Dermatica Custom Formula Lotion (Tretinoin 0.05%, Niacinamide 4%, Azelaic Acid 4%)
A vegan prescription that contains ceramides, hyaluronic acid, niacinamide, pha, retinoid and vitamin e.
Overview
What it is
Prescription with 28 ingredients that contains ceramides, hyaluronic acid, niacinamide, PHA, retinoid and Vitamin E
Cool Features
It is vegan and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates
Fun facts
Dermatica is from United Kingdom. This product is used in 3 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
About this product
Ingredients List
Dive into the full list of ingredients.
Tretinoin 0.05%
Skin ConditioningNiacinamide 4%
SmoothingAzelaic Acid 4%
BufferingWater
Skin ConditioningCarthamus Tinctorius Oleosomes
EmollientPropylene Glycol
HumectantGlycerin
HumectantPanthenol
Skin ConditioningPolyacrylate-13
Polyisobutene
Sodium Carbomer
Emulsion StabilisingGluconolactone
Skin ConditioningPolysorbate 20
EmulsifyingSorbitan Isostearate
EmulsifyingBenzoic Acid
MaskingSorbic Acid
PreservativeSodium Benzoate
MaskingPropanediol
SolventTocopheryl Acetate
AntioxidantCeramide AP
Skin ConditioningCeramide EOP
Skin ConditioningCeramide NP
Skin ConditioningPhytosphingosine
Skin ConditioningCholesterol
EmollientSodium Lauroyl Lactylate
EmulsifyingXanthan Gum
EmulsifyingCarbomer
Emulsion StabilisingSodium Hyaluronate
Humectant
Active Ingredients:
Tretinoin 0.05%, Niacinamide 4%, Azelaic Acid 4%
Inactive Ingredients:
Water, Carthamus Tinctorius Oleosomes, Propylene Glycol, Glycerin, Panthenol, Polyacrylate-13, Polyisobutene, Sodium Carbomer, Gluconolactone, Polysorbate 20, Sorbitan Isostearate, Benzoic Acid, Sorbic Acid, Sodium Benzoate, Propanediol, Tocopheryl Acetate, Ceramide AP, Ceramide EOP, Ceramide NP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Xanthan Gum, Carbomer, Sodium Hyaluronate
Key Ingredients
Benefits
Concerns
Ingredients Explained
Tretinoin is the best retinoid due to its proven skin benefits. It only available with a prescription in many countries.
All retinoids goes through a conversion line until it can become effective. The final step of conversion is retinoic acid; retinoic acid IS Tretinoin.
This is why tretinoin is so effective; it gets to work immediately on the skin.
Research on tretinoin has found it to be incredibly effective for reducing the signs of aging. It helps improve damage from the sun, even the skin tone, and smooth out wrinkles. It is also an effective acne treatment by reducing and balancing out sebum production in pores.
Tretinoin, like other forms of Vitamin A, increases the turnover cycle of skin cells. This helps the skin create newer and healthier skin cells faster.
It can cause irritation, redness, and dry skin because it is considered a "strong" ingredient. Those with sensitive skin should consult a professional about using tretinoin.
Using retinoids will increase sun-sensitivity in the first few weeks of use. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.
Read about a form of retinoid you can purchase at the store, retinol.
Learn more about TretinoinNiacinamide has emerged as an all-star ingredient due to its many benefits.
It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.
Other benefits include smoothing wrinkles and minimizing redness.
The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.
Learn more about NiacinamideAzelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.
It has been shown to reduce the growth of acne-causing bacteria and helps reduce inflammation. On top of that, it helps reduce the production of sebum and unclog pores.
Azelaic Acid also has antioxidant properties. Antioxidants protect our skin cells from free-radical damage.
One of the main benefits of azelaic acid is that it is gentle and well-tolerated by most people.
Fun fact: The lab-created form of azelaic acid is typically used within cosmetic products for its shelf-stability.
Learn more about Azelaic AcidWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterCarthamus Tinctorius Oleosomes isn't fungal acne safe.
Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Another role of this ingredient is preventing a product from melting or freezing. Propylene glycol also adds antimicrobrial properties to a product, elongating product lifespan.
