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Updated on August 14, 2023

Overview

Cool Features

They both contain hyaluronic acid and retinoid

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin and brightening skin

Free From

They both do not contain any silicones or sulfates

What's Inside

They both contain common allergens and fragrances

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Medik8 Crystal Retinal 6
Medik8 Crystal Retinal 6
Serum
British Brand United Kingdom
Obagi Tretinoin 0.05% Gel
Obagi Tretinoin 0.05% Gel
Prescription
American Brand United States

Ingredient Info

Click any item below to learn more and see relevant ingredients

Medik8 Crystal Retinal 6 41 ingredients

Obagi Tretinoin 0.05% Gel 16 ingredients

At a glance

Click on any of the items below to learn more

Medik8 Crystal Retinal 6 41 ingredients

Obagi Tretinoin 0.05% Gel 16 ingredients

Notable Ingredients

Benefits

Concerns

Notable Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Crystal Retinal 6
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Caprylic/Capric Triglyceride Masking, Skin Conditioning

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Isododecane Emollient, Solvent

Isododecane is a fragrance, emollient, and solvent.

Disliked Full details ->
Cetearyl Olivate
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Cetearyl Olivate is an emulsifier and texture enhancer. It is derived from the fatty acids of olive oil and Cetearyl alcohol, and is biodegradable.

Disliked Full details ->
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Emulsion Stabilising

This long ingredient is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers.

Disliked Full details ->
Cyclodextrin Absorbent

We don't have a description for Cyclodextrin.

Unknown Full details ->
Cetearyl Alcohol Emollient, Emulsifying, Emulsion Stabilising
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
Fatty AlcoholFatty Alcohol Icon 3 Concerns

Cetearyl alcohol is a mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is mainly used as an emulsifier. Emulsifiers help prevent the separation of oils and products. Due to its composition, it can also be used to thicken a product or help create foam.

2 Com. / 1 Irr.
Very Disliked Full details ->
Sorbitan Olivate Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

Very Disliked Full details ->
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon Helps brighten skinHelps brighten skin Icon

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Emulsion Stabilising

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

Disliked Full details ->
Hydroxyacetophenone Antioxidant
Antioxidant Icon
AntioxidantAntioxidant Icon

Hydroxyacetophenone is antioxidant and helps with skin conditioning.

3-O-Ethyl Ascorbic Acid Skin Conditioning
Vitamin C IconHelps reduce Skin Redness IconGood for Skin Texture IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing Icon
Vitamin CVitamin C Icon 5 Benefits

You might know this ingredient as Ethyl Ascorbic Acid, a more stable version of ascorbic acid.

Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Hydroxypropyl Methylcellulose Emulsion Stabilising

This ingredient is a semi-synthetic polymer created from cellulose. In case you need a refresher, cellulose is the main component of plant cell walls.

Unknown Full details ->
Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Tetrahexyldecyl Ascorbate Antioxidant, Skin Conditioning
Vitamin C IconAntioxidant IconHelps reduce Skin Redness IconGood for Skin Texture IconHelps with Anti-Aging IconGood for Dark Spots IconHelps brighten skin Icon
Vitamin CVitamin C Icon AntioxidantAntioxidant Icon 5 Benefits

Tetrahexyldecyl Ascorbate is a form of Vitamin C.

Rubus Chamaemorus Seed Oil Skin Conditioning
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Rubus Chamaemorus Seed Oil is an oil and isn't fungal acne safe.

Pentylene Glycol Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

Daucus Carota Sativa Seed Oil Emollient, Masking, Skin Conditioning
Oil Icon
OilOil Icon

Daucus Carota Sativa Seed Oil is the oil obtained from the seed of the edible carrot. The oil is created by steaming and distilling the seeds of the plant.

