Protocol Enzyme-Active Retinol Serum Ingredients Explained
Overview
What it is
Serum with 22 ingredients that contains niacinamide, PHA, retinoid and Vitamin E
Cool Features
It is vegan, cruelty-free, and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any common allergens, oils, parabens, silicones or sulfates
Fun facts
Protocol is from United States.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
Ingredient List (22)
Aloe Barbadensis Leaf Juice, Water, Niacinamide, Cyclodextrin, Caprylic/Capric Triglyceride, Gluconolactone, Carnitine, Glycerin, Polysorbate 20, Retinal, Phenylethyl Resorcinol, Bisabolol, Tocopheryl Acetate, Lonicera Japonica Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Lactate, Lecithin, Alcohol Denat., Pentylene Glycol, Maltodextrin , Xanthan Gum, Sodium Benzoate
You should know
Notable Ingredients
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Concerns
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Ingredient Info
Contains Alcohol
Ingredients in this product that are types of alcohol:
Silicon Free
This product is free of silicons 🎉
Contains Fragrance
Ingredients in this product that are forms of fragrance:
Sulfate Free
This product is free of sulfates 🎉
Paraben Free
This product is free of parabens 🎉
Oil Free
This product is free of oils 🎉
Not Malassezia Safe
Ingredients in this product that are not malassezia safe:
Reef Safe
This product is free of ingredients that damage reefs 🎉
EU Allergen Free
This product is free of EU allergens 🎉
Vegan
This product is vegan 🎉
Cruelty Free
This product is cruelty-free 🎉
Ingredients Overview
Ingredients Explained
Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.
Aloe is packed with good stuff including Vitamins A, C, and E. These vitamins are antioxidants, which help fight free-radicals and the damage they may cause. Free-radicals are molecules that may damage your skin cells, such as pollution.
Aloe Barbadensis Leaf Juice also contains sugars. These sugars come in the form of monosaccharides and polysaccharides, folic acid, and choline. These sugars are able to help bind moisture to skin.
It also contains minerals such as calcium, 12 anthraquinones, fatty acids, amino acids, and Vitamin B12.
Learn more about Aloe Barbadensis Leaf JuiceWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterNiacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about NiacinamideCaprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
Within a product, Caprylic Triglyceride can thicken the product and make spreadability easier by dissolving clumping compounds. An added benefit of Caprylic Triglyceride is its antioxidant properties.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Caprylic Triglyceride has not been found to be toxic for human use in concentrations under 50%.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideGluconolactone is a PHA. PHAs have a larger structure than AHAs and BHAs and are more gentle. It is an created by reacting gluconic acid with an alcohol.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This helps improve texture and brightens the skin.
Gluconolactone is a humectant and helps draw moisture to your skin. This helps keep your skin hydrated.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
PHAs also exhibit antioxidant activity by neutralizing free-radical molecules. This can help with anti-aging.
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells. However, we still recommend wearing SPF especially after using exfoliating ingredients.
Learn more about GluconolactoneGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Retinal is a form of retinoid. Retinoids are a group of vitamin A compounds with anti-aging and acne fighting benefits.
Retinal has many benefits as other retinoids: improve skin texture, reduce large pores, reduce the effects of aging, reduce the visibility of dark spots, heal scars, and fight acne.
Studies show retinal may work at a faster rate than retinol due to its structure. Retinoids have to be converted into retinoic acid before starting to work. Some retinoids take several steps of conversion before binding. Retinal is only one step away, making it more potent.
Like other retinoids, retinal may be irritating. It is best to ease into using this ingredient daily. It is best to avoid mixing other active ingredients if you have sensitive skin.
Learn more about RetinalBisabolol is pimarily used to add fragrance to a product. However, it is also famous for helping soothe skin.
Bisabolol comes from German chamomile essential oil. Synthetic Bisabolol has been shown to be less effective.
Bisabolol helps soothe skin. It does this by blocking the inflammatory signals, helping to reduce your body's reaction to irritation.
Bisabolol also interferes with the process of hyperpigmentation. This can help with reducing dark spots and uneven tone.
