Paula's Choice CellularYouth Longevity Serum
A serum with 40 ingredients, including exfoliants and peptides.
Overview
What it is
Serum with 40 ingredients that contains exfoliants and peptides
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for dry skin, sensitive skin and scar healing
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, parabens or sulfates
Fun facts
Paula's Choice is from United States. This product is used in 38 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningPropanediol
SolventGlycerin
HumectantTriheptanoin
Skin ConditioningMethyl Gluceth-20
HumectantSimmondsia Chinensis Seed Oil
EmollientTridecyl Trimellitate
EmollientMaltodextrin
Absorbent1,2-Hexanediol
Skin ConditioningDimethicone
EmollientTaurine
BufferingBacillus Ferment
Skin ConditioningGanoderma Lucidum Stem Extract
Skin ConditioningHelianthus Annuus Sprout Extract
Skin ConditioningLycium Barbarum Fruit Extract
AstringentAcetyl Tetrapeptide-2
Skin ConditioningIsomalt
HumectantCoco-Caprylate/Caprate
EmollientHydroxyacetophenone
AntioxidantHydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion StabilisingC9-12 Alkane
SolventDilinoleic Acid/Butanediol Copolymer
Glyceryl Behenate
EmollientPolyglyceryl-6 Octastearate
EmulsifyingSodium Phytate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion StabilisingPotassium Chloride
Acacia Senegal Gum
MaskingXanthan Gum
EmulsifyingPolysorbate 60
EmulsifyingSorbitan Isostearate
EmulsifyingSynthetic Fluorphlogopite
Caprylyl Glycol
EmollientCitric Acid
BufferingCastor Oil/Ipdi Copolymer
Lecithin
EmollientCyanocobalamin
Skin ConditioningTin Oxide
AbrasiveCI 77491
Cosmetic ColorantCI 77891
Cosmetic ColorantWater, Propanediol, Glycerin, Triheptanoin, Methyl Gluceth-20, Simmondsia Chinensis Seed Oil, Tridecyl Trimellitate, Maltodextrin, 1,2-Hexanediol, Dimethicone, Taurine, Bacillus Ferment, Ganoderma Lucidum Stem Extract, Helianthus Annuus Sprout Extract, Lycium Barbarum Fruit Extract, Acetyl Tetrapeptide-2, Isomalt, Coco-Caprylate/Caprate, Hydroxyacetophenone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C9-12 Alkane, Dilinoleic Acid/Butanediol Copolymer, Glyceryl Behenate, Polyglyceryl-6 Octastearate, Sodium Phytate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Potassium Chloride, Acacia Senegal Gum, Xanthan Gum, Polysorbate 60, Sorbitan Isostearate, Synthetic Fluorphlogopite, Caprylyl Glycol, Citric Acid, Castor Oil/Ipdi Copolymer, Lecithin, Cyanocobalamin, Tin Oxide, CI 77491, CI 77891
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.ย
Itโs often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinWe don't have a description for Triheptanoin yet.
Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.
It is created by combining polyethylene glycol with glucose.
Jojoba oil is one of the most well-studied plant-derived ingredients in cosmetics. It is an emollient with a special structure.
Because it is made up of 97-98% wax esters, it closely mirrors the linear monoesters found in human sebum. This makes it skin compatible, non-greasy, and lightweight.
Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.
Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).
Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.
Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.
Fungal acne: The Malassezia yeast is known to metabolize fatty acids in the C11-24 range and jojoba's dominant fatty acid components fall into this range. This ingredient may not be fungal acne safe.
Learn more about Simmondsia Chinensis Seed OilTridecyl Trimellitate is a synthetic ingredient with emollient and skin conditioning properties. It also acts as a texture enhancer and helps products spread easily without feeling greasy.
As an emollient, it forms a light layer on the skin that keeps moisture in and improves water resistance. This is why you'll often find this ingredient in eye creams and other rich treatments.
This ingredient is seen as the elegant alternative to mineral oil.
Learn more about Tridecyl TrimellitateMaltodextrin is a polysaccharide. It is derived from starch such as rice, corn, wheat, or potato starch.
In food, Maltodextrin is used to improve the texture and thicken a product. Due to its structure, it can help create a gel texture. As an emulsion stabilizer, it helps keep the ingredients in a product together.
As a polysaccharide, Maltodextrin has moisturizing properties. Polysaccharides are a type of carbohydrate. The top layer of skin uses polysaccharides to retain water, keeping the skin hydrated.
Maltodextrin is water soluble and has a sweet taste.
Learn more about Maltodextrin1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.ย
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservativesย
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeTaurine is an amino acid that is found in human skin as an osmolyte. An osmolyte is a small molecule that cells use to hold onto water and stay comfortable under stressful conditions.
In skin cell studies, taurine accumulation helps cells maintain hydration in low-humidity environments. Some dermatology research on osmolytes also link taurine to barrier support. Research also suggests that osomolyte systems can be disrupted in photoaged skin.
One animal study reported tropical taurine improved barrier function and collagen signaling, while another one found oral taurine can lessen UVB-related damage. It is important to note that evidence for taurine in skincare is mostly preclinical, meaning further studies are needed.
Learn more about TaurineBacillus Ferment is created by fermenting Bacillus bacteria with yeast extract and carbohydrates. It acts as a humectant and, depending on the strain, can also provide gentle enzymatic exfoliation.
Depending on the strain and formulation, it may also act as a peptide, probiotic, or prebiotic. Certain strains of Bacillus Ferment help support the skinโs microbiome, soothe inflammation, and promote barrier repair and hydration.
Itโs typically used at 0.5-5% concentration, either for mild exfoliation or to improve overall skin health and texture.
