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Neutrogena Clear & Defend Oil-Free Moisturiser Versus La Roche-Posay Effaclar Duo+ Global Acne Treatment

General Moisturizer
Facial Treatment
American Brand United States
French Brand France

Overview

Suited For

They're both likely to be good for fighting acne, dry skin, brightening skin and scar healing

Free From

They both do not contain any oils or sulfates

What's Inside

They both contain fragrances and silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Notable Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Clear & Defend Oil-Free Moisturiser
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Propylene Glycol Humectant, Skin Conditioning, Solvent
0 / 0 May worsen Eczema Icon
May worsen EczemaMay worsen Eczema Icon

Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.

0 Com. / 0 Irr.
Disliked Full details ->
Cetyl Alcohol Emollient, Emulsifying, Emulsion Stabilising
2 / 2 Fatty Alcohol Icon
Fatty AlcoholFatty Alcohol Icon

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

2 Com. / 2 Irr.
Very Disliked Full details ->
C12-15 Alkyl Benzoate Antimicrobial, Emollient, Skin Conditioning

C12-15 Alkyl Benzoate is made up of Benzoic Acid and long chain alcohols. It has a low molecular weight.

Disliked Full details ->
Stearyl Alcohol Emollient, Emulsifying, Emulsion Stabilising
2 / 2 Fatty Alcohol Icon
Fatty AlcoholFatty Alcohol Icon

Stearyl Alcohol is a type of fatty alcohol from stearic acid. It is a white, waxy compound used to emulsify ingredients.

2 Com. / 2 Irr.
Very Disliked Full details ->
Glyceryl Stearate Emollient, Emulsifying
1 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Glyceryl Stearate is a mix of glycerin and stearic acid.

1 Com. / 0 Irr.
Disliked Full details ->
Peg-100 Stearate
0 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Peg-100 Stearate is an emollient and emulsifier. PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.

0 Com. / 0 Irr.
Very Disliked Full details ->
C12-15 Alkyl Lactate Emollient, Skin Conditioning

We don't have a description for C12-15 Alkyl Lactate.

Unknown Full details ->
Aloe Barbadensis Leaf Extract Emollient, Humectant, Skin Conditioning

Aloe Barbadensis Leaf Extract is an extract of the leaves of the aloe, Aloe barbadensis, Liliaceae.

Chamomilla Recutita Extract Skin Conditioning
0 / 0 Helps reduce irritation Icon
Helps reduce irritationHelps reduce irritation Icon

Chamomilla Recutita Extract comes from the Chamomile flower.

0 Com. / 0 Irr.
Cetyl Lactate Emollient, Skin Conditioning

We don't have a description for Cetyl Lactate.

Unknown Full details ->
Cocamidopropyl Pg-Dimonium Chloride Phosphate

We don't have a description for Cocamidopropyl Pg-Dimonium Chloride Phosphate.

Unknown Full details ->
Salicylic Acid Masking, Preservative, Skin Conditioning
BHA IconPreservative IconGood for Oily Skin IconGood for Minimizing Pores IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin IconCan worsen Dry Skin IconMay cause irritation IconMay worsen Eczema IconMay worsen Rosacea Icon
BHABHA Icon PreservativePreservative Icon 5 Benefits 4 Concerns

Salicylic Acid (also known as beta hydroxy acid or BHA) is one of the most well-known ingredients for treating skin that struggles with blackheads and acne. It helps to exfoliate both the skin's surface and pores, and also acts as an anti-inflammatory agent.

Menthyl Lactate Masking, Refreshing

We don't have a description for Menthyl Lactate.

Unknown Full details ->
Dimethicone Emollient, Skin Conditioning, Skin Protecting
1 / 0 Silicon Icon
SiliconSilicon Icon

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

1 Com. / 0 Irr.
Very Disliked Full details ->
Cyclohexasiloxane Emollient, Skin Conditioning, Solvent
Silicon Icon
SiliconSilicon Icon

Cyclohexasiloxane is a type of silicone more commonly known as D6. It is an emollient and solvent.

Disliked Full details ->
Cyclopentasiloxane Emollient, Skin Conditioning, Solvent
Silicon Icon
SiliconSilicon Icon

Cyclopentasiloxane is a silicone used to improve texture and trap moisture. An easier name for this is D5.

Disliked Full details ->
Sodium Isostearoyl Lactylate Emulsifying

We don't have a description for Sodium Isostearoyl Lactylate.

Unknown Full details ->
Propylene Glycol Isostearate Skin Conditioning
3-4 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

This ingredient is created by reacting propylene glycol with isostearic acid.