Bisabolol is an antioxidant. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells. By fighting these free-radicals, Bisabolol may slow down signs of aging.
Studies have shown Bisabolol to have antimicrobial properties and may be a fungicide. These properties help preserve a product's shelf life.
Bisabolol also helps the absorption of other ingredients.
Learn more about BisabololTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateLonicera Japonica Flower Extract comes from the honeysuckle flower.
Honeysuckles have skin protecting, anti-viral, and anti-inflammatory properties. It contains many antioxidants, such as luteolin, caffeic acid, loniflavone, and chlorogenic acids.
This honeysuckle is native to East Asia and used in traditional Chinese medicine to treat fever and inflammation.
Learn more about Lonicera Japonica Flower ExtractThis Honeysuckle flower extract comes from the Italian honeysuckle. It is an antioxidant, antimicrobial, and fragrance.
Both this and the Japanese Honeysuckle are rich in a natural paraben that give it antimicrobial property. They are effective in inhibiting bacteria, yeast, and mold.
Honeysuckle contains flavonoids and saponins. Both of these components are natural antioxidants that can help soothe the skin.
As most flowers do, honeysuckle has a natural fragrance.
Learn more about Lonicera Caprifolium Flower ExtractSodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and used to adjust the pH of a product.
Sodium Lactate is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin.
It also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
Our NMF is formed from amino acids, lactic acid, sugars, minerals, peptides, and electrolytes. As we age, our NMF naturally depletes. Other sources of NMF depletion include harsh and drying ingredients such as denatured alcohol. Sodium lactate can help replenish our NMF, leading to more hydrated and plump skin.
High percentages of Sodium Lactate can have an exfoliating effect.
Sodium Lactate is produced from fermented sugar.
Learn more about Sodium LactateLecithin is a term for a group of substances found in plants, animals, and humans. They are made up of mixture of fatty acids. These fatty acids usually are a mixture of phosphoric acid's choline ester connected to stearic, oleic, and palmitic acids. Most lecithins are created from plant ingredients scuh as sunflower.
Lecithin is an emollient. Emollients help soften the skin and creates a barrier to keep moisture in.
As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can help ingredients be better absorbed by the skin. The phospholipids in Lecithin can produce liposomes. Liposomes help other ingredients get through the skin barrier.
Learn more about LecithinAlcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol and other additives. It has a low molecular weight and will evaporate quickly. This helps other ingredients become better absorbed and dry once applied.
Alcohol Denat. is volatile and may cause irritation. It helps draw out natural oils in skin and dry out your skin.
One study from 2005 found adding emollients to propanol-based sanitizer decreased irritation.
Alcohol is antibacterial by nature. This can help preserve products and increase their shelf life.
Other types of astringent alcohols include:
Learn more about Alcohol Denat.Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can help thicken or emulsify a product. Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolMaltodextrin is a polysaccharide. It is derived from starch such as rice, corn, wheat, or potato starch.
In food, Maltodextrin is used to improve the texture and thicken a product. Due to its structure, it can help create a gel texture. As an emulsion stabilizer, it helps keep the ingredients in a product together.
As a polysaccharide, Maltodextrin has moisturizing properties. Polysaccharides are a type of carbohydrate. The top layer of skin uses polysaccharides to retain water, keeping the skin hydrated.
Maltodextrin is water soluble and has a sweet taste.
Learn more about MaltodextrinXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
Sodium Benzoate is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoateBeautiful widgets for your website
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Directions
Apply one pump at night after cleansing or rinsing with water while skin is still damp. Beginning users should wait a few minutes or until dry before following up with evening moisturizer. Advanced users can wait up to 30 minutes before applying moisturizer to maximize...
Apply one pump at night after cleansing or rinsing with water while skin is still damp. Beginning users should wait a few minutes or until dry before following up with evening moisturizer. Advanced users can wait up to 30 minutes before applying moisturizer to maximize potency. This product is compatible with other toners or actives, however, as a general practice our lab team recommends a simple cleanser, active, moisturizer routine for all skin types.
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
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