Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Kiehl's 1cc Collashot Plump Serum
This anti-aging serum is formulated around Niacinamide and Ceramide NP to soften the look of wrinkles and refine skin texture.
This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles and fade the look of dark spots.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantPentylene Glycol
Skin ConditioningNiacinamide
SmoothingCetyl Alcohol
EmollientIsohexadecane
EmollientIsononyl Isononanoate
EmollientDiisopropyl Sebacate
Emollient2-Oleamido-1,3-Octadecanediol
Skin Conditioning4-T-Butylcyclohexanol
MaskingAcetyl Dipeptide-1 Cetyl Ester
Skin ConditioningAdenosine
Skin ConditioningCeramide NP
Skin ConditioningHydroxypalmitoyl Sphinganine
Skin ConditioningLauroyl Lysine
Skin ConditioningOctyldodecanol
EmollientPentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
AntioxidantSodium Chloride
MaskingSodium Hyaluronate
HumectantSodium Hydroxide
BufferingTrisodium Ethylenediamine Disuccinate
Retinol
Skin ConditioningTocopherol
AntioxidantDicaprylyl Ether
EmollientAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingBehenyl Alcohol
EmollientCaprylyl Glycol
EmollientCarbomer
Emulsion StabilisingCetearyl Alcohol
EmollientCetearyl Glucoside
EmulsifyingGlycine Soja Oil
EmollientHelianthus Annuus Seed Oil
EmollientHydroxyethylcellulose
Emulsion StabilisingLecithin
EmollientPhenethyl Alcohol
MaskingPoloxamer 188
EmulsifyingPolycaprolactone
StabilisingSorbitan Laurate
EmulsifyingSteareth-100
Gel FormingCI 40800
Cosmetic ColorantChlorphenesin
AntimicrobialPhenoxyethanol
PreservativeWater, Glycerin, Butylene Glycol, Pentylene Glycol, Niacinamide, Cetyl Alcohol, Isohexadecane, Isononyl Isononanoate, Diisopropyl Sebacate, 2-Oleamido-1,3-Octadecanediol, 4-T-Butylcyclohexanol, Acetyl Dipeptide-1 Cetyl Ester, Adenosine, Ceramide NP, Hydroxypalmitoyl Sphinganine, Lauroyl Lysine, Octyldodecanol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Chloride, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Retinol, Tocopherol, Dicaprylyl Ether, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Alcohol, Cetearyl Glucoside, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydroxyethylcellulose, Lecithin, Phenethyl Alcohol, Poloxamer 188, Polycaprolactone, Sorbitan Laurate, Steareth-100, CI 40800, Chlorphenesin, Phenoxyethanol
Water
Skin ConditioningGlycerin
HumectantRhamnose
HumectantC15-19 Alkane
SolventNiacinamide
SmoothingHydroxypropyl Tetrahydropyrantriol
Skin ConditioningButylene Glycol
HumectantPropylene Glycol
HumectantPEG-240/Hdi Copolymer Bis-Decyltetradeceth-20 Ether
StabilisingPhenoxyethanol
PreservativeAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingChlorphenesin
AntimicrobialTocopherol
AntioxidantTaurine
BufferingGrifola Frondosa Fruiting Body Extract
EmollientMaltodextrin
AbsorbentAdenosine
Skin ConditioningCitric Acid
BufferingGlycine Soja Oil
EmollientCarvone
MaskingLimonene
PerfumingCyanocobalamin
Skin ConditioningPelargonium Graveolens Flower Oil
MaskingRosmarinus Officinalis Leaf Oil
MaskingSh-Polypeptide-69
Skin ProtectingCitrus Aurantium Bergamia Peel Oil
PerfumingCitrus Aurantium Peel Oil
Citronellol
PerfumingPinene
MaskingLinalyl Acetate
MaskingLinalool
PerfumingGeraniol
PerfumingCamphor
MaskingPropanediol
SolventBeta-Caryophyllene
MaskingPotassium Laurate
EmulsifyingPentylene Glycol
Skin ConditioningBetaine
HumectantLecithin
EmollientSodium Hydroxide
BufferingWater, Glycerin, Rhamnose, C15-19 Alkane, Niacinamide, Hydroxypropyl Tetrahydropyrantriol, Butylene Glycol, Propylene Glycol, PEG-240/Hdi Copolymer Bis-Decyltetradeceth-20 Ether, Phenoxyethanol, Ammonium Polyacryloyldimethyl Taurate, Chlorphenesin, Tocopherol, Taurine, Grifola Frondosa Fruiting Body Extract, Maltodextrin, Adenosine, Citric Acid, Glycine Soja Oil, Carvone, Limonene, Cyanocobalamin, Pelargonium Graveolens Flower Oil, Rosmarinus Officinalis Leaf Oil, Sh-Polypeptide-69, Citrus Aurantium Bergamia Peel Oil, Citrus Aurantium Peel Oil, Citronellol, Pinene, Linalyl Acetate, Linalool, Geraniol, Camphor, Propanediol, Beta-Caryophyllene, Potassium Laurate, Pentylene Glycol, Betaine, Lecithin, Sodium Hydroxide
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineAmmonium Polyacryloyldimethyl Taurate is a polymer made from ammonium salts. It works as a thickener, emulsifier, and texture enhancer that gives gel-creams a silky, lightweight feel.
This ingredient is versatile and low-maintenance so manufacturers love working with it.
Typical usage levels in cosmetics are usually low and in the range of 0.015 - 2.3%.
Learn more about Ammonium Polyacryloyldimethyl TaurateButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolChlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.
Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.
Chlorphenesin is soluble in both water and glycerin.
Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.
Learn more about ChlorphenesinGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlycine Soja Oil is a plant-derived oil from soybean seeds. Like other oils, it is rich in essential fatty acids (mostly linoleic and oleic) that support skin hydration and barrier function.
The fatty acids are able to integrate into the lipid matrix of the stratum corneum to help soften skin and reduce water loss.
On top of that, soybean oil is rich in vitamins like vitamin E, a potent antioxidant.
Research on soybean's active components also point to anti-inflammatory, collagen-stimulating, antioxidant activity, and protection against UV-induced oxidative damage.
Most of this research applies to the broader soybean plant and not just the oil fraction alone.
This ingredient may not be fungal acne safe due to the oleic acid content.
Learn more about Glycine Soja OilLecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water