Two Slash Four Glaze Lip Changer
A lip gloss with 43 ingredients, including exfoliants, vitamin E, and hyaluronic acid.
Overview
What it is
Lip gloss with 43 ingredients that contains exfoliants, hyaluronic acid, peptides and Vitamin E
Cool Features
It is reef safe
Suited For
It has ingredients that are good for anti aging, dry skin, brightening skin, sensitive skin, scar healing and better texture
Free From
It doesn't contain any harsh alcohols, parabens, silicones or sulfates
Fun facts
Two Slash Four is from South Korea.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate
EmollientDiisostearyl Malate
EmollientBis-Diglyceryl Polyacyladipate-2
EmollientHydrogenated Polyisobutene
EmollientPolyglyceryl-2 Triisostearate
EmulsifyingParaffin
PerfumingMicrocrystalline Wax
Emulsion StabilisingMenthyl Lactate
Masking1,2-Hexanediol
Skin ConditioningSorbitan Isostearate
EmulsifyingCI 77891
Cosmetic ColorantTocopheryl Acetate
AntioxidantCI 77491
Cosmetic ColorantCI 15850
Cosmetic ColorantCI 42090
Cosmetic ColorantBenzyl Benzoate
AntimicrobialCI 77499
Cosmetic ColorantParfum
MaskingWater
Skin ConditioningSimmondsia Chinensis Seed Oil
EmollientButyrospermum Parkii Butter
Skin ConditioningSimmondsia Chinensis Seed Extract
AbrasiveCI 15985
Cosmetic ColorantPunica Granatum Flower Extract
Skin ConditioningButylene Glycol
HumectantPolyglyceryl-3 Diisostearate
EmulsifyingSodium Hyaluronate
HumectantHydroxypropyltrimonium Hyaluronate
Hydrolyzed Hyaluronic Acid
HumectantSodium Acetylated Hyaluronate
HumectantHyaluronic Acid
HumectantSodium Hyaluronate Crosspolymer
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningPotassium Hyaluronate
Skin ConditioningPalmitoyl Pentapeptide-4
Skin ConditioningTripeptide-2
Skin ConditioningAcetyl Hexapeptide-8
HumectantPalmitoyl Tripeptide-1
Skin ConditioningCopper Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningAcetyl Octapeptide-3
HumectantTripeptide-3
Skin ConditioningTripeptide-1
Skin ConditioningBis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate, Diisostearyl Malate, Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Polyglyceryl-2 Triisostearate, Paraffin, Microcrystalline Wax, Menthyl Lactate, 1,2-Hexanediol, Sorbitan Isostearate, CI 77891, Tocopheryl Acetate, CI 77491, CI 15850, CI 42090, Benzyl Benzoate, CI 77499, Parfum, Water, Simmondsia Chinensis Seed Oil, Butyrospermum Parkii Butter, Simmondsia Chinensis Seed Extract, CI 15985, Punica Granatum Flower Extract, Butylene Glycol, Polyglyceryl-3 Diisostearate, Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Palmitoyl Pentapeptide-4, Tripeptide-2, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Copper Tripeptide-1, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Tripeptide-3, Tripeptide-1
Key Ingredients
Benefits
Concerns
Ingredients Explained
This ingredient is an emollient and skin conditioning agent.
Diisostearyl Malate is an emollient and most often used in lip products. It comes from isostearyl alcohol, a fatty acid, and malic acid, an AHA.
As an emollient, Diisostearyl Malate helps create a thin film on your skin to trap moisture in. This helps keep your skin soft and smooth.
This ingredient is lipid-based synthetic skin-conditioning agent derived from adipic acid and a mixture of fatty acids. It is often called a lanolin substitute.
As an emollient, it helps soften and hydrate the skin. Emollients create a barrier on the skin to trap moisture in.
Due to its fatty acid base, it may not be Malassezia folliculitis safe.
Learn more about Bis-Diglyceryl Polyacyladipate-2Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.
In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.
Hydrogenated Polyisobutene is often used as a mineral oil replacement.
Learn more about Hydrogenated PolyisobuteneThis ingredient is a form of glycerin with emulsifying and emollient properties.
As an emulsifier, this ingredient helps keep products together while adding a thick texture. The manufacturer states this ingredient has emollient properties. Emollients help keep the skin hydrated by trapping moisture in.
Polyglyceryl-2 Triisostearate is created by reacting diglycerin and isostearic acid. Due to the isostearic acid base, it may not be safe for Malassezia or fungal acne.
Learn more about Polyglyceryl-2 TriisostearateParaffin is a solid created from petroleum. The term 'paraffin' can also refer to either
petroleum jelly or mineral oil.
