ISDIN Fusion Water Magic Repair SPF 50 Versus La Roche-Posay Anthelios UVMune 400 Anti Dark-Spot Fluid SPF 50+
This chemical sunscreen covers the full UV range and blocks ~98% of UVB at SPF 50.
This chemical sunscreen covers the full UV range and blocks ~98% of UVB at SPF 50.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningPropanediol
SolventDibutyl Adipate
EmollientEthylhexyl Salicylate
UV AbsorberEthylhexyl Triazone
UV AbsorberBis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Skin ConditioningDimethicone
EmollientButyl Methoxydibenzoylmethane
UV AbsorberPhenylbenzimidazole Sulfonic Acid
UV AbsorberSilica
AbrasiveDiisopropyl Sebacate
EmollientArginine
MaskingUndecane
EmollientPentylene Glycol
Skin ConditioningGlycerin
HumectantTridecane
PerfumingButylene Glycol
HumectantHydroxyacetophenone
AntioxidantLauryl PEG/PPG-18/18 Methicone
Skin ConditioningVp/Eicosene Copolymer
Polysorbate 60
EmulsifyingDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningSodium Polyacrylate Starch
AbsorbentCaprylyl Glycol
EmollientHydrated Silica
AbrasiveTocopheryl Acetate
AntioxidantPEG-10 Dimethicone
Skin ConditioningTetrasodium Glutamate Diacetate
Parfum
MaskingSclerotium Gum
Emulsion StabilisingSodium Hyaluronate
HumectantXanthan Gum
EmulsifyingCarbomer
Emulsion StabilisingPolysorbate 20
EmulsifyingSodium Lactate
BufferingPhenoxyethanol
PreservativeSodium Benzoate
MaskingLecithin
EmollientPlankton Extract
Skin ConditioningTocopherol
AntioxidantPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningPentapeptide-34 Trifluoroacetate
EmollientWater, Propanediol, Dibutyl Adipate, Ethylhexyl Salicylate, Ethylhexyl Triazone, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Dimethicone, Butyl Methoxydibenzoylmethane, Phenylbenzimidazole Sulfonic Acid, Silica, Diisopropyl Sebacate, Arginine, Undecane, Pentylene Glycol, Glycerin, Tridecane, Butylene Glycol, Hydroxyacetophenone, Lauryl PEG/PPG-18/18 Methicone, Vp/Eicosene Copolymer, Polysorbate 60, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Polyacrylate Starch, Caprylyl Glycol, Hydrated Silica, Tocopheryl Acetate, PEG-10 Dimethicone, Tetrasodium Glutamate Diacetate, Parfum, Sclerotium Gum, Sodium Hyaluronate, Xanthan Gum, Carbomer, Polysorbate 20, Sodium Lactate, Phenoxyethanol, Sodium Benzoate, Lecithin, Plankton Extract, Tocopherol, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Pentapeptide-34 Trifluoroacetate
Water
Skin ConditioningAlcohol Denat.
AntimicrobialSilica
AbrasiveDiisopropyl Adipate
EmollientDiisopropyl Sebacate
EmollientEthylhexyl Triazone
UV AbsorberButyl Methoxydibenzoylmethane
UV AbsorberBis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Skin ConditioningDicaprylyl Carbonate
EmollientGlycerin
HumectantPropanediol
SolventC12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer
StabilisingDiethylamino Hydroxybenzoyl Hexyl Benzoate
UV FilterC12-15 Alkyl Benzoate
AntimicrobialMethoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate
StabilisingPerlite
AbsorbentDrometrizole Trisiloxane
UV AbsorberAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingCitric Acid
BufferingDisodium Phosphate
BufferingHydroxyacetophenone
AntioxidantHydroxyethylcellulose
Emulsion Stabilising2-Mercaptonicotinoyl Glycine
Skin ConditioningPentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
AntioxidantPentylene Glycol
Skin ConditioningPolysorbate 60
EmulsifyingSodium Phosphate
BufferingSodium Thiosulfate
Terephthalylidene Dicamphor Sulfonic Acid
UV AbsorberTocopherol
AntioxidantTriethanolamine
BufferingTrisodium Ethylenediamine Disuccinate
Water, Alcohol Denat., Silica, Diisopropyl Adipate, Diisopropyl Sebacate, Ethylhexyl Triazone, Butyl Methoxydibenzoylmethane, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Dicaprylyl Carbonate, Glycerin, Propanediol, C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer, Diethylamino Hydroxybenzoyl Hexyl Benzoate, C12-15 Alkyl Benzoate, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate, Perlite, Drometrizole Trisiloxane, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Disodium Phosphate, Hydroxyacetophenone, Hydroxyethylcellulose, 2-Mercaptonicotinoyl Glycine, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Pentylene Glycol, Polysorbate 60, Sodium Phosphate, Sodium Thiosulfate, Terephthalylidene Dicamphor Sulfonic Acid, Tocopherol, Triethanolamine, Trisodium Ethylenediamine Disuccinate
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
This ingredient is better known as bemotrizinol or Tinosorb S and is one of the best broad-spectrum UV filters in modern sunscreen.
