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The FDA requires batch-to-batch certification for this ingredient that is held to a pretty rigorous standard. That means the CI 17200 in your cosmetics has been tested and approved before it ever reaches you.

Contact allergy to cosmetic-grade dyes used at low concentrations are uncommon but has been documented before.

This ingredient also goes by the name D&C RED NO. 33.

CI 17200 has a comedogenic rating of 1 and an irritancy rating of 2 on a scale of 0-5. This is based on peer-reviewed research from the man who invented the comedogenic scale.

A 1 on the comedogenic scale is about as low as it gets without being a flat zero, and makes sense for CI 17200.

It's a water-soluble dye used at very small concentrations (typically 0.001-0.1%), so it dissolves into the water phase of a formula rather than sitting on your skin the way an oil or wax would.

The irritancy rating of 2 reflects that, like most synthetic dyes, there's a small possibility of mild irritation ( particularly for people with existing dye sensitivities).

For the vast majority of people, it's a non-issue at typical use levels.

It's also worth keeping in mind that comedogenic and irritancy ratings are tested on individual ingredients, not finished formulas. The final product's formulation, concentration, and other ingredients all play a role in how something actually behaves on your skin.

Just so you know, the FDA ban on Red Dye No. 3 refers to CI 45430, not this ingredient. CI 45430 and CI 17200 are different chemical compounds with distinct safety and regulatory histories.

It's also worth noting that Red No. 3 (CI 45430) was already banned from cosmetics back in 1990, so the 2025 action just extended the ban to food and oral drugs. CI 17200 was never part of any of this.

Some people may experience allergies from this dye, especially asthmatics and those with an aspirin intolerance.

Similar to Red 27, this dye changes color based on pH and moisture levels.

This dye is colorless when dry but turns pink between pH levels 0.0 to ~3.0.

This dye is commonly found in makeup because it imparts a vivid color. Some types of this dye change color based on pH level and interaction with moisture:

Your skin has a natural pH of around 4.5 - 5.5.

According to the FDA, CI 45410 is not permitted for use in eye products.

Red 27 is a flourescein dye and commonly used as a fluorescent tracer in medicine.

Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

Synthetically created CI 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.

You'll likely see this in many BHA products because this is the go-to solvent for salicylic acid.

This ingredient is typically used at levels between 2-20%.

Regarding fungal acne:
In 2019, this ingredient was tested against multiple Malassezia species (the yeast that causes fungal acne) and showed no growth.

Polyglyceryl-2 Triisostearate is created by reacting diglycerin and isostearic acid. Due to the isostearic acid base, it may not be safe for Malassezia or fungal acne.

Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.

You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.

There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.