Oribe Run-Through Detangling Primer

Oribe Run-Through Detangling Primer

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Overview

What it is

Leave-in conditioner with 56 ingredients that contains AHA and exfoliants

Cool Features

It is vegan, cruelty-free, and reef safe

Suited For

It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

It doesn't contain any harsh alcohols or parabens

Fun facts

Oribe is from United States. This product is used in 1 routines created by our community.

We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.

What's inside

Ingredients List

20
22
14

Water

Skin Conditioning

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconCoconut Derived IconBad for Acne Prone Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

Parfum

Masking
Synthetic Fragrance IconFragrance IconMay worsen Eczema IconMay worsen Rosacea Icon

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconGood for Barrier Repair Icon

Phenoxyethanol

Preservative
Preservative Icon

Behentrimonium Methosulfate

Surfactant
Sulfate Icon

Cyclopentasiloxane

Emollient
Silicon Icon

PEG-12 Dimethicone

Skin Conditioning
Silicon Icon

Trimethylsiloxyamodimethicone

Silicon IconHelps hydrate Dry Skin Icon

Potassium Sorbate

Preservative
Preservative Icon

Polyquaternium-59

UV Absorber

C11-15 Pareth-7

Emulsifying

Cetrimonium Chloride

Antimicrobial
Preservative Icon

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin IconGood for Barrier Repair Icon

C12-16 Pareth-9

Emulsifying

Trideceth-12

Emulsifying

Silicone Quaternium-16

Skin Conditioning
Silicon Icon

Undeceth-11

Emollient

Glycolic Acid

Buffering
AHA IconExfoliant IconHelps fight Acne IconHelps with Anti-Aging IconHelps brighten skin IconGood for Oily Skin IconGood for Minimizing Pores IconGood for Scar Healing IconGood for Dark Spots IconGood for Skin Texture IconMay worsen Rosacea Icon

Butyloctanol

Humectant

Cocos Nucifera Oil

Masking
4 / 0 Oil IconCoconut Derived IconFragrance IconHelps hydrate Dry Skin IconBad for Acne Prone Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon

Prunus Armeniaca Kernel Oil

Masking
1-2 / 0 Oil IconNot safe for Fungal Acne Icon

Punica Granatum Seed Oil

Emollient
Oil IconHelps hydrate Dry Skin IconHelps reduce irritation IconNot safe for Fungal Acne Icon

Sodium PCA

Humectant
0 / 0 Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Barrier Repair Icon

Sodium Lactate

Buffering
Helps hydrate Dry Skin Icon

Undeceth-5

Emulsifying

Arginine

Masking
Helps hydrate Dry Skin IconGood for Scar Healing Icon

Aspartic Acid

Masking
Helps hydrate Dry Skin Icon

PCA

Humectant
Helps hydrate Dry Skin Icon

Citrullus Lanatus Fruit Extract

Skin Conditioning
Helps reduce irritation Icon

Litchi Chinensis Fruit Extract

Skin Conditioning

Phyllanthus Emblica Fruit Extract

Humectant

Wheat Amino Acids

Skin Conditioning

Helianthus Annuus Seed Extract

Skin Conditioning
Helps hydrate Dry Skin Icon

Leontopodium Alpinum Flower/Leaf Extract

Skin Conditioning

Glycine

Buffering
Helps hydrate Dry Skin Icon

Alanine

Masking
Helps hydrate Dry Skin Icon

Hibiscus Sabdariffa Flower Extract

Skin Conditioning

Serine

Masking
Helps hydrate Dry Skin Icon

Valine

Masking

Isoleucine

Skin Conditioning

Proline

Skin Conditioning
Helps hydrate Dry Skin Icon

Threonine

Helps hydrate Dry Skin Icon

Iodopropynyl Butylcarbamate

Preservative
Preservative Icon

Styrax Benzoin Resin Extract

Masking
Fragrance Icon

Histidine

Humectant
Helps with Anti-Aging IconHelps hydrate Dry Skin Icon

Phenylalanine

Masking
Helps hydrate Dry Skin Icon

Citric Acid

Buffering
AHA IconHelps brighten skin IconMay worsen Rosacea Icon

Sodium Benzoate

Masking
Preservative Icon

Caprylyl Glycol

Emollient
Fatty Alcohol Icon

Ethylhexylglycerin

Skin Conditioning

Hexylene Glycol

Emulsifying
0-2 / 0-1

Limonene

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Hexyl Cinnamal

Perfuming
Synthetic Fragrance IconFragrance IconMay cause irritation IconEU Allergen Icon

