Isispharma Ruboril Metroruboril A.Z Versus Dermatica Custom Formula (Ivermectin 1%, Metronidazole 0.75%, Niacinamide 4%)
Updated on October 22, 2023
Overview
What they are
These products are both reef safe . They have a total of 4 ingredients in common
Cool Features
They both contain niacinamide
Suited For
They're both likely to be good for fighting acne, dry skin, brightening skin, sensitive skin, oily skin, reducing pores and dark spots
Free From
They both do not contain any harsh alcohols, common allergens, oils, parabens or sulfates
What's Inside
They both contain silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Isispharma Ruboril Metroruboril A.Z 28 ingredients
Dermatica Custom Formula (Ivermectin 1%, Metronidazole 0.75%, Niacinamide 4%) 28 ingredients
At a glance
Click on any of the items below to learn more
Isispharma Ruboril Metroruboril A.Z 28 ingredients
Dermatica Custom Formula (Ivermectin 1%, Metronidazole 0.75%, Niacinamide 4%) 28 ingredients
Notable Ingredients
This product contains 1 ingredient that may have this attribute:
Benefits
This product contains 1 ingredient that may have this attribute:
This product contains 4 ingredients that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 2 ingredients that may have this attribute:
Notable Ingredients
This product contains 1 ingredient that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
Benefits
This product contains 4 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 4 ingredients that may have this attribute:
This product contains 3 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 2 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 3 ingredients that may have this attribute:
Concerns
This product contains 1 ingredient that may have this attribute:
Ingredients Side-by-side
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
Azelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.
Betaine is a common humectant (a substance that promotes retention of moisture). It's known to be gentle on the skin and can help balance hydration.
Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
We don't have a description for Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer.
This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
Lauryl Glucoside sugar- and lipid-based cleansing agent. It is created from glucose and lauryl alcohol.
Polyglyceryl-2 Dipolyhydroxystearate isn't fungal acne safe.
6 Benefits
Niacinamide has emerged as an all-star ingredient due to its many benefits.
Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.
Sclerotium Gum is a polysaccharide gum made by the fungus, Sclerotium rolfssii. It is similar to xanthan gum.
Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.
Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.
4 Benefits 2 Concerns
Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
Centella Asiatica Leaf Extract comes from the leaves of an herb plant native to Southeast Asia. Centella Asiatica is rich in antioxidants and amino acids. It can help reduce irritation and soothe the skin.
2 Benefits
Calendula Officinalis Flower Extract comes from the common Marigold plant. This ingredient is a skin conditioner.
Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.
Water, Azelaic Acid, Betaine, Caprylic/Capric Triglyceride, Glycerin, Butylene Glycol, Pentylene Glycol, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Lauryl Glucoside, Polyglyceryl-2 Dipolyhydroxystearate, Glycyrrhetinic Acid, Niacinamide, Ethylhexylglycerin, Panthenol, Sclerotium Gum, Chlorphenesin, Escin, O-Cymen-5-Ol, Polysorbate 60, Sorbitan Isostearate, Ruscus Aculeatus Root Extract, Ammonium Glycyrrhizate, Citric Acid, Centella Asiatica Leaf Extract, Hydrolyzed Yeast Protein, Calendula Officinalis Flower Extract, Sodium Citrate
6 Benefits
Niacinamide has emerged as an all-star ingredient due to its many benefits.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Glyceryl Stearate is a mix of glycerin and stearic acid.
Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.
C13-15 Alkane is a group of alkanes with 13 to 15 carbon atoms in the alkyl chain.
Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.
Propanediol helps absorb ingredients into your skin, boosting their benefits. It can act as an emollient, making your skin softer. Propanediol can help products last longer by boosting the properties of preservatives within the formulation.
Polyacrylate-13 is a type of acrylate polymer. Acrylate polymers are commonly used as adhesives in cosmetics.
Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
Antioxidant Helps brighten skin
Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
Phytosphingosine is a phospholipid naturally found in our skin. It helps moisturize, soothe, and protect skin.
Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Ivermectin 1%, Metronidazole 0.75%, Niacinamide 4%, Water, Propylene Glycol, Glycerin, Panthenol, Cetyl Alcohol, Glyceryl Stearate, Isohexadecane, Isododecane, C13-15 Alkane, Dimethicone, Propanediol, Polyacrylate-13, Polyisobutene, Polysorbate 20, Polyurethane-39, Phenoxyethanol 0.6%, Tocopheryl Acetate, Ceramide AP, Ceramide NP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Xanthan Gum, Carbomer, Sodium Hyaluronate
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinNiacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about NiacinamidePanthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.
This ingredient is also referred to as pro-vitamin B5 or dexpanthenol in dermatology.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
Learn more about PanthenolIngredient Ratings
Here's what our community thinks of the ingredients in these products.
When to use
Isispharma Ruboril Metroruboril A.Z 28 ingredients
Dermatica Custom Formula (Ivermectin 1%, Metronidazole 0.75%, Niacinamide 4%) 28 ingredients
Reviews
Here's what our community thinks
Isispharma Ruboril Metroruboril A.Z 28 ingredients
Zoe
I wanted to affordably introduce Azelaic acid into my routine for dark spots & redness. The ingredient list of this product stood out, 15% azelaic...
I wanted to affordably introduce Azelaic acid into my routine for dark spots & redness. The ingredient list of this product stood out, 15% azelaic acid not too many other ingredients. Currently in my first week of use but I’m surprised to say it’s had a quick effect on improving my redness on sensitive areas and on my cheek redness / rosacea. I’ve not had ent negative effects even on my reactive skin so I’m happy to continue using it. It has a creamy texture that absorbs quickly. Not oily at all and leaves no shine.
Two weeks in to using this and I think this is what my skin routine has been missing. It is fast becoming my favourite thing. I’m able to use it on sensitive skin both morning...
Two weeks in to using this and I think this is what my skin routine has been missing. It is fast becoming my favourite thing. I’m able to use it on sensitive skin both morning and night and it’s removed so much of my redness. I’ve experienced no new breakouts even during the build up to my period, which is normally my problem phase.
It absorbs very easily. Leaves no residue or oily finish. It’s completely matte.
