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Updated on July 18, 2023

Overview

What they are

These products are both cruelty-free and reef safe serums. They have a total of 14 ingredients in common

Cool Features

They both contain ceramides, hyaluronic acid, niacinamide, peptides and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, oils, parabens or silicones

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

cyrene Bifida Night Repair Serum
DRMTLGY Needle-Less Serum
DRMTLGY Needle-Less Serum
Serum
American Brand United States

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Notable Ingredients

Benefits

Ingredients Side-by-side

found in both products
Bifida Night Repair Serum
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Bifida Ferment Lysate Skin Conditioning
Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Hydrolyzed Yeast Protein Skin Conditioning

We don't have a description for Hydrolyzed Yeast Protein.

Unknown Full details ->
Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Pentylene Glycol Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

Palmitoyl Tripeptide-1 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tetrapeptide-7 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Beta-Glucan Skin Conditioning
Helps reduce Skin Redness Icon
Helps reduce Skin RednessHelps reduce Skin Redness Icon

Beta-Glucan is a polysaccharide. It can be derived from the cell walls of seaweed, oats, yeast, and fungi.

Anthemis Nobilis Flower Extract Masking, Perfuming, Skin Conditioning
Fragrance Icon
FragranceFragrance Icon

Anthemis Nobilis Flower Extract is from the Roman Chamomile flower.

Olea Europaea Leaf Extract Perfuming, Skin Conditioning
Fragrance Icon
FragranceFragrance Icon

Olea Europaea Leaf Extract is a fragrance.

Niacinamide Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconGood for Minimizing Pores IconGood for Dark Spots IconHelps fight Acne IconHelps brighten skin Icon
NiacinamideNiacinamide Icon 6 Benefits

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Caffeine Skin Conditioning

Caffeine is most associated with coffee, tea, and cacao. In skincare, it helps with calming inflammation and anti-aging.

Bisabolol Masking, Skin Conditioning, Soothing
Helps reduce irritation Icon
Helps reduce irritationHelps reduce irritation Icon

Bisabolol is pimarily used to add fragrance to a product. However, it is also famous for helping soothe skin.

Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Sodium Polyacrylate Absorbent, Emollient, Emulsion Stabilising

Sodium Polyacrylate is the sodium salt of polyacrylic acid.

Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon Helps brighten skinHelps brighten skin Icon

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Ceramide NP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide NP is a type of ceramide.

Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Ethylhexylglycerin Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

Polysorbate 20 Emulsifying
0 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

0 Com. / 0 Irr.
Very Disliked Full details ->
Aloe Barbadensis Leaf Juice Skin Conditioning
Helps reduce Skin Redness IconHelps reduce irritation Icon
2 Benefits

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

Needle-Less Serum
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Sodium Chondroitin Sulfate Skin Conditioning
Sulfate Icon
SulfateSulfate Icon

Sodium Chondroitin Sulfate is a type of sulfate.

Unknown Full details ->
Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon
Hyaluronic AcidHyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Pisum Sativum Extract Skin Conditioning, Skin Protecting

We don't have a description for Pisum Sativum Extract.

Bambusa Vulgaris Leaf/Stem Extract Humectant

Bambusa Vulgaris Leaf/Stem Extract comes from bamboo plant.

Palmitoyl Tripeptide-1 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tetrapeptide-7 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

Ceramide EOP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide EOP is a type of Ceramide.

Glucosamine Hcl

We don't have a description for Glucosamine Hcl.

Glycosaminoglycans Emollient, Skin Conditioning

We don't have a description for Glycosaminoglycans.

Unknown Full details ->
Ceramide NP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide NP is a type of ceramide.

Palmitoyl Tripeptide-5 Skin Conditioning
Peptide IconNot safe for Fungal Acne Icon
PeptidePeptide Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Palmitoyl Tripeptide-5 isn't fungal acne safe and is a peptide.

Ceramide AP Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconHelps with Anti-Aging Icon
CeramideCeramide Icon 4 Benefits

Ceramide AP is a type of Ceramide.

Phytosphingosine Skin Conditioning

Phytosphingosine is a phospholipid naturally found in our skin. It helps moisturize, soothe, and protect skin.