Linalool

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Citral

Perfuming
Fragrance IconMay worsen Eczema IconMay cause irritation IconMay worsen Rosacea IconEU Allergen Icon

Key Ingredients

Benefits

Concerns

Ingredients Explained

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Learn more about Water
Emollient, Emulsifying, Emulsion Stabilising

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Learn more about Cetearyl Alcohol
Masking, Perfuming

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of โ€œFRAGRANCEโ€ or โ€œPARFUMโ€ according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Learn more about Parfum
Humectant, Skin Conditioning, Skin Protecting

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Behentrimonium Methosulfate is an ammonium salt. It is mainly used to prevent static in haircare products as a surfactant.

Surfactants have differing ends: one side is hydrophilic while the other end is hydrophobic.

Surfactants also help your cleansers remove pollutants more easily from the skin.

Learn more about Behentrimonium Methosulfate
Emollient, Skin Conditioning, Solvent

Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.

Since D5 is volatile, it does its thing and then evaporates off the skin quickly.

The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics

There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.

Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.

The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.

Learn more about Cyclopentasiloxane
Skin Conditioning

PEG-12 Dimethicone is a type of water-soluble silicone. It has skin conditioning and hydrating properties.

According to a manufacturer, this ingredient's stability is decreased by strong acid or alkali.

Trimethylsiloxyamodimethicone (don't worry, we cannot pronounce this either) is a siloxane polymer. Siloxane polymers are widely used as antimicrobials and texture enhancer. This ingredient is synthetically created.

As a silicone, Trimethylsiloxyamodimethicone helps hydrate and smooth the skin. It can also be found in hair care products.

Trimethylsiloxyamodimethicone is described as "non-greasy" and "silky".

Learn more about Trimethylsiloxyamodimethicone
Preservative

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Learn more about Potassium Sorbate
UV Absorber

We don't have a description for Polyquaternium-59 yet.

Emulsifying, Surfactant

Another name for this ingredient is C11-15 Alketh-7. It has emulsifying and surfactant properties, meaning it helps keep ingredients together in a formula.

Antimicrobial, Emulsifying, Preservative

This ingredient is a preservative, antimicrobial, and emulsifier. It is often used in cosmetics for its ability to cleanse, condition, and reduce static.

Cetrimonium chloride is a quaternary ammonium salt, meaning it has a water-soluble structure.

Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Emulsifying, Surfactant

We don't have a description for C12-16 Pareth-9 yet.

Emulsifying, Surfactant

We don't have a description for Trideceth-12 yet.

Skin Conditioning

Silicone Quaternium-16 is a type of silicone.

Emollient, Emulsifying, Skin Conditioning

We don't have a description for Undeceth-11 yet.

Buffering, Exfoliating

Glycolic Acid is arguably the most famous alpha hydroxy acid (AHA) with tons of research backing its benefits.

It is found naturally in sugar cane but the form used in skincare is usually synthetic for purity and stability.

Glycolic acid removes the top layer of dead skin cells to allow newer and fresher ones to emerge.

AHAs work by breaking down the structural โ€œglueโ€ that holds old skin cells in place. When that buildup is gone, your skin can renew itself more efficiently.

Research also shows glycolic acid stimulates collagen production, helping to firm and thicken the skin over time. This is one of its biggest advantages over other AHAs.

Overall, glycolic acid helps with:

Fun fact: Glycolic acid boosts skin hydration by helping it produce molecules that increase hyaluronic acid naturally.

To work best, glycolic acid products should have a pH between 3-4 (thatโ€™s where exfoliation is most effective but still gentle on skin).

