Dr. Denese SkinScience Hemp Super Serum Versus Paula's Choice 1% Retinol Treatment - US
Updated on May 25, 2025
Overview
What they are
These products are both cruelty-free and reef safe . They have a total of 12 ingredients in common
Cool Features
They both contain ceramides, peptides, retinoid, Vitamin C and Vitamin E
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
They both do not contain any harsh alcohols, common allergens, fragrances, parabens or sulfates
What's Inside
They both contain oils and silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Dr. Denese SkinScience Hemp Super Serum 27 ingredients
Paula's Choice 1% Retinol Treatment 53 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Dr. Denese SkinScience Hemp Super Serum 27 ingredients
Paula's Choice 1% Retinol Treatment 53 ingredients
Key Ingredients
Benefits
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
C12-15 Alkyl Benzoate is made up of Benzoic Acid and long chain alcohols. It has a low molecular weight.
C12-15 Alkyl Benzoate is an emollient and texture enhancer. Due to its solubility, it is often used in sunscreens to help evenly distribute active ingredients.
As an emollient, C12-15 Alkyl Benzoate helps soften and hydrate your skin. Emollients create a film on your skin that traps moisture within.
This ingredient has been reported to cause eye irritation.
Learn more about C12-15 Alkyl BenzoateCeramide NG is a type of Ceramide. The NG stands for a sphinganine base.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Ceramide AP
Ceramide EOP
Ceramide NP
Dimethicone is a type of synthetic silicone created from natural materials such as quartz.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeDimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.
Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.
Palmitoyl Hexapeptide-12 is a synthetic peptide made with glycine, histidine, lysine, and palmitic acid.
The sequence of this peptide matches that of elastin, a key protein that plays a role in how firm our skin is.
Due to its palmitic acid base, this ingredient may not be fungal-acne safe.
Learn more about Palmitoyl Hexapeptide-12Palmitoyl Tetrapeptide-7 is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-1 is also known as pal-GHK. It is made up of 3 amino acids and palmitic acid, a fatty acid that helps it absorb into skin more easily.
This peptide is as a signal peptide, meaning it tells the skin to produce more collagen. Collagen is the key protein that helps form the skin's structure and keep it plump, firm, and hydrated.
By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.
You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.
Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1We don't have a description for PEG-10 Phytosterol yet.
Sorbitan Laurate is created from lauric acid and derivatives from sorbitol. It is an emulsifier.
Tetrahexyldecyl Ascorbate (THD) is a stable and oil-soluble form of Vitamin C.
THD is special in that it has the ability to travel deeper into skin than traditional ascorbic acid while maintaining the same skin benefits (double win!).
Because it’s oil-soluble, THD dives deep into your skin’s fatty layers (think ceramides and cholesterol) to fight off the kind of free radicals that mess with your skin barrier. This makes it a great pair with water-based vitamin C (ascorbic acid) that mainly works on the surface.
Even at just 0.1%, THD is already showing great antioxidant activity. When used up to 2%, it helps keep your skin happy and calm, especially when it’s stressed from pollution or sun.
Want to fade dark spots or tackle hyperpigmentation? You’ll want 5% or more. Pairing it with brightening buddies like niacinamide or licorice root gives even better results. One study even used 30% THD with other brighteners and saw real results on stubborn discoloration, even in melasma-prone skin.
A note on THD: It’s has a slightly silky, oily texture and usually shows up colorless or pale yellow (though the exact shade can vary by supplier).
While you can sneak it into water-based formulas, it really shines when paired with silicones or oils, which help your skin soak it up better.
THD is pretty stable, but it’s still vulnerable to degradation like ascorbic acid. Too much light or heat (above 113°F / 45°C) can break it down over time. Go for dark and opaque packaging that keeps it safe and shady!
Read more about other types of Vitamin C:
Learn more about Tetrahexyldecyl AscorbateTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateTribehenin comes from glycerin and behenic acid.
It is used as an emollient, or moisturizer. Emollients form a thin barrier on skin to prevent moisture from escaping.
This ingredient may not be Malassezia folliculitis, or fungal-acne safe.
Learn more about TribeheninIngredient Ratings
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When to use
Dr. Denese SkinScience Hemp Super Serum 27 ingredients
Paula's Choice 1% Retinol Treatment 53 ingredients

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