MediCube PDRN Gel to Foam Cleanser
A face cleanser with 36 ingredients, including AHA, niacinamide, and exfoliants.
Overview
What it is
Face cleanser with 36 ingredients that contains AHA, ceramides, exfoliants, hyaluronic acid, niacinamide and Vitamin E
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, parabens, silicones or sulfates
Fun facts
MediCube is from South Korea.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningDisodium Cocoamphodiacetate
CleansingGlycerin
HumectantSorbeth-30 Tetraoleate
EmulsifyingCocamidopropyl Betaine
CleansingSodium Chloride
MaskingAcrylates/Beheneth-25 Methacrylate Copolymer
Citric Acid
Buffering1,2-Hexanediol
Skin ConditioningCaprylyl Glycol
EmollientPotassium Cocoyl Glycinate
Hydroxyacetophenone
AntioxidantDipropylene Glycol
MaskingC12-13 Alketh-9
EmulsifyingHydroxyethyl Urea
HumectantDisodium EDTA
Ethylhexylglycerin
Skin ConditioningRosmarinus Officinalis Leaf Oil
MaskingCyanocobalamin
Skin ConditioningHydrolyzed Collagen
EmollientPanthenol
Skin ConditioningSodium Dna
Skin ConditioningNiacinamide
SmoothingCapryloyl Salicylic Acid
ExfoliatingTocopherol
AntioxidantMentha Arvensis Leaf Oil
MaskingHydrolyzed Hyaluronic Acid
HumectantCaprylic/Capric Triglyceride
MaskingCeramide NP
Skin ConditioningAdansonia Digitata Seed Oil
EmollientHydrogenated Lecithin
EmulsifyingCeramide As
Skin ConditioningCeramide Ns
Skin ConditioningCeramide EOP
Skin ConditioningCeramide AP
Skin ConditioningSodium Hyaluronate
HumectantWater, Disodium Cocoamphodiacetate, Glycerin, Sorbeth-30 Tetraoleate, Cocamidopropyl Betaine, Sodium Chloride, Acrylates/Beheneth-25 Methacrylate Copolymer, Citric Acid, 1,2-Hexanediol, Caprylyl Glycol, Potassium Cocoyl Glycinate, Hydroxyacetophenone, Dipropylene Glycol, C12-13 Alketh-9, Hydroxyethyl Urea, Disodium EDTA, Ethylhexylglycerin, Rosmarinus Officinalis Leaf Oil, Cyanocobalamin, Hydrolyzed Collagen, Panthenol, Sodium Dna, Niacinamide, Capryloyl Salicylic Acid, Tocopherol, Mentha Arvensis Leaf Oil, Hydrolyzed Hyaluronic Acid, Caprylic/Capric Triglyceride, Ceramide NP, Adansonia Digitata Seed Oil, Hydrogenated Lecithin, Ceramide As, Ceramide Ns, Ceramide EOP, Ceramide AP, Sodium Hyaluronate
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterDisodium Cocoamphodiacetate is a surfactant and helps cleanse skin. It is created from the fatty acids of coconut oil.
Surfactants help rinse oil, dirt, and other pollutants easily from skin. It has a faint fruit-like scent.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSorbeth-30 Tetraoleate is a surfactant and emulsifier.
This ingredient is a tetraester from oleic acid and polyethylene glycol ether of sorbitol.
As an emulsifier, it helps ingredients such as oil and water mix together. This allows the dirt and oils in your skin to be washed away.
One study found pumpkin oil containing Sorbeth-30 Tetraoleate helped hydrate the skin and did not cause any irritation.
Learn more about Sorbeth-30 TetraoleateCocamidopropyl Betaine is a fatty acid created by mixing similar compounds in coconut oil and dimethylaminopropylamine, a compound with two amino groups.
This ingredient is a surfactant and cleanser. It helps gather the dirt, pollutants, and other impurities in your skin to be washed away. It also helps thicken a product and make the texture more creamy.
Being created from coconut oil means Cocamidopropyl Betaine is hydrating for the skin.
While Cocamidopropyl Betaine was believed to be an allergen, a study from 2012 disproved this. It found two compounds in unpure Cocamidopropyl Betaine to be the irritants: aminoamide and 3-dimethylaminopropylamine. High-grade and pure Cocamidopropyl Betaine did not induce allergic reactions during this study.
