MediCube Hyaluronic Multi Peptide Serum Versus Depology Matrixyl 3000 Collagen Serum
Updated on October 28, 2024
Overview
What they are
These products are both cruelty-free and reef safe serums. They have a total of 13 ingredients in common
Cool Features
They both contain hyaluronic acid and peptides
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin and scar healing
Free From
They both do not contain any harsh alcohols, common allergens, parabens, silicones or sulfates
What's Inside
They both contain oils
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
MediCube Hyaluronic Multi Peptide Serum 53 ingredients
Depology Matrixyl 3000 Collagen Serum 28 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
MediCube Hyaluronic Multi Peptide Serum 53 ingredients
Depology Matrixyl 3000 Collagen Serum 28 ingredients
Key Ingredients
Benefits
Concerns
Benefits
Ingredients Side-by-side
Water
Skin ConditioningNeopentyl Glycol Dicaprate
EmollientPropanediol
Solvent
Glycerin
Humectant
1,2-Hexanediol
Skin Conditioning
Niacinamide
Smoothing
Trehalose
Humectant
Glyceryl Glucoside
Humectant
Sorbitol
Humectant
Sodium Hyaluronate
Humectant
Sodium Chloride
Masking
Panthenol
Skin Conditioning
Ethylhexylglycerin
Skin ConditioningAllantoin
Skin Conditioning
Adenosine
Skin Conditioning
Disodium EDTA
Glucose
Humectant
Melia Azadirachta Leaf Extract
Skin ConditioningMelia Azadirachta Flower Extract
Skin ConditioningButylene Glycol
Humectant
Alpha-Arbutin
Antioxidant
Squalane
Emollient
Coccinia Indica Fruit Extract
Skin ConditioningSolanum Melongena Fruit Extract
Skin ConditioningSodium Dna
Skin Conditioning
Aloe Barbadensis Flower Extract
EmollientCitrus Aurantium Bergamia Fruit Oil
Masking
Sodium Hyaluronate Crosspolymer
Humectant
Ocimum Sanctum Leaf Extract
Skin Conditioning
Simmondsia Chinensis Seed Oil
Emollient
Corallina Officinalis Extract
Skin Conditioning
Curcuma Longa Root Extract
Masking
Acetyl Hexapeptide-8
Humectant
Acetyl Tetrapeptide-3
Skin Protecting
Arginine/Lysine Polypeptide
Skin Conditioning
Collagen Extract
Skin Conditioning
Copper Tripeptide-1
Skin Conditioning
Dipeptide-2
Skin Conditioning
Hexapeptide-11
Skin Conditioning
Nonapeptide-1
Skin Conditioning
Oligopeptide-1
Skin Conditioning
Palmitoyl Hexapeptide-12
Skin Conditioning
Palmitoyl Pentapeptide-4
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Palmitoyl Tripeptide-1
Skin Conditioning
Tripeptide-1
Skin Conditioning
Hyaluronic Acid
Humectant
Hydrolyzed Hyaluronic Acid
Humectant
Hydrolyzed Sodium Hyaluronate
Skin Conditioning
Hydroxypropyltrimonium Hyaluronate
Potassium Hyaluronate
Skin ConditioningPentylene Glycol
Skin ConditioningSodium Acetylated Hyaluronate
Humectant
Water, Neopentyl Glycol Dicaprate, Propanediol, Glycerin, 1,2-Hexanediol, Niacinamide, Trehalose, Glyceryl Glucoside, Sorbitol, Sodium Hyaluronate, Sodium Chloride, Panthenol, Ethylhexylglycerin, Allantoin, Adenosine, Disodium EDTA, Glucose, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Butylene Glycol, Alpha-Arbutin, Squalane, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Sodium Dna, Aloe Barbadensis Flower Extract, Citrus Aurantium Bergamia Fruit Oil, Sodium Hyaluronate Crosspolymer, Ocimum Sanctum Leaf Extract, Simmondsia Chinensis Seed Oil, Corallina Officinalis Extract, Curcuma Longa Root Extract, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-3, Arginine/Lysine Polypeptide, Collagen Extract, Copper Tripeptide-1, Dipeptide-2, Hexapeptide-11, Nonapeptide-1, Oligopeptide-1, Palmitoyl Hexapeptide-12, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Tripeptide-1, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Pentylene Glycol, Sodium Acetylated Hyaluronate
Water
Skin ConditioningButylene Glycol
Humectant
Glycerin
Humectant
1,2-Hexanediol
Skin Conditioning
Trehalose
Humectant
Palmitoyl Tripeptide-1
Skin Conditioning
Palmitoyl Tetrapeptide-7
Skin Conditioning
Aloe Barbadensis Leaf Juice
Skin Conditioning
Portulaca Oleracea Extract
Skin Conditioning
Sodium Hyaluronate
Humectant
Hydrolyzed Sodium Hyaluronate
Skin Conditioning
Tremella Fuciformis Polysaccharide
Emulsion Stabilising
