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Updated on June 26, 2024

Overview

What they are

These products are both reef safe serums. They have a total of 4 ingredients in common

Cool Features

They both contain hyaluronic acid and peptides

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin, scar healing and better texture

Free From

They both do not contain any harsh alcohols, common allergens or parabens

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Depology Matrixyl® 3000 Collagen Boosting Serum

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Benefits

Concerns

Ingredients Side-by-side

found in both products
Peptide 21 Wrinkle Resist Serum
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Rosa Centifolia Flower Water Skin Conditioning, Skin Protecting

We don't have a description for Rosa Centifolia Flower Water.

Isopropyl Myristate Emollient, Masking
3-5 / 3 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
3 Concerns

Isopropyl Myristate is an emollient, thickening agent, and texture enhancer. It is created from isopropyl alcohol and myristic acid.

3-5 Com. / 3 Irr.
Very Disliked Full details ->
Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Mannitol Humectant, Masking, Moisturising

Mannitol is a sugar alcohol. It is a humectant and moisturizes the skin. In vitro (not tested on a living organism), mannitol displays antioxidant properties.

Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Natto Gum

Natto Gum is created by fermenting a soy protein using Bacillus natto (a bacteria). It is used as a texture enhancer.

Unknown Full details ->
Tripeptide-10 Citrulline Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Tripeptide-10 Citrulline is a peptide.

Acetyl Octapeptide-3 Humectant, Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Octapeptide-3 is a synthetic peptide. It is often called a botox alternative due to its ability to restrict the movement of muscles, and thus reduce the appearance of fine-lines.

Palmitoyl Hexapeptide-12 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Hexapeptide-12 isn't fungal acne safe and is a peptide.

Acetyl Tetrapeptide-11 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Tetrapeptide-11 is a peptide.

Acetyl Hexapeptide-8 Humectant, Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

Acetyl Hexapeptide-1 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Hexapeptide-1 is a peptide.

Palmitoyl Oligopeptide Cleansing, Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Oligopeptide is a form of peptide. It is created by blending peptides with palmitic acid. Peptides are building blocks for protein.

Acetyl Tetrapeptide-9 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Tetrapeptide-9 is a peptide.

Acetyl Tetrapeptide-2 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Tetrapeptide-2 is a peptide.

Tripeptide-1 Skin Conditioning, Skin Protecting
Peptide Icon
PeptidePeptide Icon

Tripeptide-1 is a peptide.

Palmitoyl Tetrapeptide-7 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

Hexapeptide-11 Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Hexapeptide-11 is a peptide.

Dipeptide Diaminobutyroyl Benzylamide Diacetate Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a peptide.

Palmitoyl Tripeptide-5 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-5 isn't fungal acne safe and is a peptide.

Trifluoroacetyl Tripeptide-2 Skin Conditioning, Skin Protecting
Peptide Icon
PeptidePeptide Icon

Trifluoroacetyl Tripeptide-2 is a peptide.

Palmitoyl Tripeptide-1 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Sodium Polyglutamate Humectant, Skin Conditioning

We don't have a description for Sodium Polyglutamate.

Unknown Full details ->
Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon Helps brighten skinHelps brighten skin Icon

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Retinyl Palmitate Skin Conditioning
1-3 / 1-3 Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconCan worsen Dry Skin IconMay cause irritation IconNot safe for Fungal Acne Icon
RetinoidRetinoid Icon 7 Benefits 3 Concerns

Retinyl palmitate is a form of retinoid. Retinoids are the superstar class of anti-aging ingredients that include tretinoin and retinol.

1-3 Com. / 1-3 Irr.
Ascorbic Acid Antioxidant, Buffering, Masking
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps brighten skin Icon
Vitamin CVitamin C Icon AntioxidantAntioxidant Icon 6 Benefits

Ascorbic Acid is is pure Vitamin C. This form makes up the largest amount of vitamin C found naturally in our skin.

Hydrolyzed Soy Protein Humectant, Skin Conditioning

This ingredient is a vegetable-derived protein made to mimic hydrolyzed collagen. It is created from soy, or glycine soja.