The pH and concentration of a product are key to its effectiveness:

It is normal to feel a slight stinging sensation when using glycolic acid. This usually fades as your skin adjusts.

Because glycolic acid has the smallest molecular size in the AHA family, it can penetrate deeper, which enhances its effectiveness but also makes it more likely to irritate sensitive skin.

If your skin is very sensitive or prone to rosacea, glycolic acid may be too strong; in that case, try milder options like lactic acid or a PHA instead.

Recent studies suggest glycolic acid might even help protect against UV damage. But donโ€™t skip sunscreen! Freshly exfoliated skin is more sensitive to the sun.

Glycolic acid is a skincare superstar. It smooths, brightens, hydrates, and firms the skin. Unless youโ€™re highly sensitive, itโ€™s well worth adding to your routine.

Read more about some other popular AHA's here:

Learn more about Glycolic Acid
Humectant, Solvent

We don't have a description for Butyloctanol yet.

Masking, Perfuming, Skin Conditioning

This ingredient is also known as coconut oil. It is a plant-derived ingredient with skin conditioning properties.

The fatty acid profile of coconut oil is mostly lauric acid (~54%), followed by capric, caprylic, palmitic, and myristic acids. This profile allows it to penetrate easily into skin, moisturize, and improve dry skin.

A double-blind study confirmed that extra virgin coconut oil is as effective as mineral oil for treating very dry skin. Another study found it outperformed mineral oil for mild to moderate atopic dermatitis in children.

Another study from 2018 found that virgin coconut oil can soothe inflammation and boost key skin barrier proteins. Just know this evidence is still only from lab settings and not human trials.

It has also been shown to reduce Staphylococcus aureus, a bacteria that commonly overgrows in people with eczema.

Clinical testing shows very minimal skin irritation and no evidence of sensitization or phototoxicity.

Coconut oil gets flagged as a "fragrance" because it has a natural mild scent (not because it's a synthetic perfume). The European Cosmetic ingredient database also lists "perfuming" as a function of this ingredient.

Just so you know, the term "fragrance" is completely unregulated. Some brands still use botanical extracts or essential oils in their "fragrance-free" formulas, but regulatory databases technically classify these under "fragrance".

Coconut oil has a tiny and useless bit of natural SPF. Early lab studies clocked it around SPF 7-8 but a more recent study found the real number closer to SPF 1.2. It also offers no meaningful UVA protection (SPF only overs UVB rays).

The comedogenic rating of 4/5 means it has a high potential to clog pores; but it's worth noting that comedogenicity is highly individual and ratings cannot predict how an overall formula will behave on skin.

Since lauric acid is the dominant fatty acid, this ingredient may not be fungal acne safe. The Malassezia yeast feeds on fatty acids with carbon chain lengths between 11-24, and lauric acid falls within these lengths (C12).

Learn more about Cocos Nucifera Oil
Masking, Skin Conditioning

This ingredient is the oil from the apricot.

Apricot Kernel Oil is an emollient and helps soften skin. This is due to its fatty acid components. Some of these fatty acids include linoleic and oleic acid.

This ingredient also has antioxidant properties from Vitamins A, C, and E. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells. Besides being antioxidants, these vitamins provide plenty of skin benefits as well.

Learn more about Prunus Armeniaca Kernel Oil

Punica Granatum Seed Oil is created from the seeds of the pomegranate. Pomegranate seed oil helps hydrate the skin, is anti-inflammatory, and contains antioxidants.

Pomegranates are rich in fatty acids, including an unsaturated fatty acid by the name of Punicic acid. Other components of pomegranates include Vitamin E, Vitamin C, and bioactive lipids such as phytosterols, phospholipids, and triterpenes. Punicic acid helps soothe inflammation.

As an emollient, pomegranate oil creates a thin film on the skin. This film helps prevent moisture loss, keeping your skin hydrated.

Learn more about Punica Granatum Seed Oil
Humectant, Skin Conditioning

Sodium PCA is the sodium salt of pyroglutamic acid. It is naturally occurring in our skin's natural moisturizing factors where it works to maintain hydration.

The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.

This ingredient has skin conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.