It has natural occlusive properties which can worsen oily skin. Due to its petrolatum base, this ingredient is not fungal-acne safe.
Microcrystalline Wax is derived from petroleum through a de-oiling process, then highly refined and purified before use in cosmetics.
In skincare formulations, it is used to improve texture and create a smooth, even consistency. It also helps stabilize products by preventing ingredients from separating.
Menthyl lactate is an ester of menthol and lactic acid. It is often used as a cooling agent and fragrance.
When applied topically, this ingredient leaves a refreshing sensation like menthol, but is less irritating.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.Â
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservativesÂ
Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.
As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.
Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.
Learn more about Sorbitan IsostearateCi 77891 is a white pigment from Titanium dioxide. It is naturally found in minerals such as rutile and ilmenite.
It's main function is to add a white color to cosmetics. It can also be mixed with other colors to create different shades.
Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.
Learn more about CI 77891Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateCi 77491 is also hydrated iron III oxide. It's sole purpose is to give a red/pink hue to products.
Iron III oxides are classified as inorganic chemicals for coloring.
Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.
Learn more about CI 77491Ci 15850 is the pigment color red. It is an azo dye and created synthetically.
Azo dyes need to be thoroughly purified before use. This allows them to be more stable and longer-lasting.
This ingredient is common in foundations, lipsticks, and blushes. This color is described as brown/orangey red.
It has many secondary names such as Red 6 and Red 7. According to a manufacturer, Red 6 usually contains aluminum.
Learn more about CI 15850Ci 42090 is a synthetic dye created from petroleum. It is used to give a bright blue color to cosmetics, medicine, and food.
Benzyl Benzoate is usually created from the condensation of benzoic acid and benzyl alcohol. It is used as a preservative, solvent, and has a floral/balsamic scent in large amounts.
As a preservative, Benzyl Benzoate works against bacteria and fungus. It is often used to treat scabies and lice in medicine.
Solvents are used to keep ingredients together in a product. They can help dissolve ingredients to stable bases or help evenly distribute ingredients throughout the product.
Due to its fragrance, Benzyl Benzoate can be sensitizing and may cause contact dermatitis. It is a known EU allergen. We recommend speaking with a professional if you have any concerns.
Benzyl Benzoate can be naturally found in cranberries and peaches.
Learn more about Benzyl BenzoateCi 77499 is also hydrated iron III oxide. It is created from mixing red and black iron oxides. This helps give shades of darkness to a product.
Iron III oxides are classified as inorganic chemicals for coloring.
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of âFRAGRANCEâ or âPARFUMâ according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterJojoba oil is one of the most well-studied plant-derived ingredients in cosmetics. It is an emollient with a special structure.
Because it is made up of 97-98% wax esters, it closely mirrors the linear monoesters found in human sebum. This makes it skin compatible, non-greasy, and lightweight.
Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.
Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).
Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.
Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.
Due to its fatty acid content, Jojoba oil may not be fungal acne safe.
Learn more about Simmondsia Chinensis Seed OilThis ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.
Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).
In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).
Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.
Shea butter also contains vitamins A and E which may contribute to antioxidant activity.
While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.
This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.
Learn more about Butyrospermum Parkii ButterSimmondsia Chinensis Seed Extract is an exfoliant.
Ci 15985 is a dye made from petroleum. It is synthetically created and approved by the FDA for use in foods and cosmetics.
The color of this dye is orange/yellow.
This ingredient can be found in makeup, sun care, and skincare.
Learn more about CI 15985Pomegranate flower extract has skin conditioning properties.
According to analysis of the flower, it is rich in the triterpenes ursolic acid and oleanolic acid.
Triterpenes are chemical compounds found in various plants such as pomegranates, apples, basil, and rosemary. They have been shown to have anti-inflammatory and antioxidant properties.
The flowers also contain gallic acid and ellagic acid, two types of polyphenols. They possess antioxidant, anti-inflammatory, and antimicrobial properties.
A study from 2017 found pomegranate flower to help heal scars and wounds in rats. Another study from 2020 found this ingredient to help decrease lip wrinkles and increase lip volume.
This ingredient also showed positive effects on dandruff removal in a study from 2015.
Learn more about Punica Granatum Flower ExtractButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolPolyglyceryl-3 Diisostearate is an emulsifer and emollient. It comes from Isostearic Acid and Polyglycerin-3.
As an emulsifier, it helps stabilize products by preventing oils and water from separating.
This ingredient may not be Malassezia folliculitis, or fungal acne safe.
