Dr. Dennis Gross Skincare Advanced Retinol + Ferulic Overnight Wrinkle Treatment Versus Sisley Paris Supremÿa at Night Supreme Anti-Aging Eye Serum
This anti-aging treatment is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningNiacinamide
SmoothingPropanediol
SolventCaprylic/Capric Triglyceride
MaskingGlycerin
HumectantRetinol
Skin ConditioningBakuchiol
AntimicrobialNephelium Lappaceum Leaf Extract
Skin ConditioningFerulic Acid
AntimicrobialSodium Hyaluronate
HumectantLactic Acid
BufferingLinoleic Acid
CleansingLinolenic Acid
CleansingSilybum Marianum Extract
Skin ConditioningSaccharide Isomerate
HumectantPhospholipids
Skin ConditioningOenothera Biennis Flower Extract
AstringentAdenosine
Skin ConditioningEvodia Rutaecarpa Fruit Extract
Skin ConditioningSodium PCA
HumectantCamellia Sinensis Leaf Extract
AntimicrobialPhytic Acid
ChelatingTocopherol
AntioxidantGlycolic Acid
BufferingMandelic Acid
AntimicrobialMaltodextrin
AbsorbentSodium Hydroxide
BufferingCetyl Alcohol
EmollientPvm/Ma Decadiene Crosspolymer
Behenyl Alcohol
EmollientGlyceryl Stearate Se
EmulsifyingArachidyl Glucoside
EmulsifyingOctoxynol-9
EmulsifyingArachidyl Alcohol
EmollientEthylhexylglycerin
Skin ConditioningOleth-10
EmulsifyingPEG-40 Hydrogenated Castor Oil
EmulsifyingSodium Ascorbate
AntioxidantCitrus Limon Peel Extract
EmollientCitrus Aurantium Bergamia Fruit Extract
Skin ConditioningLavandula Angustifolia Flower/Leaf/Stem Extract
MaskingPhenoxyethanol
PreservativeSodium Benzoate
MaskingPotassium Sorbate
PreservativeWater, Niacinamide, Propanediol, Caprylic/Capric Triglyceride, Glycerin, Retinol, Bakuchiol, Nephelium Lappaceum Leaf Extract, Ferulic Acid, Sodium Hyaluronate, Lactic Acid, Linoleic Acid, Linolenic Acid, Silybum Marianum Extract, Saccharide Isomerate, Phospholipids, Oenothera Biennis Flower Extract, Adenosine, Evodia Rutaecarpa Fruit Extract, Sodium PCA, Camellia Sinensis Leaf Extract, Phytic Acid, Tocopherol, Glycolic Acid, Mandelic Acid, Maltodextrin, Sodium Hydroxide, Cetyl Alcohol, Pvm/Ma Decadiene Crosspolymer, Behenyl Alcohol, Glyceryl Stearate Se, Arachidyl Glucoside, Octoxynol-9, Arachidyl Alcohol, Ethylhexylglycerin, Oleth-10, PEG-40 Hydrogenated Castor Oil, Sodium Ascorbate, Citrus Limon Peel Extract, Citrus Aurantium Bergamia Fruit Extract, Lavandula Angustifolia Flower/Leaf/Stem Extract, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantPrunus Domestica Seed Extract
EmollientButyrospermum Parkii Butter
Skin ConditioningPropylheptyl Caprylate
EmollientSodium Acrylates Copolymer
Caprylyl Methicone
Skin ConditioningGlyceryl Stearate Citrate
EmollientPvp
Emulsion StabilisingCaffeine
Skin ConditioningBisabolol
AntioxidantSaccharomyces Cerevisiae Extract
Skin ConditioningAvena Sativa Kernel Extract
AbrasiveHydrolyzed Soy Protein
HumectantSalix Alba Leaf Extract
Skin ConditioningAdenosine
Skin ConditioningPhysalis Alkekengi Calyx Extract
Skin ConditioningEuterpe Oleracea Fruit Extract
Padina Pavonica Thallus Extract
Skin ConditioningHydrolyzed Triticum Monococcum Seed Extract
Skin ConditioningOryza Sativa Extract
AbsorbentSimmondsia Chinensis Seed Oil
EmollientHydrogenated Polyisobutene
EmollientSodium Acryloyldimethyltaurate/Vp Crosspolymer
Emulsion StabilisingPhospholipids
Skin ConditioningPolyglyceryl-10 Stearate
Skin ConditioningHelianthus Annuus Seed Oil
EmollientDisodium EDTA
ChelatingPentylene Glycol
Skin ConditioningPPG-26-Buteth-26
Skin ConditioningXanthan Gum
EmulsifyingPEG-40 Hydrogenated Castor Oil
EmulsifyingSodium Hydroxide
BufferingEthylhexylglycerin
Skin ConditioningCitric Acid
BufferingPhenoxyethanol
PreservativeSorbic Acid
PreservativeSodium Benzoate
MaskingPotassium Sorbate
PreservativeTocopherol
AntioxidantWater, Glycerin, Butylene Glycol, Prunus Domestica Seed Extract, Butyrospermum Parkii Butter, Propylheptyl Caprylate, Sodium Acrylates Copolymer, Caprylyl Methicone, Glyceryl Stearate Citrate, Pvp, Caffeine, Bisabolol, Saccharomyces Cerevisiae Extract, Avena Sativa Kernel Extract, Hydrolyzed Soy Protein, Salix Alba Leaf Extract, Adenosine, Physalis Alkekengi Calyx Extract, Euterpe Oleracea Fruit Extract, Padina Pavonica Thallus Extract, Hydrolyzed Triticum Monococcum Seed Extract, Oryza Sativa Extract, Simmondsia Chinensis Seed Oil, Hydrogenated Polyisobutene, Sodium Acryloyldimethyltaurate/Vp Crosspolymer, Phospholipids, Polyglyceryl-10 Stearate, Helianthus Annuus Seed Oil, Disodium EDTA, Pentylene Glycol, PPG-26-Buteth-26, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, Sodium Hydroxide, Ethylhexylglycerin, Citric Acid, Phenoxyethanol, Sorbic Acid, Sodium Benzoate, Potassium Sorbate, Tocopherol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPEG-40 Hydrogenated Castor Oil is an emulsifier derived from castor oil.
As an emulsifying agent, it helps other ingredients like fragrances and fat-soluble vitamins dissolve cohesively.
Due to its large molecule size, it doesn't penetrate beyond the skin's surface.
This ingredient has a solid regulatory track record; the CIR Expert Panel first concluded it was safe for use in cosmetics at concentrations up to 100% in 1997. A 2012 reassessment reaffirmed that finding. Safety studies have also found no irritation or evidence of toxicity.
A 2019 study did find this ingredient to grow Malassezia, so this ingredient may not be fungal acne safe.
Learn more about PEG-40 Hydrogenated Castor OilPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPhospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.
In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).
Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.
They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.
Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.
Some types of phospholipids include:
Learn more about PhospholipidsPotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water