What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Hyaluronic Acid
Humectant
Hydrolyzed Sodium Hyaluronate
Skin Conditioning
Sodium Hyaluronate
Humectant
Sodium Hyaluronate Crosspolymer
Humectant
Hydroxypropyltrimonium Hyaluronate
C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate
Superoxide Dismutase
Antioxidant
Saccharomyces Polypeptides
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Palmitoyl Tripeptide-5
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Acetyl Octapeptide-3
Humectant
Ceramide Ns
Skin Conditioning
Saccharomyces/Copper Ferment
Skin Conditioning
Saccharomyces/Zinc Ferment
Skin Conditioning
Saccharomyces/Manganese Ferment
Skin Conditioning
Riboflavin
Cosmetic ColorantPhospholipids
Skin Conditioning
Folic Acid
Skin ConditioningEnteromorpha Compressa Extract
Skin ProtectingGlycoproteins
Skin Conditioning
Ginkgo Biloba Leaf Extract
Skin Conditioning
Serine
Masking
Proline
Skin Conditioning
Alanine
Masking
Glutamic Acid
Humectant
Niacinamide
Smoothing
Parfum
Masking
Caprylyl Glycol
Emollient
Ethylhexylglycerin
Skin ConditioningUndecylenoyl Glycine
CleansingCapryloyl Glycine
CleansingHyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Superoxide Dismutase, Saccharomyces Polypeptides, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Acetyl Octapeptide-3, Ceramide Ns, Saccharomyces/Copper Ferment, Saccharomyces/Zinc Ferment, Saccharomyces/Manganese Ferment, Riboflavin, Phospholipids, Folic Acid, Enteromorpha Compressa Extract, Glycoproteins, Ginkgo Biloba Leaf Extract, Serine, Proline, Alanine, Glutamic Acid, Niacinamide, Parfum, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine
Water
Skin ConditioningPentylene Glycol
Skin Conditioning
Hamamelis Virginiana Extract
Antiseborrhoeic
Glycerin
Humectant
Dimethyl Sulfone
SolventHuman Umbilical Mesenchymal Stem Cell Exosomes
Alpha-Arbutin
Antioxidant
Palmitoyl Tripeptide-5
Skin Conditioning
Ergothioneine
Antioxidant
Dipalmitoyl Hydroxyproline
Skin Conditioning
Ubiquinone
Antioxidant
Saccharomyces Ferment Lysate Filtrate
Skin Conditioning
Tetrahexyldecyl Ascorbate
Antioxidant
Sh-Oligopeptide-1
Skin Conditioning
Rh-Polypeptide-3
Skin Conditioning
Sh-Polypeptide-9
Skin Conditioning
Sh-Polypeptide-1
Skin Conditioning
Sh-Polypeptide-11
Human Urine Derived Stem Cell Conditioned Media
EmollientGlycereth-7 Triacetate
EmollientEthoxydiglycol
HumectantLactococcus Ferment Lysate
Skin Conditioning
Chlorella Vulgaris Extract
Skin ConditioningSaccharide Isomerate
Humectant
Tripeptide-2
Skin Conditioning
Dimer Tripeptide-43
Vitis Vinifera Flower Cell Extract
MaskingPyrus Malus Fruit Extract
Skin Conditioning
Hydroxyacetophenone
Antioxidant
Tocopheryl Acetate
Antioxidant
Propanediol
Solvent
Xanthan Gum
EmulsifyingLecithin
Emollient
Pullulan
Butylene Glycol
Humectant
Sodium Citrate
BufferingPolysorbate 20
Emulsifying
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Skin ConditioningPalmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Acetyl Hexapeptide-51 Amide
Skin Conditioning
Nannochloropsis Oculata Extract
HumectantCentella Asiatica Extract
Cleansing
Chondrus Crispus Extract
Skin Conditioning
Equisetum Arvense Extract
AstringentGeranium Maculatum Extract
TonicTaraxacum Officinale Root Extract
Skin ConditioningAchillea Millefolium Flower Extract
Antioxidant
Curcuma Longa Rhizome Extract
Skin ConditioningSpirulina Platensis Extract
Skin ProtectingAloe Barbadensis Leaf Juice
Skin Conditioning
Cassia Angustifolia Seed Polysaccharide
Skin ConditioningSimmondsia Chinensis Seed Oil
Emollient
Arginine
Masking
Aspartic Acid
Masking
Glycine
Buffering
Alanine
Masking
Serine
Masking
Valine
MaskingIsoleucine
Skin ConditioningProline
Skin Conditioning
Threonine
Histidine
Humectant
Phenylalanine
Masking
PCA
Humectant
Sodium PCA
Humectant
Sodium Lactate
Buffering
Sodium Chloride
MaskingCarbomer
Emulsion StabilisingAlcohol
Antimicrobial
Hydroxyethylcellulose
Emulsion StabilisingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingSodium Hydroxide
BufferingPotassium Sorbate
Preservative
Sodium Benzoate
Masking
Dextran
Disodium EDTA
Phenoxyethanol
Preservative
Ethylhexylglycerin
Skin ConditioningWater, Pentylene Glycol, Hamamelis Virginiana Extract, Glycerin, Dimethyl Sulfone, Human Umbilical Mesenchymal Stem Cell Exosomes, Alpha-Arbutin, Palmitoyl Tripeptide-5, Ergothioneine, Dipalmitoyl Hydroxyproline, Ubiquinone, Saccharomyces Ferment Lysate Filtrate, Tetrahexyldecyl Ascorbate, Sh-Oligopeptide-1, Rh-Polypeptide-3, Sh-Polypeptide-9, Sh-Polypeptide-1, Sh-Polypeptide-11, Human Urine Derived Stem Cell Conditioned Media, Glycereth-7 Triacetate, Ethoxydiglycol, Lactococcus Ferment Lysate, Chlorella Vulgaris Extract, Saccharide Isomerate, Tripeptide-2, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-51 Amide, Nannochloropsis Oculata Extract, Centella Asiatica Extract, Chondrus Crispus Extract, Equisetum Arvense Extract, Geranium Maculatum Extract, Taraxacum Officinale Root Extract, Achillea Millefolium Flower Extract, Curcuma Longa Rhizome Extract, Spirulina Platensis Extract, Aloe Barbadensis Leaf Juice, Cassia Angustifolia Seed Polysaccharide, Simmondsia Chinensis Seed Oil, Arginine, Aspartic Acid, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, PCA, Sodium PCA, Sodium Lactate, Sodium Chloride, Carbomer, Alcohol, Hydroxyethylcellulose, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate, Dextran, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinPalmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".
"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.
This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.
Clinical testing showed statistically significant improvements in:
Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.
You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.
Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.
That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.
Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.
In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.
Human clinical data is promising, but modest:
A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.
A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.
You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.
Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Palmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.
This peptide has a "build more, lose less" approach.
It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.
The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.
This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.
Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.
On the fungal acne front:
Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.
Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Learn more about ProlineSerine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.
Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.
Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.
Learn more about Serine
