COSRX The 6 Peptide Skin Booster Serum Versus Clinique Smart Clinical Repair Wrinkle Correcting Serum
This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and strengthen the skin barrier.
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningDipropylene Glycol
HumectantGlycerin
HumectantPentylene Glycol
Skin Conditioning1,2-Hexanediol
Skin ConditioningNiacinamide
SmoothingAcetyl Hexapeptide-8
HumectantCopper Tripeptide-1
Skin ConditioningSh-Polypeptide-121
Skin ConditioningDipeptide Diaminobutyroyl Benzylamide Diacetate
Skin ConditioningOligopeptide-68
BleachingPalmitoyl Tripeptide-8
Skin ConditioningAllantoin
Skin ConditioningSodium Hyaluronate
HumectantAcetyl Glucosamine
Skin ConditioningSerine
MaskingAlanine
MaskingGlycine
BufferingThreonine
Arginine
MaskingProline
Skin ConditioningBetaine
HumectantSodium PCA
HumectantSodium Lactate
BufferingPCA
HumectantGlutamic Acid
HumectantLysine Hcl
Skin ConditioningTocopherol
AntioxidantDextran
Glycine Soja Oil
EmollientHydrogenated Lecithin
EmulsifyingAmmonium Acryloyldimethyltaurate/Vp Copolymer
Polyacrylate Crosspolymer-6
Emulsion StabilisingButylene Glycol
HumectantXanthan Gum
EmulsifyingEthylhexylglycerin
Skin ConditioningAdenosine
Skin ConditioningPolyquaternium-51
Skin ConditioningDisodium EDTA
ChelatingCitric Acid
BufferingCaprylyl Glycol
EmollientT-Butyl Alcohol
PerfumingPotassium Sorbate
PreservativeSodium Oleate
CleansingWater, Dipropylene Glycol, Glycerin, Pentylene Glycol, 1,2-Hexanediol, Niacinamide, Acetyl Hexapeptide-8, Copper Tripeptide-1, Sh-Polypeptide-121, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Oligopeptide-68, Palmitoyl Tripeptide-8, Allantoin, Sodium Hyaluronate, Acetyl Glucosamine, Serine, Alanine, Glycine, Threonine, Arginine, Proline, Betaine, Sodium PCA, Sodium Lactate, PCA, Glutamic Acid, Lysine Hcl, Tocopherol, Dextran, Glycine Soja Oil, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyacrylate Crosspolymer-6, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Adenosine, Polyquaternium-51, Disodium EDTA, Citric Acid, Caprylyl Glycol, T-Butyl Alcohol, Potassium Sorbate, Sodium Oleate
Water
Skin ConditioningDimethicone
EmollientIsododecane
EmollientButylene Glycol
HumectantGlycerin
HumectantPolysilicone-11
Ascorbyl Glucoside
AntioxidantSodium Hyaluronate
HumectantTocopheryl Acetate
AntioxidantSqualane
EmollientHypnea Musciformis Extract
Skin ProtectingGelidiella Acerosa Extract
Skin ProtectingSigesbeckia Orientalis Extract
Skin ConditioningHelianthus Annuus Seed Extract
Skin ConditioningHordeum Vulgare Extract
EmollientTriticum Vulgare Germ Extract
Skin ConditioningCucumis Sativus Fruit Extract
EmollientCaffeine
Skin ConditioningAcetyl Hexapeptide-8
HumectantPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningPalmitoyl Hexapeptide-12
Skin ConditioningPEG-10 Dimethicone
Skin ConditioningGlycyrrhetinic Acid
Skin ConditioningWhey Protein
Skin ConditioningIsohexadecane
EmollientPropylene Glycol Dicaprate
EmollientCaprylyl Glycol
EmollientHydroxypinacolone Retinoate
Skin ConditioningAcetyl Glucosamine
Skin ConditioningCholesterol
EmollientPEG-8
HumectantFaex Extract
Skin ConditioningPEG-6
HumectantDimethyl Isosorbide
SolventGlyceryl Polymethacrylate
Polysorbate 20
EmulsifyingSodium Phosphate
BufferingSynthetic Fluorphlogopite
Polysorbate 80
EmulsifyingCarbomer
Emulsion StabilisingHexylene Glycol
EmulsifyingAmmonium Acryloyldimethyltaurate/Vp Copolymer
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingPotassium Hydroxide
BufferingTin Oxide
AbrasiveDisodium Phosphate
BufferingCitric Acid
BufferingDisodium EDTA
ChelatingSodium Citrate
BufferingPhenoxyethanol
PreservativePotassium Sorbate
PreservativeCI 77891
Cosmetic ColorantWater, Dimethicone, Isododecane, Butylene Glycol, Glycerin, Polysilicone-11, Ascorbyl Glucoside, Sodium Hyaluronate, Tocopheryl Acetate, Squalane, Hypnea Musciformis Extract, Gelidiella Acerosa Extract, Sigesbeckia Orientalis Extract, Helianthus Annuus Seed Extract, Hordeum Vulgare Extract, Triticum Vulgare Germ Extract, Cucumis Sativus Fruit Extract, Caffeine, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, PEG-10 Dimethicone, Glycyrrhetinic Acid, Whey Protein, Isohexadecane, Propylene Glycol Dicaprate, Caprylyl Glycol, Hydroxypinacolone Retinoate, Acetyl Glucosamine, Cholesterol, PEG-8, Faex Extract, PEG-6, Dimethyl Isosorbide, Glyceryl Polymethacrylate, Polysorbate 20, Sodium Phosphate, Synthetic Fluorphlogopite, Polysorbate 80, Carbomer, Hexylene Glycol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Potassium Hydroxide, Tin Oxide, Disodium Phosphate, Citric Acid, Disodium EDTA, Sodium Citrate, Phenoxyethanol, Potassium Sorbate, CI 77891
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Glucosamine is an antioxidant and humectant. It is an amino acid sugar and is naturally found in our skin.
The cool thing about this ingredient? It helps the skin produce hyaluronic acid and boost hydration. It also has antioxidant benefits to protect skin cells.
When paired with niacinamide, Acetyl Glucosamine has been shown to be effective at reducing discoloration.
Learn more about Acetyl GlucosamineAcetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Learn more about Acetyl Hexapeptide-8Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
Learn more about Ammonium Acryloyldimethyltaurate/Vp CopolymerButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Learn more about Citric AcidDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPotassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Learn more about Potassium SorbateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water