Missha Time Revolution Night Repair Ampoule 5x Versus CU Skin Bifida Barrier Ampoule
Updated on February 11, 2025
Overview
What they are
These products are both reef safe ampoules. They have a total of 20 ingredients in common
Cool Features
They both contain ceramides, hyaluronic acid and niacinamide
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots
Free From
They both do not contain any harsh alcohols, parabens, silicones or sulfates
What's Inside
They both contain fragrances
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Missha Time Revolution Night Repair Ampoule 5x 54 ingredients
CU Skin Bifida Barrier Ampoule 29 ingredients
About this product
About this product
At a glance
Click on any of the items below to learn more
Missha Time Revolution Night Repair Ampoule 5x 54 ingredients
CU Skin Bifida Barrier Ampoule 29 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.
Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.
Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.
Learn more about Bifida Ferment LysateButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
- It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
- It is a humectant, which means that it helps attract moisture into the skin.
- It helps improve product application.
- It has mild preservative properties.
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterNiacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about NiacinamideSqualane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.
Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.
Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.
Research shows that squalane is non-irritating (even at 100% concentration).
In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.
The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.
Is squalane vegan?
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Learn more about SqualaneHydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.
This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Lactobacillus Ferment Lysate is a postbiotic with skin soothing properties. Postbiotics are inactive molecules produced by probiotic bacteria that provide skin benefits.
This ingredient comes from the secretion of the bacteria, Lactobacillus.
Studies show this ingredient can help calm redness and may help treat the signs of photoaging; however, the evidence is inconclusive and further studies are needed.
Learn more about Lactobacillus Ferment LysateThis ingredient is created by fermenting soybean extract with the bacteria, lactobacillus.
Some studies have shown it to have antioxidant properties. One study found this ingredient to have stronger properties than non-fermented soybean extract.
Another study found in increase of isoflavones, amino acids, and peptides in fermented soy milk.
Learn more about Lactobacillus/Soybean Ferment ExtractThis ingredient comes from fermenting pomegranate with lactobacillus.
It displays strong antioxidant properties. One study found fermented pomegranate to help with moisture, brightness, elasticity, and collagen after 8 weeks.
Lactococcus Ferment Lysate is a postbiotic created by fermenting Lactoccus lactis, a type of bacteria more commonly used to create Lactic acid.
Postbiotics are inactive molecules produced by probiotic bacteria that provide skin benefits.
This ingredient offers promising benefits, but it is relatively new and more evidence is needed to prove its efficacy. The manufacturer claims this ingredient:
A study from 2022 found this ingredient helped protect skin against damaged from UV exposure (though this should not replace your sunscreen!).
The lysate in the ingredient name refers to a fluid that forms from breaking down the cell membrane.
Learn more about Lactococcus Ferment LysateTromethamine helps balance the pH and improve the texture of a product. It is synthetically created.
As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.
Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
Learn more about TromethamineEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumAdenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.
Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.
Studies have found adenosine may also help with wound healing.
In skincare products, Adenosine is usually derived from yeast.
Learn more about AdenosineSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateCeramide NP is a type of ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide AP Ceramide EOP
Learn more about Ceramide NPIngredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
Missha Time Revolution Night Repair Ampoule 5x 54 ingredients
CU Skin Bifida Barrier Ampoule 29 ingredients

Reviews
Here's what our community thinks
Missha Time Revolution Night Repair Ampoule 5x 54 ingredients
I have Eczema and have to be very careful about skincare products with any scents, so I was hesitant to purchase this serum. I had read that it was a dupe for the Estee Lauder’s iconic night repair serum and decided it to give it a go. To my pleasant surprise I love using it every night because of its scent. I also love it for the soft hydrated skin in the morning.
I got it to replace estee lauders advanced night repair serum. Tbh I didn’t see much difference in terms of quality but yet again none of them did wonders but none of them did harm.
Not purchasing again because now I have a much simpler routine.