Dr. Denese SkinScience SPF 40 Defense Day Cream Ingredients Explained
Published on December 12, 2022
Overview
What it is
Day moisturizer with 48 ingredients that contains exfoliants, hyaluronic acid, retinoid, SPF, Vitamin C and Vitamin E
Cool Features
It is cruelty-free
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, parabens or sulfates
Fun facts
Dr. Denese SkinScience is from United States.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
Ingredient List (48)
Titanium Dioxide 4%, Zinc Oxide 14%, Cyclopentasiloxane, Dimethicone, Octyldodecyl Neopentanoate, Propanediol, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Argania Spinosa Kernel Oil, Bis-Diglyceryl Polyacyladipate-2, Dimethicone/Peg-10/15 Crosspolymer, Peg-10 Dimethicone, Peg/Ppg-18/18 Dimethicone, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Bisabolol, Melanin, Phospholipids, Retinyl Palmitate, Calcium Pantothenate, Ascorbyl Palmitate , Tocopheryl Acetate, Sodium PCA, Sodium Lactate, Arginine, Aspartic Acid, PCA, Glycine, Alanine, Serine, Valine, Proline, Threonine, Isoleucine, Histidine, Phenylalanine, Alumina, Hydrogen Dimethicone, Triethoxycaprylylsilane, Disteardimonium Hectorite, Caprylic/Capric Triglyceride, Hydroxymethoxyphenyl Decanone, Dipotassium Glycyrrhizate, Sodium Chloride, Disodium EDTA, Phenoxyethanol, CI 77492, CI 77491, CI 77499
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Ingredient Info
Alcohol Free
This product is free of harsh alcohols 🎉
Contains Silicon
Ingredients in this product that are types of silicon:
Fragrance Free
This product is free of fragrances 🎉
Sulfate Free
This product is free of sulfates 🎉
Paraben Free
This product is free of parabens 🎉
Contains Oils
Ingredients in this product that are types of oil:
Not Malassezia Safe
Ingredients in this product that are not malassezia safe:
Not Reef Safe
Ingredients in this product that are not reef safe:
EU Allergen Free
This product is free of EU allergens 🎉
Non Vegan
This product is not vegan 😥
Cruelty Free
This product is cruelty-free 🎉
Ingredients Overview
Ingredients Explained
Titanium dioxide is known for its UVA and UVB protection properties. It is non-comedogenic and non-irritating. Titanium Dioxide is a physical sunscreen. Physical sunscreens reflect light and prevent it from reaching your skin.
Protecting your skin against UV radiation can prevent the signs of aging. Sun damage is associated with fine-lines, wrinkles, loss of firmness, and hyperpigmentation. Titanium dioxide can help prevent premature aging.
With modern production, nano-scale or fine-grade titanium dioxide can be easily produced for cosmetics. In sunscreen, titanium dioxide absorbs UV light. Our skin is not able to absorb Titanium dioxide, even nanoparticles.
Titanium itself is the 9th most common element in the Earth's crust. Titanium dioxide is formed when oxygen is introduced and can be found in ores, dust, sand, and soil.
Pure titanium dioxide is a white powder that is used in many products to add or change color.
Learn more about Titanium DioxideZinc Oxide is a mineral broad-spectrum UV filter; it is the broadest UVA and UVB reflector approved by the FDA. While it is most commonly man-made for cosmetics, it can naturally occur in zincite, a rare mineral.
Today, traditional and nano-sized zinc oxide can be found in beauty products. Nano-sized zinc oxide can enhance a product's UV protection. While it is not believed to have a negative effect on skin, nano-zinc oxide can be harmful to coral reefs.
More about harmful reef ingredients here.
Zinc Oxide also has antibacterial and calming properties. It is not water soluble.
Zinc has been used throughout history as an ingredient in paint and medicine. An Indian text from 500BC is believed to list zinc oxide as a salve for open wound. The Ancient Greek physician Dioscorides has also mentioned the use of zinc as an ointment in 1AD.
Learn more about Zinc OxideCyclopentasiloxane is a silicone used to improve texture and trap moisture. An easier name for this is D5.
