Clinique Pep Start Pout Perfecting Lip Balm

It is considered non-irritating on the skin.

Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.

The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.

Another benefit of occlusives is it protects your skin against infection or allergies.

Petrolatum is fungal acne safe. It is a hydrocarbon with no fatty acid structure, so Malassezia cannot metabolize it. In-vitro studies support negligible growth stimulation as well.

It's also worth noting that petrolatum has a comedogenic rating of 0. In updated rabbit ear testing (and in human testing), petrolatum was found to be not comedogenic. This means it didn’t promote comedone formation in standard models.

It mostly stays on the surface of skin where it helps hydrate due to its large molecular size and low water solubility.

Due to it being derived from fatty acids, this ingredient may not be Malassezia or fungal acne safe.

The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.

It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.

In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.

Studies found this ingredient did not irritate skin in concentrations below 15%.

The CIR Expert Panel has concluded this ingredient to be safe as used in cosmetics.

This ingredient is refined to a cosmetic grade with high purity. It is chemically inert, stable, and doesn't clog pores (petroleum has a comedogenic rating of 0).

Malassezia feeds on fatty acids roughly in the C11-24 range and this ingredient contains none of those. Since there's no plausible food source for it here, this ingredient is fungal acne safe.

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

This ingredient shows up on a lot of "pore-clogging" lists but there's no real evidence behind that. It doesn't even have a comedogenic rating from an actual study; the numbers you'll find online come from blogs citing other blogs.

Ratings for other ingredients mostly come from a 1980s rabbit ear test. This test doesn't translate well to human skin or to real products because the ingredient sits at a much lower percentage.

Some people still find it breaks them out. So if that's you, definitely trust your skin. Just know this one's based on experience and not evidence.

Those are medium-chain fats which is why it melts fast on skin and feels lighter than stearic-heavy butters like shea or cacao.

In skincare, this butter works as an emollient and a temporary occlusive that helps soften the skin's surface and slows water loss.

Just to be upfront: there's no published human clinical trials on this ingredient and everything known about how it behaves on skin is from the fatty acid composition + general body of data on refined plant oils. At this time, marketing claims about wrinkles, elasticity, or "deep repair" are unsupported.

Industry survey data shows concentrations between 0.001%-7% for leave-on products and rinse-off products are capped around 0.2%.

No one has tested murumuru butter for comedogenicity in humans; the comedogenic ratings floating around trace back to lauric and myristic acid scores from the 1984 rabbit ear assay.

The author of that study later said that testing on rabbit ears is not ideal and human testing found that comedogenic ratings cannot predict how a finished formula will behave. It all comes down to formula, concentration, and your skin.

Malassezia is lipid dependent and feeds on free fatty acids between C11-24 chain lengths. This ingredient is made up entirely of chains in that range, so it may not be fungal acne safe.

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.

Clinical testing showed statistically significant improvements in:

Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.

You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.

Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

Fungal acne note:
Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.

Needless to say, linoleic acid is crucial for having a strong skin barrier.

One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.

This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.

Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.

Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.

Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.

Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.

Besides holding formulas together, it also leaves a silky and lightweight feel on skin without the greasiness. A manufacturer also claims it can help with the controlled release of active ingredients.

The CIR Expert Panel found this ingredient to not be sensitizing in concentrations up to 15% in human maximazation testing and dimethicone-based compounds were not comedogenic.

It has a high molecular weight well above 1,000 g/mol which means it limits meaningful skin penetration.

A 2019 study specifically tested this ingredient and found no observable Malassezia growth in its presence.

The highest reported concentration is about 24% in eye makeup but most suppliers recommend a level below 10%.

It has a clean track record for safety and found to be non-irritating.

Because it is an ester of a C18 fatty acid, Malassezia can potentially metabolize it (it sits in the C11-24 range that Malassezia likes). Therefore, this ingredient may not be fungal acne safe.

This ingredient can also be found in pill medicines to help our bodies digest other ingredients.

Due to it being made from stearic acid, this ingredient may not be Malassezia safe.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Research shows:

A 1998 study did find that applying oleic acid at higher concentrations may cause irritation and disrupt the skin barrier. Modern formulations typically use low levels that is well-tolerated.

The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Oleic Acid, at C18, falls right into that sweet spot.

In vitro studies have shown that Oleic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

Oleic Acid is widely listed with a comedogenic rating but no published study has ever actually assigned it one.

The 0 to 5 scale everyone quotes comes from Fulton's 1989 survey in the Journal of the Society of Cosmetic Chemists and Oleic Acid does not appear in his fatty acid tables at all; what he did test were related ingredients built from it, like Decyl Oleate and Oleyl Alcohol (which did get ratings).

