Remedy Face & Neck Firming Advanced Serum Stick Versus Chemist Confessions Inc. Double Play Face & Eye Treatment Retinol + Peptides
This anti-aging serum is formulated around Helianthus Annuus Seed Oil and Retinal to soften the look of wrinkles and refine skin texture.
This anti-aging eye moisturizer is formulated around Retinol and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Helianthus Annuus Seed Oil
EmollientDimethicone
EmollientEuphorbia Cerifera Wax
Cetyl Ethylhexanoate
EmollientSynthetic Fluorphlogopite
Octyldodecanol
EmollientSilica
AbrasiveC12-15 Alkyl Benzoate
AntimicrobialMicrocrystalline Wax
Emulsion StabilisingPolyglyceryl-3 Polydimethylsiloxyethyl Dimethicone
Skin ConditioningRetinal
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningPalmitoyl Tripeptide-1
Skin ConditioningLactic Acid
BufferingSpilanthes Acmella Flower/Leaf/Stem Extract
AntimicrobialAstragalus Membranaceus Root Extract
EmollientC18-36 Acid Triglyceride
EmollientC18-36 Acid Glycol Ester
EmollientCarthamus Tinctorius Seed Oil
MaskingHydroxyapatite
AbrasiveSorbitan Laurate
EmulsifyingTocopherol
AntioxidantUbiquinone
AntioxidantHelianthus Annuus Seed Oil, Dimethicone, Euphorbia Cerifera Wax, Cetyl Ethylhexanoate, Synthetic Fluorphlogopite, Octyldodecanol, Silica, C12-15 Alkyl Benzoate, Microcrystalline Wax, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Retinal, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Lactic Acid, Spilanthes Acmella Flower/Leaf/Stem Extract, Astragalus Membranaceus Root Extract, C18-36 Acid Triglyceride, C18-36 Acid Glycol Ester, Carthamus Tinctorius Seed Oil, Hydroxyapatite, Sorbitan Laurate, Tocopherol, Ubiquinone
Water
Skin ConditioningEthyl Macadamiate
Skin ConditioningGlycerin
HumectantCetearyl Olivate
Niacinamide
SmoothingSorbitan Olivate
EmulsifyingGlyceryl Stearate
EmollientVinyl Dimethicone/Methicone Silsesquioxane Crosspolymer
Dimethicone
EmollientDimethiconol
EmollientHydrogenated Olive Oil
Skin ConditioningOlea Europaea Fruit Oil
MaskingOlea Europaea Oil Unsaponifiables
Skin ConditioningPalmitoyl Tripeptide-1
Skin ConditioningPalmitoyl Tetrapeptide-7
Skin ConditioningSodium Hyaluronate
HumectantSodium Hyaluronate Crosspolymer
HumectantSodium Acetylated Hyaluronate
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningBisabolol
AntioxidantMadecassoside
AntioxidantAsiaticoside
AntioxidantRetinol
Skin ConditioningAscophyllum Nodosum Extract
Skin ConditioningAsparagopsis Armata Extract
Skin ProtectingSteareth-20
CleansingN-Hydroxysuccinimide
Skin ConditioningChrysin
Skin ConditioningHydrogenated Starch Hydrolysate
HumectantCopernicia Cerifera Cera
EmollientHelianthus Annuus Seed Oil
EmollientDisodium Cocoamphodiacetate
CleansingPolysorbate 20
EmulsifyingEthyl Ferulate
AntioxidantTocopherol
AntioxidantHumulus Lupulus Extract
AntimicrobialXanthan Gum
EmulsifyingAmmonium Acryloyldimethyltaurate/Vp Copolymer
Ethylhexylglycerin
Skin ConditioningPentylene Glycol
Skin Conditioning1,2-Hexanediol
Skin ConditioningCaprylyl Glycol
EmollientPropanediol
SolventPhenoxyethanol
PreservativeChlorphenesin
AntimicrobialDisodium EDTA
Water, Ethyl Macadamiate, Glycerin, Cetearyl Olivate, Niacinamide, Sorbitan Olivate, Glyceryl Stearate, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Dimethicone, Dimethiconol, Hydrogenated Olive Oil, Olea Europaea Fruit Oil, Olea Europaea Oil Unsaponifiables, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Bisabolol, Madecassoside, Asiaticoside, Retinol, Ascophyllum Nodosum Extract, Asparagopsis Armata Extract, Steareth-20, N-Hydroxysuccinimide, Chrysin, Hydrogenated Starch Hydrolysate, Copernicia Cerifera Cera, Helianthus Annuus Seed Oil, Disodium Cocoamphodiacetate, Polysorbate 20, Ethyl Ferulate, Tocopherol, Humulus Lupulus Extract, Xanthan Gum, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Ethylhexylglycerin, Pentylene Glycol, 1,2-Hexanediol, Caprylyl Glycol, Propanediol, Phenoxyethanol, Chlorphenesin, Disodium EDTA
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeHelianthus Annuus Seed Oil is a plant oil derived from the seeds of a sunflower.
It is rich in fatty acids, primarily linoleic acid and oleic acid. This gives it emollient and skin conditioning properties.
The reason this ingredient is so effective is because it forms a thin film on the skin that reduces transepidermal water loss (TEWL) while supplying linoleic acid to the stratum corneum to improve barrier strength.
The high linoleic acid content is particularly noteworthy for acne-prone skin.
Research suggests that acne-prone skin tends to be deficient in linoleic acid in sebum. Topical application may help replenish this to support a healthier follicular environment and less comedone-promoting sebum.
One randomized study found sunflower seed oil preserved skin barrier integrity in adult volunteers with and without atopic dermatitis (outperforming olive oil).
This ingredient is well-studied, gentle, and an effective emollient suitable for most skin types.
On fungal acne: This ingredient may not be Fungal acne (Malassezia folliculitis) safe. This is because it contains fatty acids with carbon chain lengths in the C11-C24 range.
Learn more about Helianthus Annuus Seed OilPalmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".
"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.
This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.
Clinical testing showed statistically significant improvements in:
Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.
You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.
Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.
That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.
Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.
In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.
Human clinical data is promising, but modest:
A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.
A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.
You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.
Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Learn more about Tocopherol