Mediheal Derma 365 Mask
A sheet mask with 58 ingredients, including niacinamide, hyaluronic acid, and tranexamic acid.
Overview
What it is
Sheet mask with 58 ingredients that contains hyaluronic acid, niacinamide and tranexamic acid
Cool Features
It is vegan and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, parabens, silicones or sulfates
Fun facts
Mediheal is from South Korea.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningGlycerin
HumectantGlycereth-26
HumectantDipropylene Glycol
Humectant1,2-Hexanediol
Skin ConditioningHydroxyacetophenone
AntioxidantAminobutyric Acid
Niacinamide
SmoothingEthylhexylglycerin
Skin ConditioningStyrene/Acrylates Copolymer
Xanthan Gum
EmulsifyingButylene Glycol
HumectantCarbomer
Emulsion StabilisingPantolactone
HumectantArginine
MaskingPolyglyceryl-10 Laurate
Skin ConditioningCentella Asiatica Extract
CleansingPolyglyceryl-4 Laurate
EmulsifyingDisodium EDTA
Sodium Hyaluronate
HumectantTrehalose
HumectantGlyceryl Glucoside
HumectantPyrus Communis Fruit Extract
Skin ConditioningJuniperus Virginiana Oil
MaskingCentella Asiatica Leaf Extract
Skin ConditioningHydrogenated Lecithin
EmulsifyingGlycine
BufferingRosa Damascena Flower Water
MaskingGlutamic Acid
HumectantMel Extract
MoisturisingIris Florentina Root Extract
MaskingAspartic Acid
MaskingMyristica Fragrans Extract
MaskingSimmondsia Chinensis Seed Oil
EmollientTranexamic Acid
AstringentMadecassoside
AntioxidantHedera Helix Leaf/Stem Extract
AntimicrobialBambusa Vulgaris Leaf Extract
Skin ConditioningLinum Usitatissimum Seed Extract
PerfumingTremella Fuciformis Polysaccharide
Emulsion StabilisingPanthenol
Skin ConditioningPantothenic Acid
Skin ConditioningSodium Polyacrylate
AbsorbentPogostemon Cablin Leaf Oil
MaskingSodium Chloride
MaskingArtemisia Vulgaris Oil
PerfumingRosmarinus Officinalis Leaf Oil
MaskingHistidine
HumectantSerine
MaskingAlanine
MaskingProline
Skin ConditioningThreonine
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingMagnesium Chloride
Calcium Chloride
AstringentAsiaticoside
AntioxidantAsiatic Acid
Skin ConditioningMadecassic Acid
Skin ConditioningWater, Glycerin, Glycereth-26, Dipropylene Glycol, 1,2-Hexanediol, Hydroxyacetophenone, Aminobutyric Acid, Niacinamide, Ethylhexylglycerin, Styrene/Acrylates Copolymer, Xanthan Gum, Butylene Glycol, Carbomer, Pantolactone, Arginine, Polyglyceryl-10 Laurate, Centella Asiatica Extract, Polyglyceryl-4 Laurate, Disodium EDTA, Sodium Hyaluronate, Trehalose, Glyceryl Glucoside, Pyrus Communis Fruit Extract, Juniperus Virginiana Oil, Centella Asiatica Leaf Extract, Hydrogenated Lecithin, Glycine, Rosa Damascena Flower Water, Glutamic Acid, Mel Extract, Iris Florentina Root Extract, Aspartic Acid, Myristica Fragrans Extract, Simmondsia Chinensis Seed Oil, Tranexamic Acid, Madecassoside, Hedera Helix Leaf/Stem Extract, Bambusa Vulgaris Leaf Extract, Linum Usitatissimum Seed Extract, Tremella Fuciformis Polysaccharide, Panthenol, Pantothenic Acid, Sodium Polyacrylate, Pogostemon Cablin Leaf Oil, Sodium Chloride, Artemisia Vulgaris Oil, Rosmarinus Officinalis Leaf Oil, Histidine, Serine, Alanine, Proline, Threonine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Magnesium Chloride, Calcium Chloride, Asiaticoside, Asiatic Acid, Madecassic Acid
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlycereth-26 is a synthetic ingredient and polyethylene glycol ether of Glycerin. Glycerin is already naturally found in your skin and helps keep your skin moisturized.
