Bioderma Photoderm XDefense Ultra-Fluid SPF 50+ Invisible Versus Derma Lab Vitamin E Serum Sunscreen SPF 50 PA+++
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningC12-15 Alkyl Benzoate
AntimicrobialSilica
AbrasiveGlycerin
HumectantBis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Skin ConditioningButyl Methoxydibenzoylmethane
UV AbsorberEthylhexyl Methoxycrylene
Skin ConditioningDiethylamino Hydroxybenzoyl Hexyl Benzoate
UV FilterDiisopropyl Sebacate
EmollientLauroyl Lysine
Skin ConditioningPropanediol
SolventDicaprylyl Carbonate
Emollient1,2-Hexanediol
Skin ConditioningPolysorbate 60
EmulsifyingCetyl Phosphate
EmulsifyingArginine
MaskingBentonite
AbsorbentHydroxyacetophenone
AntioxidantParfum
MaskingCitric Acid
BufferingEctoin
Skin ConditioningMannitol
HumectantMethoxyphenylimino Dimethylcyclohexene Glycine
AntioxidantSodium Phytate
Xanthan Gum
EmulsifyingXylitol
HumectantRhamnose
HumectantO-Cymen-5-Ol
AntimicrobialBiosaccharide Gum-4
Skin ConditioningTrimethoxybenzyl Acetylsinapate
BleachingSodium Hyaluronate
HumectantTocopherol
AntioxidantWater, C12-15 Alkyl Benzoate, Silica, Glycerin, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycrylene, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Diisopropyl Sebacate, Lauroyl Lysine, Propanediol, Dicaprylyl Carbonate, 1,2-Hexanediol, Polysorbate 60, Cetyl Phosphate, Arginine, Bentonite, Hydroxyacetophenone, Parfum, Citric Acid, Ectoin, Mannitol, Methoxyphenylimino Dimethylcyclohexene Glycine, Sodium Phytate, Xanthan Gum, Xylitol, Rhamnose, O-Cymen-5-Ol, Biosaccharide Gum-4, Trimethoxybenzyl Acetylsinapate, Sodium Hyaluronate, Tocopherol
Water
Skin ConditioningButylene Glycol
HumectantC12-15 Alkyl Benzoate
AntimicrobialEthylhexyl Methoxycinnamate
UV AbsorberDiethylamino Hydroxybenzoyl Hexyl Benzoate
UV FilterBis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Skin ConditioningDimethicone
EmollientCyclopentasiloxane
EmollientTitanium Dioxide
Cosmetic ColorantSilica
AbrasiveCyclohexasiloxane
EmollientEthylhexyl Triazone
UV AbsorberPolyacrylate-13
Aluminum Stearate
Cosmetic ColorantAlumina
AbrasivePolyhydroxystearic Acid
EmulsifyingGlycerin
HumectantCarbomer
Emulsion StabilisingTocopheryl Acetate
AntioxidantAloe Barbadensis Leaf Extract
EmollientPEG-7 Glyceryl Cocoate
EmulsifyingCeramide NP
Skin ConditioningOphiopogon Japonicus Root Extract
Skin ConditioningEthyl Linoleate
EmollientDisodium EDTA
Phenoxyethanol
PreservativeChlorphenesin
AntimicrobialWater, Butylene Glycol, C12-15 Alkyl Benzoate, Ethylhexyl Methoxycinnamate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Dimethicone, Cyclopentasiloxane, Titanium Dioxide, Silica, Cyclohexasiloxane, Ethylhexyl Triazone, Polyacrylate-13, Aluminum Stearate, Alumina, Polyhydroxystearic Acid, Glycerin, Carbomer, Tocopheryl Acetate, Aloe Barbadensis Leaf Extract, PEG-7 Glyceryl Cocoate, Ceramide NP, Ophiopogon Japonicus Root Extract, Ethyl Linoleate, Disodium EDTA, Phenoxyethanol, Chlorphenesin
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
This ingredient is better known as bemotrizinol or Tinosorb S and is one of the best broad-spectrum UV filters in modern sunscreen.
It works by absorbing UV light across a whole range (280-400 nm) with peaks around 310 nm (UVB) and 340-345 nm (UVA). This means it covers UVB plus the deeper UVA wavelengths that drive photoaging and pigmentation.
Another pro?
It's exceptionally photostable, barely degrades in sunlight, and acts as a "bodyguard" for less stable filters.
That's why you'll see it paired with avobenzone or octinoxate; this team up ensures they keep working through sun exposure.
Safety reviews have been reassuring across the board. This ingredient shows low absorption through the skin, rarely irritates, and lab studies found it doesn't act like a hormone in the body (a concern that's been raised about some older sunscreen filters).
On maximum concentrations:
In 2026, the US F.D.A finally added it as an OTC sunscreen ingredient at concentrations up to 6% for adults / children 6 months and older
Learn more about Bis-Ethylhexyloxyphenol Methoxyphenyl TriazineC12-15 Alkyl Benzoate is a lightweight emollient made by combinig benzoic acid with fatty alcohols that are 12-15 carbons long.
In cosmetics, it plays several roles:
The Cosmetic Review Expert Panel has concluded the alkyl benzoate group to be safe as used in cosmetics; it wasn't found to be a skin irritant and unlikely to be absorbed due to its low water solubility.
This report recorded almost 1000 reported uses with concentrations up to 59% in leave-on products but your cosmetics will typically use 0.5-15% depending on the product.
It's often called a "SPF booster": this is because it keeps UV filters properly dissolved and evenly distributed to support a sunscreen's performance. It doesn't actually raise SPF on its own.
Overall, this ingredient is well tolerated.
This ingredient is fungal acne safe.
The Malassezia yeast feeds on free fatty acids and this ingredient is made up of an aromatic acid and fatty alcohols.
When this ingredient breaks down, it yields benzoic acid (which is antifungal) and fatty alcohols. Neither of these have been found in studies to be a known food source for Malassezia.
Learn more about C12-15 Alkyl BenzoateDiethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) is a chemical UV-A absorber. It is formulated for high UVA protection (320-400 nm).
DHHB is well-liked for:
DHHB has been approved by the EU, Japan, Taiwan, and South America for use up to 10%. Unfortunately, it has not been approved for use in the US or Canada due to slow regulatory processes.
This ingredient is soluble in oils, fats, and lipids.
Learn more about Diethylamino Hydroxybenzoyl Hexyl BenzoateGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSilica, also known as silicon dioxide, is a naturally occurring mineral. It is used as a fine, spherical, and porous powder in cosmetics.
Though it has exfoliant properties, the function of silica varies depending on the product.
The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.
It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.
In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.
Learn more about SilicaWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water