SKIN1004 Madagascar Centella Tea-Trica Spot Cream Versus Ciracle Red Spot Cica Sulfur Gel

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

In skincare, calamine can help relieve itches, calm skin, and absorb excess moisture/oil. This is why you'll often see it used for oozing rashes. Calamine is approved as a skin protectant active at 1-25% in US OTC drug products.

A big part of calamine's soothing effect comes from zinc oxide's protective properties. Since calamine can absorb excess moisture/oil, it might be drying for already dry skin types.

A review of topical medicament allergies notes that contact dermatitis from calamine isn't typically reported, but added actives in a formulation are known sensitizers.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Studies show Madecassic Acid helps soothe the skin due to its ability to block inflammation pathways.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!