Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum Versus Perricone MD High Potency Classics: Hyaluronic Intensive Moisturizer
This anti-aging eye moisturizer is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-38 to soften the look of wrinkles and refine skin texture.
This barrier-repair moisturizer is formulated around Niacinamide and Sodium Hyaluronate Crosspolymer to strengthen the skin barrier and hydrate skin.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningPropanediol
SolventPantethine
EmollientGlycerin
HumectantTetrahexyldecyl Ascorbate
AntioxidantS-Palmitoylglutathione
AntioxidantDimethyl Mea
BufferingPalmitoyl Tripeptide-38
Skin ConditioningAcetyl Tyrosine
Skin ConditioningAvena Sativa Kernel Extract
AbrasiveXanthan Gum
EmulsifyingMacadamia Ternifolia Seed Oil
EmollientLinum Usitatissimum Seed Oil
PerfumingSalvia Hispanica Seed Oil
EmollientSilica Cetyl Silylate
Ethylhexylglycerin
Skin ConditioningSodium Hyaluronate
HumectantHelianthus Annuus Seed Oil
EmollientRosmarinus Officinalis Leaf Extract
AntimicrobialTetrasodium Glutamate Diacetate
ChelatingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingCaprylyl Glycol
EmollientHydroxypropyl Cyclodextrin
MaskingPhenoxyethanol
PreservativeSilica
AbrasiveCI 77891
Cosmetic ColorantCI 77491
Cosmetic ColorantWater, Propanediol, Pantethine, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Dimethyl Mea, Palmitoyl Tripeptide-38, Acetyl Tyrosine, Avena Sativa Kernel Extract, Xanthan Gum, Macadamia Ternifolia Seed Oil, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Silica Cetyl Silylate, Ethylhexylglycerin, Sodium Hyaluronate, Helianthus Annuus Seed Oil, Rosmarinus Officinalis Leaf Extract, Tetrasodium Glutamate Diacetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Hydroxypropyl Cyclodextrin, Phenoxyethanol, Silica, CI 77891, CI 77491
Water
Skin ConditioningDimethicone
EmollientGlycerin
HumectantPentylene Glycol
Skin ConditioningNiacinamide
SmoothingButylene Glycol
HumectantCaprylic/Capric Triglyceride
MaskingAmmonium Acryloyldimethyltaurate/Vp Copolymer
Butyrospermum Parkii Butter
Skin ConditioningSqualane
EmollientSodium Hyaluronate Crosspolymer
HumectantBenzyl Alcohol
PerfumingUrea
BufferingTetrahexyldecyl Ascorbate
AntioxidantBisabolol
AntioxidantDimethyl Mea
BufferingStyrene/Acrylates Copolymer
Dimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningCarbomer
Emulsion StabilisingSodium Polyacrylate
AbsorbentPhosphatidylcholine
EmulsifyingHydrogenated Lecithin
EmulsifyingCitric Acid
BufferingAllantoin
Skin ConditioningHyaluronic Acid
HumectantPolysilicone-11
Triacetin
AntimicrobialXanthan Gum
EmulsifyingTocopheryl Acetate
AntioxidantSodium Chloride
MaskingPhenoxyethanol
PreservativeRosmarinus Officinalis Leaf Extract
AntimicrobialMagnesium Aspartate
Skin ConditioningZinc Gluconate
Skin ConditioningSodium Lactate
BufferingLactic Acid
BufferingSerine
MaskingSorbitol
HumectantPotassium Sorbate
PreservativeSodium Benzoate
MaskingSodium Hyaluronate
HumectantDocosahexaenoic Acid
Skin ConditioningCopper Gluconate
Skin ConditioningWater, Dimethicone, Glycerin, Pentylene Glycol, Niacinamide, Butylene Glycol, Caprylic/Capric Triglyceride, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Butyrospermum Parkii Butter, Squalane, Sodium Hyaluronate Crosspolymer, Benzyl Alcohol, Urea, Tetrahexyldecyl Ascorbate, Bisabolol, Dimethyl Mea, Styrene/Acrylates Copolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Carbomer, Sodium Polyacrylate, Phosphatidylcholine, Hydrogenated Lecithin, Citric Acid, Allantoin, Hyaluronic Acid, Polysilicone-11, Triacetin, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Phenoxyethanol, Rosmarinus Officinalis Leaf Extract, Magnesium Aspartate, Zinc Gluconate, Sodium Lactate, Lactic Acid, Serine, Sorbitol, Potassium Sorbate, Sodium Benzoate, Sodium Hyaluronate, Docosahexaenoic Acid, Copper Gluconate
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
We don't have a description for Dimethyl Mea yet.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolThis is a botanical extract from the rosemary plant (the same one you cook with). In skincare, it mostly works as a skin conditioning agent.
Its activity comes from a handful of polyphenols, carnosic acid, carnosol, and rosmarinic acid. Almost 90% of the antioxidant activity of this ingredient can be attributed to canosol and carnosic acid.
These compounds protect your skin two ways:
1) They fight off free radicals, or the unstable molecules from things like sun and pollution that age and damage skin.
2) They help calm inflammation by switching off the chemical signals that tell skin to get red and irritated.
Lab studies also suggest that rosmarinic acid may help protect collagen and slow sugar-related damage to it.
The Cosmetic Ingredient Review has concluded rosemary-derived ingredients to be safe when formulated to be non-sensitizing.
Rosemary can occasionally cause allergic contact dermatitis (due to carnosol), so be sure to patch test if you have reactive or fragrance-sensitive skin.
Learn more about Rosmarinus Officinalis Leaf ExtractSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateTetrahexyldecyl Ascorbate (THD) is a stable and oil-soluble form of Vitamin C.
THD is special in that it has the ability to travel deeper into skin than traditional ascorbic acid while maintaining the same skin benefits (double win!).
Because it’s oil-soluble, THD dives deep into your skin’s fatty layers (think ceramides and cholesterol) to fight off the kind of free radicals that mess with your skin barrier. This makes it a great pair with water-based vitamin C (ascorbic acid) that mainly works on the surface.
Even at just 0.1%, THD is already showing great antioxidant activity. When used up to 2%, it helps keep your skin happy and calm, especially when it’s stressed from pollution or sun.
Want to fade dark spots or tackle hyperpigmentation? You’ll want 5% or more. Pairing it with brightening buddies like niacinamide or licorice root gives even better results. One study even used 30% THD with other brighteners and saw real results on stubborn discoloration, even in melasma-prone skin.
A note on THD: It’s has a slightly silky, oily texture and usually shows up colorless or pale yellow (though the exact shade can vary by supplier).
While you can sneak it into water-based formulas, it really shines when paired with silicones or oils, which help your skin soak it up better.
THD is pretty stable, but it’s still vulnerable to degradation like ascorbic acid. Too much light or heat (above 113°F / 45°C) can break it down over time. Go for dark and opaque packaging that keeps it safe and shady!
Read more about other types of Vitamin C:
Learn more about Tetrahexyldecyl AscorbateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan Gum