Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum
This anti-aging serum is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.
This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Cyclopentasiloxane
EmollientDimethiconol
EmollientNeopentyl Glycol Diheptanoate
EmollientDicaprylyl Carbonate
EmollientCaprylic/Capric Triglyceride
MaskingPhenyl Trimethicone
Skin ConditioningSqualane
EmollientBisabolol
AntioxidantTetrahexyldecyl Ascorbate
AntioxidantRetinol
Skin ConditioningTocotrienols
Skin ConditioningTocopherol
AntioxidantLecithin
EmollientLaminaria Ochroleuca Extract
Skin ConditioningAvena Sativa Kernel Extract
AbrasiveElaeis Guineensis Oil
EmollientStearyl Glycyrrhetinate
Skin ConditioningHexylene Glycol
EmulsifyingCaprylyl Glycol
EmollientEthylhexylglycerin
Skin ConditioningPhenoxyethanol
PreservativeCyclopentasiloxane, Dimethiconol, Neopentyl Glycol Diheptanoate, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Phenyl Trimethicone, Squalane, Bisabolol, Tetrahexyldecyl Ascorbate, Retinol, Tocotrienols, Tocopherol, Lecithin, Laminaria Ochroleuca Extract, Avena Sativa Kernel Extract, Elaeis Guineensis Oil, Stearyl Glycyrrhetinate, Hexylene Glycol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol
Water
Skin ConditioningBifida Ferment Lysate
Skin ConditioningPEG-8
HumectantPropanediol
SolventBis-PEG-18 Methyl Ether Dimethyl Silane
EmollientMethyl Gluceth-20
HumectantGlycereth-26
HumectantPEG-75
HumectantButylene Glycol
HumectantAdansonia Digitata Seed Extract
Skin ConditioningTripeptide-32
Skin ConditioningSodium Hyaluronate
HumectantFaex Extract
Skin ConditioningLactobacillus Ferment
Skin ConditioningCola Acuminata Seed Extract
Skin ConditioningAnthemis Nobilis Flower Extract
MaskingHydrolyzed Algin
Pantethine
EmollientCaffeine
Skin ConditioningLecithin
EmollientSodium Rna
Skin ConditioningBisabolol
AntioxidantSqualane
EmollientGlycerin
HumectantOleth-3 Phosphate
SurfactantCaprylyl Glycol
EmollientOleth-3
EmulsifyingOleth-5
EmulsifyingCholeth-24
EmulsifyingHydrogenated Lecithin
EmulsifyingJojoba Wax PEG-120 Esters
SurfactantCeteth-24
CleansingTocopheryl Acetate
AntioxidantCarbomer
Emulsion StabilisingTriethanolamine
BufferingTetrasodium EDTA
BHT
AntioxidantXanthan Gum
EmulsifyingPotassium Sorbate
PreservativeDisodium EDTA
Phenoxyethanol
PreservativeCI 14700
Cosmetic ColorantCI 19140
Cosmetic ColorantWater, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Learn more about BisabololCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolLecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolSqualane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about Squalane