Versus

Drunk Elephant Protini Polypeptide Cream - US Versus Acure Radically Rejuvenating Whipped Night Cream

General Moisturizer
Night Moisturizer
American Brand United States
American Brand United States

Updated on March 19, 2025

Overview

What they are

These products are both vegan, cruelty-free, and reef safe . They have a total of 27 ingredients in common

Cool Features

They both contain hyaluronic acid and peptides

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin and scar healing

Free From

They both do not contain any harsh alcohols, common allergens, parabens, silicones or sulfates

What's Inside

They both contain fragrances and oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Protini Polypeptide Cream

Water

Skin Conditioning

Dicaprylyl Carbonate

Emollient

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cetearyl Olivate

Not safe for Fungal Acne Icon

Sorbitan Olivate

Emulsifying
Not safe for Fungal Acne Icon

Sclerocarya Birrea Seed Oil

Humectant
Oil IconNot safe for Fungal Acne Icon

Bacillus/Folic Acid Ferment Filtrate Extract

Antioxidant
Antioxidant Icon

Nymphaea Alba Root Extract

Skin Conditioning

Sh-Oligopeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sh-Oligopeptide-2

Skin Conditioning
Peptide Icon

Sh-Polypeptide-1

Skin Conditioning
Peptide Icon

Sh-Polypeptide-9

Skin Conditioning
Peptide Icon

Sh-Polypeptide-11

Peptide Icon

Copper Palmitoyl Heptapeptide-14

Skin Conditioning
Peptide Icon

Heptapeptide-15 Palmitate

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7

Skin Conditioning
Peptide IconHelps with Anti-Aging IconNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1

Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon

Alanine

Masking

Arginine

Masking
Good for Scar Healing IconNot safe for Fungal Acne Icon

Glycine

Buffering
Helps hydrate Dry Skin Icon

Histidine

Humectant

Isoleucine

Skin Conditioning

Phenylalanine

Masking

Proline

Skin Conditioning

Serine

Masking

Threonine

Valine

Masking

Acetyl Glutamine

Skin Conditioning

Coconut Alkanes

Emollient
Not safe for Fungal Acne Icon

Coco-Caprylate/Caprate

Emollient
Not safe for Fungal Acne Icon

Sodium Hyaluronate

Humectant
0 / 0 Hyaluronic Acid Icon

Aspartic Acid

Masking

Linoleic Acid

Cleansing
Helps hydrate Dry Skin IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Linolenic Acid

Cleansing
Fragrance IconNot safe for Fungal Acne Icon

Lecithin

Emollient

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Polyvinyl Alcohol

Sodium Lactate

Buffering

Sodium PCA

Humectant
0 / 0

PCA

Humectant

Sorbitan Isostearate

Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon

Carbomer

Emulsion Stabilising
1 / 0

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Polysorbate 60

Emulsifying
Not safe for Fungal Acne Icon

Lactic Acid/Glycolic Acid Copolymer

Skin Conditioning

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Xanthan Gum

Emulsifying

Isomalt

Humectant

1,2-Hexanediol

Skin Conditioning

Caprylyl Glycol

Emollient

Chlorphenesin

Antimicrobial
Preservative Icon

Phenoxyethanol

Preservative
Preservative Icon

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Sodium Benzoate

Masking
Preservative Icon

Phenylpropanol

Masking
Fragrance Icon

Glyceryl Caprylate

Emollient

Symphytum Officinale Callus Culture Extract

Skin Conditioning
Radically Rejuvenating Whipped Night Cream

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

Cetearyl alcohol is an emollient. Emollients help soothe and hydrate the skin by trapping moisture.

Studies show Cetearyl alcohol is non-toxic and non-irritating. The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient is usually derived from plant oils such as palm, vegetable, or coconut oils. There is debate on whether this ingredient will cause acne.

Due to the fatty acid base, this ingredient may not be Malassezia folliculitis safe.

Learn more about Cetearyl Alcohol

Cetearyl Olivate is an emulsifier and texture enhancer. It is derived from the fatty acids of olive oil and Cetearyl alcohol, and is biodegradable.

As an emulsifier, it is used to prevent oils and waters from separating. It can also

Manufacturers use the name Olivem 1000. This ingredient has been found to preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria. This ingredient is grouped with Sorbitan Olivate under the name Olivem 1000.