Disliked Full details ->
Hydrolyzed Wheat Protein Skin Conditioning

We don't have a description for Hydrolyzed Wheat Protein.

Disliked Full details ->
Lecithin Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.

Disliked Full details ->
Pseudoalteromonas Ferment Extract Humectant
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Pseudoalteromonas Ferment Extract isn't fungal acne safe.

Disliked Full details ->
Acrylates Copolymer

Acrylates Copolymer is used as a film-forming agent and texture enhancer.

Disliked Full details ->
Magnesium Chloride

We don't have a description for Magnesium Chloride.

Polysorbate 20 Emulsifying
0 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

0 Com. / 0 Irr.
Very Disliked Full details ->
Dimethyl Isosorbide Solvent

Dimethyl Isosorbide is a solvent and helps deliver actives into your skin. It is created from sorbitol.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer Emulsion Stabilising

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken and improve the texture of products.

Disliked Full details ->
Leuconostoc/Radish Root Ferment Filtrate Antimicrobial

Leuconostoc/Radish Root Ferment Filtrate is a natural preservative. It comes from fermenting radish roots with a bacteria called leuconostoc. Leuconostoc comes from lactic acid. This bacteria is used to make the traditional Korean side-dish, kimchi. It is also used to make sourdough bread (both incredibly yummy foods).

Peg-8 Dimethicone Emulsifying
Silicon Icon
SiliconSilicon Icon

Peg-8 Dimethicone is a type of silicone.

Unknown Full details ->
Disodium Phosphate Buffering, Masking

We don't have a description for Disodium Phosphate.

Unknown Full details ->
Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Dextran

We don't have a description for Dextran.

Unknown Full details ->
Sodium Lactate Buffering, Humectant

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and used to adjust the pH of a product.

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate Skin Conditioning

We don't have a description for Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate.

Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->
Triethanolamine Buffering, Emulsifying, Masking
2 / 0

Triethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.

2 Com. / 0 Irr.
Very Disliked Full details ->
Sodium Phosphate Buffering

We don't have a description for Sodium Phosphate.

Unknown Full details ->
Octyldodecanol Emollient, Masking

Octyldodecanol is a fatty alcohol. It is primarily used to enhance the texture of products.

Disliked Full details ->
Silica Abrasive, Absorbent
Exfoliant IconMay worsen Eczema IconMay worsen Rosacea Icon
ExfoliantExfoliant Icon 2 Concerns

Silica is a mineral naturally found in our skin. It helps to thicken and smooth the texture of a product. It also acts as an agent for other ingredients by increasing the absorption of other ingredients into the skin.

Disliked Full details ->
Sodium Propoxyhydroxypropyl Thiosulfate Silica
Sulfate Icon
SulfateSulfate Icon

Sodium Propoxyhydroxypropyl Thiosulfate Silica is a type of sulfate.

Unknown Full details ->
Sodium Hydroxide Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

Caprylyl Glycol Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

Potassium Sorbate Preservative
Preservative Icon
PreservativePreservative Icon

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

Disliked Full details ->
Sodium Benzoate Masking, Preservative
Preservative Icon
PreservativePreservative Icon

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Disliked Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Matrixyl® 3000 Collagen Boosting Serum
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Palmitoyl Pentapeptide-4 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

You might know this ingredients as Matrixyl. It is a peptide.

Aloe Barbadensis Leaf Juice Skin Conditioning
Helps reduce Skin Redness IconHelps reduce irritation Icon
2 Benefits

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Portulaca Oleracea Extract Skin Conditioning

Portulaca Oleracea Extract is an extract of the whole plant of the Purslane, Portulaca oleracea L., Portulacaceae. It has anti-inflammatory, antioxidant, and hydrating properties.

Hyaluronic Acid Humectant, Moisturising, Skin Conditioning
Hyaluronic Acid IconGood for Skin Texture IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin IconMay cause irritation Icon
Hyaluronic AcidHyaluronic Acid Icon 4 Benefits May cause irritationMay cause irritation Icon

Hyaluronic acid is naturally found in healthy skin. It is a humectant, meaning it draws moisture to your skin.

