La Roche-Posay Toleriane Dermallergo Creme Daily Repair Moisturizer Versus Shiseido Waso Shikulime Mega Hydrating Moisturizer
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningIsocetyl Stearate
EmollientSqualane
EmollientButyrospermum Parkii Butter
Skin ConditioningDimethicone
EmollientGlycerin
HumectantZea Mays Starch
AbsorbentPentylene Glycol
Skin ConditioningButylene Glycol
HumectantGlyceryl Stearate
EmollientPEG-100 Stearate
Cetyl Alcohol
EmollientSalvia Miltiorrhiza Root Extract
Skin ConditioningDimethiconol
EmollientSodium Hydroxide
BufferingSphingomonas Ferment Extract
Skin ConditioningCaprylyl Glycol
EmollientCitric Acid
BufferingAcetyl Dipeptide-1 Cetyl Ester
Skin ConditioningAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingWater, Isocetyl Stearate, Squalane, Butyrospermum Parkii Butter, Dimethicone, Glycerin, Zea Mays Starch, Pentylene Glycol, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Cetyl Alcohol, Salvia Miltiorrhiza Root Extract, Dimethiconol, Sodium Hydroxide, Sphingomonas Ferment Extract, Caprylyl Glycol, Citric Acid, Acetyl Dipeptide-1 Cetyl Ester, Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Water
Skin ConditioningCetyl Ethylhexanoate
EmollientHydrogenated Polydecene
EmollientButylene Glycol
HumectantDimethicone
EmollientXylitol
HumectantGlycerin
HumectantSilica
AbrasiveSqualane
EmollientPEG-60 Glyceryl Isostearate
Alcohol
AntimicrobialStearyl Alcohol
EmollientButyrospermum Parkii Butter
Skin ConditioningGlyceryl Stearate
EmollientErythritol
HumectantBehenyl Alcohol
EmollientTrehalose
HumectantCI 77891
Cosmetic ColorantPhenoxyethanol
PreservativeIsostearic Acid
CleansingHydrogenated Palm Oil
EmollientMica
Cosmetic ColorantPyrus Malus Fruit Water
MaskingElaeis Guineensis Kernel Oil
EmollientElaeis Guineensis Oil
EmollientChlorphenesin
AntimicrobialXanthan Gum
EmulsifyingDipropylene Glycol
HumectantAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingDisodium EDTA
Tin Oxide
AbrasiveSodium Metaphosphate
BufferingRosmarinus Officinalis Leaf Oil
MaskingSodium Polyacrylate
AbsorbentLimonene
PerfumingCitrus Aurantium Dulcis Oil
MaskingLavandula Angustifolia Oil
MaskingTocopherol
AntioxidantCI 77492
Cosmetic ColorantCitrus Depressa Peel Extract
HumectantSalvia Officinalis Oil
MaskingPotassium Hydroxide
BufferingPlankton Extract
Skin ConditioningCitric Acid
BufferingWater, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Butylene Glycol, Dimethicone, Xylitol, Glycerin, Silica, Squalane, PEG-60 Glyceryl Isostearate, Alcohol, Stearyl Alcohol, Butyrospermum Parkii Butter, Glyceryl Stearate, Erythritol, Behenyl Alcohol, Trehalose, CI 77891, Phenoxyethanol, Isostearic Acid, Hydrogenated Palm Oil, Mica, Pyrus Malus Fruit Water, Elaeis Guineensis Kernel Oil, Elaeis Guineensis Oil, Chlorphenesin, Xanthan Gum, Dipropylene Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Tin Oxide, Sodium Metaphosphate, Rosmarinus Officinalis Leaf Oil, Sodium Polyacrylate, Limonene, Citrus Aurantium Dulcis Oil, Lavandula Angustifolia Oil, Tocopherol, CI 77492, Citrus Depressa Peel Extract, Salvia Officinalis Oil, Potassium Hydroxide, Plankton Extract, Citric Acid
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Learn more about Acrylates/C10-30 Alkyl Acrylate CrosspolymerButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.
Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).
In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).
Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.
Shea butter also contains vitamins A and E which may contribute to antioxidant activity.
While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.
This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.
Learn more about Butyrospermum Parkii ButterCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Learn more about Glyceryl StearateSqualane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, itās technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term āoil-freeā isnāt regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about SqualaneWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water