Learn more about Cetearyl Olivate
Emulsifying

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

Manufacturers sell sorbitan olivate under the name OliveM 1000. OliveM 1000 a multifunctional ingredient. It is self-emulsifying. According to a manufacturer, OliveM 1000 does not disrupt natural skin biome.

Due to its olive oil base, this ingredient may not be fungal-acne safe.

Learn more about Sorbitan Olivate

Sclerocarya Birrea Seed Oil is the oil expressed from the seeds of the Marula plant. In South Africa, Marula is called "an elephant's favorite treat".

Marula seed oil is a non-fragrant oil. It is rich in fatty acids, such as oleic, linoleic, palmitic, stearic, and more. These fatty acids help hydrate the skin.

Other components of marula seed oil include vitamin E and antioxidants such as flavonoids.

Due to the fatty acid content, this ingredient may not be fungal-acne safe.

Learn more about Sclerocarya Birrea Seed Oil
Skin Conditioning

We don't have a description for Nymphaea Alba Root Extract yet.

Skin Conditioning

sh-Oligopeptide-1 is a peptide found naturally in our bodies. Peptides are the building blocks for collagen and elastin in our skin.

In cosmetics, this ingredient is bioengineered to be identical to a human gene that codes for epidermal growth factor (EGF). EGF are signal molecules that simulate cell growth and healing.

Studies find EGF help with:

In South Korea and China, EGF is considered a controversial ingredient. The South Korean Ministry of Food and Drug Safety has cracked down on companies with products including EGF due to false advertisement claims.

According to Dr. Zoe Draelos, growth factors have some drawbacks:

There is also controversy surrounding growth factors. The controversy is due to their mitogenic activity, or their ability to increase the number of cells. It is best to avoid using growth factors if you have psoriasis or are at risk of skin cancer. However, it should be noted EGF are not mutagenic - meaning they will not cause cancer.

Learn more about Sh-Oligopeptide-1
Skin Conditioning, Skin Protecting

This peptide has similar properties to Sh-Oligopeptide-1.

In cosmetics, this ingredient is bioengineered to be identical to a human gene that codes for epidermal growth factor (EGF). EGF are signal molecules that simulate cell growth and healing.

There is also controversy surrounding EGF. The controversy is due to their mitogenic activity, or their ability to increase the number of cells. It is best to avoid using growth factors if you have psoriasis or are at risk of skin cancer. However, it should be noted EGF are not mutagenic - meaning they will not cause cancer.

Learn more about Sh-Oligopeptide-2
Skin Conditioning

Sh-Polypeptide-1 is a signal peptide that tells our cells to create more fibroblast cells. Fibroblasts maintain skin structure and plays a role in wound healing.

It is important to note this ingredient is mitogenic and not mutagenic. Meaning it will stimulate cell multiplication, and will not cause cancer.

Skin Conditioning

Sh-Polypeptide-9 is a signal peptide that tells our body to create more blood vessels.

It is important to note, this ingredient is mitogenic and not mutagenic. Meaning it will stimulate cell multiplication, and will not cause cancer.

Sh-Polypeptide-11 is a signal protein that tells our skin to create more fibroblast cells. Fibroblasts maintain skin structure and plays a role in wound healing.

It is important to note this ingredient is mitogenic and not mutagenic. Meaning it will stimulate cell multiplication, and will not cause cancer.

This peptide is the copper salt and formed by reacting palmitic acid and heptapeptide-14.

This uses a high-tech delivery system called The Cosmetic Drone, where the peptide is enclosed in a shell made from Lactic Acid/Glycolic Acid Copolymer and Polyvinyl Alcohol. Another peptide on the outside guides the capsule to fibroblast cells, the collagen-producing cells in the skin.

Once it reaches the fibroblasts, Copper Palmitoyl Heptapeptide-14 boosts the production of collagen and elastin.

This advanced system works at an incredibly low concentration of just 0.001%.

Learn more about Copper Palmitoyl Heptapeptide-14
Skin Conditioning

Heptapeptide-15 Palmitate isn't fungal acne safe and is a peptide.

Skin Conditioning

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7
Skin Conditioning

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

This ingredient is a signal peptide, meaning it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1
Emollient, Solvent

Coconut Alkanes is created from the fatty-acids of coconut oil. It is volatile, meaning it evaporates from the skin.

This ingredient is an emollient and solvent. As an emollient, it helps keep skin soft and hydrated. Solvents help distribute and mix other ingredients. This ensures a more even consistency.

