KISOCare Houttuynia Cordata Leaf Extract 77% + Azelaic Acid 5% Lotion Versus KISOCare Hitomide Essence 10
This calming emulsion is formulated around Azelaic Acid and Madecassoside to calm redness and clear breakouts.
This barrier-repair essence is formulated around Ceramide Ng and Ceramide AP to strengthen the skin barrier and hydrate skin.
What's inside
What's inside
Key Ingredients
Benefits
Ingredients Side-by-side
Lactobacillus/Houttuynia Cordata Leaf Extract Ferment Filtrate
Skin ConditioningAzelaic Acid
BufferingButylene Glycol
HumectantPropanediol
SolventDipropylene Glycol
HumectantPentylene Glycol
Skin ConditioningSodium Hydroxide
BufferingTromethamine
BufferingPanthenol
Skin ConditioningHydrogenated Lecithin
EmulsifyingPhytosterols
Skin ConditioningDipotassium Glycyrrhizate
HumectantMadecassoside
AntioxidantAsiaticoside
AntioxidantGluconolactone
Skin ConditioningSuccinic Acid
BufferingCitric Acid
BufferingSodium Acetylated Hyaluronate
HumectantSodium Hyaluronate
HumectantSodium Hyaluronate Crosspolymer-2
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningCentella Asiatica Extract
CleansingEthylhexylglycerin
Skin ConditioningCaprylyl Glycol
EmollientPhenoxyethanol
PreservativeWater
Skin ConditioningLactobacillus/Houttuynia Cordata Leaf Extract Ferment Filtrate, Azelaic Acid, Butylene Glycol, Propanediol, Dipropylene Glycol, Pentylene Glycol, Sodium Hydroxide, Tromethamine, Panthenol, Hydrogenated Lecithin, Phytosterols, Dipotassium Glycyrrhizate, Madecassoside, Asiaticoside, Gluconolactone, Succinic Acid, Citric Acid, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer-2, Hydrolyzed Sodium Hyaluronate, Centella Asiatica Extract, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Water
Water
Skin ConditioningButylene Glycol
HumectantGlycerin
HumectantPentylene Glycol
Skin ConditioningHydrogenated Lecithin
EmulsifyingPhytosterols
Skin ConditioningCeramide Ng
Skin ConditioningCeramide AP
Skin ConditioningCeramide Ag
HumectantCeramide NP
Skin ConditioningCeramide EOP
Skin ConditioningTaurine
BufferingLysine Hcl
Skin ConditioningAlanine
MaskingHistidine Hcl
Skin ConditioningArginine
MaskingSerine
MaskingProline
Skin ConditioningGlutamic Acid
HumectantThreonine
Valine
MaskingLeucine
Skin ConditioningGlycine
BufferingAllantoin
Skin ConditioningIsoleucine
Skin ConditioningPhenylalanine
MaskingSodium Acetylated Hyaluronate
HumectantSodium Hyaluronate
HumectantSodium Hyaluronate Crosspolymer-2
HumectantHydrolyzed Sodium Hyaluronate
Skin ConditioningMelaleuca Alternifolia Leaf Extract
PerfumingCentella Asiatica Extract
CleansingScutellaria Baicalensis Root Extract
AstringentPolygonum Cuspidatum Root Extract
AntioxidantGlycyrrhiza Glabra Root Extract
BleachingCamellia Sinensis Leaf Extract
AntimicrobialRosmarinus Officinalis Leaf Extract
AntimicrobialChamomilla Recutita Flower Extract
MaskingXanthan Gum
EmulsifyingEthylhexylglycerin
Skin Conditioning1,2-Hexanediol
Skin ConditioningPhenoxyethanol
PreservativeWater, Butylene Glycol, Glycerin, Pentylene Glycol, Hydrogenated Lecithin, Phytosterols, Ceramide Ng, Ceramide AP, Ceramide Ag, Ceramide NP, Ceramide EOP, Taurine, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Allantoin, Isoleucine, Phenylalanine, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer-2, Hydrolyzed Sodium Hyaluronate, Melaleuca Alternifolia Leaf Extract, Centella Asiatica Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Glycyrrhiza Glabra Root Extract, Camellia Sinensis Leaf Extract, Rosmarinus Officinalis Leaf Extract, Chamomilla Recutita Flower Extract, Xanthan Gum, Ethylhexylglycerin, 1,2-Hexanediol, Phenoxyethanol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCentella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
Here is the short version of what they do in the skin:
So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
Centella is one of the most easygoing actives out there.
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
But as with any new active, a patch test is still a smart move for very reactive skin.
Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).
In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.
Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.
Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.
Learn more about Centella Asiatica ExtractEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinHydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Learn more about Hydrogenated LecithinThis ingredient is created by putting sodium hyaluronate through hydrolysis.
You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.
According to studies, low molecular-weight hyaluronic acid can:
One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.
Hydrolysis is a process of changing a molecule using water or enzymes.
This ingredient is water-soluble.
Learn more about Hydrolyzed Sodium HyaluronatePentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolPhytosterols are plant-derived sterols (you can think of them as the plant world's version of cholesterol). In cosmetics, this ingredient is usually sourced from soybean, rice bran, shea, sunflower, and other seed oils.
The main actors in this group are β-sitosterol, campesterol, and stigmasterol (the CIR covers 27 phytosterols).
They work by fitting perfectly into your stratum corneum's lipid matrix since they're structurally similar to cholesterol. Here, they reinforce your skin's barrier.
One small in vivo human study showed topical soybean phytosterols sped up barrier recovery within three days on tape-stripped skin.
Broader research credits them with:
Formulation use typically sit under 5%.
Testing in soy-allergic subjects found no sensitization signals, but be sure to patch test if you are unsure or have existing allergies.
Learn more about PhytosterolsSodium Acetylated Hyaluronate is a type of Hyaluronic Acid.
Hyaluronic Acids help moisturize, soothe, and protect the skin.
Read about common types of Hyaluronic Acid here:
Learn more about Sodium Acetylated HyaluronateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWe don't have a description for Sodium Hyaluronate Crosspolymer-2 yet.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water