Neutrogena Clear & Defend 0.5% Salicylic Acid SOS Gel
A facial Treatment with 37 ingredients, including BHA.
Overview
What it is
Facial treatment with 37 ingredients that contains BHA
Suited For
It has ingredients that are good for fighting acne, dry skin, brightening skin, sensitive skin, oily skin, reducing pores and scar healing
Free From
It doesn't contain any oils or sulfates
Fun facts
Neutrogena is from .
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside (and what isn't)
Ingredients List
Dive into the full list of ingredients.
Water
Skin ConditioningAlcohol Denat.
AntimicrobialGlycerin
HumectantPolyacrylate-13
Cyclopentasiloxane
EmollientPolyisobutene
C12-15 Alkyl Lactate
EmollientHamamelis Virginiana Water
AstringentCinnamomum Zeylanicum Bark Extract
AntimicrobialCedrus Atlantica Bark Extract
PerfumingPortulaca Oleracea Extract
Skin ConditioningSarcosine
Skin ConditioningCetyl Lactate
EmollientPPG-2 Isoceteth-20 Acetate
EmulsifyingButylene Glycol
HumectantHexylene Glycol
EmulsifyingCocamidopropyl Pg-Dimonium Chloride Phosphate
Salicylic Acid
MaskingCapryloyl Glycine
CleansingPropylene Glycol
HumectantAlcohol
AntimicrobialPhenethyl Dimethicone
EmollientCetyl Alcohol
EmollientPolysorbate 20
EmulsifyingPolysorbate 60
EmulsifyingDehydroxanthan Gum
Emulsion StabilisingHydroxyethylcellulose
Emulsion StabilisingSodium Chloride
MaskingDisodium EDTA
Citric Acid
BufferingDisodium Phosphate
BufferingSodium Phosphate
BufferingSodium Hydroxide
BufferingBenzalkonium Chloride
AntimicrobialPhenoxyethanol
PreservativeMethylparaben
PreservativePropylparaben
PreservativeWater, Alcohol Denat., Glycerin, Polyacrylate-13, Cyclopentasiloxane, Polyisobutene, C12-15 Alkyl Lactate, Hamamelis Virginiana Water, Cinnamomum Zeylanicum Bark Extract, Cedrus Atlantica Bark Extract, Portulaca Oleracea Extract, Sarcosine, Cetyl Lactate, PPG-2 Isoceteth-20 Acetate, Butylene Glycol, Hexylene Glycol, Cocamidopropyl Pg-Dimonium Chloride Phosphate, Salicylic Acid, Capryloyl Glycine, Propylene Glycol, Alcohol, Phenethyl Dimethicone, Cetyl Alcohol, Polysorbate 20, Polysorbate 60, Dehydroxanthan Gum, Hydroxyethylcellulose, Sodium Chloride, Disodium EDTA, Citric Acid, Disodium Phosphate, Sodium Phosphate, Sodium Hydroxide, Benzalkonium Chloride, Phenoxyethanol, Methylparaben, Propylparaben
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterAlcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.
This ingredient gets a bad rep because it is irritating and drying - mostly due to its astringent property. Astringents draw out natural oils in tissue, constricting pores and leaving your skin dried out.
However, alcohol denat. is not all that bad.
Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.
This also helps other ingredients become better absorbed upon application.
Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.
Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.
The rule of thumb is if this alcohol is near the end of an ingredients list, it will probably not affect your skin much.
Also...
This ingredient has antimicrobial and solvent properties.
The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.
Other types of astringent alcohols include:
Learn more about Alcohol Denat.Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolyacrylate-13 is a type of acrylate polymer. Acrylate polymers are commonly used as adhesives in cosmetics.
Polyacrylate-13 creates a film to protect the skin. It is also used to thicken and stabilize a product. It works by making water a gel-like consistency. This gel consistency helps suspend particles.
Polyacrylate-13 is a copolymer of acrylic acid, acrylamide, sodium acrylate, sodium acryloyldimethyltaurate monomers
Learn more about Polyacrylate-13Cyclopentasiloxane, or D5, is a silicone used to improve texture of products and trap moisture.
D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.
It is also an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.
Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.
Learn more about CyclopentasiloxanePolyisobutene is a synthetic polymer made from isobutene.
It is a film-forming agent and helps bind ingredients together.
Polyisobutene is not absorbed by the skin.
Learn more about PolyisobuteneWe don't have a description for C12-15 Alkyl Lactate yet.
Hamamelis Virginiana Water is made by distilling parts of the witch hazel plant. You can also call this ingredient "witch hazel water".
The name 'Hamamelis Virginiana Water' refers to the distillation product used in cosmetics. On the other hand, 'Witch Hazel' refers to the active drug ingredient.
Unless it is specified to be non-alcohol, many types of witch hazel ingredients are distilled in denatured alcohol.
Witch Hazel water is an astringent, anti-inflammatory antioxidant, and antibacterial ingredient.
It contains tannins. Tannins have a drying effect when used on skin by constricting proteins. The constriction also minimizes the appearance of pores.
Both the tannins and fragrance found in witch hazel may be skin-sensitizing.
Witch hazel water gets anti-inflammatory and antibacterial properties from its catechin and gallic acid content.
Indigenous groups have used witch hazel to help treat inflammation in North America for centuries.
Learn more about Hamamelis Virginiana WaterThis cinnamon tree also called true cinnamon or Ceylon cinnamon. It has antimicrobial, emollient, skin hydrating, and antioxidant properties.
This tree is native to Sri Lanka.
Cedrus Atlantica Bark Extract is a fragrance. It can cause irritation.
