Physician's Formula Skin Booster Vitamin Shot Time Restoring Versus Isntree Hyaluronic Acid Water Essence
This anti-aging serum is formulated around Niacinamide and Ceramide AP to soften the look of wrinkles and strengthen the skin barrier.
This hydrating essence is formulated around Niacinamide and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningButylene Glycol
HumectantGlycerin
HumectantNiacinamide
SmoothingPentylene Glycol
Skin ConditioningCeramide AP
Skin Conditioning1,2-Hexanediol
Skin ConditioningCarbomer
Emulsion StabilisingCaprylyl Glycol
EmollientCaesalpinia Spinosa Fruit Extract
Skin ProtectingPullulan
Chondrus Crispus Extract
Skin ConditioningPolysorbate 20
EmulsifyingDipotassium Glycyrrhizate
HumectantDisodium EDTA
ChelatingSodium Hydroxide
BufferingKappaphycus Alvarezii Extract
Skin ConditioningCollagen Amino Acids
MoisturisingIron Oxides
Leuconostoc/Radish Root Ferment Filtrate
AntimicrobialPhenoxyethanol
PreservativeTitanium Dioxide
Cosmetic ColorantAgar
MaskingCalcium Alginate
MaskingSodium Lactate
BufferingXanthan Gum
EmulsifyingHydroxyacetophenone
AntioxidantTropolone
Skin ConditioningGluconolactone
ChelatingHydrolyzed Hyaluronic Acid
HumectantSodium Benzoate
MaskingSodium Hyaluronate
HumectantCI 73360
Cosmetic ColorantRetinyl Palmitate
Skin ConditioningPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningWater, Butylene Glycol, Glycerin, Niacinamide, Pentylene Glycol, Ceramide AP, 1,2-Hexanediol, Carbomer, Caprylyl Glycol, Caesalpinia Spinosa Fruit Extract, Pullulan, Chondrus Crispus Extract, Polysorbate 20, Dipotassium Glycyrrhizate, Disodium EDTA, Sodium Hydroxide, Kappaphycus Alvarezii Extract, Collagen Amino Acids, Iron Oxides, Leuconostoc/Radish Root Ferment Filtrate, Phenoxyethanol, Titanium Dioxide, Agar, Calcium Alginate, Sodium Lactate, Xanthan Gum, Hydroxyacetophenone, Tropolone, Gluconolactone, Hydrolyzed Hyaluronic Acid, Sodium Benzoate, Sodium Hyaluronate, CI 73360, Retinyl Palmitate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
Water
Skin ConditioningMethylpropanediol
SolventPolyglycerin-3
HumectantGlycerin
HumectantCaprylic/Capric Triglyceride
Masking1,2-Hexanediol
Skin ConditioningNiacinamide
SmoothingCyclohexasiloxane
EmollientAmmonium Acryloyldimethyltaurate/Vp Copolymer
Sodium Hyaluronate
HumectantBetaine
HumectantXanthan Gum
EmulsifyingTrehalose
HumectantPanthenol
Skin ConditioningButylene Glycol
HumectantSodium PCA
HumectantEthylhexylglycerin
Skin ConditioningAdenosine
Skin ConditioningCarbomer
Emulsion StabilisingDisodium EDTA
ChelatingTromethamine
BufferingPolyquaternium-51
Skin ConditioningAvena Sativa Kernel Extract
AbrasiveBeta-Glucan
Skin ConditioningHydrogenated Lecithin
EmulsifyingPteris Multifida Extract
AntioxidantCynara Scolymus Leaf Extract
Skin ConditioningPentylene Glycol
Skin ConditioningHyaluronic Acid
HumectantSodium Hyaluronate Crosspolymer
HumectantHydrolyzed Hyaluronic Acid
HumectantAscorbyl Propyl Hyaluronate
Skin ConditioningTocopherol
AntioxidantHydroxypropyltrimonium Hyaluronate
Hydrolyzed Sodium Hyaluronate
Skin ConditioningSodium Acetylated Hyaluronate
HumectantOpuntia Ficus-Indica Seed Oil
EmollientWater, Methylpropanediol, Polyglycerin-3, Glycerin, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Niacinamide, Cyclohexasiloxane, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sodium Hyaluronate, Betaine, Xanthan Gum, Trehalose, Panthenol, Butylene Glycol, Sodium PCA, Ethylhexylglycerin, Adenosine, Carbomer, Disodium EDTA, Tromethamine, Polyquaternium-51, Avena Sativa Kernel Extract, Beta-Glucan, Hydrogenated Lecithin, Pteris Multifida Extract, Cynara Scolymus Leaf Extract, Pentylene Glycol, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Ascorbyl Propyl Hyaluronate, Tocopherol, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Opuntia Ficus-Indica Seed Oil
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCarbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Learn more about CarbomerDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinHydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Learn more about Hydrolyzed Hyaluronic AcidNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan Gum