M Picaut Diamond Extreme Pro Collagen Super Rich Cream

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

When you wash your hair and skin with a surfactant-based cleanser, the surfactants grab onto everything. This includes your skin's natural lipids, or the fats that live in your skin barrier and sebum. Once you rinse these surfactants away, it leaves your skin feeling tight, dry, and clean (in a not-good way).

Re-fatting is essentially putting some of these lipids back. Glyceryl oleate deposits a thin layer of emollient lipids back on the skin or hair surface reduce some of the barrier damage.

Also, glyceryl oleate isn't a foreign molecule to your skin. It's chemically identical to something your skin already produces and manages naturally. This is why it tends to be well-tolerated with low risk of irritation.

Typical use levels range from 0.5-5%.

Glyceryl Oleate has a function of "perfuming" in the CosIng database. This just means that the ingredient has some scent character that can contribute to the product's overall smell.

The scent of this ingredient is described as "waxy".

As an ester of oleic acid, this ingredient may not be fungal acne safe. This is because oleic acid falls into the carbon-chain length that Malassezia can use as a substrate.

Its fatty acid composition mimics that of the hydrolipidic film covering the surface of the epidermis.

This allows it to diffuse into the upper layers of the skin and integrate with the lipid matrix of the stratum corneum to improve barrier function without being greasy.

Studies have shown that it increases hydration of stratum corneum and the squalene component specifically contributes emollient properties and barrier-restoring effects.

A 2025 narrative review also highlighted olive-derived bioactives in:

Typical use levels for this ingredient run from 3-10%.

Fungal acne:
Whole olive oil contains significant triglycerides and free oleic acid that Malassezia can readily metabolize; the unsaponifiables fraction has had these fatty glycerides removed.

However, certain batches of this ingredient may contain sterol esters or free fatty acids depending on the refinement quality. These trace amounts of C12-24 fatty acids could be metabolized by Malassezia.

This ingredient may not be fungal acne safe but not everyone will react to it. It's best to patch test if you're unsure.

Typical concentrations range from 0.1-3%.

This ingredient is mild and non-irritating in nature.

Because it is derived from ricinoleic acid, this ingredient may not be fungal acne safe. Ricinoleic acid is an unsaturated fatty acid that the Malassezia yeast can metabolize.

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

The antioxidant and soothing properties of this ingredient come from Vitamin E and polyphenols.

The seed oil comes from the dried kernels of the plant.

Preclinical research has found that topical avocado oil increased collagen synthesis and reduced inflammation during wound healing, giving it some skin-repairing credibility.

The unsaponifiable fraction of the oil is also interesting: studies on avocado unsaponifiables showed that it helped skin produce more collagen and other structural compounds that support healing.

The CIR Expert Panel has found this ingredient to be non-irritating in formulations.

It's a great ingredient for dry or compromised skin. Just know it may not be fungal acne safe. This is because the oleic acid content falls within the range that Malassezia can use as a food source.

This ingredient also has antioxidant properties from Vitamins A, C, and E. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells. Besides being antioxidants, these vitamins provide plenty of skin benefits as well.

Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.

Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).

Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.

Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.

Fungal acne: The Malassezia yeast is known to metabolize fatty acids in the C11-24 range and jojoba's dominant fatty acid components fall into this range. This ingredient may not be fungal acne safe.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

What is a matrikine-mimetic compound?

This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.

Matrikines play a role in:

Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.

This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.

Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.

They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.

Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.

Some types of phospholipids include:

The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.

It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.

In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.

In cosmetics, Magnesium Sulfate is used to thicken a product or help dilute other solids. It is a non-reactive and non-irritating ingredient.

One study shows magnesium deficiency may lead to inflammation of the skin. Applying magnesium topically may help reduce inflammation.

You can find this ingredient in sea water or mineral deposits.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Beyond hydration, Biosaccharide Gum-1 gives formulas a silky, non-sticky feel.

This ingredient is gentle, versatile, and suitable for all skin types.

Fun fact: Similar sugars can be found naturally in fruits like apples and pears.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

As a co-emulsifier, its "head" and "tail" sit at the oil-water interface. But overall, the short C8 tail and not being water soluble means it doesn't really have the muscle to emulsify a formula on its own. That's why you'll often see it paired with a primary emulsifier like Cetearyl Glucoside.

Interestingly, Glyceryl Caprylate acts as a preservative booster. This is because its fatty-acid backbone disrupts microbial lipid membranes. It shows excellent activity against bacteria and yeast but is weaker against mold.

Typical concentrations range from 0.5-1% and this ingredient is generally non-irritating.

Because this ingredient has a C8 fatty acid chain, it is outside the range that the Malassezia yeast metabolizes (making it fungal acne safe).

According to a manufacturer, it also offer some moisturizing effects.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Here is the official definition from the The International Cosmetic Ingredient Dictionary and Handbook:

“Aroma is a term for ingredient labeling used to identify that a product contains a material or combination of materials normally added to a cosmetic to produce or to mask a particular flavor.”

INCI shows the only purpose of aroma to be "flavouring".

However, due to regulation differences, some companies may use aroma in place of parfum.

In Canada, this ingredient only has to be listed in concentrations above 1%.

Vanillism is the term of contact-dermatitis associated with the vanilla plant. The sap of the vanilla plant triggers skin irritation, swelling, and redness.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

It's often paired with Sodium Anisate as the two create a broad-spectrum preservative system that is popular in "natural" formulations.

This ingredient is water-soluble.

The CIR Expert Panel for Cosmetic Ingredient Safety has concluded this ingredient to be non-irritated and there are no restrictions for use in EU cosmetics. The FDA also allows this ingredient to be used as a food-grade flavoring agent.

Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.

Like glycolic acid, it can:

Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.

Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.

To get results, choose products with a pH between 3-4.

Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.

Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.

When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.

Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.

Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.

Read more about some other popular AHA's here: