Neutrogena Clear & Defend 0.5 % Salicylic Acid Moisturiser Versus Neutrogena Refreshingly Clear Moisturiser
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
HumectantPropylene Glycol
HumectantCetyl Alcohol
EmollientC12-15 Alkyl Benzoate
AntimicrobialGlyceryl Stearate
EmollientPEG-100 Stearate
Stearyl Alcohol
EmollientC12-15 Alkyl Lactate
EmollientDicaprylyl Ether
EmollientAloe Barbadensis Leaf Extract
EmollientChamomilla Recutita Extract
Skin ConditioningCocamidopropyl Pg-Dimonium Chloride Phosphate
Salicylic Acid
MaskingMenthyl Lactate
MaskingCetyl Lactate
EmollientDimethicone
EmollientPropylene Glycol Isostearate
Skin ConditioningSodium Isostearoyl Lactylate
EmulsifyingPalmitic Acid
EmollientStearic Acid
CleansingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingCarbomer
Emulsion StabilisingSodium Chloride
MaskingDisodium EDTA
Sodium Hydroxide
BufferingTocopherol
AntioxidantBenzalkonium Chloride
AntimicrobialPhenoxyethanol
PreservativeEthylparaben
PreservativeMethylparaben
PreservativePropylparaben
PreservativeParfum
MaskingBenzyl Alcohol
PerfumingWater, Glycerin, Propylene Glycol, Cetyl Alcohol, C12-15 Alkyl Benzoate, Glyceryl Stearate, PEG-100 Stearate, Stearyl Alcohol, C12-15 Alkyl Lactate, Dicaprylyl Ether, Aloe Barbadensis Leaf Extract, Chamomilla Recutita Extract, Cocamidopropyl Pg-Dimonium Chloride Phosphate, Salicylic Acid, Menthyl Lactate, Cetyl Lactate, Dimethicone, Propylene Glycol Isostearate, Sodium Isostearoyl Lactylate, Palmitic Acid, Stearic Acid, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Sodium Chloride, Disodium EDTA, Sodium Hydroxide, Tocopherol, Benzalkonium Chloride, Phenoxyethanol, Ethylparaben, Methylparaben, Propylparaben, Parfum, Benzyl Alcohol
Glycerin
HumectantPropylene Glycol
HumectantCetyl Alcohol
EmollientC12-15 Alkyl Benzoate
AntimicrobialGlyceryl Stearate
EmollientPEG-100 Stearate
Stearyl Alcohol
EmollientC12-15 Alkyl Lactate
EmollientSalicylic Acid
MaskingAloe Barbadensis Leaf Extract
EmollientCetyl Lactate
EmollientChamomilla Recutita Extract
Skin ConditioningCocamidopropyl Pg-Dimonium Chloride Phosphate
Menthyl Lactate
MaskingDimethicone
EmollientPropylene Glycol Isostearate
Skin ConditioningSodium Isostearoyl Lactylate
EmulsifyingAcrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingCarbomer
Emulsion StabilisingSodium Chloride
MaskingPalmitic Acid
EmollientStearic Acid
CleansingDisodium EDTA
Sodium Hydroxide
BufferingBenzalkonium Chloride
AntimicrobialEthylparaben
PreservativeMethylparaben
PreservativePropylparaben
PreservativePhenoxyethanol
PreservativeParfum
MaskingBenzyl Alcohol
PerfumingGlycerin, Propylene Glycol, Cetyl Alcohol, C12-15 Alkyl Benzoate, Glyceryl Stearate, PEG-100 Stearate, Stearyl Alcohol, C12-15 Alkyl Lactate, Salicylic Acid, Aloe Barbadensis Leaf Extract, Cetyl Lactate, Chamomilla Recutita Extract, Cocamidopropyl Pg-Dimonium Chloride Phosphate, Menthyl Lactate, Dimethicone, Propylene Glycol Isostearate, Sodium Isostearoyl Lactylate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Sodium Chloride, Palmitic Acid, Stearic Acid, Disodium EDTA, Sodium Hydroxide, Benzalkonium Chloride, Ethylparaben, Methylparaben, Propylparaben, Phenoxyethanol, Parfum, Benzyl Alcohol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Learn more about Acrylates/C10-30 Alkyl Acrylate CrosspolymerAloe Barbadensis Leaf Extract is an extract of the leaves of the aloe, Aloe barbadensis, Liliaceae.