D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.
D5 is an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.
Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.
Learn more about CyclopentasiloxaneDimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.
Dimethicone has been found increase absorption in skin, boosting the benefits of other ingredients. While there is concern for the safety of dimethicone, the levels used in skincare are safe for use.
We don't have a description for Octyldodecyl Neopentanoate.
Propanediol helps absorb ingredients into your skin, boosting their benefits. It can act as an emollient, making your skin softer. Propanediol can help products last longer by boosting the properties of preservatives within the formulation.
Propanediol is not likely to cause sensitivity and considered safe to use.
It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolLauryl Peg-9 Polydimethylsiloxyethyl Dimethicone is a type of silicone.
Argania Spinosa Kernel Oil is derived from the kernels of the argania spinosa tree. You may know it as argan oil.
Argan Oil is an antioxidant, hydrating, and soothing ingredient.
Studies have shown argan oil can help fight again radical damage from the sun. This makes it effective at preventing hyperpigmentation.
Large amounts of vitamin E found in argan oil helps the skin retain water. Argan oil also contains fatty acids such as linoleic acid, oleic acid, and palmitic acid. It is also a good source of lipids.
Another benefit of argan oil is skin-soothing. It can help reduce inflammation-related skin symptoms.
Argan Oil is effective at regulating sebum production in pores. This can make it effective at treating hormonal acne.
Traditionally, argan oil was used for its antibacterial and antifungal properties. However, argan oil contains fatty acids that may make it not fungal-acne safe.
Argan Trees are native to Morocco.
Learn more about Argania Spinosa Kernel OilBis-Diglyceryl Polyacyladipate-2 is lipid-based synthetic skin-conditioning agent. As an emollient, it helps soften and hydrate the skin.
Emollients create a barrier on the skin to trap moisture in.
We don't have a description for Dimethicone/Peg-10/15 Crosspolymer.
Peg-10 Dimethicone is silicone with conditioner and emulsifier properties. It mostly acts as an emollient in skincare and and humectant in haircare.
According to the manufacturer, acidic formulations decrease the stability of this ingredient. It works best in neutral or near neutral formulations.
Peg/Ppg-18/18 Dimethicone is a type of silicone.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateThis ingredient is created by putting sodium hyaluronate through hydrolysis.
You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.
According to studies, low molecular-weight hyaluronic acid can:
One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.
Hydrolysis is a process of changing a molecule using water or enzymes.
This ingredient is water-soluble.
Learn more about Hydrolyzed Sodium HyaluronateBisabolol is pimarily used to add fragrance to a product. However, it is also famous for helping soothe skin.
Bisabolol comes from German chamomile essential oil. Synthetic Bisabolol has been shown to be less effective.
Bisabolol helps soothe skin. It does this by blocking the inflammatory signals, helping to reduce your body's reaction to irritation.
Bisabolol also interferes with the process of hyperpigmentation. This can help with reducing dark spots and uneven tone.
Bisabolol is an antioxidant. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells. By fighting these free-radicals, Bisabolol may slow down signs of aging.
Studies have shown Bisabolol to have antimicrobial properties and may be a fungicide. These properties help preserve a product's shelf life.
Bisabolol also helps the absorption of other ingredients.
Learn more about BisabololPhospholipids are naturally found in our skin as they are the main component of cell membranes. Phospholipids have humectant, emollient, antioxidant properties.
The phospholipids in our skin can be naturally depleted. Replenishing the phospholipids in our skin can help hydrate your skin. Due to their hygroscopic nature, they act as humectants and emollients. Humectants draw moisture from the air to your skin, while emollients help trap moisture in. This ingredient is non-occlusive.
Studies show phospholipids display antioxidant activity and may help with reducing the signs of aging.
Phospholipids are complex lipids that contain glycerin, two fatty acids, and a phosphate group. Some foods that contain phospholipids include soybeans and milk. The phospholipids found in soy come from Lecithin. This ingredient can also be synthetically created.
Some types of phospholipids:
Learn more about PhospholipidsRetinyl palmitate is a form of retinoid. It is created from palmitic acid and retinol.