It works by absorbing UV light across a whole range (280-400 nm) with peaks around 310 nm (UVB) and 340-345 nm (UVA). This means it covers UVB plus the deeper UVA wavelengths that drive photoaging and pigmentation.
Another pro?
It's exceptionally photostable, barely degrades in sunlight, and acts as a "bodyguard" for less stable filters.
That's why you'll see it paired with avobenzone or octinoxate; this team up ensures they keep working through sun exposure.
Safety reviews have been reassuring across the board. This ingredient shows low absorption through the skin, rarely irritates, and lab studies found it doesn't act like a hormone in the body (a concern that's been raised about some older sunscreen filters).
On maximum concentrations:
In 2026, the US F.D.A finally added it as an OTC sunscreen ingredient at concentrations up to 6% for adults / children 6 months and older
Learn more about Bis-Ethylhexyloxyphenol Methoxyphenyl TriazineAlso known as Avobenzone, this ingredient is an oil-soluble used to absorb the full spectrum of UVA rays (peak 357 nm).
It's one of the most effective UVA filters available but has a major caveat of photostability: avobenzone is susceptible to photodegradation.
This means it can lose efficacy when exposed to sunlight without the help of a stabilizing agent.
Studies show antioxidants (like vitamin E or vitamin C) and some UV filters (like octocrylene and Tinosorb S) can meaningfully improve its stability in a formulation.
The maximum allowable concentration according to regulation is 3% in the US + Canada, and 5% in the EU, Australia, China, Korea, and ASEAN countries.
It has a well-support safety profile: a comprehensive 2025 review found minimal toxicity with no evidence of carcinogenicity.
Overall, avobenzone is a safe and regulated ingredient used in sunscreen for over 40 years.
Learn more about Butyl MethoxydibenzoylmethaneWe don't have a description for Diisopropyl Sebacate yet.
Ethylhexyl Triazone (aka Octyl Triazone) is an oil-soluble organic UVB filter. It has peak absorption around 314 nm, right in the middle of the UVB range.
This ingredient is described as one of the most effective UVB filters available and small concentrations are enough to deliver a high SPF thanks to its strong UV absorbing power.
Formulators love it for its stability; its ability to filter UV stays practically unchanged even under intense radiation and it can also help boost the photostability of less stable filters like avobenzone.
It's also a great pick for water resistant products because it's insoluble in water and has a good affinity for keratin.
Because it's a big, heavy molecule, the European Scientific Committee has found to to have very low dermal penetration and negative results for allergenicity.
In vitro testing also showed a low absorption rate and clean results on irritation.
Typical use levels are 1-5% with 5% being the maximum in the EU, Japan, and other markets that allow it. However, this ingredient is not approved yet in the US or Canada.
Learn more about Ethylhexyl TriazoneGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Learn more about HydroxyacetophenonePentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolPolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolSilica, also known as silicon dioxide, is a naturally occurring mineral. It is used as a fine, spherical, and porous powder in cosmetics.
Though it has exfoliant properties, the function of silica varies depending on the product.
The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.
It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.
In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.
Learn more about SilicaTocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about TocopherolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water