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SkinCeuticals Triple Lipid Restore 2:4:2 Versus La Roche-Posay Substiane

Facial Treatment
General Moisturizer
American Brand United States
French Brand France

Updated on February 16, 2024

Overview

Suited For

They're both likely to be good for dry skin and brightening skin

Free From

They both do not contain any parabens or sulfates

What's Inside

They both contain fragrances, oils and silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Benefits

Concerns

Ingredients Side-by-side

found in both products
Triple Lipid Restore 2:4:2
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Dimethicone Emollient, Skin Conditioning, Skin Protecting
1 / 0 Silicon Icon
SiliconSilicon Icon

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

1 Com. / 0 Irr.
Very Disliked Full details ->
Hydrogenated Polyisobutene Emollient, Skin Conditioning
1 / 2

Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.

1 Com. / 2 Irr.
Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Cholesterol Emollient, Emulsifying, Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness Icon
2 Benefits

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

0 Com. / 0 Irr.
C12-15 Alkyl Benzoate Antimicrobial, Emollient, Skin Conditioning

C12-15 Alkyl Benzoate is made up of Benzoic Acid and long chain alcohols. It has a low molecular weight.

Disliked Full details ->
Ceramide 3 Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide 3 is a form of ceramide.

Helianthus Annuus Seed Oil Unsaponifiables Emollient
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Helianthus Annuus Seed Oil Unsaponifiables is an oil and isn't fungal acne safe.

Bis-Peg-18 Methyl Ether Dimethyl Silane Emollient, Humectant, Skin Conditioning

Bis-Peg-18 Methyl Ether Dimethyl Silane belongs to the siloxanes and silicones classes. It is synthetically created and has a waxy composition.

Disliked Full details ->
Sodium Polyacrylate Absorbent, Emollient, Emulsion Stabilising

Sodium Polyacrylate is the sodium salt of polyacrylic acid.

Peg-10 Dimethicone Skin Conditioning
Silicon Icon
SiliconSilicon Icon

Peg-10 Dimethicone is silicone with conditioner and emulsifier properties. It mostly acts as an emollient in skincare and and humectant in haircare.

Very Disliked Full details ->
Nylon-12
Non-Reef-Safe Icon
Non-Reef-SafeNon-Reef-Safe Icon

Nylon-12 is a polymer. It is derived from 12-aminododecanoic acid, an omega-amino fatty acid

Very Disliked Full details ->
Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone Skin Conditioning
Silicon Icon
SiliconSilicon Icon

Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone is a type of silicone.

Very Disliked Full details ->
Dimethicone/Peg-10/15 Crosspolymer

We don't have a description for Dimethicone/Peg-10/15 Crosspolymer.

Very Disliked Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Disteardimonium Hectorite Stabilising

Disteardimonium Hectorite comes from the clay mineral named hectorite. It is used to add thickness to a product.

Disliked Full details ->
Hydroxyethylpiperazine Ethane Sulfonic Acid Buffering

We don't have a description for Hydroxyethylpiperazine Ethane Sulfonic Acid.

Ammonium Polyacryloyldimethyl Taurate Emulsion Stabilising

Ammonium Polyacryloyldimethyl Taurate is a polymer made from ammonium salts. It helps add stability and texture to a product.

Chlorphenesin Antimicrobial, Preservative
Preservative Icon
PreservativePreservative Icon

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Disliked Full details ->
Caprylyl Glycol Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

Peg/Ppg-18/18 Dimethicone Emulsifying
Silicon Icon
SiliconSilicon Icon

Peg/Ppg-18/18 Dimethicone is a type of silicone.

Very Disliked Full details ->
Propylene Carbonate Solvent

This ingredient is a solvent. It helps dissolve active ingredients and alter the texture of products.

Unknown Full details ->
Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer

We don't have a description for Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer.

Unknown Full details ->
Adenosine Skin Conditioning
Helps with Anti-Aging IconGood for Scar Healing Icon
2 Benefits

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Dipropylene Glycol Masking, Solvent

Dipropylene Glycol is a synthetically created stabilizer and solvent. It is a part of the glycol class in the alcohol family.

Disliked Full details ->
Lavandula Angustifolia Oil Masking, Tonic
Oil IconEU Allergen Icon
OilOil Icon EU AllergenEU Allergen Icon

Lavandula Angustifolia Oil is more commonly known as lavender essential oil. Lavandula Angustifolia is known as the English Lavender and famous for creating purple fields in Provence, France.