This extract comes from Purslane, a succulent. It has anti-inflammatory, antioxidant, and hydrating properties.
Purslane is very nutritious. It contains omega-3 fatty acids, NMFs, many vitamins, minerals, and antioxidants. The vitamins found in purslane include: Vitamin C, Vitamin A, and Vitamin E.
Fun fact: Purslane is a succulent with an extensive habitat. It is used in traditional Korean medicine to treat irritated skin.
Nowadays, purslane is becoming a superfood due to its highly nutritious content.
Learn more about Portulaca Oleracea ExtractWe don't have a description for Cetyl Lactate yet.
We don't have a description for PPG-2 Isoceteth-20 Acetate yet.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolHexylene Glycol is a surfactant. Glycols are a class of alcohols. Hexylene Glycol is a surfactant and emulsifier.
As a surfactant, Hexylene Glycol helps gather dirt and oil on your skin to be washed away.
As an emulsifier, Hexylene Glycol helps keep water and oil together. This prevents them from separating in a product. Hexylene Glycol also thins out the texture of a product by lessening viscosity.
Hexylene Glycol has a small molecular weight.
Learn more about Hexylene GlycolWe don't have a description for Cocamidopropyl Pg-Dimonium Chloride Phosphate yet.
Salicylic Acid (also known as beta hydroxy acid or BHA) is a well-known ingredient for treating skin that struggles with acne and clogged pores. It exfoliates both the skin's surface and deep within the pores to help clear out buildup, control oil, and reduce inflammation.
Unlike AHAs (alpha hydroxy acids), salicylic acid is oil-soluble. This allows it to penetrate into pores which makes it especially effective for treating blackheads and preventing future breakouts.
Salicylic acid is also known for its soothing properties. It has a similar structure to aspirin and can calm inflamed or irritated skin, making it a good option for acne-prone skin that is also sensitive.
Concentrations of 0.5-2% are recognized by the U.S. FDA as an over-the-counter topical acne product.
It can cause irritation and/or dryness if one's skin already has a compromised moisture barrier, so it's best to focus on repairing that before introducing this ingredient into your routine.
While salicylic acid does not increase sun sensitivity, it’s still important to wear sunscreen daily to protect your skin.
If you are looking for the ingredient called BHA or Butylated Hydroxyanisole, click here.
Learn more about Salicylic AcidCapryloyl Glycine is created by adding an acyl group to glycine and caprylic acid chloride.
It is a cleanser due to its surfactant properties. Surfactants help dirt, oil, and other polluants be more easily rinsed away. According to manufacturers, Capryloyl Glycine also helps soften the skin and regulate sebum production.
Emerging studies show Capryloyl Glycine may inhibit hair growth. It may also cause allergies for some people. We recommend speaking with a professional if you have any questions about this ingredient.
Learn more about Capryloyl GlycinePropylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Another role of this ingredient is preventing a product from melting or freezing. Propylene glycol also adds antimicrobrial properties to a product, elongating product lifespan.
This ingredient is considered an organic alcohol and commonly added into both cosmetics and foods.
Those with sensitive skin or conditions may develop a rash when using this ingredient.
Learn more about Propylene GlycolAlcohol comes in many different forms. Different types of alcohol will have different effects on skin. This ingredient is usually an astringent alcohol.
These alcohols are drying on the skin. They may strip away your skin's natural oils and even damage your skin barrier. Astringent alcohols may also irritate skin.
Other types of astringent alcohols include:
According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.
Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.
Fatty alcohols come from plant oils such as coconut oil. These can help hydrate the skin and are non-irritating. Some fatty alcohols include cetyl and stearyl alcohol.
Learn more about AlcoholPhenethyl Dimethicone is a type of silicone.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Cetyl AlcoholPolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60We don't have a description for Dehydroxanthan Gum yet.
Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.
This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.
This ingredient can also be found in pill medicines to help our bodies digest other ingredients.
Learn more about HydroxyethylcelluloseChances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt.
This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
There is much debate on whether this ingredient is comedogenic. The short answer - comedogenic ratings don't tell the whole story. Learn more about comegodenic ratings here.
The concensus about this ingredient causing acne seems to be divided. Research is needed to understand if this ingredient does cause acne.
Scrubs may use salt as the primary exfoliating ingredient.
Learn more about Sodium ChlorideDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTACitric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.
If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.
Read more about some other popular AHA's here:
Learn more about Citric AcidDisodium Phosphate is a water-soluble powder used as a pH adjuster.
We don't have a description for Sodium Phosphate yet.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideBenzalkonium Chloride is a preservative. It can cause irritation and worsen eczema.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Methylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.
Methylparaben can be synthetically created. It can also be found naturally in some fruits, such as blueberries.
Oftentimes, Methylparaben is combined with other parabens to help increase the shelf life.
The safety of Methylparaben is currently being studied. While ongoing studies are looking into the safety of parabens, the results have been very mixed. Some studies have not found Methylparaben to be harmful.
Learn more about MethylparabenPropylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.
This ingredient can be naturally found in plants and insects, but most of it is synthetically manufactured for human use. In cosmetics, it is usually created by reacting para-aminobenzoic acid and propanol (an alcohol).
You can usually find this ingredient in water-based products.
Parabens have come under controversy due to the claim they are hormone disruptors. Studies show conflicting results. We recommend speaking with a professional if you have any concerns.
Propylparaben is commonly found in food, medicine, and cosmetics.
Learn more about PropylparabenReviews
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Where it's from
Neutrogena is a American brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Published June 24, 2025 • Added by seangurevich