Learn more about Cocamidopropyl BetaineChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.
This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.
The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.
Scrubs may use salt as the primary exfoliating ingredient.
Learn more about Sodium ChlorideWe don't have a description for Acrylates/Beheneth-25 Methacrylate Copolymer yet.
Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.
If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.
Read more about some other popular AHA's here:
Learn more about Citric Acid1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.Â
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservativesÂ
Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.
Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.
This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.
Learn more about Caprylyl GlycolPotassium Cocoyl Glycinate is an amino acid-based surfactant and cleaning agent. This ingredient can be derived from animals or plants. It may also be synthetically created from fatty acids of the coconut and glycine.
Potassium Cocoyl Glycinate is a gentle surfactant. Surfactants help gather the dirt, oil, and other pollutants from your skin to be rinsed away. It is a mild cleanser and naturally produces foam.
Hydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.
This ingredient is not irritating or sensitizing.
Dipropylene Glycol is a synthetically created stabilizer and solvent. It is a part of the glycol class in the alcohol family.
Dipropylene Glycol helps dissolve and evenly distribute ingredients. It also helps decrease viscosity and thin out texture.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolWe don't have a description for C12-13 Alketh-9 yet.
Disodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Rosmarinus Officinalis Leaf Oil is oil expressed from the leaves of the rosemary plant.
Rosemary Leaf Oil is a fragrance and helps give your product a scent. If you are sensitive to irritating fragrances, this one contains camphor. Camphor has been found to irritate skin.
This oil also contains antioxidant and antimicrobial properties. As an antioxidant, it may protect you skin against damage. This can help slow down the signs of aging.
Learn more about Rosmarinus Officinalis Leaf OilCyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.
Hydrolyzed collagen has a misleading name because it is actually a mixture of various proteins/peptides. This ingredient has skin hydrating properties.
Collagen is the most abundant type of structural protein found in your body. In your skin, it is responsible for keeping it firm and youthful.
Hydrolyzed Collagen is created by breaking up proteins into smaller peptide bonds. These peptides act as humectants and emollients.
Humectants are great at holding onto water, keeping skin hydrated. Emollients create a thin barrier on the skin to prevent moisture from escaping.
There is ongoing debate about whether hydrolyzed collagen works because it increases skin hydration. Skin hydration is also linked to elasticity and the appearance of wrinkles.
Collagen or peptide ingredients can be used in the morning or night. They will not increase sun sensitivity, but you should always wear sunscreen during the day.
According to a manufacturer, this ingredient is a great hair conditioner as well.
This ingredient can be extracted from different sources, including:
Vegan collagen is derived from yeast, bacteria, or plant sources. Vegan collagen would go by a different INCI name, such as hydrolyzed soy protein.
The results are varied.
A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.
However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.
Further studies are needed at this time.
Learn more about Hydrolyzed CollagenPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolSodium DNA is an emerging anti-aging ingredient.
It is created by taking deoxyribonucleic acid (DNA) and purifying it with sodium hydroxide.
The DNA is extracted from several different animal sources, including: calf thymus, the gonadic tissue of a male sturgeon, or herring / salmon sperm.
You have probably seen this ingredient in anti-aging skincare. But what is it?
DNA is composed of nucleotides, or chemical building blocks. Nucleotides include adenine (A), thymine (T), guanine (G), and cytosine (C). Talk about a flashback to biology! Nucleosides are formed from these nucleotides.
The science behind Sodium DNA is based on an ingredient called Polydeoxyribonucleotide or PDRN.
PDRN are DNA fragments mainly extracted from the sperm cells of trout or salmon. Meaning, PDRN can be derived from Sodium DNA.
PDRN consists of chains of nucleotides and nucleosides mentioned above. They can range anywhere from 80 - 2000 pairs.
Studies show PDRN has the following properties:
Most of the research on PDRN has been done using injectable forms. That’s important, because PDRN is a large molecule and doesn’t absorb well through the skin. So if you’re applying it topically, the effects are likely to be much milder.
Still, topical Sodium DNA is emerging as a trendy anti-aging ingredient. It’s generally well-tolerated and offers good biocompatibility with human skin, making it a low-risk addition to most routines.
