The True Therapy PHA Gluconolactone Face Toner Versus Dr. Sheth's Medifacial @ Home High Strength Peel
This smoothing toner is formulated around Gluconolactone and Panthenol to refine skin texture and brighten dull-looking skin.
This wash off mask is formulated around Glycolic Acid to exfoliate and smooth skin.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGluconolactone
Skin ConditioningSodium Hyaluronate
HumectantPanthenol
Skin ConditioningGlycerin
HumectantLactic Acid
BufferingSodium Lactate
BufferingPropanediol
SolventLysine
Skin ConditioningHistidine
HumectantArginine
MaskingAspartic Acid
MaskingTocopherol
AntioxidantThreonine
Serine
MaskingGlutamic Acid
HumectantProline
Skin ConditioningGlycine
BufferingAlanine
MaskingValine
MaskingMethionine
Skin ConditioningIsoleucine
Skin ConditioningLeucine
Skin ConditioningTyrosine
MaskingPhenylalanine
MaskingCysteine
AntioxidantCichorium Intybus Extract
Skin ConditioningSalix Alba Extract
Skin ConditioningAloe Barbadensis Leaf Extract
EmollientXylitol
HumectantErythritol
HumectantMaltitol
HumectantTrehalose
HumectantTriethanolamine
BufferingEthylhexylglycerin
Skin ConditioningXanthan Gum
EmulsifyingPhenoxyethanol
PreservativeSodium Gluconate
Skin ConditioningDisodium EDTA
Water, Gluconolactone, Sodium Hyaluronate, Panthenol, Glycerin, Lactic Acid, Sodium Lactate, Propanediol, Lysine, Histidine, Arginine, Aspartic Acid, Tocopherol, Threonine, Serine, Glutamic Acid, Proline, Glycine, Alanine, Valine, Methionine, Isoleucine, Leucine, Tyrosine, Phenylalanine, Cysteine, Cichorium Intybus Extract, Salix Alba Extract, Aloe Barbadensis Leaf Extract, Xylitol, Erythritol, Maltitol, Trehalose, Triethanolamine, Ethylhexylglycerin, Xanthan Gum, Phenoxyethanol, Sodium Gluconate, Disodium EDTA
Water
Skin ConditioningGlycolic Acid
BufferingLactic Acid
BufferingMandelic Acid
AntimicrobialGluconolactone
Skin ConditioningAloe Barbadensis Leaf Juice
Skin ConditioningPropylene Glycol
HumectantPolyacrylate Crosspolymer-6
Emulsion StabilisingSodium Hydroxide
BufferingSalicylic Acid
MaskingGlycerin
HumectantTasmannia Lanceolata Fruit Extract
Skin ConditioningSyzygium Luehmannii Fruit Extract
AntioxidantKunzea Pomifera Fruit Extract
Skin ConditioningPyrus Malus Fruit Extract
Skin ConditioningSalix Alba Bark Extract
AstringentCitrus Junos Fruit Extract
Skin ConditioningPanthenol
Skin ConditioningVaccinium Angustifolium Fruit Extract
Skin ProtectingSodium Hyaluronate
HumectantXanthan Gum
EmulsifyingPhenoxyethanol
PreservativeChlorphenesin
AntimicrobialSodium Benzoate
MaskingDisodium EDTA
Water, Glycolic Acid, Lactic Acid, Mandelic Acid, Gluconolactone, Aloe Barbadensis Leaf Juice, Propylene Glycol, Polyacrylate Crosspolymer-6, Sodium Hydroxide, Salicylic Acid, Glycerin, Tasmannia Lanceolata Fruit Extract, Syzygium Luehmannii Fruit Extract, Kunzea Pomifera Fruit Extract, Pyrus Malus Fruit Extract, Salix Alba Bark Extract, Citrus Junos Fruit Extract, Panthenol, Vaccinium Angustifolium Fruit Extract, Sodium Hyaluronate, Xanthan Gum, Phenoxyethanol, Chlorphenesin, Sodium Benzoate, Disodium EDTA
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.
When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.
PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.
Gluconolactone has some interesting properties:
In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.
This ingredient is is an created by reacting gluconic acid with an alcohol.
Learn more about GluconolactoneGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinLactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Learn more about Lactic AcidPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan Gum