Very Disliked Full details ->
Rosmarinus Officinalis Leaf Oil Masking, Skin Conditioning
Oil Icon
OilOil Icon

Rosmarinus Officinalis Leaf Oil is oil expressed from the leaves of the rosemary plant.

Very Disliked Full details ->
T-Butyl Alcohol Perfuming, Solvent
Alcohol IconFragrance Icon
AlcoholAlcohol Icon FragranceFragrance Icon

T-Butyl Alcohol it is most commonly used as a solvent.

Very Disliked Full details ->
Mentha Piperita Oil Masking, Perfuming, Refreshing
Fragrance IconOil IconEU Allergen Icon
FragranceFragrance Icon OilOil Icon EU AllergenEU Allergen Icon

Mentha Piperita Oil is the volatile oil obtained from the whole plant of the Peppermint plant.

Very Disliked Full details ->
Sodium Citrate Buffering, Masking

Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.

Linalool Perfuming
Fragrance IconMay cause irritation IconEU Allergen Icon
FragranceFragrance Icon 2 Concerns

Linalool is a fragrance and helps add scent to products. It's derived from common plants such as cinnamon, mint, citrus, and lavender.

Very Disliked Full details ->
Isobutane

We don't have a description for Isobutane.

Unknown Full details ->
Ceramide EOP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide EOP is a type of Ceramide.

BHT Antioxidant, Masking
Antioxidant Icon
AntioxidantAntioxidant Icon

BHT is a synthetic antioxidant and preservative.

Very Disliked Full details ->
Tocopherol Antioxidant, Masking, Skin Conditioning
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin IconMay cause irritation Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon 4 Benefits May cause irritationMay cause irritation Icon

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

0-3 Com. / 0-3 Irr.
Limonene Perfuming, Solvent
Fragrance Icon
FragranceFragrance Icon

Limonene is a fragrance that adds scent and taste to a formulation.

Very Disliked Full details ->
Ceramide AP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide AP is a type of Ceramide.

Substiane
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Paraffinum Liquidum Emollient, Skin Protecting, Solvent
0-2 / 0 Oil IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon
OilOil Icon 2 Concerns

Paraffinum Liquidum is also known as liquid paraffin. It is a type of highly refined mineral oil.

0-2 Com. / 0 Irr.
Very Disliked Full details ->
Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Dimethicone Emollient, Skin Conditioning, Skin Protecting
1 / 0 Silicon Icon
SiliconSilicon Icon

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

1 Com. / 0 Irr.
Very Disliked Full details ->
Isocetyl Stearate Emollient, Skin Conditioning
0-1 / 0 May worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
3 Concerns

Isocetyl Stearate is an ester of isocetyl alcohol and stearic acid.

0-1 Com. / 0 Irr.
Unknown Full details ->
Hydrogenated Polyisobutene Emollient, Skin Conditioning
1 / 2

Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.

1 Com. / 2 Irr.
Butyrospermum Parkii Butter Skin Conditioning
Helps hydrate Dry Skin IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon 2 Concerns

Butyrospermum Parkii Butter is a plant lipid from the fruit of the Shea Tree. It is an effective skin hydrator and emollient.

Very Disliked Full details ->
Cera Alba Emollient, Emulsifying
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Cera alba is beeswax, or the wax used by bees to make honeycombs. It is a texture-enhancer and emollient. A study from 2003 found beeswax to be a stronger emollient than ingredients such as petroleum jelly.

Disliked Full details ->
Beeswax Emulsion Stabilising, Masking, Skin Conditioning
0-2 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Beeswax is natural wax produced by honey bees and can be synthetically created. It consists mainly of fatty acid esters and long-chain alcohols.

0-2 Com. / 0 Irr.
Very Disliked Full details ->
Cetyl Alcohol Emollient, Emulsifying, Emulsion Stabilising
2 / 2 Fatty Alcohol Icon
Fatty AlcoholFatty Alcohol Icon

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

2 Com. / 2 Irr.
Very Disliked Full details ->
Glyceryl Stearate Emollient, Emulsifying
1 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Glyceryl Stearate is a mix of glycerin and stearic acid.

1 Com. / 0 Irr.
Disliked Full details ->
Peg-100 Stearate
0 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Peg-100 Stearate is an emollient and emulsifier. PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.

0 Com. / 0 Irr.
Very Disliked Full details ->
Copernicia Cerifera Wax
1 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Copernicia Cerifera Wax comes from a palm tree native to Brazil. This wax is added to help give a thicker texture. It also helps create a film when applied.

1 Com. / 0 Irr.
Very Disliked Full details ->
Cera Microcristallina Emulsion Stabilising
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Cera Microcristallina isn't fungal acne safe.

