Dr.G R.E.D Blemish Clear Soothing Cream Versus Dr.G R.E.D Blemish Clear Moisture Cream

You'll usually find this in concentrations between 0.2-5%.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.

Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.

Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.

Here is the short version of what they do in the skin:

So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.

Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:

Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.

Centella is one of the most easygoing actives out there.

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.

Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.

But as with any new active, a patch test is still a smart move for very reactive skin.

Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Concentrations up to 100% in guinea pig tests found it to be non-sensitizing and completely safe for use in cosmetics.

First, it turns down inflammation so it helps with things like redness and general upset skin.

Second, it acts as an antioxidant which means it helps protect skin from daily stress and damage.

And third, it nudges the skin to make more collagen and rebuild its support structure.

That combination is why the whole Centella family is known for calming skin, strengthening the barrier, fading redness, and giving anti-aging benefits.

It's worth being honest about the evidence here; a lot of the strongest data is on the full extract or a Madecassoside/Asiaticoside rather than Madecassic Acid alone. Reviewers also note more long-term clinical trials are needed to confirm the full potential.

Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%.

Finished products typically run somewhere in the 0.1-10% range depending on the format.

In real-world tolerance tests, a repeat-insult patch test on an eye lotion with 0.2% Centella extract showed no irritation or allergic contact dermatitis in 54 subjects. And a mascara with 0.5% Madecassoside caused neither irritation nor sensitization in 109 subjects.

Allergy risk is very low, but not zero. Centella and its constituents are classified as weak contact sensitizers and some rare cases of allergic contact dermatitis exist.

Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!