Hmsc Skincare Boost

Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.

Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).

Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.

Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.

Due to its fatty acid content, Jojoba oil may not be fungal acne safe.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

As a humectant, Sorbitol helps draw water to the skin. This helps keep the skin hydrated. Sorbitol also helps create a thicker texture in products. You might find sorbitol in your toothpaste and other gels.

It is a non-irritating ingredient that is great for those with dry skin.

Sorbitol is a prebiotic. It helps promote the growth of healthy bacteria on your skin. The bacteria on your skin form a microbiome. This microbiome helps protect your skin from infection and harmful bacteria.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Unrefined sesame oil has a comedogenic rating of 3, while refined sesame oil has a rating of 1. This ingredient may not be fungal-acne safe.

The fatty acids in sesame oil include linoleic acid (41%), oleic acid (39%), palmitic acid (8%), stearic acid (5%), and some small traces of others.

The content of sweet almond oil makes it a great emollient; it can help soften and hydrate your skin. Emollients create a barrier over your skin to trap moisture in. Sweet almond oil has antioxidant properties.

Those with an almond allergy should be careful of this ingredient and speak with a professional about using it in your skincare.

This ingredient may not be fungal-acne safe.

These fatty acids help hydrate and soften the skin. It may increase collagen content in the skin. Collagen helps keep your skin plump and firm. This ingredient helps reduce inflammation and has not shown to clog pores.

This ingredient may not be fungal-acne safe due to its high fatty acid content.

Avocados also have B vitamins, vitamin K, vitamin C, vitamin E, and potassium.

As an emollient, pomegranate oil creates a thin film on the skin. This film helps prevent moisture loss, keeping your skin hydrated.

While glutathione is said to help with fading dark spots, the results from research are inconclusive. Further studies are needed. With that said, gluthatione has been shown to protect our skin from UV-B induced damage.

This ingredient is naturally occurring in plants, animals, fungi, and some bacteria.

This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.

Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.

Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).

Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.

Read more about other common types of peptides here:

Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.

So while Argireline isn’t a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.

Read more about other common types of peptides here:

Fun fact: Methionine can be found in meat, fish, and dairy. It cannot be naturally produce and requires dietary intake.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

This ingredient can either be derived from an animal product or be synthetically created.

An in-vitro study from 2024 found glutamic acid to play a role in inhibiting inflammation and thus a potential skin-soothing ingredient.

Other studies show it to be have potential wound healing, skin barrier repair, and hair growth properties.

Glutamic acid has poor solubility in water and other solvents.

Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.

Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.

Part of what helps hold water in the skin is something called Natural Moisturizing Factors (NMF). These include amino acids or the same building blocks that make up proteins in your body.

Since glutamine is an amino acid, it falls into the “barrier-friendly, skin-conditioning” category. That’s why you’ll usually find it in hydrating and soothing formulas.

There's some experimental evidence that glutamine can calm inflammation-related skin reactions when applied topically in a contact-dermatitis model. However, it's not the same as a proven eczema fix.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Hydrolyzed Collagen is created by breaking up proteins into smaller peptide bonds. These peptides act as humectants and emollients.

Humectants are great at holding onto water, keeping skin hydrated. Emollients create a thin barrier on the skin to prevent moisture from escaping.

There is ongoing debate about whether hydrolyzed collagen works because it increases skin hydration. Skin hydration is also linked to elasticity and the appearance of wrinkles.

Collagen or peptide ingredients can be used in the morning or night. They will not increase sun sensitivity, but you should always wear sunscreen during the day.

According to a manufacturer, this ingredient is a great hair conditioner as well.

This ingredient can be extracted from different sources, including:

Vegan collagen is derived from yeast, bacteria, or plant sources. Vegan collagen would go by a different INCI name, such as hydrolyzed soy protein.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

It is also used to boost the efficacy of exfoliating actives like AHAs by improving skin feel and reducing irritation potential.

Studies show this ingredient supports hydration through two actions:

1) Limiting water evaporation
2) Enhancing the spreadability of emulsion products to disperse humectants and emollients across the skin's surface

Additionally, galactoarabinan can improve makeup wear and reduce "tightness" after cleansing.

Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells. The antioxidants in Alpha Lipoic Acid have been shown to fight damage from cigarette smoke.

Studies also show Alpha Lipoic Acid plays a role in wound healing.