Learn more about Sodium PCA
Buffering, Humectant

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.

This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

High percentages of Sodium Lactate can have an exfoliating effect.

Fun fact: Sodium Lactate is produced from fermented sugar.

Learn more about Sodium Lactate
Emulsifying, Surfactant

We don't have a description for Undeceth-5 yet.

Masking, Skin Conditioning

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Learn more about Arginine
Masking, Skin Conditioning

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

PCA
Humectant, Moisturising

PCA is derived from amino acids and is naturally found in our skin's barrier.

As a humectant, PCA helps draw and hold moisture to the skin. Studies show it is effective at helping the skin stay hydrated long-term.

Citrullus Lanatus Fruit Extract comes from the watermelon. Watermelon has antioxidant and anti-inflammatory properties.

Watermelons are rich in antioxidants such as Vitamin A, Vitamin C and lycopene. It also contains sugars and amino acids, such as arginine and glutathione.

Lycopene is a potent antioxidant. Besides helping to protect your skin against free-radical molecules, it also helps soothe the skin. Lycopene gives watermelon the distinct red color.

Learn more about Citrullus Lanatus Fruit Extract
Skin Conditioning

We don't have a description for Litchi Chinensis Fruit Extract yet.

Humectant, Skin Conditioning

This ingredient is also known as Indian Gooseberry or Amla Berry. It is skin hydrating and antioxidant rich.

Indian gooseberry is rich in antioxidants such as polyphenols, tannins, and vitamin C compounds.

Skin Conditioning, Skin Protecting, Soothing

We don't have a description for Wheat Amino Acids yet.

Skin Conditioning

Helianthus Annuus Seed Extract comes from sunflower seeds.

Sunflower seeds are rich in vitamin E. Studies show sunflowers contain antimicrobial and antioxidant properties.

The fatty acids found in sunflower seeds include (from highest amount to least): linoleic acid, myristic acid, palmitic acid, stearic acid, arachidic acid, oleic acid, and linolenic acid.

These fatty acids hydrate your skin. Emollients create a film on the skin to prevent moisture from escaping.

Learn more about Helianthus Annuus Seed Extract

This ingredient comes from the edelweiss plant. It has skin conditioning properties.

Phytochemical studies show edelweiss contains compounds such as leontopodic acids, flavonoids, caffeic acids that have strong antioxidant and anti-inflammatory activity.

Clinical research on leontopodium alpinum callus culture extract showed topical application in humans demonstrates improvements on wrinkles, skin elasticity, and dermal density. In vitro and cell-based studies support anti-inflammatory effects.

Learn more about Leontopodium Alpinum Flower/Leaf Extract
Buffering, Skin Conditioning

Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.

Masking, Skin Conditioning

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

This extract comes from the Roselle flower, or Hibiscus Sabdariffa. Roselle flowers are rich in antioxidants.

Studies found the antioxidants in Roselle flowers to potentially help reduce UV-B damage.

Masking, Skin Conditioning

Serine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.

Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.

Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.

Learn more about Serine
Masking, Skin Conditioning

Valine is an essential amino acid. It is used by our bodies for tissue repair and muscle growth.

An essential amino acid is one in which our bodies cannot naturally produce so we must get them through diet. Foods such as eggs, dairy, red meat, and fish contain valine.

This ingredient can either be derived from an animal product or be synthetically created.

Learn more about Valine
Skin Conditioning

Isoleucine is an amino acid that helps reinforce our skin barrier. This amino acid plays a role in creating protein for the body.

Fun fact: Isoleucine is found in meat, fish, dairy, legumes, and nuts.

Skin Conditioning

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Learn more about Proline

Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.

Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

Iodopropynyl Butylcarbamate (IPBC) is a preservative that is especially good at getting fungi and mold out of your cosmetics.

IPBC works by leveraging the antimicrobial properties of its iodine containing structure. Iodine has been used as a germicide since the late 1800s and IPBC is a more refined and stable derivative of it.

It is typically used at very low levels in cosmetics, with most formulations using 0.0125% or less (well below its approved maximum).

In the EU, IPBC concentration limits are set at 0.02% in rinse-off products and 0.01% in leave-on products.

