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However, it is slightly photounstable and loses about 10% of its protective power after 65 minutes (but it can still stabilize the famously unstable avobenzone).

Historically, the maximum permitted usage concentration in the EU was 4% though it was banned in the US, Japan, and Denmark.

As of 2025, the European Commission has placed it on the list of prohibited substances.

This regulation change isn't about skin irritation or allergic reactions; the EU's Scientific Committee on Consumer Safety (SCCS) has concluded there's enough evidence to suggest it may mess with your hormones. There are also questions about whether it could damage DNA that scientists haven't been able to rule out yet.

At the same time, the UK's Scientific Advisory Group on Chemical Safety (SAG-CS) independently concluded that 4-MBC cannot be considered safe for use in cosmetic products at any concentration due to these same concerns.

Aloe Barbadensis Leaf Juice also contains sugars. These sugars come in the form of monosaccharides and polysaccharides, folic acid, and choline. These sugars are able to help bind moisture to skin.

It also contains minerals such as calcium, 12 anthraquinones, fatty acids, amino acids, and Vitamin B12.

This means it can lose efficacy when exposed to sunlight without the help of a stabilizing agent.

Studies show antioxidants (like vitamin E or vitamin C) and some UV filters (like octocrylene and Tinosorb S) can meaningfully improve its stability in a formulation.

The maximum allowable concentration according to regulation is 3% in the US + Canada, and 5% in the EU, Australia, China, Korea, and ASEAN countries.

It has a well-support safety profile: a comprehensive 2025 review found minimal toxicity with no evidence of carcinogenicity.

Overall, avobenzone is a safe and regulated ingredient used in sunscreen for over 40 years.