I'm Sorry For My Skin Honey Beam Ampoule
A ampoule with 47 ingredients, including niacinamide, hyaluronic acid, and propolis.
This hydrating ampoule is formulated around Niacinamide and Royal Jelly Extract to hydrate skin and brighten dull-looking skin.
Worth noting
Contains drying alcohol, which absorbs quickly but can be dehydrating.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningPolyglycerin-3
HumectantDiglycerin
HumectantMethylpropanediol
SolventAlcohol
AntimicrobialGlycerin
HumectantDipropylene Glycol
HumectantNiacinamide
SmoothingDioscorea Japonica Root Extract
Skin Conditioning1,2-Hexanediol
Skin ConditioningRoyal Jelly Extract
Skin ConditioningBetaine
HumectantHoney Extract
HumectantOenothera Biennis Flower Extract
AstringentLilium Candidum Flower Extract
Skin ConditioningPrunus Serrulata Flower Extract
Skin ConditioningPropolis Extract
Skin ConditioningPiper Methysticum Leaf/Root/Stem Extract
Skin ConditioningCentella Asiatica Extract
CleansingPanax Ginseng Berry Extract
Skin ConditioningPrunus Mume Fruit Extract
HumectantChaenomeles Sinensis Fruit Extract
AntioxidantOpuntia Coccinellifera Fruit Extract
Skin ConditioningCornus Officinalis Fruit Extract
Skin ConditioningPunica Granatum Fruit Extract
AntioxidantSchisandra Chinensis Fruit Extract
Skin ConditioningCitrus Junos Fruit Extract
Skin ConditioningPoncirus Trifoliata Fruit Extract
Skin ConditioningNelumbo Nucifera Flower Extract
Skin ConditioningCitrus Aurantium Bergamia Fruit Oil
MaskingSodium Hyaluronate
HumectantHydrogenated Lecithin
EmulsifyingOctyldodeceth-16
EmulsifyingCarbomer
Emulsion StabilisingTromethamine
BufferingPolyquaternium-51
Skin ConditioningGlycosyl Trehalose
Emulsion StabilisingHydrogenated Starch Hydrolysate
HumectantRaffinose
Skin ConditioningBiosaccharide Gum-1
HumectantAdenosine
Skin ConditioningDisodium EDTA
Lecithin
EmollientCellulose Gum
Emulsion StabilisingBeta-Glucan
Skin ConditioningHydroxyacetophenone
AntioxidantEthylhexylglycerin
Skin ConditioningWater, Polyglycerin-3, Diglycerin, Methylpropanediol, Alcohol, Glycerin, Dipropylene Glycol, Niacinamide, Dioscorea Japonica Root Extract, 1,2-Hexanediol, Royal Jelly Extract, Betaine, Honey Extract, Oenothera Biennis Flower Extract, Lilium Candidum Flower Extract, Prunus Serrulata Flower Extract, Propolis Extract, Piper Methysticum Leaf/Root/Stem Extract, Centella Asiatica Extract, Panax Ginseng Berry Extract, Prunus Mume Fruit Extract, Chaenomeles Sinensis Fruit Extract, Opuntia Coccinellifera Fruit Extract, Cornus Officinalis Fruit Extract, Punica Granatum Fruit Extract, Schisandra Chinensis Fruit Extract, Citrus Junos Fruit Extract, Poncirus Trifoliata Fruit Extract, Nelumbo Nucifera Flower Extract, Citrus Aurantium Bergamia Fruit Oil, Sodium Hyaluronate, Hydrogenated Lecithin, Octyldodeceth-16, Carbomer, Tromethamine, Polyquaternium-51, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate, Raffinose, Biosaccharide Gum-1, Adenosine, Disodium EDTA, Lecithin, Cellulose Gum, Beta-Glucan, Hydroxyacetophenone, Ethylhexylglycerin
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterPolyglycerin-3 is a 3-unit glycerin polymer.
Like glycerin, this ingredient is a humectant. Humectants help hydrate your skin by drawing water to it.
Having moisturized skin helps improve the skin barrier. Your skin barrier helps protect against irritants and bacteria.