Though IPBC is a relatively uncommon contact allergen, patch testing studies show positive reaction rates ranging from 0.3%-0.9% of patients tested. This is still quite low compared to preservatives like methylisothiazolinone which sits at around 4-5%.

Researchers note that existing iodine sensitives or rubber allergies may be the cause of this as IPBC shares a structure with both thiuram (used in rubber) and iodine.

Be sure to patch test if you are unsure and speak with a medical professional about using this ingredient.

Learn more about Iodopropynyl Butylcarbamate
Masking, Perfuming

This ingredient is used to add a warm, sweet, and vanilla-like scent to products.

Humectant, Skin Conditioning

Histidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.

Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.

One study found histidine and carnosine to be a dynamic duo for your skin:

Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.

Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.

Learn more about Histidine
Masking, Skin Conditioning

Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.

This ingredient is also used to help even out skin tone due to its ability to disrupt the melanin production process.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

Learn more about Phenylalanine
Buffering, Masking

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Read more about some other popular AHA's here:

Learn more about Citric Acid
Masking, Preservative

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Learn more about Sodium Benzoate
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Learn more about Caprylyl Glycol
Skin Conditioning

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Learn more about Ethylhexylglycerin
Emulsifying, Skin Conditioning, Solvent

Hexylene Glycol is a multitasker ingredient that works as a solvent, humectant, emulsifier, viscosity reducer, and preservative booster.

It is able to dissolve both water and oil-soluble ingredients to stabilize tricky actives and make products spread more easily.

As a humectant, it pulls water into the skin. But it's a pretty minor moisturizing ingredient compared to other humectants, like glycerin.

Interestingly, it can act as a mild penetration enhancer. One in vitro study on human skin found a 12% concentration upped the absorption of mometasone furoate (a medicinal ingredient used to treat inflammatory skin conditions) up to 7%.

This ingredient is typically used at levels of 0.1-10% depending on the role it's playing.

A patch test study on eczema patients didn't find a significant increase in irritation versus the control group, but the potential for irritation rises at higher concentrations.

Learn more about Hexylene Glycol
Perfuming, Solvent

Limonene is a fragrance that adds scent and taste to a formulation.

It's found in the peel oil of citrus fruits and other plants such as lavender and eucalyptus. The scent of limonene is generally described as "sweet citrus".

Limonene acts as an antioxidant, meaning it helps neutralize free radicals.

When exposed to air, oxidized limonene may sensitize the skin. Because of this, limonene is often avoided by people with sensitive skin.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

Learn more about Limonene
Perfuming

Hexyl Cinnamal is a fragrance ingredient with a similar scent to jasmine. It can be naturally found in chamomile essential oil.

This ingredient is a known EU allergen and may sensitize the skin. The EU requires this ingredient to be listed separately on an ingredients list.

Hexyl Cinnamal is not water soluble but is soluble in oils.

Learn more about Hexyl Cinnamal
Perfuming

Linalool is a fragrance and helps add scent to products. It's derived from common plants such as cinnamon, mint, citrus, and lavender.

Like Limonene, this ingredient oxidizes when exposed to air. Oxidized linalool can cause allergies and skin sensitivity.

This ingredient has a scent that is floral, spicy tropical, and citrus-like.

Learn more about Linalool
Perfuming

Citral is the molecule responsible for the fresh lemon scent in lemon, lime, and lemongrass. It is a fragrance ingredient that can be created from plant essential oils or synthetically.

Though Citral has documented antimicrobial activity against acne bacteria (which is where the marketing claims about it being good for acne-prone skin originate), real formulas use it at fragrance-level concentrations under 1% so there's likely no skin benefit.

You should know this ingredient is a known EU fragrance allergen.

Animal studies classifies this ingredient as a weak-to-moderate skin sensitizer and clinical patch testing on eczema patients confirmed it to be both a contact allergen and irritant.

The term 'citral' is a collective term for two geometric isomers: geranial/Citral A and neral/Citral B.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.

Learn more about Citral

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ยท Updated January 15, 2024 Added by tsmeu