Aloe is one of the most well-known natural soothing ingredients, and for good reason. It’s full of water and has a cooling, calming effect on the skin, especially when it’s sunburned, itchy, or irritated. Aloe also helps your skin stay hydrated and smooth by mimicking what healthy skin naturally produces. On top of that, it contains vitamins and nutrients that support skin recovery.
It doesn’t protect you from the sun, but it can help your skin bounce back after too much time in it.
Let’s get into the details:
Aloe contains antioxidant Vitamins A, C, and E, which help fight off free radicals (unstable molecules from things like pollution that can damage your skin).
It’s also rich in polysaccharides, which are natural sugars that help hydrate the skin by acting like the skin’s own moisturizing agents. These, along with other sugars like monosaccharides, help form a protective barrier that locks in moisture.
Aloe works as both a humectant and an emollient. That means it draws water into the skin (humectant) and helps trap it there (emollient), making it an effective natural moisturizer.
You’ll also find a mix of other skin-supporting ingredients in aloe, including folic acid, choline, calcium, amino acids, fatty acids, and even Vitamin B12.
Out of the 420+ species of aloe, Aloe barbadensis is the most widely used in skincare products thanks to its gentle yet effective properties.
There are over 420 species of aloe but Aloe Barbadensis is the most commonly used for topical products.
Learn more about Aloe Barbadensis Leaf ExtractBenzalkonium Chloride (aka BAC) is a preservative that has been around since the 1930's. It is also a surfactant that gives it mild cleansing and antistatic properties.
BAC works because it carries a positive electrical charge that attract the negative charge of microbe cells (like a magnet). Once BAC sticks to a microbe, it breaks the microbe cell's outer wall and scrambles its proteins to kill it.
The maximum usage percentage for this ingredient is 0.1% in both the EU and Chinese cosmetic regulations.
The CIR Expert Panel has concluded it to be a safe antimicrobial agent in concentrations up to 0.1% and it is permitted up to 3% in rinse off hair products.
BAC can be irritating at higher concentrations but a true allergy to it is pretty rare. Be sure to patch test if you have a damaged skin barrier or just sensitive skin.
Because it's a cation, it is incompatible with anionic surfactants like SLS (they neutralize each other).
Learn more about Benzalkonium ChlorideBenzyl Alcohol is most commonly used as a preservative. It also has a subtle, sweet smell. Small amounts of Benzyl Alcohol is not irritating and safe to use in skincare products. Most Benzyl Alcohol is derived from fruits such as apricots.
Benzyl Alcohol has both antibacterial and antioxidant properties. These properties help lengthen the shelf life of products. Benzyl Alcohol is a solvent and helps dissolve other ingredients. It can also improve the texture and spreadability.
Alcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is an astringent alcohol.
Using high concentrations of these alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.
Other types of astringent alcohols include:
According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.
Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.
Learn more about Benzyl AlcoholC12-15 Alkyl Benzoate is made up of Benzoic Acid and long chain alcohols. It has a low molecular weight.
C12-15 Alkyl Benzoate is an emollient and texture enhancer. Due to its solubility, it is often used in sunscreens to help evenly distribute active ingredients.
As an emollient, C12-15 Alkyl Benzoate helps soften and hydrate your skin. Emollients create a film on your skin that traps moisture within.
This ingredient has been reported to cause eye irritation.
Learn more about C12-15 Alkyl BenzoateWe don't have a description for C12-15 Alkyl Lactate yet.
Carbomer is a high-molecular weight polymer of acrylic acid. It is used to form gels and thicken formulas.
Due to its large molecular size, carbomer has minimal skin penetration and is considered an inert ingredient.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Learn more about CarbomerCetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Cetyl AlcoholCetyl Lactate is an emollient and texture enhancer. It gives a silky smooth feel to hair and skin.
This ingredient comes from the Chamomile flower.
Chamomile is rich in antioxidants and has anti-inflammatory properties. Several compounds found in chamomile help with soothing, such as bisbolol.
Antioxidant components in chamomile help fight free-radical molecules. These unstable molecules may damage your skin cells. By stabilizing them, antioxidants may help reduce the signs of aging.
Ancient Greeks, Romans, and Egyptians used Chamomile to treat skin redness and dryness. Chamomile has also been used to help with stomach issues.
Learn more about Chamomilla Recutita ExtractWe don't have a description for Cocamidopropyl Pg-Dimonium Chloride Phosphate yet.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAEthylparaben is a preservative, is a paraben, and is not reef safe.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Learn more about Glyceryl StearateMenthyl lactate is an ester of menthol and lactic acid. It is often used as a cooling agent and fragrance.
When applied topically, this ingredient leaves a refreshing sensation like menthol, but is less irritating.
Methylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.
Methylparaben can be synthetically created. It can also be found naturally in some fruits, such as blueberries.
Oftentimes, Methylparaben is combined with other parabens to help increase the shelf life.
The safety of Methylparaben is currently being studied. While ongoing studies are looking into the safety of parabens, the results have been very mixed. Some studies have not found Methylparaben to be harmful.
Learn more about MethylparabenPalmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.
In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.
Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.
The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.
The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.
In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.
Learn more about Palmitic AcidParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumPeg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.
PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolThis ingredient is created by reacting propylene glycol with isostearic acid.
The skin conditioning property of this ingredient is both emollient and occlusive. Due to this, this ingredient may not be acne or fungal-acne safe.
Propylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.
This ingredient can be naturally found in plants and insects, but most of it is synthetically manufactured for human use. In cosmetics, it is usually created by reacting para-aminobenzoic acid and propanol (an alcohol).
You can usually find this ingredient in water-based products.
Parabens have come under controversy due to the claim they are hormone disruptors. Studies show conflicting results. We recommend speaking with a professional if you have any concerns.
Propylparaben is commonly found in food, medicine, and cosmetics.
Learn more about PropylparabenSalicylic Acid (also known as beta hydroxy acid or BHA) is a well-known ingredient for treating skin that struggles with acne and clogged pores. It exfoliates both the skin's surface and deep within the pores to help clear out buildup, control oil, and reduce inflammation.
Unlike AHAs (alpha hydroxy acids), salicylic acid is oil-soluble. This allows it to penetrate into pores which makes it especially effective for treating blackheads and preventing future breakouts.
Salicylic acid is also known for its soothing properties. It has a similar structure to aspirin and can calm inflamed or irritated skin, making it a good option for acne-prone skin that is also sensitive.
Concentrations of 0.5-2% are recognized by the U.S. FDA as an over-the-counter topical acne product.
It can cause irritation and/or dryness if one's skin already has a compromised moisture barrier, so it's best to focus on repairing that before introducing this ingredient into your routine.
While salicylic acid does not increase sun sensitivity, it’s still important to wear sunscreen daily to protect your skin.
If you are looking for the ingredient called BHA or Butylated Hydroxyanisole, click here.
Learn more about Salicylic AcidChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt. This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient.
You might see this ingredient used in scrubs as a primary exfoliating ingredient.
Learn more about Sodium ChlorideSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideWe don't have a description for Sodium Isostearoyl Lactylate yet.
Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.
In cosmetics, it is a multitasker:
Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.
Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.
Learn more about Stearic AcidStearyl Alcohol is a type of fatty alcohol from stearic acid. It is a white, waxy compound used to emulsify ingredients used as an emollient or to thicken a product.
Emollients help soothe and hydrate the skin by trapping moisture.
Fatty alcohols are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent (ethanol) alcohols.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Stearyl Alcohol