Cholesterol Emollient, Emulsifying, Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness Icon
2 Benefits

Cholesterol is a class of organic molecules called lipids. It helps hydrate your skin and is essential to having a healthy skin barrier.

0 Com. / 0 Irr.
Niacinamide Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconGood for Minimizing Pores IconGood for Dark Spots IconHelps fight Acne IconHelps brighten skin Icon
NiacinamideNiacinamide Icon 6 Benefits

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Sodium Lauroyl Lactylate Emulsifying

Sodium Lauroyl Lactylate is the lauric acid sodium salt of lactyl lactate.

Methylglucoside Phosphate Skin Conditioning

We don't have a description for Methylglucoside Phosphate.

Unknown Full details ->
Copper Lysinate/Prolinate Skin Conditioning

We don't have a description for Copper Lysinate/Prolinate.

Unknown Full details ->
Panthenol Skin Conditioning
0 / 0 Helps reduce irritation Icon
Helps reduce irritationHelps reduce irritation Icon

Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.

0 Com. / 0 Irr.
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0 Vitamin E IconAntioxidant IconHelps brighten skin Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon Helps brighten skinHelps brighten skin Icon

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Phenoxyethanol Preservative
Preservative Icon
PreservativePreservative Icon

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Polysorbate 20 Emulsifying
0 / 0 Not safe for Fungal Acne Icon
Not safe for Fungal AcneNot safe for Fungal Acne Icon

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

0 Com. / 0 Irr.
Very Disliked Full details ->
Ethylhexylglycerin Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Masking, Skin Conditioning
Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Skin Conditioning
Liked

Palmitoyl Tripeptide-1 is a 3-amino acid peptide. Peptides are building blocks for protein.

Palmitoyl Tripeptide-1 is a signal peptide. This means it tells our skin to create collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Palmitoyl Tripeptide-1 can help reduce wrinkles and make the skin look more youthful.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tripeptide-1
Skin Conditioning
Liked

Palmitoyl Tetrapeptide-7 is a peptide. Peptides are building blocks for protein.

This ingredient consists of four amino acids and palmitic acid. These amino acids are arginine, proline, glutamine, and glycine.

This ingredient has many benefits. These benefits include boosting collagen production, fighting inflammation, and reversing UV damage.

By preventing our bodies from producing interleukins, Palmitoyl Tetrapeptide-7 helps fight inflammation. An interleukin is a chemical that signals to the body to produce an inflammatory response. Interleukin production is accelerated by UV radiation.

Palmitoyl Tetrapeptide-7 tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Palmitoyl Tetrapeptide-7
Humectant, Skin Conditioning
Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Smoothing
Loved

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Antioxidant, Skin Conditioning
Liked

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Learn more about Tocopheryl Acetate
Skin Conditioning
Loved

Ceramide NP is a type of ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here: Ceramide AP Ceramide EOP

Learn more about Ceramide NP
Emulsion Stabilising, Gel Forming
Disliked

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

Carbomer is commonly found in many types of cosmetics products. It is found to be safe in concentrations up to 15%. However, a high amount of carbomer can cause pilling or balling up of products. Most products contain 1% of less of carbomer.

Emulsifying, Emulsion Stabilising, Gel Forming
Disliked

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Learn more about Xanthan Gum
Preservative
Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Skin Conditioning
Mixed

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Emulsifying
Very Disliked

Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.

As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.

Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.

The lauric acid used to create Polysorbate 20 is often derived from coconuts.

Polysorbate 20 may not be fungal acne safe.

Learn more about Polysorbate 20

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

Bifida Night Repair Serum
14
6
4
1
liked
mixed
disliked
not rated
Needle-Less Serum
17
3
5
4
liked
mixed
disliked
not rated

When to use

124 Routines
44% use in am
56% use in pm
97% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

cyrene Bifida Night Repair Serum 25 ingredients

Bifida Night Repair Serum hasn't been rated yet.
Rate it now

DRMTLGY Needle-Less Serum 29 ingredients

5.0 /5
from 2 ratings
Works Well (1)
MalloryZirpel_678's avatar

MalloryZirpel_678

8 months ago · Dry Skin
Review

Helps with fine lines

mandilou79's avatar

mandilou79

1 month ago · Dry Skin
Review

Love it