Coconut Alkanes may not be fungal-acne safe.

Learn more about Coconut Alkanes
Humectant, Skin Conditioning

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Masking, Skin Conditioning

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

Cleansing, Emollient, Skin Conditioning

Linoleic Acid is Vitamin F and a fatty acid. It is an emollient and helps thicken texture. Linoleic acid helps with hydrating skin and nourishing the skin's barrier. The top layer of skin, or epidermis, contains high amounts of linoleic acid naturally.

Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier plump and firm. Prosaglandins help control inflammation and healing.

This makes linoleic acid effectives for reducing inflammation, hydrating skin, and firming skin. A side effect may include extra protection against UV damage and free radicals. This is due to linoleic acid strengthening the skin barrier.

Low levels of linoleic acid is also associated with acne-prone skin. By keeping sebum soft, it prevents pores from clogging.

Linoleic acid can is in common foods such as nuts, sunflower oil, corn oil, and soybean oil.

This ingredient may not be Malassezia folliculitis, or fungal-acne safe.

Learn more about Linoleic Acid
Cleansing, Emollient, Perfuming

Linolenic Acid is a fatty acid. Linolenic Acid helps condition and restore skin.

It is also used to treat inflammation and hyperpigmentation. It works to reduce hyperpigmentation by disrupting melanin production.

You can find this ingredient in many oils, include argan, rosehip, and hemp seed.

Read about Linoleic Acid

Learn more about Linolenic Acid
Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.

This ingredient has emollient and emulsifying properties.

As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.

This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.

Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.

We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.

Learn more about Lecithin
Humectant, Skin Conditioning

Sodium PCA is the sodium salt of pyroglutamic acid. It is naturally occurring in our skin's natural moisturizing factors where it works to maintain hydration.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

This ingredient has skin conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Learn more about Sodium PCA
PCA
Humectant, Moisturising

PCA is derived from amino acids and is naturally found in our skin's barrier.

As a humectant, PCA helps draw and hold moisture to the skin. Studies show it is effective at helping the skin stay hydrated long-term.

Emulsifying

Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.

As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.

Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.

Learn more about Sorbitan Isostearate

This ingredient is a combination of two AHAs, lactic acid and glycolic acid. It has exfoliating properties

We don't have a description for Symphytum Officinale Callus Culture Extract yet.

When to use

591 Routines
52% use in am
48% use in pm
94% use every day
When to use See routines that use it ->
43 Routines
26% use in am
74% use in pm
93% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Drunk Elephant Protini Polypeptide Cream 58 ingredients

3.7 /5
from 18 ratings
Expensive (7) Hydrating (6) Works Well (4)
sillygirl's avatar

char

1 year ago
Review

for the price point of this moisturizer i feel like i expected a lot more?

i mostly used this moisturizer at night paired with my tretinoin and i found that the 2 worked well with each other. it’s a really nice almost gel-like cream texture with a light fragrance. i found it a little hard to blend while my face was still damp which is when i usually apply moisturizer. i don’t feel like it did Show more

#expensive
#hydrating
#works well
zankhaft's avatar

zankhaft

1 year ago
Review

My HG facial moisturizer. It makes my face feel so soft and velvety. It dries quickly, is gentle even when my face is on fire and it has a slight "chemical" smell that I tend to like. I love the pump as well. I use this when I need a good hit of luxury.

#expensive
#hydrating
#light
#absorbs well

Acure Radically Rejuvenating Whipped Night Cream 31 ingredients

4.0 /5
from 4 ratings
Works Well (2) Hydrating (2) No Scent (2)
HarrietandValentine's avatar

HarrietandValentine

1 year ago
Review

I use this as my daily moisturizer and love that it is packed with peptides and growth factors. The research is still not solid on those particular ingredients - other than that they are hydrating - but the price point on this product and how good it feels on my skin makes it feel like a worthwhile experiment. It takes a few minutes to soak in but once it does, it looks and feels good.

#hydrating
#light
#no scent
#works well
ClaireEstelle's avatar

Claire L.

11 months ago
Review

I'm hooked on the texture of this cream - rich, but not heavy, feels great on the skin. Edit: after using this up, I've decided it's maybe just a little too rich for my skin. Still love it, but only for when my skin feels really dry.

#great value
#hydrating
#absorbs well
#no scent