MediCube Azelaic Acid 16 BB Calming Serum Versus APLB Azelaic Acid Peptide Ampoule Serum
Updated on March 29, 2025
Overview
What they are
These products are both cruelty-free and reef safe serums. They have a total of 10 ingredients in common
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any common allergens, parabens, silicones or sulfates
What's Inside
They both contain fragrances
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
MediCube Azelaic Acid 16 BB Calming Serum 31 ingredients
APLB Azelaic Acid Peptide Ampoule Serum 39 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
MediCube Azelaic Acid 16 BB Calming Serum 31 ingredients
APLB Azelaic Acid Peptide Ampoule Serum 39 ingredients
Key Ingredients
Benefits
Concerns
Benefits
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterAzelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.
It has been shown to reduce the growth of acne-causing bacteria and helps reduce inflammation. On top of that, it helps reduce the production of sebum and unclog pores.
Azelaic Acid also has antioxidant properties. Antioxidants protect our skin cells from free-radical damage.
One of the main benefits of azelaic acid is that it is gentle and well-tolerated by most people.
Fun fact: The lab-created form of azelaic acid is typically used within cosmetic products for its shelf-stability.
Learn more about Azelaic AcidButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about Propanediol1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.
If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.
Read more about some other popular AHA's here:
Learn more about Citric AcidWe don't have a description for Solanum Melongena Fruit Extract yet.
Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.
Some studies have shown this ingredient can promote wound healing with higher concentrations.
Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.
Learn more about AllantoinPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolSqualane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.
Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.
Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.
Research shows that squalane is non-irritating (even at 100% concentration).
In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.
The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.
Is squalane vegan?
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Is squalane an oil?
Squalane is often called an oil, but it’s technically not; it’s a hydrocarbon, meaning it’s only made of carbon and hydrogen, unlike true oils which are triglycerides made of fatty acids and glycerol.
The term “oil-free” isn’t regulated, so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
While some people avoid oils thinking they cause breakouts, the right kind of oil (or oil-like ingredient like squalane) can actually help balance and hydrate your skin. It’s worth testing out simple oils or squalane to see what works best for your skin.
Learn more about SqualaneIngredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
MediCube Azelaic Acid 16 BB Calming Serum 31 ingredients
APLB Azelaic Acid Peptide Ampoule Serum 39 ingredients

Reviews
Here's what our community thinks
MediCube Azelaic Acid 16 BB Calming Serum 31 ingredients
APLB Azelaic Acid Peptide Ampoule Serum 39 ingredients
most calming and hydrating azelaic acid product I've ever used! I experienced no irritation and overall this is a nice serum - but I think that might be partly because there's just not enough azelaic acid in this, unfortunately. APLB don't seem to obviously display their ingredient concentrations so I could only find one source that stated the concentration was 3-4% which isn't enough for me. Show more