Moringa Oleifera Seed Oil
Emollient
Polyglyceryl-10 Laurate
Skin Conditioning
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Allantoin
Skin Conditioning
Ethylhexylglycerin
Skin ConditioningCarbomer
Emulsion StabilisingPolysorbate 20
Emulsifying
Collagen Extract
Skin Conditioning
Glyceryl Glucoside
Humectant
Pullulan
Fructooligosaccharides
Humectant
Beta-Glucan
Skin Conditioning
Maltodextrin
Absorbent
Pistacia Lentiscus Gum
MaskingPalmitoyl Tripeptide-5
Skin Conditioning
Xanthan Gum
EmulsifyingWater, Butylene Glycol, Glycerin, 1,2-Hexanediol, Trehalose, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Aloe Barbadensis Leaf Juice, Portulaca Oleracea Extract, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Tremella Fuciformis Polysaccharide, Moringa Oleifera Seed Oil, Polyglyceryl-10 Laurate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Allantoin, Ethylhexylglycerin, Carbomer, Polysorbate 20, Collagen Extract, Glyceryl Glucoside, Pullulan, Fructooligosaccharides, Beta-Glucan, Maltodextrin, Pistacia Lentiscus Gum, Palmitoyl Tripeptide-5, Xanthan Gum
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.
Some studies have shown this ingredient can promote wound healing with higher concentrations.
Allantoin is derived from the comfrey plant but produced synthetically for cosmetic products to ensure purity.
Learn more about AllantoinButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCollagen extract is derived from parts of animals. It has skin conditioning properties and is mostly comprised of glycine, proline, and hydroxypoline. These are amino acids.
While our skin does have collagen, this ingredient is not used by the skin for anti-aging. Applying collagen topically has not been linked to helping with collagen loss in skin. All the benefits of collagen are related to hydration.
This ingredient will not increase sun sensitivity, but you should always wear sunscreen during the day.
Learn more about Collagen ExtractEthylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.
You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlyceryl Glucoside is made from glycerol and glucose.
It is a humectant. Humectants help hydrate your skin by drawing moisture to it from the air.
Some foods that contain glyceryl glucoside include sake, miso, and wines.
Learn more about Glyceryl GlucosideThis ingredient is created by putting sodium hyaluronate through hydrolysis.
You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.
According to studies, low molecular-weight hyaluronic acid can:
One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.
Hydrolysis is a process of changing a molecule using water or enzymes.
This ingredient is water-soluble.
Learn more about Hydrolyzed Sodium HyaluronatePalmitoyl Tetrapeptide-7 is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-1 is also known as pal-GHK. It is made up of 3 amino acids and palmitic acid, a fatty acid that helps it absorb into skin more easily.
This peptide is as a signal peptide, meaning it tells the skin to produce more collagen. Collagen is the key protein that helps form the skin's structure and keep it plump, firm, and hydrated.
By boosting collagen production, this ingredient supports a stronger skin barrier and helps reduce the appearance of wrinkles.
You'll most likely see this ingredient paired with Palmitoyl Tetrapeptide-7 in the well-known Matrixyl 3000 complex. While results from in-house testing should be viewed cautiously, this peptide duo is among the most studied and widely used in modern skincare.
Due to its palmitic acid base, this ingredient may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tripeptide-1Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateTrehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.
As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.
Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.
In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.
Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.
Learn more about TrehaloseWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
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