Thioctic Acid will break down when exposed to sunlight.

Many foods contain thioctic acid, including tomato, brussel sprouts, spinach, and broccoli.

A 2025 review of 18 human studies found that using Ferulic Acid (0.5-1%) daily for one to three months showed improvements in:

As far as allergies go, Ferulic acid is generally well-tolerated but can cause an allergic reaction in very rare cases. It's also worth noting that Ferulic acid is often extracted from plant sources like rice bran or wheat bran, so be sure to path test if you have known grain allergies.

Outside of skincare, researchers are also looking into Ferulic Acid for its potential benefits in areas like diabetes, Alzheimer's, and heart health.

Vaccinium Myrtillus Fruit Extract also helps reduce irritation.

You can also find carbohydrates, lipids, proteins, minerals, vitamin A, and Vitamin C in these berries.

Astaxanthin is also great at soothing skin due to its ability to block molecules that signal inflammation. It is currently being studied for preventing chronic inflammatory diseases.

Plus, a study from 2012 found Astaxanthin in liposomes protected mouse skin from UV-damage.

Fun fact: Astaxanthin is responsible for giving salmon a pink color.

It doesn’t protect you from the sun, but it can help your skin bounce back after too much time in it.

Let’s get into the details:

Aloe contains antioxidant Vitamins A, C, and E, which help fight off free radicals (unstable molecules from things like pollution that can damage your skin).

It’s also rich in polysaccharides, which are natural sugars that help hydrate the skin by acting like the skin’s own moisturizing agents. These, along with other sugars like monosaccharides, help form a protective barrier that locks in moisture.

Aloe works as both a humectant and an emollient. That means it draws water into the skin (humectant) and helps trap it there (emollient), making it an effective natural moisturizer.

You’ll also find a mix of other skin-supporting ingredients in aloe, including folic acid, choline, calcium, amino acids, fatty acids, and even Vitamin B12.

Out of the 420+ species of aloe, Aloe barbadensis is the most widely used in skincare products thanks to its gentle yet effective properties.

There are over 420 species of aloe but Aloe Barbadensis is the most commonly used for topical products.

Antioxidants help fight free-radical molecules that may damage your skin's DNA. This may help with the signs of aging. Due to its antioxidant property, it is used to help treat chronic inflammation.

In cosmetics, SOD is usually obtained from marine phytoplankton, bovine liver, horseradish, cantaloupe, and certain bacteria.

The three major families of SOD include: Copper/Zinc, Iron/Manganese, and Nickel.

When eating SOD-rich foods, our bodies break it down into amino acids before absorption. Foods that contain SOD include: melons, citrus, spinach, broccoli, kale, almonds, sunflower seeds, and blue-green algae.

Studies show this ingredient may be an effective wrinkle reducer as it can deeply penetrate into skin. It has also been show to help with wound healing.

When applied topically, beta-carotene accumulates in your outermost layer of skin and acts as a first-line defense against photo-oxidative stress.

Research has established that carotenoids like beta-carotene boosts your skin's innate resistance against UVB induced erythema. Please know this does not mean beta-carotene can replace your sunscreen.

Newer studies show it can also help inhibit molecular markers of oxidative stress like MMP-1 and MMP-9, enzymes that break down collagen.

In some cases, it can be used as a cosmetic colorant as well (INCI name: CI 40800).

Beta-carotene pairs well with other antioxidants like Vitamin E and Vitamin C for a synergistic effect.

Research suggests tocotrienols can help with several signs of skin aging, including:

There are four types of tocotrienols: alpha, beta, gamma, and delta.

Fun fact: You can find tocotrienols in ingredients like rice bran oil, palm oil, anatto beans, oats, and hazelnuts.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Read more about some other popular AHA's here:

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

This ingredient has skin conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Due to this ingredient having a similar composition to cetearyl alcohol, this ingredient may not be malassezia folliculitis safe. However, the risk is low and has been only shown by a single study, so SkinSort does not currently flag C14-22 Alcohols as a fungal acne trigger.

Fatty alcohols are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent (ethanol) alcohols.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

Because it is not a free-fatty acid or alcohol, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Potassium Sorbate, another commonly-used preservative, is the potassium salt of Sorbic Acid.

Sorbic Acid may worsen eczema. We recommend speaking with a professional if you have any concerns.

Potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.