Retinal Skin Conditioning
Retinoid IconGood for Oily Skin IconGood for Skin Texture IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconCan worsen Dry Skin IconMay cause irritation IconMay worsen Rosacea Icon
RetinoidRetinoid Icon 7 Benefits 3 Concerns

Retinal is a form of retinoid. Retinoids are the gold-standard class of anti-aging ingredients.

Alumina Abrasive, Absorbent
Exfoliant Icon
ExfoliantExfoliant Icon

Alumina is another name for the compound aluminum oxide. It is used as a thickener, absorbent, and abrasive.

Very Disliked Full details ->
Isostearic Acid Cleansing, Emulsifying
Bad for Acne Prone Skin IconNot safe for Fungal Acne Icon
2 Concerns

Isostearic acid is a saturated fatty acid. Its structure makes it a great surfactant.

Very Disliked Full details ->
Lecithin Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.

Disliked Full details ->
Sodium Polyaspartate Humectant, Skin Conditioning

We don't have a description for Sodium Polyaspartate.

Unknown Full details ->
Polyglyceryl-3 Polyricinoleate Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

This ingredient is an emulsifier. It is created from Polyglycerin-3 and Ricinoleic Acid.

Very Disliked Full details ->
Lonicera Japonica Flower Extract Skin Conditioning

Lonicera Japonica Flower Extract comes from the honeysuckle flower.

Lonicera Caprifolium Flower Extract Perfuming, Skin Conditioning
Fragrance Icon
FragranceFragrance Icon

This Honeysuckle flower extract comes from the Italian honeysuckle. It is an antioxidant, antimicrobial, and fragrance.

Polyhydroxystearic Acid Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polyhydroxystearic Acid is a soft wax made from castor oil.

Disliked Full details ->
Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Ethylhexylglycerin Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

Stearic Acid Cleansing, Emulsifying, Emulsion Stabilising
2-3 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Stearic Acid is a fatty acid. It is an emollient, emulsifier, and texture enhancer.

2-3 Com. / 0 Irr.
Very Disliked Full details ->
Polysorbate 60 Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Very Disliked Full details ->
Sorbitan Isostearate Emulsifying
1-2 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.

1-2 Com. / 0 Irr.
Very Disliked Full details ->
BHT Antioxidant, Masking
Antioxidant Icon
AntioxidantAntioxidant Icon

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

Very Disliked Full details ->
Vanilla Planifolia Fruit Extract Skin Conditioning, Skin Protecting, Smoothing

Vanilla Planifolia Fruit Extract comes from the vanilla orchid native to central America. It is a skin-soothing ingredient.

Dipteryx Odorata Bean Extract Masking, Perfuming
Fragrance Icon
FragranceFragrance Icon

Dipteryx Odorata Bean Extract is a fragrance.

Unknown Full details ->
Coumarin Perfuming
Fragrance IconEU Allergen Icon
FragranceFragrance Icon EU AllergenEU Allergen Icon

Coumarins are a group of substances found naturally in plants. There are over 1300 types of coumarins identified. It has a natural vanilla scent.

Very Disliked Full details ->
CI 14700 Cosmetic Colorant
2 / 1

Ci 14700 is a synthetic red dye.

2 Com. / 1 Irr.
Unknown Full details ->
Titanium Dioxide Cosmetic Colorant, UV Absorber, UV Filter
0 / 0 Mineral UV Filter IconNon-Reef-Safe Icon
Mineral UV FilterMineral UV Filter Icon Non-Reef-SafeNon-Reef-Safe Icon

Titanium dioxide is known for its UVA and UVB protection properties. It is non-comedogenic and non-irritating. Titanium Dioxide is a physical sunscreen. Physical sunscreens reflect light and prevent it from reaching your skin.

0 Com. / 0 Irr.
Tretinoin 0.05% Gel
Tretinoin
Retinoid IconHelps with Anti-Aging IconHelps fight Acne IconHelps brighten skin IconMay cause irritation IconMay worsen Rosacea Icon
RetinoidRetinoid Icon 3 Benefits 2 Concerns

Tretinoin is the best retinoid due to its proven skin benefits. It only available with a prescription in many countries.

Benzyl Alcohol Perfuming, Preservative, Solvent
Alcohol IconFragrance IconPreservative IconCan worsen Dry Skin IconMay worsen Oily Skin IconMay cause irritation IconEU Allergen IconMay worsen Eczema IconMay worsen Rosacea Icon
AlcoholAlcohol Icon FragranceFragrance Icon PreservativePreservative Icon 6 Concerns

Benzyl Alcohol is most commonly used as a preservative. It also has a subtle, sweet smell. Small amounts of Benzyl Alcohol is not irritating and safe to use in skincare products. Most Benzyl Alcohol is derived from fruits such as apricots.

Very Disliked Full details ->
Butylparaben Masking, Preservative
Preservative IconParaben IconCan worsen Dry Skin IconNon-Reef-Safe IconMay worsen Eczema Icon
PreservativePreservative Icon ParabenParaben Icon 3 Concerns

Butylparaben is a preservative, is a paraben, and is not reef safe. It can be bad for dry skin and worsen eczema.

Very Disliked Full details ->
BHT Antioxidant, Masking
Antioxidant Icon
AntioxidantAntioxidant Icon

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

Very Disliked Full details ->
Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Ethylparaben Preservative
Preservative IconParaben IconNon-Reef-Safe Icon
PreservativePreservative Icon ParabenParaben Icon Non-Reef-SafeNon-Reef-Safe Icon

Ethylparaben is a preservative, is a paraben, and is not reef safe.

Very Disliked Full details ->
Hydrolyzed Collagen Emollient, Humectant, Skin Conditioning
Helps with Anti-Aging Icon
Helps with Anti-AgingHelps with Anti-Aging Icon

Hydrolyzed collagen has a misleading name because it is actually a mixture of various proteins/peptides. This ingredient has skin hydrating properties.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Isobutylparaben Antimicrobial
Paraben IconCan worsen Dry Skin Icon
ParabenParaben Icon Can worsen Dry SkinCan worsen Dry Skin Icon

Isobutylparaben is a paraben. It can be bad for dry skin.

Very Disliked Full details ->
Methylparaben Preservative
0 / 0 Preservative IconParaben IconNon-Reef-Safe IconMay worsen Eczema Icon
PreservativePreservative Icon ParabenParaben Icon 2 Concerns

Methylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.

0 Com. / 0 Irr.
Very Disliked Full details ->
Octoxynol-9 Emulsifying
0-1 / 0

Octoxynol-9 are part of a group called ethoxylated alkyl phenols. Octoxynols are usually found in hair-coloring products.

0-1 Com. / 0 Irr.
Unknown Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Propylparaben Preservative
0 / 0 Preservative IconParaben IconCan worsen Dry Skin IconNon-Reef-Safe Icon
PreservativePreservative Icon ParabenParaben Icon 2 Concerns

Propylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.

0 Com. / 0 Irr.
Very Disliked Full details ->
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Triethanolamine Buffering, Emulsifying, Masking
2 / 0

Triethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.

2 Com. / 0 Irr.
Very Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Preservative
Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Humectant, Skin Conditioning
Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
BHT
Antioxidant, Masking
Very Disliked

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

BHT also helps stabilize products and prevent them from degrading. Many products are sensitive to air and light. BHT prevents them from breaking down when exposed.

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

Crystal Retinal 6
12
6
18
5
liked
mixed
disliked
not rated
Tretinoin 0.05% Gel
5
10
1
liked
mixed
disliked
not rated

When to use

Medik8 Crystal Retinal 6 41 ingredients

Obagi Tretinoin 0.05% Gel 16 ingredients

34 Routines
0% use in am
100% use in pm
74% use every day
When to use See routines that use it ->
35 Routines
0% use in am
100% use in pm
86% use every day
When to use See routines that use it ->