It is a humectant and helps add texture to products. It can make your product thicker.
As a humectant, it helps draw moisture from the air to your skin. This helps your skin stay hydrated.
Learn more about Glycereth-26Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene Glycol1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Hydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.
Though naturally occuring in Norwegian spruce needles, this ingredient is usually synthetically created.
This ingredient is not irritating or sensitizing. Recent research also suggests it may have skin-brightening effects through tyrosinase inhibition.
Learn more about HydroxyacetophenoneAminobutyric Acid is an antioxidant. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
Studies have shown Gamma-Aminobutyric Acid may reduce hyperpigmentation.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinThis ingredient is a synthetic polymer that mainly works as a film former. It creates a thin, flexible film on the surface of your skin. Once applied, it helps improves wear, durability, and resistance to water/smudging.
Due to its large molecule size, it sits on top of your skin rather than absorbing into it.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCarbomer is a high-molecular weight polymer of acrylic acid. It is used to form gels and thicken formulas.
Due to its large molecular size, carbomer has minimal skin penetration and is considered an inert ingredient.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Learn more about CarbomerPantolactone is a synthetically created humectant.
As a humectant, Pantolactone helps draw moisture to the skin. It can help add hydration to your skin.
Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
Learn more about ArgininePolyglyceryl-10 Laurate is a cleansing agent and emulsifier.
It rounds up dirt, oil, and grime, so they can be rinsed off easily as a cleanser. On the emulsifier side, it keeps your formula smooth and well-mixed by playing peacekeeper for ingredients that don't naturally get along (like oil and water).
Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne. The Malassezia yeast prefers esters with C11-C24 fatty acids If you're prone to flare-ups, you might want to patch-test or skip this one.
This ingredient is an ester of lauric acid and Polyglycerin-10.
Learn more about Polyglyceryl-10 LaurateCentella Asiatica Extract (Centella) is derived from an herb native to Southeast Asia. It is famous for its anti-inflammatory and soothing properties.
Centella is rich in antioxidants and amino acids, such as Madecassic Acid and Asiaticoside.
Studies show the compounds in centella help with:
The combination of all these properties makes centella effective at soothing, hydrating, and protecting the skin.
Other great components of centella include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractPolyglyceryl-4 Laurate isn't fungal acne safe.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTASodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateTrehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.
As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.
Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.
In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.
Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.
Learn more about TrehaloseGlyceryl Glucoside is made from glycerol and glucose.
It is a humectant. Humectants help hydrate your skin by drawing moisture to it from the air.
Some foods that contain glyceryl glucoside include sake, miso, and wines.
Learn more about Glyceryl GlucosideThis ingredient comes from the common pear and has skin conditioning/skin protecting properties. Pears are rich in bioactive phenolic compounds, with the most notable ones being Arbutin, Chlorogenic Acid, and Catechin.
A small in-vivo study with 13 volunteers found using a 5% pear extract gel over 12 weeks significantly improved skin moisture and elasticity, and decreased melanin and sebum levels compared to placebo.
In phytochemical analysis, this extract has also demonstrated anti-tyrosinase activity which further supports its brightening properties.
Just so you know, individuals with birch pollen allergy should be careful and patch test this ingredient as pears belong to the same family. But topical use of this ingredient is generally well-tolerated.
Learn more about Pyrus Communis Fruit ExtractJuniperus Virginiana Oil is the volatile oil obtained from the fruits and leaves of the Red Cedar tree. This tree is native to North America.
Centella Asiatica Leaf Extract comes from the leaves of an herb plant native to Southeast Asia. Centella Asiatica is rich in antioxidants and amino acids. It can help reduce irritation and soothe the skin.
Many active components found in centella asiatica, such as Madecassic Acid and Asiaticoside, encourage the skin to naturally produce hyaluronic acid. This helps keep our skin hydrated. Many of these components also show antioxidant activity and may help reduce the signs of aging.
Research shows centella asiatica can help increase Type I collagen production by increasing fibroblast production. Fibroblast helps form connective tissue.
The combination of all these properties makes centella asiatica leaf extract effective at soothing the skin.
Other components of centella asiatica leaf extract include Vitamin A, vitamin C, several B vitamins, and Asiatic Acid.
Recent studies found madecassoside may help prevent damage from UV rays by preventing UV-induced inflammation. Further research is needed.