Further studies are needed to truly confirm this ingredients anti-aging ability (Remember, retinol has decades of research!).
When using this ingredient, is is best to ask a brand about the source of their Sodium DNA. You'll want to find products where the Sodium DNA is sourced from fish. Some Sodium DNA is derived from calf / cow thymus.
Needless to say, this ingredient is not vegan.
Learn more about Sodium DnaNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideCapryloyl Salicylic Acid comes from salicylic acid, the famous acne-fighting BHA.
It usually goes by a more common name of LHA, or lipohydroxy acid.
Like salicylic acid, this ingredient is a chemical exfoliant that can help break down the oil in your pores and reduce inflammation.
Though studies for LHA do show it to be less effective than salicylic acid. To be fair, salicylic acid is the reigning monarch of acne treatments.
However, a study from 2009 found LHA to be comparable to BPO, making it a good alternative for people with sensitive skin. Another study of 14 patients found a significant decrease in comedones after using LHA.
Another pro of LHA? It is less irritating than salicylic acid due to its large molecule size.
Large molecules cannot penetrate skin as well, so they are gentler on the skin. LHA is much less penetrative than salicylic acid.
An in-vitro study (not done on a living organism) found only 6% of LHA penetrated past the statum corneum compared to 58% of salicylic acid. An in-vivo (done on a living organism) analysis revealed ~17% of LHA was still present in the top layer of skin after 4 days, versus ~9% of salicylic acid.
Interestingly, a study from 2008 found LHA comparable to another famous acid, glycolic acid.
This study found about 10% of LHA is as effective as 20-50% of glycolic acid in treating hyperpigmentation and fine-lines.
Hydroxy acids have been found to stimulate skin protein, lipids, and thermal thickening. This may have anti-aging benefits.
Learn more about Capryloyl Salicylic AcidTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolMentha Arvensis Leaf Oil is an oil.
Hydrolyzed Hyaluronic Acid is a form of hyaluronic acid. It is created by the hydrolysis of hyaluronic acid with a high molecular weight. Once created, Hydrolyzed Hyaluronic Acid has a low molecular weight.
Low molecular weight HA has been shown to hydrate and increase elasticity of the skin. Increasing elasticity is also associated with reduction of wrinkle depth.
One study found topical low molecular weight hyaluronic acid may be considered for the treatment of rosacea in the adult population. However, we always recommend speaking with a professional about your skin concerns.
Hyaluronic acids are a humectant. This means they draw moisture from the air. Hyaluronic acids help moisturize, soothe, and protect the skin.
Read more about other common forms of hyaluronic acid:
Learn more about Hydrolyzed Hyaluronic AcidThis ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideCeramide NP is a type of ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Ceramide AP
Ceramide EOP
Baobab seed oil is an emollient. It is rich in fatty acids and vitamins A, E, and D.
The fatty acid content of this oil is roughly 30-40% oleic acid, 24-34% linoleic acid, and 18-30% palmitic acid. This gives it skin hydrating and nourishing properties.
Due to this fatty acid content, this ingredient may not be fungal-acne safe.
Fun fact: Our skin uses fatty acids, and especially linoleic acid, for creating ceramides.
Learn more about Adansonia Digitata Seed OilHydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.
This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Ceramide AS is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramide NS is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramide NG,Ceramide NS,1,3-Hexadecanediol, 2-Hexadecanamide,Palmitoyl-C16-Dihydrosphingosine,1-Stearoyl-C18-Sphingosine
Ceramide EOP is a type of Ceramide.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
Ceramides are intercellular lipids naturally found in our skin. They bind dead skin cells together to create a barrier. The ceramides in our skin have the ability to hold water to keep our skin hydrated.
Ceramides are an important building block for our skin barrier. A strong skin barrier helps with:
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Learn more about Ceramide EOPCeramide AP is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. Having a strong skin barrier leads to more firm and hydrated skin.
They are known for their ability to hold water and thus are a great ingredient for dry skin. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Ceramide NP
Ceramide EOP
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateReviews
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Where it's from
MediCube is a Korean brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Published July 27, 2025 • Added by roseballmelody