This ingredient is considered an organic alcohol and commonly added into both cosmetics and foods.
Those with sensitive skin or conditions may develop a rash when using this ingredient.
Learn more about Propylene GlycolGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolPolyacrylate-13 is a type of acrylate polymer. Acrylate polymers are commonly used as adhesives in cosmetics.
Polyacrylate-13 creates a film to protect the skin. It is also used to thicken and stabilize a product. It works by making water a gel-like consistency. This gel consistency helps suspend particles.
Polyacrylate-13 is a copolymer of acrylic acid, acrylamide, sodium acrylate, sodium acryloyldimethyltaurate monomers
Learn more about Polyacrylate-13Polyisobutene is a synthetic polymer made from isobutene.
It is a film-forming agent and helps bind ingredients together.
Polyisobutene is not absorbed by the skin.
Learn more about PolyisobuteneSodium Carbomer is used to thicken products and create a gel-like consistency.
It is synthetically created from carbomer and sodium salt.
Gluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
Gluconolactone has some interesting properties:
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.
This ingredient is is an created by reacting gluconic acid with an alcohol.
Learn more about GluconolactonePolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.
As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.
Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.
Learn more about Sorbitan IsostearateBenzoic Acid is used to preserve and adjust the pH of products.
The antimicrobial property of Benzoic Acid helps elongate a product's shelf life. Its main role is to reduce fungi growth and is not found to be effective at fighting bacteria. Therefore Benzoic Acid is always added along with other preservatives.
In its pure form, Benzoic Acid looks like a white crystalline solid. It has slight solubility in water.
The name of Benzoic Acid comes from gum benzoin, which used to be the sole source of deriving this ingredient. Benzoic Acid is the most simple aromatic carboxylic acid.
Benzoic Acid is naturally occuring in strawberries, mustard, cinnamon, and cloves. It has a slight scent but is not considered to be a fragrance.
Learn more about Benzoic AcidSorbic Acid is a preservative. It is the most commonly used food preservative in the world.
Sorbic Acid is a natural antibiotic and highly effective at preventing the growth of fungus. It is less effective against bacteria.
Potassium Sorbate, another commonly-used preservative, is the potassium salt of Sorbic Acid.
Sorbic Acid may worsen eczema. We recommend speaking with a professional if you have any concerns.
Potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
Learn more about Sorbic AcidSodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Learn more about Sodium BenzoatePropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateCeramide AP is a type of Ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. Having a strong skin barrier leads to more firm and hydrated skin.
They are known for their ability to hold water and thus are a great ingredient for dry skin. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide NP Ceramide EOP
Learn more about Ceramide APCeramide EOP is a type of Ceramide.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
Ceramides are intercellular lipids naturally found in our skin. They bind dead skin cells together to create a barrier. The ceramides in our skin have the ability to hold water to keep our skin hydrated.
Ceramides are an important building block for our skin barrier. A strong skin barrier helps with:
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here:
Learn more about Ceramide EOPCeramide NP is a type of ceramide.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide AP Ceramide EOP
Learn more about Ceramide NPPhytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Learn more about PhytosphingosineCholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.
Our skin naturally contains cholesterol in the outermost layer. Besides cholesterol, it also contains ceramides and fatty acids. Cholesterol makes up about 1/4 of your skin's outer layer and barrier. Your skin barrier is responsible for keeping allergens and microbes out. Having a healthy skin barrier is also responsible for keeping your skin firm and plump.
Our bodies use cholestrol to create vitamin D, steroid hormones, and more.
Learn more about CholesterolSodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.
Sodium Lauroyl Lactylate is an emulsifier and surfactant.
Emulsifiers help stabilize a product. They do this by preventing ingredients from separating, such as oils and water which do not mix naturally. Surfactants reduce surface tension, making it easier to rinse pollutants off skin.
Due to its relation to lauric acid, it may provide antimicrobial benefits.
Learn more about Sodium Lauroyl LactylateXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumCarbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateReviews
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Where it's from
Dermatica is a British brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated March 6, 2025 • Added by milomayeleatlestam