Learn more about Polyglycerin-3Diglycerin is a humectant. It is derived from glycerin, which is naturally found in your skin.
As a humectant, it helps draw moisture to the skin from the air.
Methylpropanediol is a synthetic solvent and humectant.
As a solvent, it helps dissolve other ingredients, helping to evenly distribute ingredients throughout the product. This ingredient has also been shown to have antimicrobial properties which makes it a preservative booster.
Methylpropanediol is able to add a bit of moisture to the skin. It also helps other ingredients be better absorbed into the skin, such as salicylic acid.
Learn more about MethylpropanediolThis ingredient is also called ethanol or ethyl alcohol. It is denatured, meaning made undrinkable for cosmetic use.
In formulas, it:
Is it bad for your skin?
The answer comes down to concentration. Patch and wash studies have found highly concentrated alcohol-based hand rubs (60-100%) cause less barrier disruption than washing with a basic detergent like SLS. The only measurable effect in these studies was a temporary dip in skin hydration.
Concentrations below 12-15% in leave-on cosmetics is generally well-tolerated. Concentrations above start to see increased transepidermal water loss (TEWL) and reduced hydration.
In concentrations about 58%, it creates temporary channels in your skin's lipid layers to become more permeable and allow other ingredients to slip through easily.
This ingredient can be up to 80% of the formula in alcohol-based perfumes.
Overall, this ingredient is probably harmless if found lower down an ingredients list but worth side-eyeing if it's high up (especially if your barrier is already struggling).
Alcohol can worsen dry skin, eczema, and oily skin, especially at higher concentrations. This is because it can increase transepidermal water loss and decrease hydration to disrupt the skin barrier.
According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.
True allergic contact dermatitis to ethanol is uncommon, but be sure to patch test if you have dry or sensitive skin.
Learn more about AlcoholGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinDipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideThis ingredient comes from the Asian mountain yam and has skin conditioning properties. Clinical studies have confirmed this ingredient to work as an effective moisturizer.
The extract is rich in compounds like diosgenin, polysaccharides, and polyphenols, gallic acid, and vanillic acid. Research on these extracts has demonstrated antioxidant effects in-vitro and anti-inflammatory activity in animal models.
The bioactives in the root extract have also been shown in lab tests to have anti-wrinkle, antioxidant, and anti-allergy properties.
A big 2022 review looked at the whole Dioscorea family and found these plants consistently showed antioxidant activity across the board.
This ingredient is gentle and well-tolerated by all skin types.
Learn more about Dioscorea Japonica Root Extract1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Royal Jelly Extract comes from a secretion made by worker honeybees. This secretion is white and described as creamy.
This compound has antibacterial, anti-aging, and anti-inflammatory properties.
Studies show Royal Jelly to contain amino acids, fatty acids, and a variety of vitamins, including Vitamin Bs. Many of these components are antioxidants, which help with anti-aging. The fatty acids in Royal Jelly make it a hydrating ingredient.
Several animal studies show Royal Jelly to boost collagen production and reduce inflammation.
The Vitamin Bs found in Royal Jelly include:
Royal Jelly is derived from honeybees. This means it is not vegan.
Learn more about Royal Jelly ExtractBetaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Learn more about BetaineThis ingredient comes from honey made by bees. It is hydrating, antibacterial, anti-aging, and skin soothing.
Honey also contains amino acids, peptides, Vitamins A, C, and E.
The humectant property of honey draws moisture from the air to your skin. This makes it great at helping to hydrate the skin.
Honey may help reduce the signs of aging due to its antioxidant properties. Fun fact: darker honey has more antioxidants than light honey. The antibacterial property of honey may make it effective at helping to treat acne by killing acne-causing bacteria.
Many people wonder if honey extract is vegan. It is technically a byproduct from bees. This is because honey is created from the digestive enzymes in a bee's stomach.
Remember to be kind to bees :) They are important for many ecosystems and are endangered.
Learn more about Honey ExtractWe don't have a description for Oenothera Biennis Flower Extract yet.
We don't have a description for Lilium Candidum Flower Extract yet.
This ingredient comes from the flowers of the cherry blossom tree native to Japan, Korea, China, and Vietnam.