Codium Tomentosum Extract Skin Protecting

We don't have a description for Codium Tomentosum Extract.

Unknown Full details ->
Citrus Paradisi Seed Extract Masking, Perfuming
Fragrance Icon
FragranceFragrance Icon

Citrus Paradisi Seed Extract is a fragrance.

Unknown Full details ->
Cereus Grandiflorus Extract Antioxidant, Astringent, Skin Conditioning
Antioxidant Icon
AntioxidantAntioxidant Icon

Cereus Grandiflorus Extract is an antioxidant.

Unknown Full details ->
Polyglyceryl-6 Caprylate Emulsifying

Polyglyceryl-6 Caprylate comes from caprylic acid and Polyglycerin-6. It is an emulsifier, emollient, and cleansing agent.

Unknown Full details ->
Trehalose Humectant, Moisturising

Trehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.

Hydroxyacetophenone Antioxidant
Antioxidant Icon
AntioxidantAntioxidant Icon

Hydroxyacetophenone is antioxidant and helps with skin conditioning.

1,2-Hexanediol Skin Conditioning, Solvent

1,2-Hexanediol is a multi-tasker ingredient. It acts as a preservative to increase shelf-life and can aid other preservatives in preventing microbe growth. 1,2-Hexanediol also helps the skin retain moisture as a humectant.

Cocos Nucifera Oil Masking, Perfuming, Skin Conditioning
4 / 0 Fragrance IconOil IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
FragranceFragrance Icon OilOil Icon 2 Concerns

Cocos Nucifera Oil is obtained from the kernels of the coconut fruit. In other words, this is coconut oil.

4 Com. / 0 Irr.
Very Disliked Full details ->
Rosa Canina Fruit Oil Emollient, Skin Conditioning
Oil IconGood for Scar Healing IconNot safe for Fungal Acne Icon
OilOil Icon Good for Scar HealingGood for Scar Healing Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Rosehip Oil is a nonfragrant plant oil. Rosehips are a fruit from a rose bush and are edible. This oil helps even out skin tone, has anti-aging properties, and is good for reducing inflammation.

Helianthus Annuus Seed Oil Emollient, Masking, Skin Conditioning
0 / 0 Oil IconHelps hydrate Dry Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon
OilOil Icon Helps hydrate Dry SkinHelps hydrate Dry Skin Icon 2 Concerns

Helianthus Annuus Seed Oil is the oil derived from the seeds of a Sunflower. Sunflower seed oil is non-fragrant. It is an emollient, meaning it helps to soften the skin.

0 Com. / 0 Irr.
Disliked Full details ->
Allantoin Skin Conditioning, Skin Protecting, Soothing
0 / 0 Helps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon
3 Benefits

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

0 Com. / 0 Irr.
Stearic Acid Cleansing, Emulsifying, Emulsion Stabilising
2-3 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Stearic Acid is a fatty acid. It is an emollient, emulsifier, and texture enhancer.

2-3 Com. / 0 Irr.
Very Disliked Full details ->
Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Humectant, Masking, Skin Conditioning
Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Emulsifying, Emulsion Stabilising, Gel Forming
Disliked

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

Peptide 21 Wrinkle Resist Serum
27
6
16
7
liked
mixed
disliked
not rated
Matrixyl® 3000 Collagen Boosting Serum
9
3
4
4
liked
mixed
disliked
not rated

When to use

16 Routines
56% use in am
44% use in pm
88% use every day
19 Routines
32% use in am
68% use in pm
100% use every day

Reviews

Here's what our community thinks

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 56 ingredients

Peptide 21 Wrinkle Resist Serum hasn't been rated yet.
Rate it now

Depology Matrixyl® 3000 Collagen Boosting Serum 20 ingredients

5.0 /5
from 1 rating
Nanciel's avatar

Nanciel

8 months ago · Sensitive Skin
Review

Absorbs nicely removed my wrinkles in between brows