Learn more about Polyglyceryl-3 DiisostearateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateThis form of hyaluronic acid is produced through fermentation.
According to a manufacturer, it has a positive charge by ionic binding to help moisturize and give hair a smooth feel. This is why you'll find this ingredient in shampoos and body washes.
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Learn more about Hydrolyzed Hyaluronic AcidSodium Acetylated Hyaluronate is a type of Hyaluronic Acid.
Hyaluronic Acids help moisturize, soothe, and protect the skin.
Read about common types of Hyaluronic Acid here:
Learn more about Sodium Acetylated HyaluronateHyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Learn more about Hyaluronic AcidSodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.
A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.
More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.
Learn more about Sodium Hyaluronate CrosspolymerThis ingredient is created by putting sodium hyaluronate through hydrolysis.
You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.
According to studies, low molecular-weight hyaluronic acid can:
One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.
Hydrolysis is a process of changing a molecule using water or enzymes.
This ingredient is water-soluble.
Learn more about Hydrolyzed Sodium HyaluronatePotassium hyaluronate (PH) is a salt form of hyaluronic acid and has similar skin hydrating benefits.
Similar to hyaluronic acid, PH is able to draw and hold moisture to your skin. This helps keep skin soft and hydrated.
Fun fact: PH is used in eye drops and injectable treatments for joint disorders. It has lubricating and tissue-repair properties.
Learn more about Potassium HyaluronateYou might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.
As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.
A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.
The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.
The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.
Due to its palmitic acid base, it may not be fungal acne safe.
Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.
Read more about other common types of peptides here:
Learn more about Palmitoyl Pentapeptide-4Tripeptide-2 protects our collagen and elastin fibers to slow down the process of aging. It does this by inhibiting the proteins responsible for the breakdown of collagen and elastin.
Acetyl Hexapeptide-8, commonly known as Argireline or Acetyl Hexapeptide-3, is a popular peptide in skincare. Itâs often referred to as a âBotox-likeâ ingredient because it helps reduce muscle movement.
By relaxing these micro-movements, Argireline may help minimize the appearance of fine lines and wrinkles. That said, itâs not as powerful as Botox, and research on its long-term effectiveness is still limited.
Beyond smoothing, Argireline may also support collagen production. Collagen is the protein that helps keep your skin firm, bouncy, and well-hydrated by strengthening the skin barrier.
So while Argireline isnât a miracle fix, it can be a helpful addition to a routine focused on both prevention and skin health.
Read more about other common types of peptides here:
Learn more about Acetyl Hexapeptide-8Palmitoyl Tripeptide-1 is also known as pal-GHK. It is made up of 3 amino acids and palmitic acid, a fatty acid that helps it absorb into skin more easily.
This peptide is as a signal peptide, meaning it tells the skin to produce more collagen. Collagen is the key protein that helps form the skin's structure and keep it plump, firm, and hydrated.
By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.
You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.
Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.
While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.
Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesnât turn soft, barely-visible facial hairs into thick, dark ones.
Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isnât backed by large-scale studies.
Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.
For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.
After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.
While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.
Read more about other common types of peptides here:
Learn more about Copper Tripeptide-1Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. Itâs commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Acetyl Octapeptide-3 is a synthetic peptide also commonly known as SNAP-8. It is a lab-made peptide often marketed as a gentler, topical alternative to Botox.
It works by mimicking part of a protein involved in muscle contractions, which may help relax facial tension and reduce the appearance of fine lines (mostly around the eyes and forehead).
Itâs considered a ânext-genâ version of Argireline (Acetyl Hexapeptide-8), an older peptide with more research behind it that also supports collagen production.
SNAP-8 showed slightly better results than Argireline in one small manufacturer-funded study, but thereâs limited independent research. Plus, most tests use concentrations higher than whatâs typically found in skincare products.
This ingredient might offer a subtle smoothing effect but it won't donât deliver the dramatic results of actual Botox injections.
Think of it more like a supporting actor in your skincare lineup.
Learn more about Acetyl Octapeptide-3Tripeptide-3 is a peptide.
Tripeptide-1, also known as GHK), is a small, three-amino-acid peptide made up of glycine, histidine, and lysine.
This ingredient is a signal peptide and tell your skin to start producing fresh collagen, elastin, and other key structural proteins. This helps maintain firmness and reduces the look of fine-lines/wrinkles.
GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.
In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.
Both of these compounds also help balance enzymes that control collagen breakdown.
Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.
A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.
While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.
Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.
Learn more about Tripeptide-1Reviews
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Where it's from
Two Slash Four is a Korean brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated April 3, 2026 • Added by stellastarly