This ingredient has antioxidant and exfoliating properties. Like other types of retinols, retinyl palmitate increases cell turnover. Removing dead skin cells and encouraging the growth of new ones improves skin tone and unclogs pores. This in turn promotes brighter looking skin and even skin texture.
As an antioxidant, retinyl palmitate helps neutralize free-radical molecules. These molecules have the potential to damage skin cells. Thus, antioxidants may help with anti-aging.
Retinyl palmitate can be good for be good for oily skin by helping to unclog pores. However, it may not be good for dry skin and fungal acne.
After using this product, you should follow up with sunscreen.
This ingredient is often added to low-fat milk to increase the levels of Vitamin A.
Learn more about Retinyl PalmitateCalcium Pantothenate is calcium salt from Vitamin B5. It can be naturally found in plants and animals.
Calcium Pantothenate is a potent antioxidant. Antioxidants help fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Antioxidants help stabilize free-radicals by donating extra electrons. This may help reduce the signs of aging.
Our bodies use Calcium Pantothenate for various metabolic functinos. These functions include metabolizing carbohydrates, proteins, and fatty acids.
Learn more about Calcium PantothenateAscorbyl Palmitate is created by combining pure Vitamin C and palmitic acid. It is an antioxidant and helps reduce hyperpigmentation.
Antioxidants help fight free-radical molecules, or molecules that may break down skin cells. Antioxdants help reduce signs of aging.
Ascorbyl Palmitate is a stable version of Vitamin C, meaning it does not disintegrate when exposed to sunlight. However, studies show it does not penetrate skin as well as pure Vitamin C.
Read more about other types of Vitamin C:
Learn more about Ascorbyl PalmitateTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateSodium PCA is the sodium salt of pyroglutamic acid and is naturally occurring on human skin.
The PCA stands for pyrrolidone carboxylic acid, a natural amino acid derivative.
Sodium PCA is a has conditioning, anti-inflammatory, and humectant properties. Humectants help hydrate your skin by drawing moisture from the air. This helps keep your skin moisturized.
Learn more about Sodium PCASodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and used to adjust the pH of a product.
Sodium Lactate is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin.
It also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
Our NMF is formed from amino acids, lactic acid, sugars, minerals, peptides, and electrolytes. As we age, our NMF naturally depletes. Other sources of NMF depletion include harsh and drying ingredients such as denatured alcohol. Sodium lactate can help replenish our NMF, leading to more hydrated and plump skin.
High percentages of Sodium Lactate can have an exfoliating effect.
Sodium Lactate is produced from fermented sugar.
Learn more about Sodium LactateArginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.
As a cosmetic ingredient, Arginine has antioxidant properties and can also help repair damaged skin. This ingredient is derived either synthetically or from animals.
Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.
Learn more about ArginineAspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.
Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.
Antioxidants help mitigate damage from free-radical molecules. These are molecules that originate from external sources such as pollution, cigarette smoke, or the sun.
Learn more about Aspartic AcidPCA is derived from amino acids and is naturally found in our skin's barrier.
As a humectant, PCA helps draw and hold moisture to the skin. Studies show it is effective at helping the skin stay hydrated long-term.
Glycine is an amino acid that helps build proteins. It is already present in our skin as our bodies produce them naturally.
Glycine helps keep skin hydrated and reduce signs of aging. Amino acids help transport moisture throughout our skin; glycine already plays a role in helping keep our skin moisturized.
As collagen is made up of glycine and other amino acids, it is believed Glycine may help our skin produce more collagen. Collagen helps keep skin plump and firm.
Learn more about GlycineAlanine is an amino acid and is already found in the human body.
Alanine has antioxidant properties and can help with anti-aging.
Alanine is used by fibrous proteins such as collagen, elastin, and keratin. These three help make a strong skin barrier. Having a healthy skin barrier leads to more plump and youthful skin.
Learn more about AlanineSerine is an amino acid naturally found in our body. Our bodies use amino acids to create protein.
Amino-acids help give keep our skin hydrated. They play an important role in the skin barrier, which keeps the skin plump and firm.
