Lancôme Advanced Génifique Youth Activating Concentrate Versus ma:nyo Bifida Biome Concentrate Serum
This anti-aging serum is formulated around Bifida Ferment Lysate and Ascorbyl Glucoside to soften the look of wrinkles and strengthen the skin barrier.
This barrier-repair serum is formulated around Bifida Ferment Lysate and Niacinamide to strengthen the skin barrier and hydrate skin.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningBifida Ferment Lysate
Skin ConditioningGlycerin
HumectantAlcohol Denat.
AntimicrobialDimethicone
EmollientHydroxyethylpiperazine Ethane Sulfonic Acid
BufferingAscorbyl Glucoside
AntioxidantSodium Hyaluronate
HumectantSodium Hydroxide
BufferingSodium Benzoate
MaskingPhenoxyethanol
PreservativeAdenosine
Skin ConditioningYeast Extract
Skin ConditioningPEG-20 Methyl Glucose Sesquistearate
EmulsifyingPEG-60 Hydrogenated Castor Oil
EmulsifyingSalicyloyl Phytosphingosine
Skin ConditioningAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingLimonene
PerfumingXanthan Gum
EmulsifyingCaprylyl Glycol
EmollientDisodium EDTA
Octyldodecanol
EmollientCitronellol
PerfumingParfum
MaskingWater, Bifida Ferment Lysate, Glycerin, Alcohol Denat., Dimethicone, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ascorbyl Glucoside, Sodium Hyaluronate, Sodium Hydroxide, Sodium Benzoate, Phenoxyethanol, Adenosine, Yeast Extract, PEG-20 Methyl Glucose Sesquistearate, PEG-60 Hydrogenated Castor Oil, Salicyloyl Phytosphingosine, Ammonium Polyacryloyldimethyl Taurate, Limonene, Xanthan Gum, Caprylyl Glycol, Disodium EDTA, Octyldodecanol, Citronellol, Parfum
Bifida Ferment Lysate
Skin ConditioningGlycerin
HumectantDipropylene Glycol
HumectantPropanediol
Solvent1,2-Hexanediol
Skin ConditioningWater
Skin ConditioningButylene Glycol
HumectantNiacinamide
SmoothingRosa Damascena Flower Water
MaskingPanthenol
Skin ConditioningCutibacterium Granulosum Ferment Extract Filtrate
EmollientPhytosphingosine
Skin ConditioningAcetylphytosphingosine
Skin ConditioningSodium Hyaluronate
HumectantHydroxypropyltrimonium Hyaluronate
Hydrolyzed Hyaluronic Acid
HumectantSodium Acetylated Hyaluronate
HumectantSodium Hyaluronate Crosspolymer
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningHyaluronic Acid
HumectantPotassium Hyaluronate
Skin ConditioningCaprylic/Capric Triglyceride
MaskingGlyceryl Acrylate/Acrylic Acid Copolymer
HumectantAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingAdenosine
Skin ConditioningSqualane
EmollientPolyglyceryl-10 Laurate
Skin ConditioningPolyglyceryl-10 Myristate
Skin ConditioningCeramide NP
Skin ConditioningCeramide Ns
Skin ConditioningCeramide AP
Skin ConditioningCeramide EOP
Skin ConditioningCholesterol
EmollientCentella Asiatica Leaf Water
Skin ConditioningCamellia Sinensis Leaf Extract
AntimicrobialOlea Europaea Fruit Oil
MaskingButyrospermum Parkii Butter
Skin ConditioningHydrogenated Lecithin
EmulsifyingPolyglyceryl-4 Oleate
EmulsifyingEthylhexyl Olivate
Skin ConditioningEthylhexylglycerin
Skin ConditioningDisodium EDTA
Arginine
MaskingCarbomer
Emulsion StabilisingPortulaca Oleracea Extract
Skin ConditioningLinalool
PerfumingCitronellol
PerfumingBenzyl Salicylate
PerfumingParfum
MaskingBifida Ferment Lysate, Glycerin, Dipropylene Glycol, Propanediol, 1,2-Hexanediol, Water, Butylene Glycol, Niacinamide, Rosa Damascena Flower Water, Panthenol, Cutibacterium Granulosum Ferment Extract Filtrate, Phytosphingosine, Acetylphytosphingosine, Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hyaluronic Acid, Potassium Hyaluronate, Caprylic/Capric Triglyceride, Glyceryl Acrylate/Acrylic Acid Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Adenosine, Squalane, Polyglyceryl-10 Laurate, Polyglyceryl-10 Myristate, Ceramide NP, Ceramide Ns, Ceramide AP, Ceramide EOP, Cholesterol, Centella Asiatica Leaf Water, Camellia Sinensis Leaf Extract, Olea Europaea Fruit Oil, Butyrospermum Parkii Butter, Hydrogenated Lecithin, Polyglyceryl-4 Oleate, Ethylhexyl Olivate, Ethylhexylglycerin, Disodium EDTA, Arginine, Carbomer, Portulaca Oleracea Extract, Linalool, Citronellol, Benzyl Salicylate, Parfum
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineBifida Ferment Lysate is a postbiotic ingredient made by fermenting Bifidobacterium to extract a nutrient-rich mix of peptides, amino acids, vitamins, organic acids, and polysaccharides.
These components are basically the building blocks that your skin already uses to stay hydrated, repair itself, and maintain its barrier. That's why this ingredient helps your skin hold onto moisture and stay resilient against irritation.
One in-vitro study found that this ingredient tells your skin cells to produce more of the proteins (filaggrin, loricrin, and involucrin) for building a strong and healthy barrier. This study also found this ingredient to be a solid antioxidant that helped neutralize damage against UV and pollution.
A study with people from 2010 found that sensitive, reactive skin using a cream with 10% of this ingredient for a month became noticeably less dry, less reactive, and harder to irritate compared to the group using a plain cream.
In short, this ingredient is a well-tolerated ingredient that can help with barrier repair, antioxidant protection, and calming reactive skin.
This ingredient is generally considered fungal acne (Malassezia) safe; Bifidobacterium is a bacterium, not a yeast or fungus.
The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it.
Bifida is a completely different organism, so on its own it doesn't provide a food source for the Malassezia yeast that causes fungal acne.
Learn more about Bifida Ferment LysateCitronellol is used to add fragrance/parfum to a product. It is often derived from plants such as roses. In fact, it can be found in many essential oils including geranium, lavender, neroli, and more. The scent of Citronellol is often described as "fresh, grassy, and citrus-like".
Since the Citronellol molecule is already unstable, Citronellol becomes irritating on the skin when exposed to air.
Citronellol is a modified terpene. Terpenes are unsaturated hydrocarbons found in plants. They make up the primary part of essential oils.
Citronellol is not able to be absorbed into deeper layers of the skin. It has low permeability,
Citronellol is also a natural insect repellent.
Learn more about CitronellolDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water