Propolis Extract is a natural ingredient derived from propolis (also known as bee glue). Bees make propolis by mixing their saliva and beeswax with resins collected from tree buds and plants.
This ingredient is packed with bioactive compounds like flavonoids, phenolic acids, and amino acids that give it antioxidant and anti-inflammatory properties.
Research shows it can help:
It also pairs nicely with hydrating ingredients like niacinamide and ceramides.
Just so you know, Propolis Extract is recognized as a contact allergen. In patch tests done in the EU, roughly 1-6% of patients react to it. Be sure to steer clear of this ingredient if you have a known allergy to bee products.
Since it is an animal-derived product, this ingredient is not considered vegan. For vegan alternatives, check out Galactomyces Ferment Filtrate or Centella Asiatica Extract.
Learn more about Propolis ExtractPiper Methysticum is also known as the Kava Kava plant, native to Pacific islands. This ingredient is derived from the leaf, root, and/or stem of the plant.
A safety assessment from 2019 deemed the safety studies for this ingredient to be insufficient. Amounts between 0.0001% to 0.01% of this ingredient can be found in cosmetics.
Some sources suggest this ingredient may cause skin sensitivity but further studies are needed.
Learn more about Piper Methysticum Leaf/Root/Stem ExtractCentella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
Here is the short version of what they do in the skin:
So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
Centella is one of the most easygoing actives out there.
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
But as with any new active, a patch test is still a smart move for very reactive skin.
Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).
In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.
Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractThis berry comes from the ginseng plant. It has antioxidant and skin soothing properties.
The antioxidant properties of this ingredient come from their phenolic compounds. Another compound found in this ingredient is ginsenoside; ginsenoside is known to help soothe inflammation.
Prunus Mume extract comes from the Asian plum. This plum is AKA 'plum blossom'. Plum blossom has hydrating and antibacterial properties.
Plum Blossoms are rich in nutrients, including Vitamin A, Vitamin B, and Vitamin C.
A study from 2021 found this ingredient to inhibit melanin production. An animal study found plum blossom to help increase collagen production.
Learn more about Prunus Mume Fruit ExtractChaenomeles Sinensis Fruit Extract is an antioxidant.
We don't have a description for Opuntia Coccinellifera Fruit Extract yet.
We don't have a description for Cornus Officinalis Fruit Extract yet.
You might know this ingredient as pomegranate fruit. It has been shown to have antioxidant, skin soothing and anti-aging benefits.
Pomegranates are rich in antioxidant compounds such as polyphenolic compounds such as ellagic acid, phenolic acids, anthocyanins, and flavonoids.
Both in-vivo and in-vitro studies show pomegranate fruit helps with:
These benefits offer skin anti-aging and skin soothing benefits.
Fun fact: The name pomegranate comes from two latin words: "pome" or apple, and "granate" or "many seeded".
Pomegranate flower extract is often confused for pomegranate fruit extract, but comes from the flowers of the tree.
Learn more about Punica Granatum Fruit ExtractThis ingredient comes from the "five-flavor" berry native to northeast Asia. It has skin conditioning properties and is rich in antioxidants.
In lab models, this ingredient displays antioxidant effects in keratinocytes (the main cells in the epidermis). Some studies also report tyrosinase inhibiting or skin brightening activity.
One study using reconstructed human epidermis found this ingredient to help counter pollution-like inflammatory signaling in skin exposed to urban dust.
Learn more about Schisandra Chinensis Fruit ExtractCitrus Junos Fruit Extract comes from the Citrus Junos tree, or the Yuzu plant.
Yuzu has many skin benefits. It contains antioxidants and a variety of Vitamins. The vitamins found in yuzu include: Vitamin C, Vitamin A, Vitamin B6, and Vitamin B5.
Vitamins C and A also provide plenty of skin benefits such as boosting collagen production and helping to reduce the signs of aging.
For those with allergies, Yuzu does contain limonene and linalool. Both these compounds may cause skin sensitivity. If you have concerns, we recommend speaking with a professional.
Learn more about Citrus Junos Fruit ExtractWe don't have a description for Poncirus Trifoliata Fruit Extract yet.