3-4 Com. / 0 Irr.
Unknown Full details ->
Palmitic Acid Emollient, Emulsifying
2 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Palmitic Acid is a fatty acid found in our skin. In cosmetics, it is usually derived from palm oil. It is a cleanser, emollient, and emulsifier.

2 Com. / 0 Irr.
Very Disliked Full details ->
Stearic Acid Cleansing, Emulsifying, Emulsion Stabilising
2-3 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Stearic Acid is a fatty acid. It is an emollient, emulsifier, and texture enhancer.

2-3 Com. / 0 Irr.
Very Disliked Full details ->
Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Acrylates/C10-30 Alkyl Acrylate Crosspolymer Emulsion Stabilising

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken and improve the texture of products.

Disliked Full details ->
Sodium Chloride Masking
Can worsen Dry Skin IconBad for Acne Prone Skin IconMay worsen Rosacea Icon
3 Concerns

Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.

Very Disliked Full details ->
Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Sodium Hydroxide Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

Benzalkonium Chloride Antimicrobial, Preservative
Preservative IconMay cause irritation IconMay worsen Eczema Icon
PreservativePreservative Icon 2 Concerns

Benzalkonium Chloride is a preservative. It can cause irritation and worsen eczema.

Very Disliked Full details ->
Methylparaben Preservative
0 / 0 Preservative IconParaben IconNon-Reef-Safe IconMay worsen Eczema Icon
PreservativePreservative Icon ParabenParaben Icon 2 Concerns

Methylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.

0 Com. / 0 Irr.
Very Disliked Full details ->
Propylparaben Preservative
0 / 0 Preservative IconParaben IconCan worsen Dry Skin IconNon-Reef-Safe Icon
PreservativePreservative Icon ParabenParaben Icon 2 Concerns

Propylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.

0 Com. / 0 Irr.
Very Disliked Full details ->
Ethylparaben Preservative
Preservative IconParaben IconNon-Reef-Safe Icon
PreservativePreservative Icon ParabenParaben Icon Non-Reef-SafeNon-Reef-Safe Icon

Ethylparaben is a preservative, is a paraben, and is not reef safe.

Very Disliked Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Parfum Masking, Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon
FragranceFragrance Icon 2 Concerns

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Very Disliked Full details ->
Benzyl Alcohol Perfuming, Preservative, Solvent
Alcohol IconFragrance IconPreservative IconCan worsen Dry Skin IconMay worsen Oily Skin IconMay cause irritation IconEU Allergen IconMay worsen Eczema IconMay worsen Rosacea Icon
AlcoholAlcohol Icon FragranceFragrance Icon PreservativePreservative Icon 6 Concerns

Benzyl Alcohol is most commonly used as a preservative. It also has a subtle, sweet smell. Small amounts of Benzyl Alcohol is not irritating and safe to use in skincare products. Most Benzyl Alcohol is derived from fruits such as apricots.

Very Disliked Full details ->
Effaclar Duo+ Global Acne Treatment
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Dimethicone Emollient, Skin Conditioning, Skin Protecting
1 / 0 Silicon Icon
SiliconSilicon Icon

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

1 Com. / 0 Irr.
Very Disliked Full details ->
Isocetyl Stearate Emollient, Skin Conditioning
0-1 / 0 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
3 Concerns

Isocetyl Stearate is an ester of isocetyl alcohol and stearic acid.

0-1 Com. / 0 Irr.
Unknown Full details ->
Isopropyl Lauroyl Sarcosinate Skin Conditioning

We don't have a description for Isopropyl Lauroyl Sarcosinate.

Unknown Full details ->
Silica Abrasive, Absorbent
Exfoliant IconMay worsen Eczema IconMay worsen Rosacea Icon
ExfoliantExfoliant Icon 2 Concerns

Silica is a mineral naturally found in our skin. It helps to thicken and smooth the texture of a product. It also acts as an agent for other ingredients by increasing the absorption of other ingredients into the skin.

Disliked Full details ->
Ammonium Polyacryloyldimethyl Taurate Emulsion Stabilising

Ammonium Polyacryloyldimethyl Taurate is a polymer made from ammonium salts. It helps add stability and texture to a product.

Methyl Methacrylate Crosspolymer

We don't have a description for Methyl Methacrylate Crosspolymer.

Disliked Full details ->
Sodium Hydroxide Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

Poloxamer 338 Emulsifying

We don't have a description for Poloxamer 338.

Unknown Full details ->
Polysorbate 80 Emulsifying
0 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Polysorbate 80 is a surfactant and emulsifier. It is used to keep ingredients together, and prevent oils and waters from separating.

0 Com. / 0 Irr.
Very Disliked Full details ->
Mannose Humectant

We don't have a description for Mannose.

Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->
Zinc PCA Humectant, Skin Conditioning
Good for Scar Healing IconHelps fight Acne Icon
2 Benefits

Zinc PCA (or "zinc salt") differs slightly from zinc itself. PCA stands for pyrrolidone carboxylic acid. However, Zinc PCA comes from zinc.

Isohexadecane Emollient, Skin Conditioning, Solvent

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

2-Oleamido-1,3-Octadecanediol Skin Conditioning

We don't have a description for 2-Oleamido-1,3-Octadecanediol.

Unknown Full details ->
Capryloyl Salicylic Acid Skin Conditioning

Capryloyl Salicylic Acid comes from salicylic acid, the famous acne-fighting BHA.

Caprylyl Glycol Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

Piroctone Olamine Preservative
Preservative Icon
PreservativePreservative Icon

Piroctone Olamine is a preservative.

Myristyl Myristate Emollient, Skin Conditioning
0-5 / 2 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
3 Concerns

Myristyl Myristate is created from the fatty acids of myristyl alcohol and myristic acid. In skincare, it is an emollient and texture enhancer.

0-5 Com. / 2 Irr.
Very Disliked Full details ->
Acrylamide

We don't have a description for Acrylamide.

Unknown Full details ->
Sorbitan Oleate Emulsifying
3 / 0 Bad for Acne Prone Skin IconNot safe for Fungal Acne Icon
2 Concerns

Sorbitan Oleate is created from compounds in oleic acid and sorbitol. It is used to stabilize a product by preventing ingredients from separating.

3 Com. / 0 Irr.
Very Disliked Full details ->
Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Potassium Cetyl Phosphate Emulsifying

Potassium Cetyl Phosphate is the potassium salt of a mixture. This mixture consists of the esters from phosphoricacid and cetyl alcohol.

Vitreoscilla Ferment Skin Conditioning

Vitreoscilla Ferment is a probiotic derived from the Vitreoscilla bacteria.

Aluminum Starch Octenylsuccinate Absorbent

Aluminum Starch Octenylsuccinate is a synthetic powder used as an absorbent, thickener, and anti-caking agent.

Disliked Full details ->
Glyceryl Stearate Se Emulsifying
3 / 2 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Glyceryl Stearate Se is a self-emulsifying (SE) form of glyceryl stearate. Self-emusifying means this ingredient automatically blends with water. It is an emulsifier, emollient, and cleansing agent.

3 Com. / 2 Irr.
Very Disliked Full details ->
Parfum Masking, Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon
FragranceFragrance Icon 2 Concerns

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Very Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Skin Conditioning, Skin Protecting
Very Disliked

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

Dimethicone has been found increase absorption in skin, boosting the benefits of other ingredients. While there is concern for the safety of dimethicone, the levels used in skincare are safe for use.

Disliked

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Buffering
Mixed

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Learn more about Sodium Hydroxide
Masking, Perfuming
Very Disliked

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

In the US, the alternative name for parfum is 'fragrance'.

The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Learn more about Parfum

Ingredient Ratings

Here's what our community thinks of the ingredients in these products.

Clear & Defend Oil-Free Moisturiser
5
1
22
6
liked
mixed
disliked
not rated
Effaclar Duo+ Global Acne Treatment
10
2
11
5
liked
mixed
disliked
not rated

When to use

18 Routines
50% use in am
50% use in pm
94% use every day
262 Routines
44% use in am
56% use in pm
86% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Neutrogena Clear & Defend Oil-Free Moisturiser 34 ingredients

3.0 /5
from 1 rating
Expensive (1)
Hubayobi's avatar

Hubayobi

5 months ago · Combination Skin
Review

Simple moisturizer. There’s better ones out there

La Roche-Posay Effaclar Duo+ Global Acne Treatment 28 ingredients

4.0 /5
from 2 ratings
YousifShamoon's avatar

YousifShamoon

1 year ago · Combination Skin
Review

interesting to say the least
no one warned me about the purge i was gonna get from this. the crease on my nose and my chin turned red and were...

interesting to say the least
no one warned me about the purge i was gonna get from this. the crease on my nose and my chin turned red and were peeling for weeks but i think it paid off in the end. it handled my sebum production and pimples very well, but unfortunately i can't say the same for my blackheads and whiteheads, which remained unbothered by this product. another thing i wasn't warned about when i used this is that it is not hydrating enough to be used as a moisturiser. i only realised this when i switched to byoma's gel cream moisturiser but you have to use this as a facial or spot treatment and follow up with a proper moisturiser. overall i liked this but i had to stop using it because it was constantly sold out and i think it is so expensive right now and i also needed to stop using benzyl peroxide so i can switch to retinol.