Some studies show that Bacillus species can inhibit certain plant fungi (such as Fusarium verticillioides and Fusarium oxysporum) used in agricultural biocontrol. However, these are filamentous molds, not the yeast (Malassezia furfur) responsible for fungal acne.
At this time, there are no studies showing that Bacillus Ferment inhibits Malassezia or that it has been tested on human skin or in cosmetic formulations. Because of this lack of cosmetic and dermatological research, we list Bacillus Ferment as not safe for fungal acne as a precaution. However, it may not trigger breakouts for everyone.
Learn more about Bacillus FermentThis ingredient is the stem of the Reishi mushroom.
The Reishi mushroom has antioxidant, anti-inflammatory, and antimicrobial properties.
This is due to its content of terpenoids, polysaccharides, macronutrients, and phenolic acids.
Learn more about Ganoderma Lucidum Stem ExtractWe don't have a description for Helianthus Annuus Sprout Extract yet.
Lycium Barbarum Fruit Extract comes from the Goji Berry. Goji berries are native to China and can be found across Eurasia.
Goji berries contain polysaccharides, carotenoids and flavonoids. Antioxidants help your body fight off free-radical molecules. These molecules are unstable and may damage your skin. By making free-radicals more stable, antioxidants can help with anti-aging.
Polysaccharides help hydrate the top layer of skin due to its ability to mimic natural carbohydrates.
Learn more about Lycium Barbarum Fruit ExtractThis peptide is more commonly known as Thymulen 4 BG.
It is derived from a youth hormone called thymopoietin. Thymopoietin helps regulate the immune system and decreases naturally with age.
According to the manufacturer, this peptide boosts the skin's immune defenses and regenerates the outer layers of skin.
Learn more about Acetyl Tetrapeptide-2We don't have a description for Isomalt yet.
Coco-Caprylate/Caprate is a lightweight ester created from coconut oil fatty acids, caprylic acid, and capric acid.
It is an emollient that helps soften skin and reduce transepidermal water loss (TEWL). What sets it apart from heavier emollients is its ultralight, non-greasy feel.
Once applied, this ingredient dries down quickly and leaves a dry, silky finish behind. This also helps improve spreadability and texture.
This ingredient has an excellent safety-record and is non-irritating.
Typical concentrations for cosmetics range from 0.5-62%.
Research on Malassezia growth found no growth on fatty acid esters with chain lengths shorter than 12 carbons (it prefers C11-24).
Since Coco-Caprylate/Caprate is built on C8 and C10 fatty acids, it is out of the range that Malassezia metabolizes, and therefore safe for fungal acne.
Learn more about Coco-Caprylate/CaprateHydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.
Though naturally occuring in Norwegian spruce needles, this ingredient is usually synthetically created.
This ingredient is not irritating or sensitizing. Recent research also suggests it may have skin-brightening effects through tyrosinase inhibition.
Learn more about HydroxyacetophenoneThis is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
C9-12 Alkane is synethically created using alkanes, or paraffins. It is added to products as a solvent. This means its main purpose is to help dissolve ingredients and create even texture.
We don't have a description for Dilinoleic Acid/Butanediol Copolymer yet.
Glyceryl Behenate is an emollient and emulsifier.
It has a lipophilic-hydrophilic structure that lets it sit at the oil-water interface to keep emulsions stable while leaving skin feeling soft and smooth.
In pressed powder cosmetics, it double as a compacting agent.
This ingredient can be synthetically created or plant-derived. Safety-wise, it has a solid track record.
One thing to flag for fungal acne: since this ingredient is the monoester of behenic acid (C22), it falls within the C11-24 range that Malassezia can metabolize.
Learn more about Glyceryl BehenateWe don't have a description for Polyglyceryl-6 Octastearate yet.
Sodium Phytate is the synthetic salt form of phytic acid. Phytic acid is an antioxidant and can be found in plant seeds.
Sodium Phytate is a chelating agent. Chelating agents help prevent metals from binding to water. This helps stabilize the ingredients and the product.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Learn more about Acrylates/C10-30 Alkyl Acrylate CrosspolymerWe don't have a description for Potassium Chloride yet.
Acacia Senegal Gum has skin soothing, thickening, and formulation stabilizing properties. It comes from the Acacia tree that is native to sub-Saharan Africa.
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumPolysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Learn more about Polysorbate 60Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Learn more about Sorbitan IsostearateSynthetic Fluorphlogopite is the synthethic version of mica. It consists of fluorine, aluminum and silicate.
Synthetic Fluorphlogopite is used to add volume to products.
It is considered non-irritating on the skin.
Learn more about Synthetic FluorphlogopiteCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidCastor Oil/Ipdi Copolymer is an oil and isn't fungal acne safe.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinCyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.
Tin Oxide is an inorganic oxide used to add opacity and volume to a product. In nature, it is already found in mineral form. The main ore of tin is an opaque and shiny mineral called casseterite.
Tin Oxide helps remove translucency in a product, or make it more opaque. Besides adding opacity, tin oxide is used for bulking to add volume.
Ci 77491 is also hydrated iron III oxide. It's sole purpose is to give a red/pink hue to products.
Iron III oxides are classified as inorganic chemicals for coloring.
Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.
Learn more about CI 77491Ci 77891 is a white pigment from Titanium dioxide. It is naturally found in minerals such as rutile and ilmenite.
It's main function is to add a white color to cosmetics. It can also be mixed with other colors to create different shades.
Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.
Learn more about CI 77891Reviews
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Where it's from
Paula's Choice is a American brand
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We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about usยท Updated December 2, 2025 • Added by anemone