Versus

Drunk Elephant Protini Polypeptide Cream - US Versus NeoStrata Dermal Replenishment

General Moisturizer
General Moisturizer
American Brand United States
American Brand United States

Updated on March 19, 2025

Overview

What they are

These products are both reef safe general moisturizers. They have a total of 21 ingredients in common

Cool Features

They both contain peptides

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin and scar healing

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain fragrances

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Benefits

Concerns

Ingredients Side-by-side

found in both products
Protini Polypeptide Cream

Water

Skin Conditioning

Dicaprylyl Carbonate

Emollient

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cetearyl Olivate

Not safe for Fungal Acne Icon

Sorbitan Olivate

Emulsifying
Not safe for Fungal Acne Icon

Sclerocarya Birrea Seed Oil

Humectant
Oil IconNot safe for Fungal Acne Icon

Bacillus/Folic Acid Ferment Filtrate Extract

Antioxidant
Antioxidant Icon

Nymphaea Alba Root Extract

Skin Conditioning

Sh-Oligopeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sh-Oligopeptide-2

Skin Conditioning
Peptide Icon

Sh-Polypeptide-1

Skin Conditioning
Peptide Icon

Sh-Polypeptide-9

Skin Conditioning
Peptide Icon

Sh-Polypeptide-11

Peptide Icon

Copper Palmitoyl Heptapeptide-14

Skin Conditioning
Peptide Icon

Heptapeptide-15 Palmitate

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Alanine

Masking

Arginine

Masking
Good for Scar Healing IconNot safe for Fungal Acne Icon

Glycine

Buffering
Helps hydrate Dry Skin Icon

Histidine

Humectant

Isoleucine

Skin Conditioning

Phenylalanine

Masking

Proline

Skin Conditioning

Serine

Masking

Threonine

Valine

Masking

Acetyl Glutamine

Skin Conditioning

Coconut Alkanes

Emollient
Not safe for Fungal Acne Icon

Coco-Caprylate/Caprate

Emollient
Not safe for Fungal Acne Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Aspartic Acid

Masking

Linoleic Acid

Cleansing
Helps hydrate Dry Skin IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Linolenic Acid

Cleansing
Fragrance IconNot safe for Fungal Acne Icon

Lecithin

Emollient

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Polyvinyl Alcohol

Sodium Lactate

Buffering

Sodium PCA

Humectant
0 / 0

PCA

Humectant

Sorbitan Isostearate

Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon

Carbomer

Emulsion Stabilising
1 / 0

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Polysorbate 60

Emulsifying
Not safe for Fungal Acne Icon

Lactic Acid/Glycolic Acid Copolymer

Skin Conditioning

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Xanthan Gum

Emulsifying

Isomalt

Humectant

1,2-Hexanediol

Skin Conditioning

Caprylyl Glycol

Emollient

Chlorphenesin

Antimicrobial
Preservative Icon

Phenoxyethanol

Preservative
Preservative Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sodium Benzoate

Masking
Preservative Icon

Phenylpropanol

Masking
Fragrance Icon

Glyceryl Caprylate

Emollient

Symphytum Officinale Callus Culture Extract

Skin Conditioning
Dermal Replenishment

Water

Skin Conditioning

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Maltobionic Acid

Buffering

Acetyl Glucosamine

Skin Conditioning

Octyldodecyl Neopentanoate

Emollient

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Skin Conditioning

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7
Skin Conditioning

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

This ingredient is a signal peptide, meaning it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1
Masking, Skin Conditioning

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

Masking, Skin Conditioning

Arginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.

As a cosmetic ingredient, Arginine has antioxidant properties and can also help repair damaged skin. This ingredient is derived either synthetically or from animals.

Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.

Learn more about Arginine
Buffering, Skin Conditioning

This ingredient is an amino acid that helps build proteins and moisturizes skin. It is already present in our skin as our bodies produce them naturally.

Glycine already plays a role in helping keep our skin moisturized as amino acids transport moisture throughout our skin.

As collagen is made up of glycine and other amino acids, it is believed glycine may help our skin produce more collagen.

Learn more about Glycine
Skin Conditioning

Proline is an amino-acid. It helps moisturize the skin and plays an important role in creating proteins.

Our skin uses proline as one of the building blocks for producing collagen.

In medicine, proline is used as an osmoprotectant. This means it helps prevent oxidative degradation in other drugs.

Our bodies are able to produce proline naturally, but certain conditions may inhibit this production. In that case, proline can be obtained from eating egg whites, soy protein, dairy products, asparagus, mushrooms, and seaweed.

Learn more about Proline
Masking, Skin Conditioning

Serine is an amino acid naturally found in our body. Our bodies use amino acids to create protein.

Amino-acids help give keep our skin hydrated. They play an important role in the skin barrier, which keeps the skin plump and firm.

Serine is a non-essential amino acid, meaning we don't need to obtain it from eating foods.

Learn more about Serine

Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.

Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.
  • It has mild preservative properties.

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Humectant, Skin Conditioning

Sodium PCA is the sodium salt of pyroglutamic acid. It is naturally occurring in our skin's natural moisturizing factors where it works to maintain hydration.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

This ingredient has skin conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Learn more about Sodium PCA
Emulsifying

Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.

As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.

Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.

Learn more about Sorbitan Isostearate
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Emulsifying

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20
Emulsifying

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Learn more about Polysorbate 60

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol
Antimicrobial, Preservative

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Learn more about Chlorphenesin
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

When to use

590 Routines
52% use in am
48% use in pm
95% use every day
When to use See routines that use it ->
1 Routine
0% use in am
100% use in pm
100% use every day

Reviews

Here's what our community thinks

Drunk Elephant Protini Polypeptide Cream 58 ingredients

3.7 /5
from 18 ratings
Expensive (7) Hydrating (6) Works Well (4)
sillygirl's avatar

sillygirl

1 year ago
Review

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream texture with a light fragrance. i found it a little hard to blend while my face was still damp which is when i usually apply moisturizer. i don’t feel like it did Show more

#expensive
#hydrating
#works well
zankhaft's avatar

zankhaft

1 year ago
Review

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a good hit of luxury.

#expensive
#hydrating
#light
#absorbs well

NeoStrata Dermal Replenishment 51 ingredients

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