This plant has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica Leaf ExtractHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinGlycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.
Rosa Damascena Flower Water is the water-based byproduct of steam-distilling damask rose petals. It has skin conditioning, masking, and skin protecting properties.
Research shows that Rosa damascena is rich in flavonoids and phenolic compounds like gallic acid that contribute to its antioxidant activity.
In vitro studies have shown that Rosa damascena can scavenge free radicals and reduce melanin overproduction. Research has also found this extract offers some degree of UV absorption but this should not replace your sunscreen.
Learn more about Rosa Damascena Flower WaterGlutamic Acid is an amino acid that is found in all living organisms. Our bodies use this to help nerve cells in the brain communicate with other cells.
In cosmetics, glutamic acid is a famous humectant. It draws water from the air to your skin, keeping your skin hydrated (like hyaluronic acid).
An in-vitro study from 2024 found glutamic acid to play a role in inhibiting inflammation and thus a potential skin-soothing ingredient.
Other studies show it to be have potential wound healing, skin barrier repair, and hair growth properties.
Glutamic acid has poor solubility in water and other solvents.
Learn more about Glutamic AcidWe don't have a description for Mel Extract yet.
We don't have a description for Iris Florentina Root Extract yet.
Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.
Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.
We don't have a description for Myristica Fragrans Extract yet.
Jojoba oil is one of the most well-studied plant-derived ingredients in cosmetics. It is an emollient with a special structure.
Because it is made up of 97-98% wax esters, it closely mirrors the linear monoesters found in human sebum. This makes it skin compatible, non-greasy, and lightweight.
Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.
Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).
Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.
Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.
Due to its fatty acid content, Jojoba oil may not be fungal acne safe.
Learn more about Simmondsia Chinensis Seed OilTranexamic Acid (TXA) is a synthetic lysine derivative that is becoming one of the most exciting brightening ingredients in skincare.
Originally used in medicine as an anti-hemorrhagic agent, its skin brightening potential was discovered by accident; patients taking it orally started noticing their melasma was fading.
Unlike most brighteners that target tyrosinase (the enzyme that synthesizes melanin), TXA works further upstream. It basically blocks your cells from receiving the signal to produce pigment.
This makes it one of the rare actives that works on three pathways at once:
This makes it effective for treating melasma, post-inflammatory hyperpigmentation (PIH), and sun-induced dark spots.
The most effective cosmetic concentration sits between 2-5% and going higher doesn't boost results.
Side effects are generally mild; occasional irritation, flaking, or dryness have been reported at the start of use. Overall, this ingredient is pretty well tolerated, even by sensitive skin types.
Another perk of this ingredient is that it does not cause photosensitivity, so it's safe to use in the AM and PM.
Learn more about Tranexamic AcidMadecassoside is one of four active compounds found in Centella asiatica and is one of the main reasons Centella is so effective at calming irritated skin and supporting the moisture barrier.
There's a solid body of peer-reviewed research backing Madecassoside for several skin benefits. Studies have found:
Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.
Learn more about MadecassosideThis ingredient comes from the English Ivy, a climbing evergreen plant. The extract is rich in compounds that give it antioxidant, skin conditioning, and anti-inflammatory properties.
Two of the compounds, Alpha-Hederin and Hederasaponin-C, showed strong inhibition of shown to be effective at protecting against oxidative damage as well as synthetic antioxidants like butylated hydroxyanisole and BHT.
Bambusa Vulgaris Leaf Extract comes from bamboo plant.
Bamboo leaf extract has antioxidant properties. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
A recent study found bamboo extract might interrupt the process of hyperpigmentation.
Learn more about Bambusa Vulgaris Leaf ExtractThis ingredient is also known as flaxseed extract. It has skin conditioning and perfuming properties.
Flaxseed naturally contains polysaccharides (sugars) and small amounts of fatty acid-related compounds to help hydrate the skin. The seed also contains antioxidants being studied for its effects on inflammation pathways.
A small clinical trial found topical flaxseed oil improved hand eczema over the course of 4 weeks. In an animal study, topical flaxseed cream supported wound-healing outcomes.
Overall, flaxseed is a great hydrating and barrier supporting ingredient. Like other plant extracts, some rare cases of allergic reactions can occur.
Though flaxseed has a perfuming function according to INCI, this doesn't mean the ingredient is added as a fragrance. It just means the material can contribute an odor or modify the scent of a formula.