Somewhere along the way people seem to have borrowed those numbers for Oleic Acid itself.

So why is it considered comedogenic? Oleic Acid has been studied. Researchers in 1971 and 1983 applied it to rabbit ears (the standard test back then) and it did clog pores. The 1983 study also found something useful: oxidized Oleic Acid, meaning the kind that's gone rancid, clogged pores noticeably more than fresh Oleic Acid did.

It's just worth keeping in mind that these tests used rabbit skin which reacts more easily than ours. They also used much higher concentrations than you'd ever find in a real product.

A 2006 study on actual people found finished products made with comedogenic ingredients often turn out not to be comedogenic at all. As always, listen to your skin.

This ingredient is typically used at low levels (up to 2.5% in eyeshadow and 1% in lipstick).

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

This ingredient is often coated with metal oxides like titanium dioxide. Trace amounts of heavy metals may be found in mica, but these metals are not harmful in our personal products.

Mica has been used since prehistoric times throughout the world. Ancient Egyptian, Indian, Greek, Roman, Aztec, and Chinese civilizations have used mica.

Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.

This ingredient is common in foundations, lipsticks, and blushes. This color is described as brown/orangey red.

It has many secondary names such as Red 6 and Red 7. According to a manufacturer, Red 6 usually contains aluminum.

Some people may experience allergies from this dye, especially asthmatics and those with an aspirin intolerance.

Synthetically created CI 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

This dye is commonly found in makeup because it imparts a vivid color. Some types of this dye change color based on pH level and interaction with moisture:

Your skin has a natural pH of around 4.5 - 5.5.

According to the FDA, CI 45410 is not permitted for use in eye products.

Red 27 is a flourescein dye and commonly used as a fluorescent tracer in medicine.

Similar to Red 27, this dye changes color based on pH and moisture levels.

This dye is colorless when dry but turns pink between pH levels 0.0 to ~3.0.

Because this ingredient is a regulated cosmetic colorant, its purity, manufacturing standards, and allowed uses are defined by cosmetic regulations in major markets.

Due to its structure as flat, plate-like crystals that stack like tiles, it feels silky and sticks to skin well. This also makes it very chemically stable and insoluble under normal skin conditions (this just means it sits on top of skin rather than going into it).

It has an interesting quirk: it slowly goes gray in sunlight and the graying is partly reversible in the dark.

At this time, there's no legal cap on how much a brand can use. Both the FDA and the EU permit it without restriction so real-world concentration levels come down to formulation:

Allergy risk is low as well since it's insoluble and doesn't release free metal ions into skin. True allergic contact dermatitis to it is rare enough that there's very little published cases.

However, mineral makeup users do report itching or stinging. The leading explanation for this is irritation from those stiff platelet crystals rubbing on skin (also more likely with heavy, high-percentage loose mineral powders) rather than an immune reaction.

This ingredient shows up on a lot of "pore-clogging" lists but there's no real evidence behind that. It doesn't even have a comedogenic rating from an actual study; the numbers you'll find online come from blogs citing other blogs.

Some people still find it breaks them out. So if that's you, definitely trust your skin.

The FDA requires batch-to-batch certification for this ingredient that is held to a pretty rigorous standard. That means the CI 17200 in your cosmetics has been tested and approved before it ever reaches you.

Contact allergy to cosmetic-grade dyes used at low concentrations are uncommon but has been documented before.

This ingredient also goes by the name D&C RED NO. 33.

CI 17200 has a comedogenic rating of 1 and an irritancy rating of 2 on a scale of 0-5. This is based on peer-reviewed research from the man who invented the comedogenic scale.

A 1 on the comedogenic scale is about as low as it gets without being a flat zero, and makes sense for CI 17200.

It's a water-soluble dye used at very small concentrations (typically 0.001-0.1%), so it dissolves into the water phase of a formula rather than sitting on your skin the way an oil or wax would.

The irritancy rating of 2 reflects that, like most synthetic dyes, there's a small possibility of mild irritation ( particularly for people with existing dye sensitivities).

For the vast majority of people, it's a non-issue at typical use levels.

It's also worth keeping in mind that comedogenic and irritancy ratings are tested on individual ingredients, not finished formulas. The final product's formulation, concentration, and other ingredients all play a role in how something actually behaves on your skin.

Just so you know, the FDA ban on Red Dye No. 3 refers to CI 45430, not this ingredient. CI 45430 and CI 17200 are different chemical compounds with distinct safety and regulatory histories.

It's also worth noting that Red No. 3 (CI 45430) was already banned from cosmetics back in 1990, so the 2025 action just extended the ban to food and oral drugs. CI 17200 was never part of any of this.

This ingredient can be found in makeup, sun care, and skincare.