Nelumbo Nucifera Flower Extract is also known as Lotus Flower Extract and it's mainly valued as an antioxidant + soothing ingredient for skincare.
It's rich in polyphenols and flavonoids that protect skin against radical damage from UV rays and pollution.
Lab studies on human skin show it calms inflammation by reducing inflammatory signals in skin cells without causing cell damage.
Cell and formulation studies also point to whitening/brightening + anti-wrinkle effects; the extracts from the leaf, seed, and flower showed measurable elastase (wrinkle-related enzyme) and tyrosinase (pigment related enzyme) inhibition.
A cream containing lotus extract also no significant irritation and stayed stable over a month of storage.
Typical usage in cosmetics is usually on the lower end (~0.5-5%) depending on the formula.
Allergy-wise, this ingredient is considered low risk and often included in products made for sensitive/irritated skin. But like any plant extract, it carries a small possibility of contact allergy in people sensitive to plant extracts.
Learn more about Nelumbo Nucifera Flower ExtractCitrus Aurantium Bergamia Fruit Oil is the oil from the bergamot orange and is primarily used as a fragrance. It has a "fresh" and "bright orange" scent.
The main aroma compounds found in this ingredient are limonene (~27-52%), linalool (~2-22%), and linalyl acetate (~27-40%). These are known EU fragrance allergens.
The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.
When used topically, Citrus Aurantium Bergamia Fruit Oil is a photosensitizer due to the furanocoumarin content. Furanocoumarins absorb UV-A and cause phytophotodermatitis; this can look like redness, blistering, and lasting brown pigmentation on sun-exposed skin.
Due to this, this ingredient is capped at 0.4% in leave-on products applied to sun exposed skin.
Many modern formulas used a "furanocoumarin-free" version that sidesteps the phototoxicity issue, but still contains the fragrance allergens.
Learn more about Citrus Aurantium Bergamia Fruit OilSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinOctyldodeceth-16 is a lab-made ingredient that acts as an emulsifier that helps blend water + oil ingredients.
The Cosmetic Ingredient Review has deemed it safe for as in cosmetics and usage concentrations typically range from 0.1-2%.
Like other emulsifiers, this ingredient can cause mild skin irritation or sensitivity in a small amount of people. A patch test is reasonable if you have sensitive skin.
Learn more about Octyldodeceth-16Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Learn more about CarbomerTromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Learn more about TromethaminePolyquaternium-51 is a polymer salt. It helps hydrate the skin by creating a film on top. This film traps moisture in, keeping your skin soft and hydrated.
We don't have a description for Glycosyl Trehalose yet.
Hydrogenated Starch Hydrolysate is a made up of a mixture of sugar alcohols (like sorbitol) and is created by hydrogenating corn, wheat, or potato starch.
It acts as a humectant and draws water to the skin to keep it hydrated. Generally, this is a well-tolerated and non-irritating ingredient.
We don't have a description for Raffinose yet.
Biosaccharide Gum-1 is a sugar created by fermenting sorbitol (which usually comes from potato starch!). It is known for its soothing and moisturizing properties.
Manufacturer tests show this ingredient helped reduce irritation from lactic acid by almost half and kept skin hydrated long-term as a humectant
Beyond hydration, Biosaccharide Gum-1 gives formulas a silky, non-sticky feel.
This ingredient is gentle, versatile, and suitable for all skin types.
Fun fact: Similar sugars can be found naturally in fruits like apples and pears.
Learn more about Biosaccharide Gum-1Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTALecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinCellulose Gum is a water-soluble polymer that comes from cellulose. It is used to change the texture of a product and to help stabilize emulsions.
As an emulsifier, cellulose gum specifically thicken the texture of water-based products.
This ingredient is considered hypoallergenic and non-toxic. Cellulose Gum can be found in cosmetics, food, and other household goods such as paper products.
Learn more about Cellulose GumBeta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.
It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.
On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin
The more interesting story is underneath:
Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.
A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.
It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.
This ingredient gets along with pretty much everything and is typically used around 0.1-1%.
Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.
Learn more about Beta-GlucanHydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Learn more about HydroxyacetophenoneEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinReviews
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Read more about us· Published December 2, 2023 • Added by Hubayobi