Fun fact: Betaine is naturally created in the skin and body. The kind found within cosmetic products can be either plant-derived or synthetic.

Another name for betaine is trimethylglycine.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Thus, Matrixyl may help improve the look of wrinkles.

Read more about other common types of peptides here:

By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.

You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.

Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.

Read more about other common types of peptides here:

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

Polyglyceryl-10 Laurate may not be fungal acne safe.

Salicin does have anti-inflammatory and antioxidant properties. It has shown to decrease the formation of inflammatory mediators, such as tumor necrosis factor-α and nuclear factor-kappa B. Salicin also has a mildly exfoliating effect on the skin.

Several other components in salix alba bark extract also contain antioxidant properties, such as flavonoids and polyphenols. Antioxidants may help with anti-aging as they neutralize harmful free-radical molecules.

Willow Bark extract has been used for thousands of years. Ancient civilizations used white willow to help treat pain and fevers.

Snail mucin has numerous skin benefits:

On top of this, Snail Secretion Filtrate contains a variety of vitamins and minerals. These include copper peptides, Vitamin A, and vitamin E. Vitamins A and E are antioxidants. Antioxidants help fight free-radicals that damage skin cells.

Being cruelty-free means a brand does not experiment on animals.
If you're worried about the well-being of the snails, we recommend looking more into the company of the product. Many brands have developed humane methods to collect snail mucin.

There is much debate on this subject. On one hand, this ingredient comes from an animal. On the other hand, many will argue the ingredient is naturally secreted (like a natural by-product) and therefore vegan. If you have reservations, you can look into Galactomyces Ferment Filtrate or Centella Asiatica Extract as alternatives.

GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.

In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.

Both of these compounds also help balance enzymes that control collagen breakdown.

Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.

A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.

While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.

Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!