Serine is a non-essential amino acid, meaning we don't need to obtain it from eating foods.
Learn more about SerineWe don't have a description for Valine.
Proline is an amino-acid. It helps moisturize the skin and plays an important role in creating proteins.
Proline is one of the building blocks for producing collagen. As we age, our bodies produce less collagen. Collagen helps the skin look plump and firm.
In medicine, proline is used as an osmoprotectant. This means it helps prevent oxidative degradation in other drugs.
Our bodies are able to produce proline naturally, but certain conditions may inhibit this production. In that case, proline can be obtained from eating egg whites, soy protein, dairy products, asparagus, mushrooms, and seaweed.
Learn more about ProlineThreonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.
Threonine is vital for creating collagen and elastin. Collagen and elastin support youthful and firm skin. Our bodies decrease collagen production naturally with age.
Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.
Learn more about ThreonineWe don't have a description for Isoleucine.
We don't have a description for Histidine.
Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.
Phenylalanine is also used to help even out skin tone due to its ability to disrupt the melanin production process.
Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.
Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.
Learn more about PhenylalanineAlumina is another name for the compound aluminum oxide. It is used as a thickener, absorbent, and abrasive.
As an absorbent, alumina can give a mattifying effect. It is used in mineral sunscreens to help coat nano-sized filters, such as titanium dioxide. By increasing the size of the UV filters, these ingredients stay on the skin for a longer time. By coating small sized ingredients, alumina helps thicken a product.
Alumina may be used as an abrasive, or exfoliant.
Alumina is naturally occurring in the mineral corundum. Certain varieties of corundum create rubies and sapphires. Corundum is also the crystalline form of alumina.
Learn more about AluminaTriethoxycaprylylsilane is a silicone used to bind and stabilize ingredients.
As an emulsifier, it helps prevent ingredients from separating. This can help elongate the shelf life of products.
Triethoxycaprylylsilane is often used to coat mineral sunscreens ingredients to help give a better feel. It also helps reduce oxidative stress in sunscreens.
Learn more about TriethoxycaprylylsilaneDisteardimonium Hectorite comes from the clay mineral named hectorite. It is used to add thickness to a product.
It can also help stabilize a product by helping to disperse other ingredients.
Hectorite is a rare, white clay mineral.
Learn more about Disteardimonium HectoriteCaprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
Within a product, Caprylic Triglyceride can thicken the product and make spreadability easier by dissolving clumping compounds. An added benefit of Caprylic Triglyceride is its antioxidant properties.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Caprylic Triglyceride has not been found to be toxic for human use in concentrations under 50%.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideHydroxymethoxyphenyl Decanone is a synthetically created molecule made to mimic ginger extract.
Ginger has anti-inflammatory properties and helps to soothe skin.
According to one study, it is an HA booster, antioxidant, and anti-irritant.
In this study, this ingredient was able to stimulate higher hyaluronic acid levels of the dermal and epidermal layers on a skin-like model. Hyaluronic Acid is a humectant, which means it helps attract moisture to your skin. Humectants help keep skin hydrated.
As an antioxidant, Hydroxymethoxyphenyl Decanone is able to fight off damage from free-radical molecules.
Learn more about Hydroxymethoxyphenyl DecanoneDipotassium Glycyrrhizate comes from licorice root.
Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.
One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.
Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.
Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.
Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.
Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.
Learn more about Dipotassium GlycyrrhizateChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.
This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.
The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.
Scrubs may use salt as the primary exfoliating ingredient.
Learn more about Sodium ChlorideDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ci 77492 is also hydrated iron III oxide. It's sole purpose is to give a yellow hue to products.
Iron III oxides are classified as inorganic chemicals for coloring.
Synthetically created Ci 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.
Learn more about CI 77492Ci 77491 is also hydrated iron III oxide. It's sole purpose is to give a red/pink hue to products.
Iron III oxides are classified as inorganic chemicals for coloring.
Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.
Learn more about CI 77491Ci 77499 is also hydrated iron III oxide. It is created from mixing red and black iron oxides. This helps give shades of darkness to a product.
Iron III oxides are classified as inorganic chemicals for coloring.
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