Very Disliked Full details ->
Microcrystalline Wax Emulsion Stabilising
Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Microcrystalline Wax is created by de-oiling petroleum. It is highly refined and purified before being added to cosmetics.

Very Disliked Full details ->
Paraffin Perfuming, Skin Conditioning
Fragrance IconMay worsen Oily Skin IconNot safe for Fungal Acne Icon
FragranceFragrance Icon 2 Concerns

Paraffin is a solid created from petroleum. The term 'paraffin' can also refer to either petroleum jelly or mineral oil.

Very Disliked Full details ->
Sorbitan Tristearate Emulsifying

We don't have a description for Sorbitan Tristearate.

Unknown Full details ->
Dimethiconol Emollient, Moisturising

Dimethiconol is a silicone that resembles the popular dimethicone. Like other silicones, it is an emollient. Emollients create a thin film on skin to prevent moisture from escaping.

Disliked Full details ->
Isohexadecane Emollient, Skin Conditioning, Solvent

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Sodium Hydroxide Buffering

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

Arginine PCA Humectant, Skin Conditioning

We don't have a description for Arginine PCA.

Serine Masking, Skin Conditioning

Serine is an amino acid naturally found in our body. Our bodies use amino acids to create protein.

Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Propylene Glycol Humectant, Skin Conditioning, Solvent
0 / 0 May worsen Eczema Icon
May worsen EczemaMay worsen Eczema Icon

Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.

0 Com. / 0 Irr.
Disliked Full details ->
Hydrolyzed Linseed Extract Skin Conditioning

We don't have a description for Hydrolyzed Linseed Extract.

Unknown Full details ->
Hydroxypropyl Tetrahydropyrantriol Skin Conditioning

We don't have a description for Hydroxypropyl Tetrahydropyrantriol.

Unknown Full details ->
Acetyl Dipeptide-1 Cetyl Ester Skin Conditioning
Peptide Icon
PeptidePeptide Icon

Acetyl Dipeptide-1 Cetyl Ester is a peptide.

Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->
Polysorbate 80 Emulsifying
0 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon
2 Concerns

Polysorbate 80 is a surfactant and emulsifier. It is used to keep ingredients together, and prevent oils and waters from separating.

0 Com. / 0 Irr.
Very Disliked Full details ->
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Emulsion Stabilising

We don't have a description for Acrylamide/Sodium Acryloyldimethyltaurate Copolymer.

Disliked Full details ->
Acrylates Copolymer

Acrylates Copolymer is used as a film-forming agent and texture enhancer.

Disliked Full details ->
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Antioxidant
Antioxidant Icon
AntioxidantAntioxidant Icon

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate (long name, huh?) is a synthetic antioxidant.

Sodium Benzoate Masking, Preservative
Preservative Icon
PreservativePreservative Icon

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Disliked Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Benzoic Acid Masking, Preservative
Preservative IconMay worsen Eczema Icon
PreservativePreservative Icon May worsen EczemaMay worsen Eczema Icon

Benzoic Acid is used to preserve and adjust the pH of products.

Disliked Full details ->
Parfum Masking, Perfuming
Fragrance IconMay worsen Eczema IconMay worsen Rosacea Icon
FragranceFragrance Icon 2 Concerns

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Very Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Emollient, Skin Conditioning, Skin Protecting
Very Disliked

Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.

Dimethicone has been found increase absorption in skin, boosting the benefits of other ingredients. While there is concern for the safety of dimethicone, the levels used in skincare are safe for use.

Emollient, Skin Conditioning
Liked

Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.

In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.

Hydrogenated Polyisobutene is often used as a mineral oil replacement.

Learn more about Hydrogenated Polyisobutene
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Preservative
Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Disliked

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA

Ingredient Ratings

Here's what our community thinks of the ingredients in these products.

Triple Lipid Restore 2:4:2
12
3
20
3
liked
mixed
disliked
not rated
Substiane
8
2
23
4
liked
mixed
disliked
not rated

When to use

139 Routines
41% use in am
59% use in pm
95% use every day
When to use See routines that use it ->
20 Routines
50% use in am
50% use in pm
100% use every day

Reviews

Here's what our community thinks

SkinCeuticals Triple Lipid Restore 2:4:2 38 ingredients

5.0 /5
from 2 ratings
JeremyAnderson_665's avatar

JeremyAnderson_665

1 year ago · Dry Skin
Review

Hydrated well

La Roche-Posay Substiane 37 ingredients

Substiane hasn't been rated yet.
Rate it now