Learn more about Linum Usitatissimum Seed ExtractTremella Fuciformis Polysaccharide are the sugars from the snow mushroom.
Snow mushroom is rich in polysaccharides, giving it moisturizing benefits. As a humectant, snow mushroom helps draw moisture from the air to the skin. Polysaccharides are able to mimic our skin's natural carbohydrates to help the skin retain water.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolPantothenic Acid is also known as Vitamin B5. It is a water-soluble vitamin with skin hydrating and soothing properties.
Research shows pantothenic acid help support the skin's natural barrier by improving moisture retention. This is why you'll likely find this ingredient in soothing products or formulations for sensitive skin.
Some studies have explored oral supplementation of pantothenic acid in the acne context and found it to help reduce blemishes over time.
Though oral and topical use are different, this research helps explain why vitamin B5 is often included in skincare routines aimed at keeping skin balanced and hydrated.
Learn more about Pantothenic AcidSodium Polyacrylate is the sodium salt of polyacrylic acid. It is used as an absorber, emollient, and stabilizer.
This ingredient is a super-absorbent polymer - meaning it can absorb 100 to 1000 times its mass in water. As an emollient, Sodium Polyacrylate helps soften and soothe skin. Emollients work by creating a barrier to trap moisture in. This helps keep your skin hydrated.
This ingredient is commonly known as Patchouli oil.
Patchouli exhibits slight antibacterial and antifungal activity from its patchoulol and alpha-patchoulene content.
However, it also contains known skin-irritating fragrances. A study from 2015 found limonene and camphor as active components of this ingredient.
Limonene and camphor are both known EU allergens.
Learn more about Pogostemon Cablin Leaf OilChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt. This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient.
You might see this ingredient used in scrubs as a primary exfoliating ingredient.
Learn more about Sodium ChlorideArtemisia Vulgaris Oil is a fragrance and is an oil.
Rosmarinus Officinalis Leaf Oil is oil expressed from the leaves of the rosemary plant.
Rosemary Leaf Oil is a fragrance and helps give your product a scent. If you are sensitive to irritating fragrances, this one contains camphor. Camphor has been found to irritate skin.
This oil also contains antioxidant and antimicrobial properties. As an antioxidant, it may protect you skin against damage. This can help slow down the signs of aging.
Learn more about Rosmarinus Officinalis Leaf OilHistidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.
Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.
One study found histidine and carnosine to be a dynamic duo for your skin:
Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.
Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.
Learn more about HistidineSerine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.
Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.
Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.
Learn more about SerineAlanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Learn more about ProlineThreonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.
Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Learn more about Acrylates/C10-30 Alkyl Acrylate CrosspolymerMagnesium chloride is a mineral salt made from magnesium and chloride. It is mainly used to control product stability and texture in cosmetics.
This ingredient can also play a role in soothing the skin and supporting normal skin function.
Magnesium chloride is water-soluble, generally well tolerated, and does not act as a strong “active” ingredient on its own.
Learn more about Magnesium ChlorideCalcium chloride is a white, odorless, crystalline solid. It is an astringent and can be used to change the viscosity of products.
This ingredient is highly soluble in water, acetic acid, and ethanol.
There are many forms of this ingredient, including monohydrate, dihydrate, tetrahydrate, and hexahydrate.
Learn more about Calcium ChlorideAsiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.
Research from 2016-2025 supports its role in:
You'll usually find this in concentrations between 0.2-5%.
Learn more about AsiaticosideAsiatic Acid is a major component of Centella Asiatica Extract. It has wound-healing, anti-inflammatory, and antioxidant properties.
Studies show Asiatic Acid is able to block the pathway for skin inflammation receptors, helping to soothe skin.
As an antioxidant, asiatic acid helps protect our skin against damaging environmental factors.
Learn more about Asiatic AcidMadecassic Acid is a major component of Centella Asiatica Extract. It has anti-inflammatory and antioxidant properties.
It is a triterpenoid, meaning it naturally acts as an antioxidant. Antioxidants protect your skin against damage from environmental factors such as pollution and UV.
Studies show Madecassic Acid helps soothe the skin due to its ability to block inflammation pathways.
Learn more about Madecassic AcidReviews
Where it's from
Mediheal is a Korean brand
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The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated January 7, 2026 • Added by crescendolls