermal Replenishment 51 ingredients

Dermal Replenishment hasn't been rated yet.
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